1999 terpenes

terpenesU 0200

07 - 194A Concise Total Synthesis of Triptolide. — A total synthesis ofditerpenoid (X), isolated from the chinese medicinal herb Tripterygium wilfordiiHook F (Lei Gong Teng), is developed in connection with structure-activityrelationship studies. Triptolide (X) exhibits potent antileukemic and antitumoractivities and also inhibits lymphocyte proliferation and interleukin-2 produc-tion. — (YANG, D.; YE, X.-Y; XU, M.; PANG, K.-W.; ZOU, N.; LETCHER,R. M.; J. Org. Chem. 63 (1998) 19, 6446-6447; Dep. Chem., Univ. Hong Kong,Hong Kong, Peop. Rep. China; EN)

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