2007 FASEB Summer Research Conferences“Signal Transduction in the Immune System”

June 23-28, 2007Snowmass Village, Colorado

Chair: André Veillette, IRCM, Montreal, CanadaCo-chairs: Clifford Lowell, UCSF, San Francisco, California

andJuan Rivera, NIH, Bethesda, MD

Saturday, June 23, 2007

4:00p.m. – 9:00p.m. Conference Registration

6:00p.m. – 7:00 p.m. FASEB Opening Reception

7:00p.m. – 8:30 p.m. Dinner

8:45p.m. – 10:00p.m. Keynote speaker: Alain Fischer, INSERM 429, Hôpital Necker pour enfants malades, Paris, France“Natural mutants impairing lymphocyte signal transduction in humans”

Sunday, June 24, 2007

7:30a.m. – 9:00a.m. Breakfast

Session 1: 9:00a.m. – 12:30p.m. Immunoreceptor signaling I Chair: Arthur Weiss, UCSF, San Francisco

9:00a.m. – 9:45a.m. Andrey Shaw, Washington University School of Medicine, St.Louis, MO“Signaling in the immunological synapse”

9:45a.m. – 10:30a.m. Michael Dustin, Skirball Institute, New York, NY“A dynamic view of the immunological synapse”

10:30a.m. – 11:00a.m. Group photo and FASEB Sponsored Coffee Break

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11:00a.m. – 11:45a.m. Arthur Weiss, UCSF, San Francisco, CA“Regulation, structure and function of ZAP-70”

11:45a.m. – 12:30p.m. André Veillette, IRCM, Montreal, Quebec, Canada

“SLAM-SAP families in immune cell activation”

12:30p.m. – 1:30p.m. Lunch

Free Afternoon

4:00p.m. – 6:00p.m. Poster Session 1 (Posters #1 to #38)

6:00p.m. – 7:00p.m. Dinner

Session 2: 7:00p.m. – 10:15p.m. Immunoreceptor signaling IIChair: Susan Pierce, NIAID, NIH, Bethesda, MD

7:00p.m. – 7:45p.m. Susan Pierce, NIAID, NIH, Bethesda, MD“Viewing the initiation of B cell receptor signaling in living cells”

7:45p.m. – 8:30p.m. Michael Reth, Max-Planck-Institute for Immunobiology, Freiburg, Germany“The adaptor function of SYK during B cell activation”

8:30p.m. – 8:45p.m. Break

8:45p.m. – 9:30p.m. Tomohiro Kurosaki, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan“Roles of BCAP and BANK in B cell development and activation”

9:30p.m. – 9:50p.m. Sho Yamasaki, RIKEN, RCAI, Yokohama, Kanagawa, Japan“Differential regulation of pre-TCR- and TCR-mediated signaling”

9:50p.m. – 10:10p.m. Diane Lidke, University of New Mexico, Albuquerque, NM“Single quantum dot imaging of FcRI dynamics and topography”

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Monday, June 25, 2007

7:30a.m. – 9:00a.m. Breakfast

Session 3: 9:00a.m. – 12:15p.m. Kinases and phosphatasesChair: Doreen Cantrell, University of Dundee, Scotland, UK

9:00a.m. – 9:45a.m. Leslie Berg, University of Massachusetts, Worcester, MA“The Tec kinases Itk and Rlk regulate conventional versus innate T cell development”

9:45a.m. – 10:30a.m. Pamela Schwartzberg, NIH, Bethesda, MD “Integrating T cell signals”

10:30a.m. – 10:45a.m. FASEB Sponsored Coffee Break

10:45a.m. – 11:30a.m. Juan Rivera, NIAMS, NIH, Bethesda, MD “Lipid kinases and phosphatases in the regulation of IgE/Fc epsilon homeostasis and function”

11:30a.m. – 12:15p.m. Doreen Cantrell, University of Dundee, Scotland, UK“The role of serine kinases in lymphocytes”

