Chemical and Biomedical Engineering Cluster 2012

Chemical and

Biomedical Engineering2012

3Biomedical EngineeringCONTENTS

Biomedical Engineering 3Chemical Engineering 14

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Pruitt and

ChakravartulaM

echanics of Biomaterials

CAMBRIDGE TEXTS IN BIOMEDICAL ENGINEERING

Fundamental Principles for Implant Design

Mechanics of Biomaterials

Lisa A. Pruitt and Ayyana M. Chakravartula

CAMBRIDGE TEXTS IN BIOMEDICAL ENGINEERINGSeries EditorsProfessor W. Mark Saltzman, Yale UniversityProfessor Shu Chien,University of California, San Diego

Teaching mechanical and structural biomaterials concepts for

successful medical implant design, this self-contained text provides

a complete grounding for students and newcomers to the field.

Split into three sections – Materials, Mechanics, and Case Studies – it

begins with a review of sterilization, biocompatibility, and foreign

body response before presenting the fundamental structures of

synthetic biomaterials and natural tissues. Mechanical behavior of

materials is then discussed in depth, covering elastic deformation,

viscoelasticity and time-dependent behavior, multiaxial loading

and complex stress states, yielding and failure theories, and fracture

mechanics. The final section on clinical aspects of medical devices

provides crucial information on FDA regulatory issues and presents

case studies in four key clinical areas: orthopedics, cardiovascular

devices, dentistry, and soft tissue implants. Each chapter ends with

a list of topical questions, making this an ideal course textbook for

senior undergraduate and graduate students, and also a self-study

tool for engineers, scientists, and clinicians.

Lisa A. Pruitt is the Lawrence Talbot Chair of Engineering at the University of California, Berkeley and also serves as an Adjunct Professor in the Department of Orthopedic Surgery at the University of California, San Francisco. She recently served as the Associate Dean of Lifelong Learning and Outreach Education in the College of Engineering and has received numerous awards including the Presidential Award for Excellence in Science, Mathematics, and Engineering Mentoring (2004) and the Graduate Student Instructor Mentor Award from UC Berkeley (2009).

Ayyana M. Chakravartula received her Ph.D. in Mechanical Engineering from the University of California, Berkeley in 2005. She currently works at Exponent, Inc. in Menlo Park, CA in its Mechanics and Materials practice. She has worked as a research scientist at the Cambridge Polymer Group in Boston, MA, and has served as an Adjunct Lecturer at Boston University. She has mentored numerous students, interns, and research assistants in her graduate and post-graduate career.

Cover illustration (left top): bileaflet heart valve (Craig Hansen); (left center): total hip replacement (Amir Mehdizadeh); (left bottom): TMJ dental implant (Craig Hansen); (right): topographical surface damage map of femoral head (Eli Patten).

“Mechanics of Biomaterials is the textbook I have been waiting for. … an outstanding text and reference book that should be required reading for all who aspire to design, develop and evaluate medical devices.” Jeremy L. Gilbert, Syracuse University

“The authors have written a detailed yet easy-to-read book that can be used by materials scientists and biomedical engineers… rich in practical examples of biomaterials used in permanent implants currently on the market.” Stephen Spiegelberg, Cambridge Polymer Group, Inc., MA, USA

“…provides a much needed comprehensive resource for engineers, physicians, and implant designers at every level of training and practice.” Michael Ries, University of California, San Francisco

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Chemical Engineering

AN INTRODUCTIONM O RT O N M. D E N N

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Chemical Engineering AN INTRODUCTION

“Chemical engineering is the fi eld of applied science that employs physical, chemical, and

biochemical rate processes for the betterment of humanity.” This opening sentence of Chapter 1

is the underlying paradigm of chemical engineering. Chemical Engineering: An Introduction is

designed to enable the student to explore the activities in which a modern chemical engineer

is involved by focusing on mass and energy balances in liquid-phase processes. Applications

explored include the design of a feedback level controller, membrane separation, hemodialysis,

optimal design of a process with chemical reaction and separation, washout in a bioreactor,

kinetic and mass transfer limits in a two-phase reactor, and the use of a membrane reactor to

overcome equilibrium limits on conversion. Mathematics is employed as a language at the most

elementary level. Professor Morton M. Denn incorporates design meaningfully; the design and

analysis problems are realistic in format and scope. Students using this text will appreciate why

they need the courses that follow in the core curriculum.

MORTON M. DENN is the Albert Einstein Professor of Science and Engineering and Director

of the Benjamin Levich Institute for Physico-Chemical Hydrodynamics at the City College of

New York, CUNY. Prior to joining CCNY in 1999, he was Professor of Chemical Engineering at

the University of California, Berkeley, where he served as Department Chair, as well as Program

Leader for Polymers and Head of Materials Chemistry in the Materials Sciences Division of

the Lawrence Berkeley National Laboratory. He previously taught chemical engineering at the

University of Delaware, where he was the Allan P. Colburn Professor. Professor Denn was Editor

of the AIChE Journal from 1985 to 1991 and Editor of the Journal of Rheology from 1995 to

2005. He is the recipient of a Guggenheim Fellowship; a Fulbright Lectureship; the Professional

Progress, William H. Walker, Warren K. Lewis, Institute Lectureship, and Founders Awards of

the American Institute of Chemical Engineers; the Chemical Engineering Lectureship of the

American Society for Engineering Education; and the Bingham Medal and Distinguished Service

Awards of the Society of Rheology. He is a member of the National Academy of Engineering

and the American Academy of Arts and Sciences, and he received an honorary DSc from

the University of Minnesota. His previous books are Optimization by Variational Methods;

Introduction to Chemical Engineering Analysis, coauthored with T. W. Fraser Russell; Stability

of Reaction and Transport Processes; Process Fluid Mechanics; Process Modeling; and

Polymer Melt Processing: Foundations in Fluid Mechanics and Heat Transfer.

Cover photo: Stellarator II. © Kim Dylla. Used with permission.

Cover design by Alice Soloway

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Biomedical Engineering

HIGHLIGHT

TEXTBOOK

Mechanics of BiomaterialsFundamental Principles for Implant DesignLisa A. PruittUniversity of California, Berkeley

and Ayyana M. ChakravartulaExponent, Inc., Menlo Park, California

Teaching mechanical and structural biomaterial concepts for successful implant design, this self-contained text is suitable for engineers, scientists and clinicians. Medical device case studies (including orthopedics, cardiovascular medicine, dentistry and soft tissues), step-by-step design guidelines and prob-lem sets throughout, make this book ideal for course use and for self study.

