1998 reduction, hydrogenation

reduction, hydrogenationO 0220

10 - 065Design, Reactivities, and Practical Application of Dialkylzinc Hy-dride Ate Complexes Generated in situ from Dialkylzinc and MetalHydride. A New Methodology for Activation of NaH and LiH underMild Conditions. — The study on the reactivities of dialkylzinc hydride atecomplexes toward carbonyl compounds reveals that dimethylzink hydrides arethe most powerful and selective zincates for the reduction of the carbonyl group.To discuss and clarify the active species and the mechanism of this reductionsome diastereoselective reductions of some carbonyl compounds with an adjacentchiral center are carried out. A catalytic version of this reducing system by usingLiH–ZnMe2–ultrasound is developed. — (UCHIYAMA, M.; FURUMOTO, S.;SAITO, M.; KONDO, Y.; SAKAMOTO, T.; J. Am. Chem. Soc. 119 (1997)47, 11425-11433; Fac. Pharm. Sci., Tohoku Univ., Aoba, Sendai 980, Japan; EN)

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1998 reduction, hydrogenation

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