Chromatography: Reverse Phase HPLC System with 200mm ID ... · DAC-ID200mm Chromatography Column with 100bar and 650mm length . 1 : 3 . Total Amount FOBSHANGHAI, China 4 : Shipping

[email protected] (740) 444 -HEMP

GLOBAL HEMPSOLUTIONS

Chromatography:

Reverse Phase HPLC Systemwith 200mm ID High Pressure Column

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mailto:[email protected]



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Index 1. VIP Offer Price .............................................................................. 01 2. Reverse Phase High Pressure Liquid Chromatography

System (RPC) 100L/ H Technical Details .................................... 04 3. Skid System P & ID ...................................................................... 05 4. Skid System Configuration Table ................................................. 06 5. Component Description ............................................................. 07 6. DAC 200mm ID High Pressure columns Technical Details ........ 10 7. DAC 200mm ID Configuration Table .......................................... 10 8. RPC System with 200mm DAC Dimensions ............................... 16 9. Equipment Test/ Acceptance documents Description .................. 16 10. Company Profile ........................................................................... 19 11. Indian Customer List .................................................................... 21



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1. VIP Offer Price:

Item Description Qty Price(USD)

1 Reverse Phase High Pressure Liquid Chromatography System(100bar) 1

2 DAC-ID200mm Chromatography Column with 100bar and 650mm length 1

3 Total Amount FOB SHANGHAI, China

4 Shipping cost by air flight to one of the American Airport if you want us to be responsible:

USD $30,000.00

5

The payment terms:

50% Advance payment, 50% before shipment.

The official Delivery period is 1.5 to 2 months, from the date of 50% Advance payment receipt, Installation will require 1 week.

Notes

2) Manufacturer provides the installation, training and DQ/IQ/OQ/FAT certification.Manufacturer will invite 2 people from Client to visit them and inspect the required HPLCsystems. The flights and hotel accommodations will be paid by Manufacturer.

3) Warranty: 2 years from the installation date.



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2. Reverse Phase High Pressure Liquid Chromatography System(RPC) 100L/ H Technical Details

Keywords:

1. Fully Automated.2. Compliance with 21 CFR Part 113. Conformity of European Certified4. Explosion Proof Level: ATEX zone 2 or Class 1 Div 25. Configurable DAC Columns ID 200mm with 100bar design pressure



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3. Skid System P & ID

CS-Prep200 HPLC system with LEWA diaphragm pump(ATEX)

Item Description

valve Pneumatic two-way ball (AV0101/0102/0103/0104)

Pneumatic two-way ball valve is used for the choice of mobile phase

Check Valve(CV0101~CV0102) To prevent fluid back-flow

valve Flow regulating (FCV0101~FCV0102)

Pneumatic flow regulating valve, used for low pressure gradient model

Mass Flow Meter（FIT0101） Displays the output mass flow rate of infusion pump. The same can be used to display the totals (Totalizer).

Static Mixer（SM0101） For mixing two different solvents.

Switching Valve for Injection (AV0105）

For low pressure injection switching valve

Air Sensor(AS0101) It is used for the low pressure injection line and also to avoid air into the low pressure feed line.



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Pressure Transmitter(PT0101) It checks the pressure before the pump, if the pressure is zero before the pump, pump will automatically turn off. PT0101 is responsible to safe guard pump membrane.

Infusion pump（P0101） The triplex diaphragm (PTFE) pump, Flow rate accuracy + / - 2%, Pressure

resistance:100bar; Max Flow rate :100L/H.

Pressure transmitter（PT0103） To display the system pressure after the pump and make sure the membrane is working safely., automatic alarm, stop,

Exhausting Valve（AV0106） A pneumatic three-way ball valve is used for pump head online cleaning and exhaust

Online filter switching valve

（AV0108-AV0109） Used for switching the online filter connection

Online Filter（M0101-M0102） Stainless steel, the absolute porosity is 5 microns, rated porosity is 2 microns.

High pressure Injection(Feed) It is used for the High pressure injection line and also to avoid air into the High pressure feed line.

Injection pump (P0102), the double diaphragm pump head, max flow rate: 100 L/ H, pressure: 100bar, Flow rate accuracy ±2%, high pressure gradient model, the gradient range: 5% - 95%, gradient deviation ± 2%;

Pressure transmitter (PT0104), show sample pump output pressure, automatic alarm, downtime.