‘Mechanics of Biomaterials is the textbook I have been waiting for. … an outstanding text and reference book that should be required reading for all who aspire to design, develop and evaluate medical devices.’Jeremy L. Gilbert, Syracuse University

Contents: Part I. Materials: 1. Biocompatibility, sterilization and materials selection for implant design; 2. Metals for medical implants; 3. Ceramics; 4. Polymers; 5. Mechanical behavior of structural tissues; Part II. Mechanics: 6. Elasticity; 7. Viscoelasticity; 8. Failure theories; 9. Fracture mechanics; 10. Fatigue; 11. Friction, lubrication and wear; Part III. Case Studies: 12. Regulatory affairs and testing; 13. Orthopedics; 14. Cardiovascular devices; 15. Oral and

maxillofacial devices; 16. Soft tissue replacements; Appendix A. Selected topics from mechanics of materials; Appendix B. Table of material properties of engineering biomaterials and tissues; Appendix C. Teaching methodologies in biomaterials; Glossary; List of symbols.Cambridge Texts in Biomedical Engineering

2011 246 x 189 mm 696pp 375 b/w illus. 35 tables 115 exercises 978-0-521-76221-2 Hardback £65.00

eBook availablewww.cambridge.org/9780521762212

TEXTBOOK

BiosimulationSimulation of Living SystemsDaniel A. BeardMedical College of Wisconsin

A hands-on guide to devising, designing and analysing simulations of biophysical processes for applications in biological and biomedical sciences. Practical examples are given throughout, representing real-world case studies of key application areas, and all data and complete codes for simulation and data analysis are provided online.Contents: 1. Introduction to simulation of biological systems; 2. Transport and reaction of solutes in biological systems; 3. Physiologically-based pharmacokinetic modeling; 4. Cardiovascular systems simulation; 5. Chemical reaction systems: thermodynamics; 6. Chemical reaction systems: kinetics; 7. Chemical reaction systems: large-scale systems simulation; 8. Cellular electrophysiology; 9. Appendices: mathematical and computational techniques.Cambridge Texts in Biomedical Engineering


www.cambridge.org/9780521768238

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TEXTBOOK

Numerical and Statistical Methods for BioengineeringApplications in MATLABMichael R. Kingand Nipa A. ModyCornell University, New York

The fi rst MATLAB-based numerical methods textbook specifi cally for bioengineers, including topics on hypothesis testing, plus numerous examples drawn exclusively from biomedical engineering applications.

This is an ideal core text for one-semester undergraduate courses, and is also a valuable reference for anyone interested in the quantitative aspects of biology research.

‘I think this book is a winner … [it] is really easy to read and places frameworks for numerical analysis into realistic bioengineering concepts that students will fi nd familiar and relevant. This is most evident in the excellent boxed examples, but also in many of the homework problems.’K. Jane Grande-Allen, Rice University

Cambridge Texts in Biomedical Engineering

2010 246 x 189 mm 594pp 102 b/w illus. 978-0-521-87158-7 Hardback £65.00


TEXTBOOK

Introduction to Medical ImagingPhysics, Engineering and Clinical ApplicationsNadine Barrie SmithPennsylvania State University

and Andrew WebbLeiden University Medical Center

Covering the basics of X-rays, CT, PET, nuclear medicine, ultrasound, and MRI, this textbook is for a one-semester senior undergraduate/graduate course in medical imaging. Together with the state-of-the-art concepts and theory, it also provides relevant clinical applications, solved and open-ended example problems, and future prospects for the fi eld.Cambridge Texts in Biomedical Engineering



TEXTBOOK

FORTHCOMING

Fundamentals of Systems BiologyIntegrating Experiments with ModelingJason Papin, Timothy AllenShayn Pierceand Jeff SaucermanUniversity of Virginia

Practical introduction to the integration of experimental data and mathematical models needed to study life at a systems-wide level.Cambridge Texts in Biomedical Engineering

246 x 189 mm 400pp978-0-521-19641-3 Hardback c. £70.00

Publication January 2013www.cambridge.org/9780521196413

TEXTBOOK

BiodesignThe Process of Innovating Medical TechnologiesStefanos Zenios, Josh MakowerPaul Yock, Todd J. BrintonUday N. Kumar, Lyn Denendand Thomas M. KrummelStanford University, California

Recognise market opportunities, master the design process, and develop business acumen with this step-by-step ‘how-to’ guide for medical technology innovation.

‘Everything you ever wanted to know about medical device entrepreneurship and more. Paul, Josh and Stefanos have led an A class team of experienced device company builders to produce a reference document to guide an aspiring device entrepreneur through all the challenges of getting an idea to market. These are tough

times. Whether you’re a physician with an idea, an engineer or a businessman, this is a unique and powerful resource.’John Abele, Founder Chairman, Boston Scientifi c

‘… fascinating … I would recommend this book strongly to SMEs … in Europe who wish to penetrate the American market with medical device related products.’Scope

Contents: Preface; Community; Biographies; Glossary; Part I. Identify; Section 1. Needs Finding: 1. Strategic focus; 2. Observation and problem identifi cation; 3. Need statement development; Case study; Section 2. Needs Screening: 4. Disease state fundamentals; 5. Treatment options; 6. Stakeholder analysis; 7. Market analysis; 8. Needs fi ltering; Case study; Part II. Invent; Section 3. Concept Generation: 9. Ideation and brainstorming; 10. Concept screening; Case study; Section 4. Concept Selection: 11. Intellectual property basics; 12. Regulatory basics; 13. Reimbursement basics; 14. Business models; 15. Prototyping; 16. Final concept selection; Case study; Part III. Implement; Section 5. Development Strategy and Planning: 17. IP strategy; 18. R&D strategy; 19. Clinical strategy; 20. Regulatory strategy; 21. Quality and process management; 22. Reimbursement strategy; 23. Marketing and stakeholder strategy; 24. Sales and distribution strategy; 25. Competitive advantage and business strategy; Case study; Section 6. Integration: 26. Operating plan and fi nancial model; 27. Business plan development; 28. Funding sources; 29. Licensing and alternate pathways; Case study; Index.2009 276 x 219 mm 778pp 106 b/w illus. 79 tables 978-0-521-51742-3 Hardback £61.00



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TEXTBOOK

Biomedical Engineering for Global HealthRebecca Richards-KortumRice University, Houston

Can technology transform world health? For visionary general science and biomedical engineering courses, Rebecca Richards-Kortum examines biomedical technology and the regulatory, economic, social and ethical issues surrounding global health. With engaging learning features including classroom activities, project assignments and homework problems, this textbook will inspire undergraduates to fi nd solutions.

‘Professor Richards-Kortum has been in the forefront of giving bioengineers a conscience. This book is an excellent fi rst step in educating engineers as to medical problems in the developing worlds and ways in which bioengineers can make a difference.’Paul Yager, Department of Bioengineering, University of Washington, Seattle

Contents: Preface; 1. Emerging medical technologies: high stakes science and the need for technology assessment; 2. Bioengineering and technology assessment; 3. Health and economic data: a global comparison; 4. World health and global health challenges; 5. Healthcare systems: a global comparison; 6. Healthcare costs vs. time: trends and drivers; 7. The evolution of technology: scientifi c method, engineering design, and translational research; 8. Prevention of infectious disease; 9. Ethics of clinical research; 10. Technologies for early detection and prevention of cancer; 11. Cost-effectiveness of screening for disease; 12. Technologies

for treatment of heart disease; 13. Clinical trial design and sample size calculation; 14. Technology diffusion; 15. Regulation of health care technologies; 16. Future of bioengineering and world health; Index.Cambridge Texts in Biomedical Engineering

2009 276 x 219 mm 416pp 114 b/w illus. 60 tables 978-0-521-87797-8 Hardback £53.00


An Introduction to Modeling of Transport ProcessesApplications to Biomedical SystemsAshim Dattaand Vineet RakeshCornell University, New York

Organised around problem solving, this book introduces the reader to computational simulation of biomedical transport processes, bridging fundamental theory with real-world applications. Step-by-step instructions enable a newcomer to get started immediately and the inclusion of property data and case studies provide usable models that can be applied further afi eld.Cambridge Texts in Biomedical Engineering



Introduction to the Science of Medical ImagingEdited by R. Nick BryanUniversity of Pennsylvania

Biological systems are characterized by complex structures that are invisible to the human eye. Biomedical imaging such as MRI, CT, ultrasound enable us to view these structures non-invasively. This book describes and illustrates how these images are created, analyzed and applied to important biomedical problems such as diseases.

