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CM-Path Network Development
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What is CM-Path?
• Severe decline in the number of clinical academic pathologists over the past 15 years compared with other
clinical academic specialties
• Increasing need for molecular testing within the NHS
- New technologies
- New skills required
- Pathology capacity
• Disconnect between pathology research, clinical practice and industry
What is CM-Path?
CM-Path Executive Group
Skills and capacity
Clinical trials DiscoveryTechnology and
information
Input from
trial
designers
and funders
Input from
patients and
public
Supporting
Trainees
Engaging
with wider
initiatives
Patient and
Public
Engagement
Biosample
Consent
Cross-cutting themes
Louise Jones Abeer Shaaban Gareth Thomas Clare Verrill
Karin Oien (Chair), Andy Hall (Deputy Chair)
CM-Path Vision: Working Together
Cancer Research UK Stratified Medicine Programme
CRUK Accelerator Awards
MRC/EPSRC Molecular Pathology Nodes
Genomics England and related
Exemplar trials e.g. SMP2/Matrix
Supporting clinical trials and
tissue-based research
Coordinating new approaches
to diagnosis
Pathology
research across
NHS, academia and industry
MRC Nodes
CRUK Accelerators
NCRI
CSGsGenomics England
CRUK Strat Med
CM-Path
Clinical Trials
Academic training
Biobanking
Biomarker Research
Technology &
innovation
CCB/UKCRC
Sanger Institute
PathSoc
RCPath
NC3RMolecular pathology
CM-Path Vision: Working Together
The ambition:
A UK-wide network of CM-Path ‘badged’ pathology centres
The purpose/objectives:
• Help establish UK-wide best practice for molecular
testing across the UK
• Support pathology centres to engage in research-based
activities: biobanking, clinical trials, tissue-based
research
• Support academic training and development
CM-Path NetworkNetwork
Anatomical clinical-molecular dimension of pathology
Salto-Tellez M. Clinical Chemistry 2007 Jul;53(7):1188-90
Clinical Medicine
Traditional Pathology
Molecular
Pathology
(Molecular
Diagnostics)
1. The future of modern medicine will be dictated by technical advancement, management advancements, and
advancements in molecular medicine – stratified medicine
2. Molecular Diagnostics in the fastest growing area in modern medicine
Changing the way we handle human tissues
• Optimal fixation for immunohistochemistry
• Routine handling of fresh tissue
• Optimal tissue selection for molecular analysis
• Better regional/ national standardisation
• Biobanking – a focus on tissue quality
• Engagement with industrial partners
100,000 Genomes Project
Transformational project
• Rare genetic diseases
• Cancer samples
• Fresh samples 5 x 5 x 5mm
• Cellularity score (EQA)
• Consent by Genomic staff
• HRA/HTA statement April 2017
Handling the tissues
• WGS - formalin fragments the DNA
• Eliminating formalin from theatres
• Small diagnostic biopsies best in 10% NBF
• Training staff to sample fresh tissue
• Fresh tissue can be stored at 4oC for ? *
• Maintenance at 4oC during transport
• Recording time of removal and arrival
* Currently under discussion
CM-Path Network: An Inclusive NetworkNetwork
CM-Path Network Requirements
• Named CM-Path representative in each department
• Best practice guidelines for molecular testing
• SOPs for tissue processing re genomics (fixation times etc.)
• Judging tumour content/quality
• Pathway for frozen tissue analysis/collection
CM-Path Network Aspirations
• Research/ training activities
• SOP for releasing tissues for research
• Accessing diagnostic archives for research – creating research biobanks
• Training/research opportunities – workshops, meetings, grants, directory
What will you get for signing up to the CM-Path NetworkNetwork
• Add your name to the pathology directory – become involved in research
• contact departments/fellow pathologists for advice
• Advice on obtaining research funding
• Check out information on training courses, workshops, funding opportunities and
more
• See case studies from fellow pathologists
• Check out our academic roadmap and advice on training
• Download and utilise our SOPs for best practice guidelines for molecular testing,
tissue processing re genomics (fixation times etc.), judging tumour content/quality,
pathway for frozen tissue analysis/collection
• Routinely updated SOPs based on changes in pathology practice
• Quarterly newsletter – linking you to CM-Path activity, opinion pieces, workshops,
training, opportunities to input into calls for information
• Opportunity to advertise specific projects
CM-Pathologists (The Pathology Directory)Network
I'm a pathologist, what will I get out of being on the directory
• Tell us your name, email, area of interest, what you might be interested in getting involved in an we can match
you up to various opportunities/you may be contacted by various people to get involved with projects or
scientific review committees
• Easily link up with fellow pathologists interested in research or trainees looking for projects to get involved in
I'm a research funding organisation what will I get out of using the directory:
• CM-Path encourages funding organisations that award research grants to incorporate a pathology review
• The pathology directory will help you to identify pathologists across the country that might be interested in
joining a funding committee. You will be able to see their speciality and any previous experience they might
have
I'm part of an industrial organisation or a researcher what will I get out of using the directory:
• Want to involve a pathologist in your work or need help developing a research proposal, use the directory to
more easily link yourself up to pathologists who want to be involved in research.
CM-Path Network – More ideas?Network
In the future what you will be able to access through the Network
• Cost recovery tool for tissue
• Contracts
• Business cases
• Links to CCB and CM-Path biobank network
• Case studies from pathologists involved in research
Do you have any other ideas you would like to see on the CM-Path Network – please get in touch by emailing
The Alternative
https://goo.gl/images/wh434K https://goo.gl/images/bRlhmX
Find out more about what CM-Path is doing…
cmpath.ncri.org.uk
Pathology collaborations
Pathology advice
Further information
for…