2001 antibiotics

antibioticsU 1200

12 - 225Synthesis of the Functionalized Tricyclic Core of Lactonamycin byOxidative Dearomatization. — The key steps in the synthesis of theCDEF ring system (VII) of lactonamycin are intramolecular Wessely oxidativelactonization of the acid (II) and oxidation of the enol ether (V). — (COX,CHRISTOPHER; DANISHEFSKY, SAMUEL J.; Org. Lett. 2 (2000) 22,3493-3496; Dep. Chem., Columbia Univ., New York, NY 10027, USA; EN)

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