‘Very well written … Excellent images and diagrams … concise and up to date … a landmark text on the science of image interpretation. The authors manage to make a very complex subject very readable … relevant fi gures are exceptional …’BMA Medical Book Awards reviewer

Contents: Preface; Part I. Introduction: 1. What is an image?; 2. How to make an image; 3. How to analyze an image; Part II. Biomedical Images: 4. Nuclear medicine; 5. X-ray: non-ionizing radiation; 6. Ultrasound; 7. Magnetic resonance imaging; 8. Optical imaging; Part III. Sample Labeling: 9. Contrast agents; 10. Molecular labeling; Part IV. Image Analysis: 11. Human observer; 12. Digital image processing; 13. Registration and atlas building; 14. Statistical atlases; Part V. Biomedical Applications: 15. Morphological imaging; 16. Physiological imaging; 17. Molecular imaging; Appendices: 1. Linear systems; 2. Transforms and k space; 3. Probability, Bayesian statistics and information theory; Index.2009 246 x 189 mm 334pp 159 b/w illus. 31 tables 978-0-521-74762-2 Paperback £79.00


Ultra Low Power BioelectronicsFundamentals, Biomedical Applications, and Bio-Inspired SystemsRahul SarpeshkarMassachusetts Institute of Technology

Learn how to architect ultra low power robust electronics with applications to implantable and non-invasive medicine, and how bio-inspired principles from cell biology and neurobiology can revolutionize low power electronics design, with this all-inclusive guide. Effi cient, sustainable energy harvesting is also covered, and a wealth of practical examples and case studies are included.

‘… an excellent overview of ten key fundamental principles related to ultra low power circuit and system design. Examples of many practical, experimental micro-power systems in cardiac, neural,and other medical-electronics applications make the text highly useful. Practitioners in this fi eld will gain insight from his system-level analysis, which is presented at a level deeper than that found in most texts. In fact, the focus on systems thinking and connections made to a diverse set of problems – natural and man-made, from medical implants, to cells, to low-power cars – truly sets this book apart.’Tim Denison, Medtronic Fellow




Handbook of Neural Activity Measurement

Edited by Romain Brette and Alain Destexhe

eBooks available at www.cambridge.org/ebookstore eBooks available at www.cambridge.org/ebookstore

Multiscale Modeling of the Skeletal SystemMarco VicecontiIstituti Ortopedici Rizzoli, Bologna, Italy

Systematically working from the whole body down to the cellular level, this book presents an integrative, multiscale computational approach to skeletal research. Addressing biomechanical and mechanobiological processes, the reader will learn how computational modeling can determine the relationship between bone mechanics and disease.

‘Professor Viceconti is one of the pioneers of the integrative approach to biological systems and his book is a beautiful illustration of this approach. Beautiful in all senses: sound intellectual argument, clear informative illustrations, fascinating practical applications, and it forms a sustained development of a fi eld of research that is fundamental to the success of any attempt to create the Virtual Physiological Human.’Denis Noble, University of Oxford

2011 247 x 174 mm 222pp 40 b/w illus. 978-0-521-76950-1 Hardback £65.00


Multiscale Modeling of CancerAn Integrated Experimental and Mathematical Modeling ApproachVittorio CristiniUniversity of Texas Health Science Center, Houston

and John LowengrubUniversity of California, Irvine

Uniquely connecting theory with experimental data, this book highlights the potential of advanced computational methods in cancer research. Beginning

with a biological background, the reader is introduced to the principles of mathematical modeling, before being guided through case studies that demonstrate how modeling can aid our understanding of tumour biology.2010 247 x 174 mm 298pp 55 b/w illus. 5 tables 978-0-521-88442-6 Hardback £83.00


Handbook of Neural Activity MeasurementEdited by Romain BretteEcole Normale Supérieure, Paris

and Alain DestexheCentre National de la Recherche Scientifi que (CNRS), Paris

Leading experts describe the various existing techniques for measuring neural activity (for example, intracellular recording and electroencephalograms). Readers will come to understand the physical principles underlying each technique and the precise relationship between the measured signals and neural activity.2012 247 x 174 mm 254pp 95 b/w illus. 30 colour illus. 978-0-521-51622-8 Hardback c. £70.00

Publication August 2012www.cambridge.org/9780521516228

The Mechanics of the CirculationSecond editionC. G. CaroImperial College London

T. J. PedleyUniversity of Cambridge

R. C. SchroterImperial College London

and W. A. SeedImperial College London

Assisted by K. H. ParkerImperial College London

Finally back in print, this classic book is of value to students, researchers and practitioners in bioengineering, physiology and human and veterinary medicine, particularly those working in the cardiovascular fi eld. It is also useful for engineers and physical scientists with multidisciplinary interests.

‘This splendid book is so well written that one would seriously question the vocation of an investigator who couldn’t understand it. It is essential reading for anyone who is interested in the mechanics of the circulation. The normally incomprehensible mechanical laws are explained so clearly that even the non-mathematically minded will have no diffi culty, which makes me very sorry that it was not available when I was grappling with these problems.’David Mendel, Journal of the Royal Society of Medicine

2011 228 x 152 mm 550pp 285 b/w illus. 15 tables 978-0-521-15177-1 Paperback £29.99


Mathematical Foundations and Biomechanics of the Digestive SystemRoustem N. Miftahofand Hong Gil NamPohang University of Science and Technology, Republic of Korea

Mathematical models are used to explain and study organ biomechanics of the abdominal viscera. Beginning with the fundamentals of thin shell theory, it leads to description of the function of abdominal organs. Finite deformations, effects of boundary conditions, electrodynamics dynamics, related medical conditions and effects of drugs are investigated.

‘Biomedical engineers, gastrointestinal physiologists, medical physicists, and experts in drug discovery will fi nd the insights and comprehensiveness of this mathematical modeling framework to have breakthrough potential … this book introduces a model that explains drug effects, their interactions, and reveals the mechanism for pathophysiological consequences of common disorders.’Michael W. Vannier, University of Chicago Medical Center

2010 247 x 174 mm 240pp 237 b/w illus. 42 exercises 978-0-521-11662-6 Hardback £77.00



Partial Differential Equation Analysis in Biomedical EngineeringCase Studies with Matlab

William E. Schiesser


Complex WebsAnticipating the ImprobableBruce J. WestArmy Research Offi ce

and Paolo GrigoliniUniversity of North Texas

Presenting the common principles, algorithms, and tools governing network behaviour, dynamics, and complexity, this book synthesises modern mathematical developments with the broad range of network applications of interest to the engineer and system scientist. It is richly illustrated with real-world examples from physiology, bioengineering, biophysics, and informational and social networks.

