1999 cyclohexane derivatives

cyclohexane derivativesQ 0040

18 - 075Asymmetric Spirocyclization: A New Type of Acid-Catalyzed In-tramolecular 1,4-Addition to Form Carba-spirocyclic Compounds.— Treatment of the ketones (Ia) and (Ib) with Lewis acids and 1,2-diols offersa novel spirocyclization to form carba-spirocyclic compounds. In the presenceof optically active 1,2-diols asymmetric spirocyclization is possible. — (YA-MADA, SATOSHI; KARASAWA, SATORU; TAKAHASHI, YOUICHI; ASO,MARIKO; SUEMUNE, HIROSHI; Tetrahedron 54 (1998) 51, 15555-15566; Fac.Pharm. Sci., Kyushu Univ., Fukuoka 812, Japan; EN)

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