Exhausting valve (AV0107): used for sample online cleaning pump and exhaust.

Online filter (M0103): Sample filter material: SUS316L stainless steel, 5 microns absolute porosity, porosity rating 2 microns.

Sample switch valve (AV0110): Used for sampling \ mobile phase switching.

Mass Flow meter(FIT0102) Display the total mass flow rate of the system mobile phase with a built in totalizer option.

Pressure transmitter（PT0105） Display the pressure of the system, due to back pressure in column and is located in front of the column and after the online filter



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Manual Sampling switching valve （AV0111-AV0112）

Injection will go through the manual loop. Used for manual injection.

Top Down and back-flushing switching valve

AV0114/15/16/17)

To switch the column flow direction, it may be top-down or back flushing.

Bypass switch valve （ AV0113-- AV0118）

It will bypass the flow from column.

UV Detector（UV0101） It is used to detect the samples.

pH/ CD pH/ conductivity detector

Check Valve（CV0103） To prevent fluid backflow

Valve Collection (AV0119/20/21/22/23/24/25/26)

Pneumatic two-way ball valve, which is used for fraction collection, 8th by default dedicated as waste collection valve,remaining 7 are to collect the fractions.

4. Skid System Configuration Table:

No. Name Specifications/material/brand/requirements Qty

1. Main Body Frame SUS304Stainless steel 1Set

2.

Infusion/ Injection

Pump Type

Pump type Model：LEWA diaphragm pump with three heads for infusions and two heads for injection Pump.

Brand：LEWA

2Piece

Pump head Product Contact Material: SUS316L steel/PTFE

Flow rate range

Infusion Pump with 3 pump heads and Flow Rate:100L/H，

Injection Pump with 2 pump heads Flow rate: 100LPH

Operating Flow Rate: 10 – 90%

Maximum pressure：100bar

Flow rate accuracy: ± 2%



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3. Static Mixer Product Contact Material：SUS316Lstainess steel and

provide the materials certificates 1pieces

4.

Pneumatic flow regulating valve

Brand: Masoneilan;

Sliding window control valve

Product Contact Material: SUS316L

Gradient range is: 5% - 95%, gradient Deviation ± 2 %.

2pieces

5. Flow-meter

German E+H Promass Mass 80 Series

Range:0-1000L/H with inbuilt Totalizer Option Flow

meter Accuracy：±0.15%

Product Contact Material: SUS316L

2pieces

6.

Manual Injection Valve

Valve Body SUS316L stainless steel 1pieces

Loop 250ml per loop; Materials: SUS316L 1pieces

7. Exhausting valve SUS316L stainless steel pneumatic three-way ball vale 2pieces

8. On Line

Filter

Filter cartridge

SUS316L stainless steel and provides the material certificate ， OD ： Φ100 mm ， absolute porosity 5μm，Rated porosity:2um

2Sets

End cap SUS316L stainless steel，Connection type：bolt joint 4Sets

Seal ring Cladding O-ring(FEP+SI) 4pieces

9. UV detector

NU3000 Series Preparative optical detector, Brand: Hambom; Dual wavelength detection; Wavelength Range： 190nm～ 700nm ； wavelength accuracy：±2nm ； Wavelength repeatability:0.1nm; Noise ：2×10-5

AU ； Drift ： 4*10-4AU/h （ 254nm).Measurement range：greater than or equal to 3AU.

1pieces

10. Flow cell Large capacity fiber optic flow cell ， Material ：quartz，Optical path length: 2mm(Variable)

1pieces

11. Fraction Fraction 8 numbers, by default 7 dedicated for Fractions and 1 8pieces



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collection collection joints

is for waste ≥700mm

collection, Height to the ground

Valves Pneumatic switch (explosion), materials that contact with liquid：SUS316L/PTFE

12. Solvent

Tubes

Solvent tube before pump

Materials：SUS316L ID:1/2"

Polish internal surface Ra≤0.2um；

Joint Connection：SUS316L Stainless steel joint

1Set

Solvent tube after the pump

SUS 316L；ID：1/4"; Accuracy: ±0.15%

Polish ： Internal Surface Ra≤0.2um ； Joint Connection：PEEK or 316L

1Set

13. Transmitter

Pressure Transmitter

Brand：E+H PMP41; Accuracy: ±0.15% Range：0-10bar-2 No’s; 0-100 bar-3 No’s,

Material that contact with liquid: SUS316L

5pieces

14. Switch Valve

Pneumatic switch valve

Pneumatic switch valve (Two/ three/ four-way), material that contact with liquid: SUS316L