‘Recent books highlighting different aspects of network science can be roughly separated into popular works that lay out an integrated scientifi c view of humans and modern technology; manuals and references focused on specifi c application areas such as biophysics, econophysics, or sociophysics; and texts that explore advanced networks-related topics that go beyond particular disciplines. Complex Webs most closely matches the last (and smallest) category, as it interweaves various topics from statistical physics to support the understanding of complex networks; perhaps in the future those topics will form the foundation of a network science.’H. Eugene Stanley, Physics Today



TEXTBOOK

Partial Differential Equation Analysis in Biomedical EngineeringCase Studies with MatlabWilliam E. SchiesserLehigh University, Pennsylvania

Aimed at graduates and researchers, this introduction to computer-based partial differential equation (PDE) modeling provides readers with the practical tools necessary to develop and use mathematical models in biomedical engineering. With step-by-step guidelines and detailed examples, the reader will learn how PDE analysis is formulated, implemented and tested.2012 247 x 174 mm 350pp 20 b/w illus. 15 tables 978-1-107-02280-5 Hardback c. £65.00

Publication July 2012www.cambridge.org/9781107022805

Cellular Materials in Nature and MedicineLorna J. GibsonMassachusetts Institute of Technology

Michael F. AshbyUniversity of Cambridge

and Brendan A. HarleyUniversity of Illinois, Urbana-Champaign

Describing the structure and mechanics of a wide range of natural materials with a honeycomb- or foam-like structure (e.g. wood, cork, trabecular bone and coral), this book shows how models for cellular materials can be applied in medicine, such as metal foams in orthopedics and porous scaffolds for tissue engineering.2010 247 x 174 mm 320pp 149 b/w illus. 21 colour illus. 34 tables 978-0-521-19544-7 Hardback £52.00


Dendrimers, Dendrons, and Dendritic PolymersDiscovery, Applications and the FutureDonald A. TomaliaNanoSynthons, LLC

Jørn B. ChristensenUniversity of Copenhagen

and Ulrik BoasTechnical University of Denmark, Lyngby

Dendrimer science has exploded onto the polymer science scene, presenting a completely new polymeric architecture. It offers unique architecturally driven properties which promise exciting advancements in nanotechnology. This book presents the history of dendrimer discovery, synthetic strategies, characterisation methodologies, dendritic effects and the future impact on nanotechnology and commercial applications.2012 247 x 174 mm 344pp 269 b/w illus. 2 tables 978-0-521-51580-1 Hardback c. £60.00

Publication August 2012www.cambridge.org/9780521515801

TEXTBOOK

Micro- and Nanoscale Fluid MechanicsTransport in Microfl uidic DevicesBrian KirbyCornell University, New York

This text brings together several areas that are often taught separately – namely fl uid mechanics, electrodynamics, and interfacial chemistry and electrochemistry – with a focused goal of preparing the modern microfl uidics researcher to analyse and model continuum fl uid mechanical systems encountered when working with micro- and nanofabricated devices.2010 253 x 215 mm 534pp 228 b/w illus. 23 tables 360 exercises 978-0-521-11903-0 Hardback £75.00


Electrokinetically-Driven Microfl uidics and Nanofl uidicsHsueh-Chia ChangUniversity of Notre Dame, Indiana

and Leslie Y. YeoMonash University, Victoria

In this book, Leslie Yeo and Hsueh-Chia Chang aim to elucidate the fundamental mechanisms governing both DC and AC electrokinetic phenomena with a particular emphasis on the practical design of microfl uidic and nanofl uidic devices for a variety of biological applications.2010 253 x 215 mm 526pp 283 b/w illus. 978-0-521-86025-3 Hardback £72.00



BIOPHYSICSA Physiological Approach

Patrick F. Dillon

Dillon BIOPHYSICS

C O V E R D E S I G N E D B Y R O B L O C K

Specifi cally tailored to life science

students, this textbook explains

quantitative aspects of human biophysics

with examples drawn from contemporary

physiology, genetics, and nanobiology.

It outlines important physical ideas,

equations, and examples at the heart of

contemporary physiology, along with the

organization necessary to understand that

knowledge.

The wide range of biophysical topics

covered includes energetics, bond

formation and dissociation, diffusion and

directed transport, muscle and connective

tissue physics, fl uid fl ow, membrane

structure, electrical properties and

transport, pharmacokinetics, and system

dynamics and stability. Enabling students

to understand the uses of quantitation in

modern biology, equations are presented

in the context of their application, rather

than derivation. They are each directed

toward the understanding of a biological

principle, with a particular emphasis on

human biology.

“This book offers rigorous but accessible

explanations of basic mechanisms and

also presents biomedical applications in a

manner that heightens understanding of

the biological context. The book presents

the biophysical basis of an impressive

number of physiological and biochemical

mechanisms in a manner that is not found

in traditional textbooks. It should certainly

help to broaden the knowledge base of

students and researchers in biomedicine

and life science and thereby facilitate

cross-disciplinary understanding and

interaction.”

Per Hellstrand, Lund University, Sweden

Patrick F. Dillon is Professor in the

Department of Physiology at Michigan

State University. He has taught physiology

for more than 30 years, ranging from

high school to medical school level. He

was awarded the Outstanding Faculty

Award from Michigan State University in

recognition of his teaching achievements.

A range of test questions and solutions

www.cambridge.org/Dillon

Dill

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Mechanics of the CellMechanics of the CellS e c o n d e d i t i o n M

echanics of the CellS

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david Boal

Se c o nd e di t i o n

exploring the mechanical features of biological cells, including their architecture and

stability, this textbook is a pedagogical introduction to the interdisciplinary fields of cell

mechanics and soft matter physics from both experimental and theoretical perspectives.

this second edition has been greatly updated and expanded, with new chapters on

complex filaments, the cell division cycle, the mechanisms of control and organization in

the cell, and fluctuation phenomena. the textbook is now in full color which enhances the

diagrams and allows the inclusion of new microscopy images.

With more than 300 end-of-chapter exercises exploring further applications, this

textbook is ideal for advanced undergraduate and graduate students in physics and

biomedical engineering. A website hosted by the author contains extra support material,

diagrams and lecture notes, and is available at www.cambridge.org/Boal.

David Boal is Professor emeritus in the department of Physics at Simon Fraser University,

canada. He has been working in the field of biophysics for the past 20 years, and he now

studies the mechanical issues in the origin of life.

cover illustration: image of a primary cultured hippocampal neuron

stained for nuclear dnA (blue), the Golgi apparatus (yellow), dendrites

(red), and secretory vesicles (green). Photo credit: Pouya Mafi and

Michael Silverman.

Boal

Cover designed by Hart McLeod Ltd.

