8/18/2019 Chlosite Comparison Table

1/1

PERIODONTAL ADJUNCTS IN THE UK

 Antibiot ic Chlorhexidine

Characteristics

Dentomycin Elyzol Periochip Chlosite

 Active

Minocyclinehydrochloride(equivalent toMinocycline 2%w/w)

Metronidazolebenzoate(equivalent to250mgMetronidazole)

Chlorhexidinedigluconate 2.5mg(not an antibiotic)

Chlorhexidinedigluconate andChlorhexidinedihydrochloride

Indication

Moderate tosevere chronicadult periodontitisas adjunct to SRPin pockets of 5mmor greater

Treatment ofchronicperiodontaldisease in adultsas adjunct toconventional

therapy

Treatment ofchronicperiodontitis asadjunct toconventional SRPin pockets of 5mm

or greater

 As adjunct to SRPin treatment ofmoderate to severeperiodontitis inpockets of 5mm orgreater

DeliverySystem

Light yellowcoloured gel to beapplied intoperiodontal pocket

Semi solidsuspension to beapplied intoperiodontalpocket

Gelatin chip(4x5x0.35mm) tobe inserted intoperiodontal pocket

Flowable xanthangel with muco-adhesion tostabilise in theperiodontal pocket

Bio-absorption YES YES YES YES

Mechanism of

action

Inhibits growth ofperiodontalpathogens

Inhibits growth ofperiodontalpathogens

Inhibits growth ofperiodontalpathogens

Inhibits growth ofperiodontalpathogens

Duration o f Action

 Approximately 1day

Up to 36 hours inthe gingivalpocket

7 days 15 days

 Administrat ion

By dentalprofessional every14 days for 3-4applications. Notto be repeated

within 6 months

By dentalprofessional twiceat 1 weekintervals. Not tobe repeated

within 6 months

By dentalprofessional once.May be repeatedin 3 monthintervals

By dentalprofessional once.May be repeated in3 month intervals

Dosage1 syringe treatsmultiple pockets

1 syringe treatsmultiple pockets

1 chip treats 1pocket. Maximum2 chips per pocket

1 syringe treatsmultiple pockets

Storage 2-8°C Below 25°C 2-8°C Room temperature