Multi-membered N-heterocyclesR 0690 DOI: 10.1002/chin.201149166

Efficient Synthesis of Antifungal Active 9-Substituted-3-aryl-5H,13aH-quinoli-no[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in Ionic Liquids. — Title com-pounds, e.g. (III), are synthesized from quinolines (I) and triazoles (II) in a new ionic liquid as solvent under microwave-assisted irradiation as well as under conventional heating. Using 5 mmol of each of (I) and (II), and 1 ml of ionic liquid under both mi-crowave irradiation and oil-bath heating afford the maximum yield under mild condi-tions. Compounds (III) show moderate to excellent antifungal activity against four spe-cies. The ionic liquid is recyclable for at least three consecutive runs. — (GUPTA, M.; Bioorg. Med. Chem. Lett. 21 (2011) 16, 4919-4923, http://dx.doi.org/10.1016/j.bmcl.2011.06.007 ; Dep. Chem., Univ. Jammu, Jammu 180 006, India; Eng.) — H. Hoennerscheid

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