BOAL: MECHANICS OF THE CELL PPC CMYBLK


TEXTBOOK

Essentials of Micro- and Nanofl uidicsWith Applications to the Biological and Chemical SciencesA. Terrence ConliskOhio State University

This book introduces students to the physical principles to analyze fl uid fl ow in micro and nano-size devices. This is the fi rst book that unifi es the thermal sciences with electrostatics and electrokinetics and colloid science; electrochemistry; and molecular biology. This textbook includes exercises, modern examples and applications, and a solutions manual available to qualifi ed instructors.2012 253 x 177 mm 548pp 117 b/w illus. 40 tables 170 exercises 978-0-521-88168-5 Hardback TBA


TEXTBOOK

BiophysicsA Physiological ApproachPatrick F. DillonMichigan State University

Specifi cally tailored to life science students, this textbook outlines the important physical ideas, equations and examples at the heart of contemporary physiology, along with the organisation necessary to understand that knowledge. The equations are designed to help students understand biological principles, with a particular emphasis on human biology.

‘The book presents the biophysical basis of an impressive number of physiological and biochemical mechanisms in a manner that is not

found in traditional textbooks. It should certainly help to broaden the knowledge base of students and researchers in biomedicine and life science and thereby facilitate cross-disciplinary understanding and interaction.’Per Hellstrand, Lund University, Sweden


978-0-521-17216-5 Paperback £38.00


TEXTBOOK

Mechanics of the CellSecond editionDavid BoalSimon Fraser University, British Columbia

Exploring the mechanical features of biological cells, this second edition now covers complex fi laments, the cell division cycle, cell control and organisation, and fl uctuation phenomena. In full color and with over 300 end-of-chapter exercises, this textbook is ideal for advanced undergraduate and graduate students in physics and biomedical engineering.

Review of the fi rst edition: … for graduate students in the general fi eld and for biotechnologists required to consider added dimensions to their work this book represents a comprehensive text that ought to make it a standard reference for many years.’Ian Jones, Chemistry in Britain

2012 246 x 189 mm 622pp 282 colour illus. 283 exercises 978-0-521-11376-2 Hardback £90.00

978-0-521-13069-1 Paperback £50.00


Plasma MedicineApplications of Low Temperature Gas Plasmas in Medicine and Biology

M. Laroussi, M. Kong, G. Morfill and W. Stolz

The Toxicology of Carbon NanotubesEdiTEd by

Ken Donaldson, Craig Poland, Rodger Duffin and James Bonner

Systems Biology: Simulation of Dynamic Network StatesBernhard Ø. PalssonUniversity of California, San Diego

Large omics data sets are diffi cult to interpret and use, but this practical book teaches how to build complex dynamical models of biochemical networks and simulate their responses. All examples in the text are available in MATLAB and MATHEMATICA® workbooks, allowing easy hands-on practice.2011 247 x 174 mm 332pp 126 b/w illus. 978-1-107-00159-6 Hardback £45.00


Cellular MechanotransductionDiverse Perspectives from Molecules to TissuesEdited by Mohammad R. K. MofradUniversity of California, Berkeley

and Roger D. KammMassachusetts Institute of Technology

This book focuses on the process of stress sensing and transducing mechanical force into biochemical signals. It helps defi ne mechanomics, which describes the mechanical state of a biological system.2009 253 x 215 mm 478pp 240 b/w illus. 8 colour illus. 4 tables 978-0-521-89523-1 Hardback £77.00


Plasma MedicineApplications of Low Temperature Gas Plasmas in Medicine and BiologyEdited by M. LaroussiOld Dominion University, Virginia

M. G. KongLoughborough University

G. Morfi llMax-Planck-Institut für Plasmaphysik, Garching, Germany

and W. StolzLudwig-Maximilians-Universität Munchen

The fi rst book dedicated exclusively to plasma medicine, covering the fundamental theory and examples of its applications in different fi elds. Devised to meet the needs of researchers from different scientifi c communities, this volume is a reference tool for graduate students and researchers in physics, engineering, biology, medicine and biochemistry.2012 247 x 174 mm 416pp 140 b/w illus. 15 tables 978-1-107-00643-0 Hardback c. £75.00

Publication May 2012www.cambridge.org/9781107006430

The Toxicology of Carbon NanotubesEdited by Kenneth DonaldsonUniversity of Edinburgh

Craig PolandInstitute of Occupation Medicine

Rodger Duffi nUniversity of Edinburgh

and James BonnerNorth Carolina State University

Compiled by leading experts, this is the fi rst book dedicated to this subject. It provides state-of-the-science information, from the aerodynamic behaviour of carbon nanotubes to their

Biomedical Engineering14 Biomedical Engineering14 15Chemical Engineering


effect at molecular level in the lungs, and is invaluable to the many groups involved with research in this area.2012 247 x 174 mm 264pp 58 b/w illus. 978-1-107-00837-3 Hardback c. £85.00


Femtosecond BiophotonicsCore Technology and ApplicationsMin GuSwinburne University of Technology, Victoria

Damian BirdUniversal Biosensors Pty Ltd

Daniel DaySwinburne University of Technology, Victoria

Ling FuHuazhong University of Science and Technology

and Dru MorrishSwinburne University of Technology, Victoria

Covering key techniques for optical microscopy and micro-fabrication, this book provides the fi rst detailed treatment of femtosecond laser-based biophotonics. After a review of the techniques for nonlinear and multiphoton imaging, applications for laser-based manipulation of micro-particles are introduced. The fi nal chapter focuses on the burgeoning fi eld of femtosecond micro-engineering.2010 247 x 174 mm 248pp 159 b/w illus. 6 tables 978-0-521-88240-8 Hardback £83.00


ChemicalEngineering

HIGHLIGHT

TEXTBOOK

Chemical Product DesignSecond editionE. L. CusslerUniversity of Minnesota

and G. D. MoggridgeUniversity of Cambridge

This revised and expanded edition of a groundbreaking textbook provides a four-step process for chemical product design: needs, ideas, selection and manufacture. Numerous real-world examples and homework problems give ample illustrative and assessment material, whilst four new chapters set out the different product types (commodities, devices, molecules/drugs and microstructures).

‘I have been anticipating the launch of this book since Dr Moggridge told me back in 2009 that he had been working on the second edition. This is the long-awaited update of the book which was the fi rst of its kind in the chemical engineering literature. The book had served as the foundation of my chemical product design course. Cussler and Moggridge’s clear writing style and abundance of real-world examples in the book make it a must-have for any faculty interested in this fast emerging fi eld of product design in chemical engineering.’Sin-Moh Cheah, Singapore Polytechnic

Chemical Engineering

AN INTRODUCTIONM O RT O N M. D E N N

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Chemical Engineering AN INTRODUCTION

“Chemical engineering is the fi eld of applied science that employs physical, chemical, and

biochemical rate processes for the betterment of humanity.” This opening sentence of Chapter 1

is the underlying paradigm of chemical engineering. Chemical Engineering: An Introduction is

designed to enable the student to explore the activities in which a modern chemical engineer

is involved by focusing on mass and energy balances in liquid-phase processes. Applications

explored include the design of a feedback level controller, membrane separation, hemodialysis,

optimal design of a process with chemical reaction and separation, washout in a bioreactor,

kinetic and mass transfer limits in a two-phase reactor, and the use of a membrane reactor to

overcome equilibrium limits on conversion. Mathematics is employed as a language at the most

elementary level. Professor Morton M. Denn incorporates design meaningfully; the design and

analysis problems are realistic in format and scope. Students using this text will appreciate why

they need the courses that follow in the core curriculum.