12:15p.m. – 1:30p.m. Lunch

Free Afternoon

4:00p.m. – 6:00p.m. Poster Session 2 (Posters #1 to #38)

6:00p.m. – 7:00p.m. Dinner

Session 4: 7:00p.m. – 10:15p.m Lymphoid development and maintenanceChair: Rose Zamoyska, National Institute for Medical Research, London, UK

7:00p.m. - 7:45p.m. Rose Zamoyska, National Institute for Medical Research, London, UK“The influence of Src-family kinases in regulating T cell responsiveness”

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7:45p.m. – 8:30p.m. Sasha Tarakhovsky, Rockefeller University, New York, NY“Non histone protein lysine methylation”

8:30p.m. – 8:45p.m. Break

8:45p.m. – 9:30p.m. John O’Shea, NIAMS, NIH, Bethesda, MD“Cytokine signaling and new paradigms in helper/effector cell differentiation”

9:30p.m. – 9:50p.m. Celine Dumont, National Institute for Medical Research, London, United Kingdom“Critical roles of Rac1 and Rac2 small GTPases in T cell development”

9:50p.m. – 10:10p.m. Amy Andreotti, Iowa State University, Ames, IA“Tec family kinase activity and substrate recognition: insights at the molecular level”

Tuesday, June 26, 2007

7:30a.m. – 9:00a.m. Breakfast

Session 5: 9:00a.m. – 12:15p.m. Co-stimulators and inhibitorsChair: Arlene Sharpe, Brigham and Women’s Hospital, Boston, MA

9:00a.m. – 9:45a.m. Arlene Sharpe, Brigham and Women’s Hospital, Boston, MA“Roles of PD-1 and its ligands in regulating T cell activation and tolerance”

9:45a.m. – 10:30a.m. Christopher Rudd, University of Cambridge, Cambridge, UK “SLP-76 SUMOylation is central to microcluster formation and TcR-CD28 signalling in T-cells”

10:30a.m. – 10:45a.m. FASEB Sponsored Coffee Break

10:45a.m. – 11:05a.m. Martin Turner, The Babraham Institute, Cambridge, UK“Regulation of B and T cell differentiation by microRNA 155”

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11:05a.m. – 11:25a.m. Qijing Li, HHMI/Stanford University, School of Medicine, Palo Alto, CA“microRNA as an intrinsic modulator for T cell receptor sensitivity”

11:30a.m. – 11:50a.m. Louis Justement, University of Alabama at Birmingham, Birmingham, AL“HSH2 functions downstream of CD40 and BAFF-R to regulate the humoral immune response”

11:50a.m. – 12:10p.m. Stephen Bunnell, Tufts University Medical School, Boston, MA“Transient lateral interactions between distinct signaling domains are stabilized in response to VLA-4-mediated T cell co-stimulation.”

12:15p.m. – 1:30p.m. Lunch

Free Afternoon

4:00p.m. – 6:00p.m. Poster Session 3 (Posters #39 to #82)

6:00p.m. – 7:00p.m. Dinner

Session 6: 7:00p.m. – 10:15p.m Downstream effectors in immune regulationChair: Lawrence Samelson, NIH, Bethesda, MD

7:00p.m. - 7:45p.m. Lawrence Samelson, NIH, Bethesda, MD“Signaling at the TCR and the effect on calcium regulation”

7:45p.m. – 8:30p.m. Burkhart Schraven, Otto von Guericke University, Madgeburg, Germany“Molecular networks regulating TCR-mediated inside-out-signaling”

8:30p.m. – 8:45p.m. Break

8:45p.m. – 9:30p.m. Gary Koretzky, University of Pennsylvania, Philadelphia, PA

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“Regulation of Immune Cell Development and Function by the Adapter Proteins, SLP-76 and SAP”

9:30p.m. – 9:50p.m. Xiaoping Zhong, Duke University Medical Center, Durham, NC“Diacylglycerol kinases in immune cell development and function”