MOD VT Series; Max. Pressure: 8 bar

24piece s

Manual switch valve

Manual switch valve （ three-way ， material that contact with liquid: SUS316L

MOD VT Series; Max. Pressure: 8 bar

2pieces

15. pH Sensor Range: 0-14, material that contact with liquid:

SUS316L; Accuracy: ± 0.1% 1 piece

15. Conductivity Sensor 500mS/ CM, material that contact with liquid:

SUS316L; Accuracy: ± 4% 1 piece

16. Check Valves

NRV To restrict the back flow.

material that contact with liquid: SUS316L; 5 pieces

17. PLC Automation S7-300 along with Power Unit, CPU, DI, DO, AI, AO Modules and 128kb Memory Card

1 Piece

18. PC Control System

IPC-610, Processor: I7 3220, RAM: 8GB×2, HDD: 1TB × 2, RAID 1, Display Make: HP-19”.

1 Piece


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19. Bubble Sensor

Air Sensor 4-25Vt-t;

material that contact with liquid: SUS316L 2 Pieces

No. Requirement

1 All solvent pipe are connected with modules through double ferrules, easy to install and dismantle, all ports have no leakage under high pressure.

2 The material of all pipes and other fittings contact with solvent are PEEK, SUS316L, or PTFE.

The material report should be provided.

3 The weld of all pipes uses automatic welding, the polish degree of welding spot of pipes in wall is Ra≤0.8, and the ektexine polish degree of other welding spot of pipes is Ra≤1.4μm.

4 Whether it needs to connect with online filter according to the needs of selection valves, online filter is easy to install and remove, all ports have no leakage under high pressure and sealing is very tight and the cartridge can be cleaned by ultrasonic.

5 If the positive and back-flushing goes through the ID, it can be decided by choosing the three-way ball.

6 The rest material of pump body should have no rust in the corrosive liquid, and correspond with related hygiene and clean demand; there should be no reveal of dust and particle when pump is working.

7 One fraction valve is fixed as the liquid line, all the collection valves’s drive adopts pneumatic drive.

9 Pressure sensor can indicate the system pressure and if the pressure is overload and the system will have the automatic alarm.


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5. Component Description:

Mobile Phase and Sample Pumps:

Mobile Phase Pump Sample/ Feed Pump

German LEWA diaphragm pump, Solvent pump maximum flow rate 100 L/h, Injection pump flow rate: 100L/H; Pressure resistance is up to 100bar, the designed working temperature is not less than 60℃and the designed standard satisfied with ATEX relevant requirements; The internal surface roughness satisfied with SF4 level requirement, the materials that contact all liquid and medium is not less than 316L, Explosion-proof standards for design: ExdIIBT4;

Characteristics: Maintenance costs are very low and maintenance interval period is very long; Mechanical efficiency is very high; The security of Resistance to overload is very high; Stroke adjustment doesn't need too much energy; Stroke control linear is very good. Replicability is very high; When it is running, you can also adjust the stroke. It can provide a variety of drive configuration and pipeline connection scheme to you.

It is equipped with high pressure protection valve.

When the pressure is over than the maximum working pressure (100bar or can set by the operators), the system will stopped automatically and release the over pressure by waster liquid outlets and protect the system. The check valve material is SUS316L, PTFE.


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UV Detector:

NU3000 Series Preparative optical detector. Brand: Hambom ， Double wavelength detection at a time. Wavelength Range：190nm～700nm; Path Length: 2mm; wavelength accuracy：± 2nm； Wavelength repeatability:0.1nm; Noise ： 2×10-5 AU ； Drift ： 4*10-4AU/h （254nm ） . Measurement range：greater than or equal 3AU.

Mass Flow Meter:

E+H Promass Mass flow meter from Germany is a multivariate flow rate measurement system and can be measured by liquid or gas Explosion the authentication： ATEX、FM、CSA、TIIS. Food industry Explosion authentication/health requirements: 3A 、 FDA; Multivariate measurement: It can simultaneously measure the mass flow rate, density and temperature . Flow Rate: 0-1000 L/ H, Accuracy: liquid ± 0.15%, Material of liquid contact: SUS316L

Pressure Transmitter:

E+H Promass Mass flow meter from Germany is a Hydrostatic pressure transmitter.