MORTON M. DENN is the Albert Einstein Professor of Science and Engineering and Director

of the Benjamin Levich Institute for Physico-Chemical Hydrodynamics at the City College of

New York, CUNY. Prior to joining CCNY in 1999, he was Professor of Chemical Engineering at

the University of California, Berkeley, where he served as Department Chair, as well as Program

Leader for Polymers and Head of Materials Chemistry in the Materials Sciences Division of

the Lawrence Berkeley National Laboratory. He previously taught chemical engineering at the

University of Delaware, where he was the Allan P. Colburn Professor. Professor Denn was Editor

of the AIChE Journal from 1985 to 1991 and Editor of the Journal of Rheology from 1995 to

2005. He is the recipient of a Guggenheim Fellowship; a Fulbright Lectureship; the Professional

Progress, William H. Walker, Warren K. Lewis, Institute Lectureship, and Founders Awards of

the American Institute of Chemical Engineers; the Chemical Engineering Lectureship of the

American Society for Engineering Education; and the Bingham Medal and Distinguished Service

Awards of the Society of Rheology. He is a member of the National Academy of Engineering

and the American Academy of Arts and Sciences, and he received an honorary DSc from

the University of Minnesota. His previous books are Optimization by Variational Methods;

Introduction to Chemical Engineering Analysis, coauthored with T. W. Fraser Russell; Stability

of Reaction and Transport Processes; Process Fluid Mechanics; Process Modeling; and

Polymer Melt Processing: Foundations in Fluid Mechanics and Heat Transfer.

Cover photo: Stellarator II. © Kim Dylla. Used with permission.

Cover design by Alice Soloway

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Colloidal Suspension RheologyJan Mewis and Norman J. Wagner

Colloidal suspensions are encountered in a multitude of natural, biological,

and industrially relevant products and processes. Understanding what

affects the fl ow behavior, or rheology, of colloid suspensions, and how this

fl ow behavior can be manipulated, is important for successful formulation

of products such as paint, polymers, foods, and pharmaceuticals.

This book is the fi rst devoted to the study of colloidal rheology in all its

aspects. With material presented in an introductory manner, and complex

mathematical derivations kept to a minimum, the reader will gain a strong

grasp of the basic principles of colloid science and rheology. Beginning

with purely hydrodynamic effects, the contributions of Brownian motion

and interparticle forces are covered, before the reader is guided through

specifi c problem areas, such as thixotropy and shear thickening; special

classes of colloid suspensions are also treated. The techniques necessary

for measuring colloidal suspension rheology are presented along with

methods to correlate and interpret the results. An essential guide for

academic and industrial researchers, this book is also ideal for graduate

course use.

Jan Mewis is Emeritus Professor of the Chemical Engineering Department

at the Katholieke Universiteit Leuven. He is involved in industrial and

academic research in complex fl uids such as suspensions and polymer

blends. Professor Mewis has lectured all over the world and has written over

200 publications on colloid science and rheology. He was Chairman of the

International Committee on Rheology and is a recipient of the Gold Medal

of the British Society of Rheology and the Bingham Medal of The Society of

Rheology (USA).

Norman J. Wagner received his Doctorate from Princeton University and

is a named Professor and Chair of the Department of Chemical Engineering

at the University of Delaware. He has extensive international teaching

and research experience, and leads an active research group covering

fi elds such as rheology, complex fl uids, polymers, nanotechnology, and

particle technology. Professor Wagner has received several awards for his

research developments, has co-authored over 150 scientifi c publications

and patents, and is on the editorial boards of fi ve international journals. He

currently serves on the executive board of the Society of Rheology and the

Neutron Scattering Society of America.

“Appropriately, the fi rst book to span

the subject of suspension rheology

is authored by Jan Mewis, a pioneer

in the fi eld, and Norm Wagner,

whose research has advanced

many of the modern frontiers.”

William B. Russel,

Princeton University

“The elegant presentation style,

focusing on the fundamental

concepts, bridging engineering

and physics, experiment and

theory, and paying attention to the

interplay between microstructure

and rheology, refl ects the vast

teaching and research experience

of the authors, and makes the

book a much needed reference

for practitioners, researchers and

graduate students.”

Dimitris Vlassopoulos,

IESL-FORTH, Greece

“Ever since I learned that Mewis and

Wagner were preparing Colloidal

Suspension Rheology I have been

eagerly awaiting its arrival. I was

not disappointed! … The concise

review of colloidal phenomena

in Chapter 1 is outstanding and

the Advanced Topics in the fi nal

chapter (microrheology, electro

and magneto-rheology and 2

dimensional rheology) are a

special treat.”

Chris Macosko,

University of Minnesota & IPRIME

Cover designed by Hart McLeod Ltd

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Contents: 1. An introduction to chemical product design; 2. Needs; 3. Ideas; 4. Selection; 5. Product manufacture; 6. Commodity products; 7. Devices; 8. Molecular products; 9. Microstructures; 10. A plan for the future.Cambridge Series in Chemical Engineering

2011 247 x 174 mm 452pp 76 b/w illus. 80 tables 81 exercises 978-0-521-16822-9 Paperback £40.00


TEXTBOOK

Chemical EngineeringAn IntroductionMorton DennCity College, City University of New York

Chemical Engineering: An Introduction enables students to explore the activities a modern chemical engineer is involved with, by focusing on mass and energy balances in liquid-phase processes.Contents: Preface; 1. Introduction; 2. Basic concepts of analysis; 3. The balance equation; 4. Component mass balances; 5. Membrane separation; 6. Reacting systems; 7. Designing reactors; 8. Bioreactors and nonlinear systems; 9. Overcoming equilibrium; 10. Two-phase systems and interfacial mass transfer; 11. Equilibrium staged processes; 12. Energy balances; 13. Heat exchange; 14. Energy balances for multi-component systems; 15. Energy balances for reacting systems.Cambridge Series in Chemical Engineering


978-1-107-66937-6 Paperback £35.00


Colloidal Suspension RheologyJan MewisKatholieke Universiteit Leuven, Belgium

and Norman J. WagnerUniversity of Delaware

With material presented in an introductory manner, and complex mathematical derivations kept to a minimum, this is the fi rst book devoted to the comprehensive study of colloidal rheology in all its aspects. An essential guide for industrial researchers and practitioners, this book is also ideal for specialised graduate courses.Cambridge Series in Chemical Engineering



Dynamics and Nonlinear Control of Integrated Process SystemsMichael BaldeaUniversity of Texas, Austin

and Prodromos DaoutidisUniversity of Minnesota

Aimed at researchers and engineers interested in analysing and controlling integrated chemical plants as well as other systems with complex interconnections (reaction networks, power grids, information networks, supply chains), this monograph combines a pedagogical style of exposition, technical rigor,

Biomedical Engineering14

17Chemical EngineeringChemical Engineering16


practical examples, case studies and implementation guidelines.Cambridge Series in Chemical Engineering

2012 247 x 174 mm 270pp 115 b/w illus. 7 tables 978-0-521-19170-8 Hardback c. £75.00


FORTHCOMING

Chemistry of Fossil Fuels and BiofuelsHarold SchobertPennsylvania State University

