1999 sulfonamides

sulfonamides (hydrazides, ureides) (benzene compounds)Q 0560

24 - 089Synthetic and Photochemical Studies of N-Arenesulfonyl AminoAcids. — Irradiation of the title compounds (V), (VII), (X), and (XI)results in cleavage of the sulfonamide with very sub-stoichiometric release of theintact amino acid because of concurrent decarboxylation during photoreaction.Best release (30%) of free amino acid is observed for compound (VIIa) having anortho carboxylate group. This indicates that such molecules are not effective forphotorelease of neuroactive amino acids. — (PAPAGEORGIOU, GEORGE;CORRIE, JOHN E. T.; Tetrahedron 55 (1999) 1, 237-254; Natl. Inst. Med.Res., London NW7 1AA, UK; EN)

1