Smart and reliable pressure transmitter, with piezo resistive measuring cell and metal welded process isolating diaphragm and diaphragm seal. Supply voltage is 4…20mA HART. Accuracy: 0.15 %. Range 0-10 bar, 0-100 bar


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Online Filter:

Contact material SUS316L/PTFE, filter sieve plate: material: SUS316L, porosity: 5 microns. Seal material: coated o-rings + SI (FEP), resilient seal (PTFE)

Masoneilan Flow Control Valve:

Designed specifically for low flow applications, the Masoneilan 28000 Series Varipak provides excellent throttling control performance with a wide range of options and capabilities. Design optimization has also resulted in an extremely integrated and compact assembly.

Varipak is far superior to conventional microflow valves in that it provides the user with a very wide range of nominal Cv ranges from 0.0016 to 2, using only eight plugs and five seats. Gradient range: 5% - 95%, gradient Deviation ± 2%.

Control System

Control Parts Table:

No. Name Design, Manufacturing Standard

01 Positive pressure

explosion-proof Cabinet

It is combined by the keyboard of positive pressure explosion-proof and LCD screen. The operators can set up the flow rates and then start the Infusion pumps. If there is an abnormal problem, the pumps can be stopped by operation of keyboard and the display screen can display flow rates.

02 Local Control

Valves Control

All kinds of valve switching will be controlled by the connection of Computer and PLC in order to realize all kinds of liquid selection and trend.

Pressure and flow control

PLC will read pressure transmitter, Mass flow meter current electricity output, display system pressure, control and display different solvent flow.

Collection It can collect the Chromatographic signal and also solve the waste


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System Control

liquid based on the UV detector communication protocol. Fraction Collectors will be used by electric control and air driven method.

Emergency Brake Control

System has an emergency break switch which can rapidly stop the system if an emergency occurs. After the treatment of system problems, the system will be recovered to the previous process. It has the emergency stop button and can easily touch it and stop the system according to the requirements.

03 Software Configuration Meet FDA CRF part II related requirements with historical records, all data has the traceability, It can keep record of all operation status.

04 Interface

Overall Requirements

Including monitoring procedures, operating procedures and external equipment; User control system can ensure the safe, reliable and continuous; Automatic control system is safe, easy to operation, the structure is reasonable, Through the line or other way connection, can be in equipment remote operation and monitoring.

Monitoring interface

Display the running state of the equipment (such as: preparation, operation, stop, etc.),

Display system running program process (such as: the stage operation, operation etc.),

Display equipment real-time online detection data, including pressure, flow rates, UV detector;

Others It Can set the alarm

05

Data

acquisition and store

Data

acquisition

Automatic record and storage

Data can be preserved and kept record

Process record printout

The report printout

Data is reliable

Raw data cannot be changed

Data need to be collected and automatic

Valves in and out position and switch status

Pipeline flow direction

Pipeline flow direction


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recorded. Flow rates

Pressure

UV Absorption (preserve the chromatogram)

Alarm information

Operation and program operation record

Gradient elution curve

Data preservation

Provide the system data storage medium capacity size requirements

Key Parts of Control system

Industrial control computer

Advantec from Taiwan, China. 19 "rugged 4 u mounted case, it is equipped with 14 passive back plane or industrial motherboard, the resistant disk drive bays can support three 5.25" and one 3.5 "disk drive, the front end is equipped with two USB or PS / 2 keyboard I/O interface, the system status LED indicator on the chassis front panel can display power supply, hard disk, and the operation of the system voltage, the

blowing cooling fan can maintain positive air circulation within the whole case. Due to these characteristics, it makes the system have the stronger anti interference, dustproof, shockproof, anti interference flow ability.

PLC Control system

Siemens PLC controller: the maintenance workload is small, easy maintenance, low failure rate, and can improve the diagnosis and display function. PLC or external input device has failure with actuator, the operators can quickly find out the cause of the failure according to the light emitting diode or PLC programmer information and use replacement modules can be ruled out very fast.