Focusing on today’s major fuel resources, this book discusses the natural processes by which they formed; their composition and properties; and the ways in which they are converted or upgraded into the forms in commercial use. It is ideal for graduate students and professionals in chemical engineering and energy technology.Cambridge Series in Chemical Engineering

247 x 174 mm 600pp 200 b/w illus. 54 tables 978-0-521-11400-4 Hardback c. £65.00


TEXTBOOK

FORTHCOMING

Separations of Molecules, Macromolecules and ParticlesPrinciples, Phenomena and ProcessesKamalesh SirkarNew Jersey Institute of Technology

Written for an advanced separation process course in chemical engineering, this textbook provides students with a basic understanding of molecular, macromolecular and particle separation techniques. With a wide range of industrial examples, worked through problems, homework sets, and a solutions manual for instructor use, this is the complete textbook package.Contents: Introduction to the book; 1. Description of separation in a closed system; 2. Description of separation in open separators; 3. Physicochemical basis for separation; 4. Separation in a closed vessel; 5. Effect of chemical reaction on separation; 6. Open separators: bulk fl ow parallel to force and continuous stirred tank separators; 7. Separation in bulk fl ow of feed-containing phase perpendicular to the direction of the force; 8. Bulk fl ow of two phases/regions perpendicular to the direction(s) of the force(s); 9. Cascades; 10. Energy required for separation; 11. Common separation sequences.Cambridge Series in Chemical Engineering

246 x 189 mm 1000pp 450 b/w illus. 40 tables 300 exercises 978-0-521-89573-6 Hardback c. £55.00


TEXTBOOK

FORTHCOMING

Chemical, Biological and Materials Engineering ThermodynamicsJuan J. de PabloUniversity of Wisconsin, Madison

Nicholas L. AbbottUniversity of Wisconsin, Madison

and Jay P. SchieberCenter for Molecular Study of Condensed Soft Matter

Integrates classical, statistical and molecular thermodynamics, for instructors teaching a modern thermodynamics course.Cambridge Series in Chemical Engineering

247 x 174 mm 650pp978-0-521-76562-6 Hardback c. £60.00


NEW IN PAPERBACK

TEXTBOOK

Advanced Transport PhenomenaFluid Mechanics and Convective Transport ProcessesL. Gary LealUniversity of California, Santa Barbara

Advanced Transport Phenomena is ideal as a graduate textbook. It contains a detailed discussion of modern analytic methods for the solution of fl uid mechanics and heat and mass transfer problems, focusing on approximations based upon scaling and asymptotic

methods. The book is also focused on the solutions of representative problems.

‘… provides a solid fundamental and detailed description of mathematical and physical principles of fl uid mechanics and mass transfer problems, pointing out the most important practical applications … extremely well written … very easily readable … I believe that the concepts presented in this book will deeply stimulate new research in fl uid mechanics and heat and mass transfer.’Ioan Pop, Zentralblatt MATH

Cambridge Series in Chemical Engineering

2010 253 x 215 mm 934pp 100 b/w illus. 4 tables 227 exercises 978-0-521-17908-9 Paperback £60.00


PUBLISHED IN PARTNERSHIP WITH THE MATERIALS RESEARCH SOCIETY

HIGHLIGHT

TEXTBOOK

Fundamentals of Materials for Energy and Environmental SustainabilityEdited by David S. GinleyNational Renewable Energy Laboratory, Golden, Colorado

and David CahenWeizmann Institute of Science, Israel

How will we meet rising energy demands? What are our options? Are there viable long-term solutions for the future? Whether you are a student taking an energy course or a newcomer to the fi eld, using this textbook you will understand the critical relationships



between the environment, energy and sustainability.Contents: Part I. Energy and the Environment; Part II. Nonrenewable Energy Sources; Part III. Renewable Energy Sources; Part IV. Transportation; Part V. Energy Effi ciency; Part VI. Energy Storage, High-Penetration Renewables and Grid Stabilization.2012 276 x 219 mm 772pp 450 colour illus. 80 tables 978-1-107-00023-0 Hardback £65.00


Engineering Strategies for Greenhouse Gas MitigationIan S. F. JonesUniversity of Sydney

This book gives a concise review of current knowledge required for engineers to develop strategies to help us manage and adapt to climate change. It is written without technical jargon so as to be accessible to a wide range of students and policymakers.2011 247 x 174 mm 184pp 42 b/w illus. 16 tables 18 exercises 978-0-521-51602-0 Hardback £55.00

978-0-521-73159-1 Paperback £24.99


Fundamentals of Polymer-Clay NanocompositesGary W. Bealland Clois E. PowellTexas State University, San Marcos

Written for researchers and practitioners, this book provides a complete introduction to the science, engineering, and commercial applications of polymer-clay nanocomposites. Physical and mechanical properties are explained, with chapters on thermodynamics and kinetics, barrier properties, and fl ame retardancy. Coverage of fabrication methods and material characterisation make this the must-have reference.2011 247 x 174 mm 194pp 36 b/w illus. 1 table 978-0-521-87643-8 Hardback £70.00


Polymer PhysicsApplications to Molecular Association and Thermoreversible GelationFumihiko TanakaKyoto University, Japan

Maintaining a balance between theoretical descriptions and practical applications, Fumihiko Tanaka provides an up-to-date, unifi ed treatment of polymer association and thermoreversible gelation. Fundamental laws of polymer physics, recent developments are explored, along with relevant case studies. This book will appeal to both researchers and students.2011 247 x 174 mm 404pp 185 b/w illus. 8 tables 978-0-521-86429-9 Hardback £80.00


Y i a n n i s n . K a z n e s s i s

statistical Thermodynamics

and stochastic Kinetics

an introduction for engineers

Presenting the key principles of thermody-

namics from a microscopic point of view, this

book provides engineers with the knowledge

they need to apply thermodynamics and solve

engineering challenges at the molecular level.

it clearly explains the concepts of entropy

and free energy, emphasizing key ideas used

in equilibrium applications, whilst stochastic

process, such as stochastic reaction kinetics,

are also covered. it provides a classical micro-

scopic interpretation of thermodynamic prop-

erties, which is key for engineers, rather than

focussing on more esoteric concepts of statis-

tical mechanics and quantum mechanics.

Coverage of molecular dynamics and Monte

Carlo simulations as natural extensions of the

theoretical treatment of statistical thermo-

dynamics is also included, teaching readers

how to use computer simulations, and thus

enabling them to understand and engineer the

microcosm. Featuring many worked examples

and over 100 end-of-chapter exercises, it is

ideal for use in the classroom as well as for

self-study.

Yiannis n. Kaznessis is a Professor in the Depart-ment of Chemical engineer-ing and Materials science at the University of Minnesota, where he has taught statistical thermodynamics since 2001. He has received several awards and recognitions, including the Fulbright award, the Us national science Foundation CaReeR award, the 3M non-Tenured Faculty award, the iBM Young Faculty award, the aiChe Computers and systems Technology Division Outstand-ing Young Researcher award, and the University of Minne-sota College of science and engineering Charles Bowers Faculty Teaching award.

