136 Abstracts/Lung Cancer 10 (1993) 123-150

patieotswithsmmIIcellbmgcaocer, 19Rofsubjectswitbdeamcsr&ome end not-identified long hmwr and 15 56 of patients with squamous cell long cancer. They circulated in596 ofcontrol personsonly. Tbehigbest values of their titers were observed in tbe edvancal stages of diwase. In 55% of anti-elastin antibody positive small cell lung canca patieas, antibodies were of tbe IgM type, suggesting the initial step of the autoimmunization to elastin.

Supeiorv~clrPdwtnrtioninoptientwi~ebronielplphoeytic Ieuk&atmdltq- De Mayo10 J. A.V. Sridhar KS. Kunherdt B. Rae R.K. Univ. ofMiutti School of Medicine, P. 0. Box 016960, Miami, FL 33136. Am J Clin Oncol Cancer Clii Trials, 1992;15:352-5.

A patient with cervical lymphadeuopetby -da-y to cbmoic lymphocyticI~e~e(CLL)dcveloped~utcsuperiorvauuve(SVC) obstmctioo. Poor response to chemotherapy, e history of smoking, and lobar etelectasis suggested a different dianosis. Bronchoscopy

0f tbc owti& ~rsed w OUI e~peri~ffi review of the liteatwe, we recommend that if * patient with CLL or 1 diflitse well-differentiated lymphocytic lympbome presents with or develops SVC obstruction, additional iovasive diegnostic tests mull be in&ted to exclude the possibility of a coexisteat second malignancy or

- . . P search for another diagnosis are lack of the expected response to glwocwticoids, chemothenpy, or radiation theapy.

Taoio Y, Watanetc M, Osaki T, Techibans I. Kawase I, Kuiteni T et al. Deporhnenl of Medicine III, Osoko Uniwrsity Medical School, I-I- 50, Fukwhimo. Fukushima-ku. Osaka 553. Jpo J Cancer Res 1992;83:736-45.

Three cell linea of small cell lung cancer (SCLC), which were established from specimens of untreated primary tumors biopsied by diagnostic bmnchotiberscopy, were aoelyzed for immunological characteristics. These cell lines showed considerable hetenxteneih in

ofthexspectivehuoorsors, but tbsirHLAzIrssIlatigenexpressiolls_ equally depressed and they were susceptible to peripheral blood lymphocytes (PBL) end lymphokine-activated killer &AK) cells, irrespective of their diverse chemo-radiosensitivity. TrrPtment of the cell lines with recombiiant immune interferon (rIFN-gemme) increased their HLA-cless I antigen expmssioo and wnvemely depressed PBL sensitivity but not LAK sensitivity. This inverse rel&mship between HLA-cIees I expressiw and PBL susceptibility was also demoostrated using other pairs of autologoos PBL and SCLC cell lies. rIFN-gamma chewed neither HLA-clees II antigen nor SCLC-soxific eotinen

~fnellogmeic peripheral b&d lymphocytes with rIFN-gemma-treated SCLC cells induced allo-specific kiIler cells which lyeed rIFN-gamma- treated more strongly then non-tleated SCLC cells. Tllez& results suggest that reduced HLA-cless I antigen expression of SCLC could protect the ceocer horn attack of killer T cells in spite of the higher sensitivity to PBL or LAK cells.,

Intlllence of altti-cancer chemotherapy on function ofmomxytes in patie& with lung - Kawasaki M, Ichinose Y, Hera N. Ohta M, Shimim T, Asoh H et al. Department of Chest Surgery. National Kywhu Gmnr Center, 3-l-l Notame. Mittanti-ku. Fttkttoka 815. Cancer J 199Z5290-4.

Backgrowd - Momxytea play an essential role in host defense mechanisms such es those against microbial infection end the immune response. The purpose of the present study wee to chify whether mtismcer chemotherapy influences moeocyte 6mctioo. Mcrhadr-MononuclearfelIs(MNC)wereobtninedfrom 14l1mgw1cer petitts who had received anti-center chemotherapy. Superoxide anion (0;) production by phorbol myristete (PMA)-ectivated MNC was