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Workstation:

Cs Prep ATEX HPLC Controlling Software Suite is a solution for controlling and tracking changes to automation programs, devices, and other documents being used in a manufacturing facility. Because of this key feature set, it becomes ideal for addressing 21CFR Part 11 issues for FDA regulated companies. The software has more structures, like login in and off and others.

Key Features:

1. User Management: This includes user creation, group allocation, login policy, etc.

2. Method Creation: Recipe creation, includes, solvent, sample, UV parameters.

3. System Parameters: Interlocks will be available

4. Alarms: List of alarms will be displayed, the same can be printed.5. Audit Trails: Detailed audit trail can be viewed and the same can be printed.6. Reports: Batch report, alarm report7. Chromatogram: which includes data acquisition, data analysis tools, integration, etc.


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6. ID200mm ID High Pressure

Columns Technical Details.

Key words:

1. Uses Dynamic Axial Compression Technique2. Packing media replaced by any number of times.3. Easy to operate.4. Low maintenance.5. Conformity of European certification


Hydraulic System Flow Chart:

1. Air compressor 2. Filter 3. Air source Main Switch 4. Air Pressure Regulation Valve 5. Barometer 6.Pneumatic pump 7. Overflow valve 8. Barometer 9. Pneumatic four way valve 10. Hydraulic cylinder

Hydraulic Cylinder:

Hydraulic cylinder jacket ：Material：45#steel, Thermal refining ： 25 ～ 30HRC.Adopt the automatic welding, detection treatment; ensure no leakage porosity and welding defects. Piston rod ： Hard chromium plating surface treatment, plating chromic layer in the atmosphere and has stronger passivation ability, can keep the metal luster, It can't produce the chemical reaction in a variety of acid medium.

Coating hardness will be reached to 1000 HV, excellent wear resistance

Seal ring: the Parker precision O-rings and block circle, and to ensure the hydraulic cylinder will not have the leakage under high pressure and longtime wear-resisting performance.

The hydraulic cylinder surface: the primer is the anti-rusting paint, paint processing outer lacquer.

The hydraulic cylinder strictly comply with JB/T 10205-2000 “The inspection standard of hydraulic cylinder technology conditions". Under the 35 Mpa pressure, there is no external and internal leakage.

The hydraulic oil: the viscosity is 46 ~ 68 CST, anti-wear hydraulic oil.

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Piston Parts:

Piston main parts: Seat Connection, orientation cycle, and active sealing rings, bowl type seal ring, distributor, type of mesh filter board, O-rings, etc.

Piston parts material: SUS316L/PTFE/PEEK, all materials meet FDA, NSF standards and the bolt connection between piston and cylinder, very easy to dismounting and the floating piston design will eliminate the coaxial tolerance between hydraulic cylinder and column tube.

The pistons used the three seals design, bowl type of seal ring and active sealing ring and oriented ring, all these will ensure the column tube sealing performance;

The piston distributor adopted H-Tree style, the end cap of column tube design adopted the sector distribution methods, and to ensure the fluid will be converged rapidly. Clean of piston specially turn equipment of cleaning piston, easy operation and economize labor.


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Control System:

The imported gas and oil circuit element can improve the whole system sealing performance without leakage; it has the higher reliability and improve the service life of the product. If any emergency stop, the air valve will be adjusted.

Column Tube:

It is using the most advanced domestic grinding technology, It can guarantee that column wall cylindricity will be ≦0.02 mm, also greatly enhance the degree of finish and reduce the column wall effect to improve the performance of column.

7. ID450mm Configuration Table:

No Name Specifications/material/brand/requirements Qty

01 Rack Material SUS304 stainless steel with material report 1set


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02 Column Tube

Material SUS316L stainless steel

1set

ID 200mm，design pressure：100bar

Length 650mm， Effective packing height can be up to : ≤ 450mm

Grinding degree Internal surface Ra≤0.2μm, outside surface≤1.4μm

03 End-cap

Material SUS316L stainless steel ——

Seal Ring Material: cladding O-ring (FEP + SI) 2pcs

Grinding degree Internal surface Ra≤0.2μm, outside surface≤1.6μm,Rated porosity 5 μ m

——

Distributor Sector distribution, ensure that the mobile phase distributes uniformly in the chromatographic column

1pc

Frits Materials：SUS316L

Porosity 5 μ m 1pc


Porosity 5 μ m

04 Piston

Materials SUS316L/PTFE Stainless ——

Distributor Sector distribution, ensure that the mobile phase distributes uniformly in the chromatographic column

1pc

Frits Material：SUS316L

Porosity 2 μ m. 1pc


Porosity 10 μ m

Seal ring Material: cladding o-ring (FEP + SI) and provide the materials report

2pcs

05 Compression Control Panel Material: stainless steel SUS304 1pc


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system Pressure gauge Brand: MAXIMATOR range: 0-250 bar/PSI 1pc

Air-driven hydraulic pump

Brand: MAXIMATOR 1pc

Manual four- way Valve

Brand: EAGLE

Manual four-way valve: control hydraulic rod moving direction.