Cover illustration: the phase space

of a microcanonical ensemble.

statistical Thermodynam

ics and stochastic KineticsK

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statistical Thermodynamics and stochastic Kinetics

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THERMODYNAMICS

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Statistical Thermodynamics and Stochastic KineticsAn Introduction for EngineersYiannis N. KaznessisUniversity of Minnesota

Presenting the principles of thermodynamics from a microscopic point of view, this book provides engineers with the knowledge they need to solve engineering challenges at the molecular level. Featuring many worked examples and over 100 end-of-chapter exercises, it is ideal for use in the classroom as well as for self-study.2011 228 x 152 mm 328pp 79 b/w illus. 6 tables 106 exercises 978-0-521-76561-9 Hardback £50.00


Computational Fluid Dynamics for EngineersBengt AnderssonChalmers University of Technology, Gothenberg

Ronnie AnderssonChalmers University of Technology, Gothenberg

Love HåkanssonEngineering Data Resources (EDR), Norway

Mikael MortensenNorwegian Defence Research Establishment (FFI)

Rahman SudiyoUniversitas Gadjah Mada, Indonesia

and Berend van WachemImperial College London

An introduction to a fast growing discipline, this book delivers the knowledge required to use CFD successfully in a wide range of engineering applications. Ideal for engineers wanting to enter the fi eld or widen their understanding and project

managers requiring the basics in order to negotiate with consulting companies.2011 247 x 174 mm 202pp 76 b/w illus. 11 tables 978-1-107-01895-2 Hardback £65.00


TEXTBOOK

ThermodynamicsSanford KleinUniversity of Wisconsin, Madison

and Gregory NellisUniversity of Wisconsin, Madison

Provides students and practitioners with the concepts, tools and experience needed to solve practical energy problems by integrating computer tools with thermodynamic concepts.2012 253 x 215 mm 1100pp 612 b/w illus. 72 tables 289 exercises 978-0-521-19570-6 Hardback £79.00




TEXTBOOK

Convective Heat and Mass TransferS. Mostafa GhiaasiaanGeorgia Institute of Technology

This book is ideal for a graduate course on convection heat and mass transfer. It treats well-established theory and practice but is also enriched by its coverage of modern areas such as fl ow in microchannels and computational fl uid dynamics-based design and analysis methods. It includes numerous examples and exercises.2011 253 x 215 mm 548pp 140 b/w illus. 34 tables 147 exercises 978-1-107-00350-7 Hardback £90.00


Introductory Fluid MechanicsJoseph KatzSan Diego State University

Designed as a fi rst course on this subject, Katz introduces the principles of fl uid mechanics, and at the same time it provides suffi cient analytical background for more specifi c courses in this fi eld. The reader will understand the basic principles and have the ability to use these skills for engineering design.2010 253 x 215 mm 456pp 264 b/w illus. 4 tables 461 exercises 978-0-521-19245-3 Hardback £80.00


Fluid Dynamics and Transport of Droplets and SpraysSecond editionWilliam A. SirignanoUniversity of California, Irvine

This book explores the theoretical and computational aspects of the fl uid dynamics and transport of sprays and droplets. Two new chapters introduce liquid-fi lm vaporisation as an alternative to sprays for miniature applications and a review of liquid-stream distortion and break-up theory.2010 253 x 215 mm 480pp 161 b/w illus. 10 tables 978-0-521-88489-1 Hardback £70.00


Hydrodynamic InstabilitiesFrançois CharruUniversité Paul Sabatier (Toulouse III)

Translated by Patricia de Forcrand-Millard

Written for any student, researcher or practitioner working in the area, this modern introduction brings this mathematical subject to life by emphasising the physical mechanisms involved. The book includes numerous experimental studies as well as over 150 exercises and references to video material.Cambridge Texts in Applied Mathematics, 37

2011 247 x 174 mm 410pp 200 b/w illus. 165 exercises 978-0-521-76926-6 Hardback £75.00

978-0-521-14351-6 Paperback £40.00


Spouted and Spout-Fluid BedsFundamentals and ApplicationsEdited by Norman Epsteinand John R. GraceUniversity of British Columbia, Vancouver

Comparing and combining data from internationally renowned research groups, this is the only up-to-date book on spouted bed research and practice. Guiding the reader through new developments, insights and models, this is a valuable resource for chemical and mechanical engineers in research and industry.2010 247 x 174 mm 360pp 100 b/w illus. 40 tables 978-0-521-51797-3 Hardback £80.00


An Introduction to Fluid MechanicsFaith MorrisonMichigan Technological University

This is a modern and elegant introduction to engineering fl uid mechanics enriched with numerous examples, exercises, and applications. Based on Faith Morrison’s vision that fl ows are both beautiful and complex, it delves deeply into the mathematical analysis of fl ows on the basis that such analysis is essential to designing and optimizing modern systems and devices.2012 253 x 177 mm 800pp 520 b/w illus. 40 tables 500 exercises 978-1-107-00353-8 Hardback c. £75.00

Publication September 2012www.cambridge.org/9781107003538

NEW IN PAPERBACK

TEXTBOOK

Statistical ThermodynamicsFundamentals and ApplicationsNormand M. LaurendeauPurdue University, Indiana

This popular 2006 textbook discusses the fundamentals and applications of statistical thermodynamics for beginning graduate students in the physical and engineering sciences. It features a step-by-step development of the subject assuming that the reader has no previous exposure to statistics, quantum mechanics or spectroscopy. Numerous examples and prompted homework problems enrich the text.2011 253 x 215 mm 466pp 96 b/w illus. 64 tables 117 exercises 978-0-521-15419-2 Paperback £47.00


Chemical Engineering22

Order online at www.cambridge.org/chembio

NEW IN PAPERBACK

TEXTBOOK

Combustion PhysicsChung K. LawPrinceton University, New Jersey

A graduate text on the fundamentals of chemically reacting fl ows for students of applied physics, aerospace, mechanical, and chemical engineering.

Its distinguishing feature is the rigorous, yet approachable, presentation. It provides a solid foundation for a graduate program in combustion and a starting point for research on new projects.

‘Combustion Physics is an excellent text that is comprehensive in coverage, rigorous yet expeditious in the analytical developments, insightful in the physical descriptions, and above all, very readable. It is not only an invaluable reference for combustion researchers, but its emphasis on clarity and logical presentation makes it particularly attractive for classroom adoption for a graduate course on combustion in aerospace, mechanical, or chemical engineering and the physical sciences … The author is to be congratulated for having made this valuable, lasting contribution to combustion literature and education.’AIAA Journal

2010 253 x 215 mm 742pp 16 tables 104 exercises 978-0-521-15421-5 Paperback £53.00


TEXTBOOK

Gasoline, Diesel and Ethanol Biofuels from Grasses and PlantsRam B. GuptaAuburn University, Alabama

and Ayhan DemirbasSirnak University

The fi rst-generation biofuels – ethanol from sugar or corn and biodiesel from vegetable oils – created to replace petroleum are already in the market, with limited success. Alternatives to petroleum must be technically feasible, economically competitive, environmentally acceptable, and easily available. This textbook introduces readers to second-generation biofuels from non-food biomass.2010 253 x 215 mm 246pp 104 b/w illus. 83 tables 978-0-521-76399-8 Hardback £47.00


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PUBLISHED IN PARTNERSHIP WITH THE MATERIALS RESEARCH SOCIETY

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Documents

Chemical and Biomedical Engineering Cluster 2012