9:50p.m. – 10:10p.m. Masatsugu Ohora, Harvard Medical School, The CBR Institute, Boston, MA“Roles of the ER calcium sensors STIM1 and STIM2 in T cell development and function”

Wednesday, June 27, 2007

7:30a.m. – 9:00a.m. Breakfast

Session 7: 9:00a.m. – 12:15p.m. Innate immunityChair: David Raulet, University of California, Berkeley, CA

9:00a.m. – 9:45a.m. David Raulet, University of California, Berkeley, CA“Activation and tolerance of Natural Killer cells”

9:45a.m. – 10:30a.m. Wayne Yokoyama, Washington University School of Medicine, St. Louis, MO “Licensing and tolerance of Natural Killer cells”

10:30a.m. – 10:45a.m. FASEB Sponsored Coffee Break

10:45a.m. – 11:30a.m. Marco Colonna, Washington University School of Medicine, St. Louis, MO

“P110γ and p110δ PI-3K signaling pathways synergize to control development and effector functions of NK cells”

11:30a.m. – 12:15p.m. Clifford Lowell, UCSF, San Francisco, CA “Convergence of integrin and immunoreceptor signaling pathways”

12:15p.m. – 1:30p.m. Lunch

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Free Afternoon

4:00p.m. – 6:00p.m. Poster Session 4 (Posters #39 to #82)

6:00p.m. – 7:30p.m. Dinner

Session 8: 7:30p.m. – 10:45p.m Lymphoid interactions and regulationChair: Alexander Rudensky, University of Washington, Seattle, WA

7:30p.m. - 8:15p.m. Alexander Rudensky, University of Washington, Seattle, WA“Molecular and cellular mechanisms of dominant tolerance”

8:15p.m. – 9:00p.m. Federica Sallusto, Institute for Research in Biomedicine, Bellinzona, Switzerland“Central and effector memory T cells”

9:00p.m. – 9:15p.m Break

9:15p.m. – 10:00p.m. Jeffrey Ravetch, Rockefeller University, New York, NY “Inhibitory Fc receptors in immune regulation”

10:00p.m. – 10:20p.m. Weiguo Zhang, Duke University Medical Center, Durham, NC “LAT in T development, activation, and survival”

10:20p.m. – 10:40p.m Deborah Yablonski, Technion – Israel Institute of Technology, Haifa, Israel“Mechanisms of signaling by the adaptor protein, SLP-76”

Thursday, June 28, 2007

7:30a.m. – 9:00a.m. Breakfast

Session 9: 9:00a.m. – 12:15p.m. Effector functionsChair: Steven Reiner, University of Pennsylvania, Philadelphia, PA

9:00a.m. – 9:45a.m. Steven Reiner, University of Pennsylvania, Philadelphia, PA

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“Asymmetric Division of a T Lymphocyte in the initiation of adaptive immunity”

9:45a.m. – 10:30a.m. Anjana Rao, Harvard Medical School, Boston, MA

“Regulators of NFAT nuclear transport”

10:30a.m. – 10:45a.m. FASEB Sponsored Coffee Break

10:45a.m. – 11:30a.m. Michael Lenardo, NIAID, NIH, Bethesda, MD “Germline N-Ras mutation causes a human lymphoproliferative syndrome ”

11:30a.m. – 11:50a.m. Adam Mor, NYU, New York, NY“The Lymphocyte Function Associated-1 Receptor Co-stimulates Plasma Membrane Ras Via Phospholipase D2”

11:50a.m. – 12:10p.m. Wojciech Swat, Washington University School of Medicine, St. Louis, MO“DLGH1 is a negative regulator of T lymphocyte proliferation”

12:15p.m. – 1:30p.m. Box Lunches Available

END OF CONFERENCE

For additional information contact:

FASEB Summer Research Conferences9650 Rockville Pike

Bethesda, MD 20814

http://src.faseb.org

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