1pc

Check Valve Brand：EAGLE 1pc

Pressure

retaining

valve

Brand：EAGLE

1pc

06 Pneumatic unit Air source switch

Brand：Legris 1pc

Pressure regulating valve/oil-water separator

Brand: SMC, control air pressure

1pc

07 Maximator Air Driven

Liquid Pump For 1200mm ID High Pressure Column

Make: Maximator;

Pressure Exchange Ratio: 1:30

1 pc

08 Over Flow Valve Pressure Relief

Valve Range: 2250-3000 psig

2 pc

09 Slurry Tank For Slurry

preparation Capacity:200 L

Material: SUS316L 1 pc


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8. RPC System with 200mm ID Dimensions:

RPC System with 200mm ID Column Dimensions

9. Equipment Test/Acceptance Document Description:The other requirements of systemNO. Requirements

1 All the measurement use metric system.

2 Supplier should provide a control platform with a stable system performance, and equip necessary communication interface.

3 Supplier should provide related software instruction files of program development, encoding procedure usage and so on.

4 Supplier should list the power supply which meet the usage of equipment and other requirements of utility system.

5 Equipment/system is scheduled to run for 10 years, 24 hours a day and 120 hours per week

6 Equipment running noise is less than 60bd ( within three inch from equipment)


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7

This equipment should be provided with the ability of anti-electromagnetic interference and radio wave interference. The release and electromagnetic interference should meet the requirements of CE certification.

8 All the material contact with products should meet requirements of current EU cGMP, FIDGMP, USP Class Ⅵ and Chinese GMP.

9 All the pipeline’s welding points which contact with products should meet the requirements of current ASME BPE specification.

10 The material of system pipeline is polypropylene or similar polymer system, the material of pipeline gasket/joint ring should be EPDM or PTFE.

11 Suppler should provide supporting documents and Compatibility list of material of system.

12 The whole surface of system should meet the requirement of wipe disinfection and air sterilization.

13 All the assembly, control circuit, connecting line etc. should be marked and easy to be identified.

Accompanying documents items

No. Name QTY

1 Design Qualification 1pcs

2 Quality Project Plan 1pcs

3 Functional Design Specification 1pcs

4 Hardware Design Specification 1pcs

5 Software Design Specification 1pcs

6 Impact Assessment 1pcs

7 Required Traceability Matrix 1pcs

8 Factory Acceptance Test 1pcs

9 Installation Qualification 1pcs

10 Operational Qualification 1pcs

11 Installation manual 1pcs


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12 Operational Manual 1pcs

13 Standard Operating Procedure 1pcs

14 Drawings 1pcs

15 All Certificates (MOC, EU, etc) 1pcs

16 Software Backup CD’s 1pcs

12 Packing list 1pcs

13 Spare parts list 1pcs

After Sales Service Requirement:

No. Requirements

1 Provides computer program CD backups 1pc

2 Provides computer and PLC data line 1pc for each

3 Provides Written equipment maintenance, maintenance plan

4 Provides record and control software maintenance plan

5 Provides the equipment maintenance tools 1set

6 Supply of equipment spare parts within the service life and provide preferential supply commitment.

7 To provide users with equipment excellent performance that meet the user's technical parameters

8 After Equipment arrives, the internal connection of pipeline and control line installation, public line connection.

9 If Equipment fails, we shall respond upon receipt of notification within 24 hours

10 Provide users with equipment excellent performance that meet the user's technical parameters

11 Provide help if needed for the proper maintenance.

Provide ONLINE troubleshooting for the System and the Softare.

12 Regular inspection on equipment, freely assist the equipment examination and basic maintenance without additional cost.