tmaswed by the rate of redwtioo of fenicytochmme C. Determination of Interleukio-I (IL-l) activity io the supematant of MNC cultured in medium cootaining PMA for 24h was performed by e A375-U gmwtb inhibition assay. Theemount of IL-1 was also nwsomd bymew= imnumway. As only monocytes in MNC prodwed O,- and IL-l, the ~~KWNS of 9’ and IL-1 gmsnted by tbe monocyta were calculated from the pmpwtica of monocm in MNC. Rewlts -‘be amount of O* gewated by the monocytea of patients before chemotheqy was 7.54 + 1.97 nmollmio/2xlQ cells (mean f SE). The v&e decreased gmduIlyaodracbedanedirof3.Ol+0.662we&saRerchemotberPpy. As with 0; generating activity, tbe monocytea obtained 2 weeks al&r chemotheraw modwed oolv 40% of the emoont of IL-l neneratcd bv

influences monocyte fUnction in terms of 0; end IL-l generating activity.

Lungcancerinyolutgp Capewell S, Wethea CG, Saokamo R, Sudlow MF, Ciuwmn EW, ~~gJet~.~#qfM~i~~,Royoll~~,~i~urgh EH3 9rw. Keqir hied 1992;86: 499-502.

During 1981-1986 the Edinburgh Luog Ceocer Group pnwpectively registered 3560 oew patients with long caocer of whom only48(1.3%)waee~lese~45ye9rs.wheafo~with3512 older petieob aged amm than 45 years, e similar pmpxtion of youog patienbwerefemale(l7/48; 35% vs. 28% oftbeolderpatieab) aodhad equally edvemxd disease (30148; 62% vs. 58% io stage 111). Slightly more yooq p&ieab were in better Kamofsky performsn~e status gmups (28/48; 59% vs. 45%. score > 80) and duration of symptoms was considerably shorter (tiea 45 vs. 93 days); only three of the younger patieab were non-smokers. A pathological diagnc& wes obtained more oftm in young patients (47148; 98% vs. 81%). The common& cell type was smell call (16/48; 34% vs. 24%) with IO/48 edeoocarcinoma(2046”s. 13%)~llesssq-~urcinonv(11148; 23% vs. 48%). Although only 12/48 young patients (25% vs. 19%) underwent sorgial resection, six of these wene still alive after 5 years (50% vs. 30% io older patients). More young pattiarts received chemotbenpyeitber~a(l4)orcomb~~~~io~~py(6)~2% vs. 16% in older patients. There were no loog-tenn survivors and the median survival was 8 months in I3 patients with small all and only 4 mooths ill wee with oott-MMII cell catcinoma.

Clinical~d’o~nljgra~iotbomcictlml~ Suga K, Kewamun M. Nishigeocbi K, Yonedhim S Pujita T, Oboe Y ct al. Department of Radiology, Yamagwhi Univ. School of Medicine. Yamaguchi 753. Jpe J Nucl Med 1992;29: 1143-9.

==Tc-hexemethylpmpyIene amineoxime WC-HMPAO) scintigraphy was performed in 15 meligoant ttmxm? in 1 I pet&b aad P p&eat with bmnclmpntia. A b&k *Tc-HMPAO affioity for the mmms was dxwved oo SPECT, however, the mean tumor/ contmlateral normal lung ratios of *Tc-HMPAO activity (1.26) was Iowcrthpn~of”n~hloride(2.29). ~c-HMPAOU~~~~~.S=I not only in the tumors but also in the brcmchopo-nia, ntelectasis, end inndieted lung (wnt&ieg radiation fibrosis). Moreova, e diffuse up~einthclungwreses~ine~tieotncsivcdreputsdchemothenpy. Therefore, it is empbesizd that there is a mm-specific RCTc-HMPAO uptake in those various pldmaury conditimls.

Pmgmstic rahe of deoxyribonucleic acid aneuploidy in primary non-small- ceIl long carcinomas and their met&as Lieweld F, Hatz R, Storck M, Oread K-H, Weiss M, Wulf G, Valet G, Sunder- Plassmenn L. Department of Sttrgay, Rlidxm Grosshadem, Ludwig-Marimilians-Univ. Med. School, Mar&ioninistr. IS. D-&X70 Munich 70. J Thonc Cadiovasc Surg 1992; 104: 1476-82.

The ploidy stahu of tbe deoxyribonucleic acid of a melignrnt lung tumor provides additiooal informatioo besides histologic gradiig and tumor sbgieg wording to lymph node infiltration and tumor maastasis. Ninety-nine surgical specimens from patieob with non- smellcell lung carcinome were investigated by flow cytomeZry. Deoxyribmwleic acid pneuploidy w found in 48% of the primary