13

Equipment supplier is responsible for user training, and the content includes: ---

HPLC basic principle; equipment basic composition；

--- Understanding of each component of the new technology；

--- Assembly and disassembly on ID column and internal structure； --- The

operation status under running circumstances.

--- Operating system interface and method of operation；

--- Equipment daily maintenance; ；

--- Equipment failure analysis method and solving steps。 14 Equipment supplier provides wearing parts, consumable list, the use of brand and

specifications/model.

10. Company Profile:

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CS-Prep500 HPLC system with diaphragm pump at customer’s site

CS-Prep800HPLC system with diaphragm pump

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The company includes more professional Labs for samples analysis, Preparative process scale- up, process optimization, QC and so on. It is focus on technology innovation and Prep Chromatography equipment construction. We have more than 200 employees who are engaged in Preparative Chromatography Industry. All these are very professional and technical.

In 2005, the first Chinese ID column with our Chinese first intellectual property patents was developed by us. In 2006, the simulated moving bed chromatography equipment for sugar alcohol, chemical and pharmaceutical industries was successively developed by us with our Chinese first patents.

The same year, the development of five separation projects for Chromatography Industry was listed into"2006 Jiangsu Sciences &Tech. project" "2006 Innovative Project" and other awards. The manufacturer has more than 13 patents, 3 high tech products in china and 20 registration trademarks.

In 2009, we established "Biological Process Control center" with a Chinese Academy of Sciences (CAS) . All these are the first in china. At the same time, we are establishing the best long-term business relationship with many famous International Pharmaceutical companies in the world. We have the best professional International team to market our own products. They will provide the best technical services to you quickly.

Also, we have built more local sales partnership in many countries; they can also provide the best local services for you. We are the company with better reputation and experience on Chinese Chromatography Technical Application Field. We hope to serve you and help you on your Bio-process development.



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11. Part of International Customer list:

S.NO User Name Product Name and Specification

Preparative Column

Quantity

(Set)

01 MSN Laboratories Pvt Ltd R&D

100 ml Prep System – 01 50 mm DAC Column - 01

01

02 MSN Life Sciences Unit II 300 ml – 01, 600ml – 01 Prep Systems

300 ml – 02, 600 ml – 02 Prep Pumps

100 mm–02 80 mm – 03 50 mm – 01Columns

06

03 Hetero Drugs R & D 300 ml – 01 Perp System

20mm – 0130mm 50mm – 01

Columns

– 0101

04 ISSAR Pharmaceuticals Pvt Ltd

100 ml– 01, 1000ml-01, 3000ml –01 Preparative Systems

20mm – 0130mm – 0150mm – 01

150mm – 01200mm – 01

Columns

05

05 DRL Pharma Pvt Ltd Unint 8 3000ml –02 Preparative System

200mm – 02

Columns

02

06 DRL Pharma Pvt Ltd RC 2 N/A 50mm – 01100mm – 01 02

07 DR.Reddy’s Labs CTO 6

200LPH – 01, 1200LPH ATEX Preparative System

150mm – 01

600mm – 02

Columns

03

600ml - 01, 1000ml – 01 80mm – 01



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08 Laurus Labs R&D Preparative System 150mm – 01

Columns

02

09 Laurus Labs Unit I 200LPH – 01, 300LPH -01 ATEX Preparative System

200mm – 01

300mm – 01

Columns

02

10 Anthem Bio Sciences

1000ml – 01 Preparative System

ATEX 1200LPH – 01 Preparative System

100mm – 01

150mm – 01

450mm – 01

Columns

03

11 Zydus Cadilla 3000ml – 01 Preparative System

300mm – 01

Column 01

12 Concord Preparative System 100mm – 01

Column 02

13 Avra Labs Preparative System 100mm – 01

Column

01

14 Swyser Labs Preparative System 30mm – 01 Column

01

15 Vardaman Chemicals Analytical HPLC System N/A 05

16 Steils Bio Pharma Pvt Ltd

1000ml – 01 Preparative System

200LPH – 01 ATEX Preparative System

50mm – 01

80mm – 01

100mm – 01

150mm – 01

200mm – 01

Columns

05

Documents

Chromatography: Reverse Phase HPLC System with 200mm ID ... · DAC-ID200mm Chromatography Column with 100bar and 650mm length . 1 : 3 . Total Amount FOBSHANGHAI, China 4 : Shipping