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Stop- Color time!!
Complete the coloring packet and questions.• Turn in by end of class
• Chapter 9 in the book will help!!
Bio NOTES: Regulation of the Cell Cycle
Factors that regulate cell division: 1. internal factors 2. external factors 3. apoptosis
Internal Factors
- come from inside the cell and are triggered by external factors
Cell growth and division must be controlled and regulatedwithin the cell or serious problems can occur, like cancer.
cyclins - proteins that activate kinases - rapidly made and destroyed at certain points of cell cycle
External Factors
External factors – come from outside the cell, from nearby cells and distant parts of body
2. growth factors - growth factors are proteins that stimulate cell division - these come from other cells - cells grow and divide in response to a combination of different growth factors, not just one
Include physical and chemical signals:
1. cell-to-cell contact - once a cell touches other cells, it stops dividing
3. hormones - may stimulate the growth of certain cell types - one growth hormone results in bone growth
webbed fingers
Uses of apoptosis: - embryonic and infant development - cell death of old cells
Apoptosis
Apoptosis – programmed cell death (cell suicide)
- caused by a cell’s production of self-destructive enzymes
- it is a normal feature of healthy organisms
In early stages of development, human embryos have webbing between fingers and toes. These cells typically go throughapoptosis before a baby is born.
- the nucleus will shrink and break apart, and cells from the immune system will gobble up the cell and recycle its parts
• Cancer is caused by changes in the genes that control normal cell growth and death• Cancer occurs when cells continue to grow and divide and do not die when they should
What is Cancer?Cancer Basics
cancer cellbloodstream
normal cell
- Benign tumors remain clustered and can be removed.- Malignant tumors metastasize, or break away, and can form more tumors.
Cancer cells form disorganized clumps called tumors.
The changes that cause cancer may be inherited, or may result from environmental or lifestyle factors.
Causes of Cancer:• external factors – tobacco, chemicals, radiation, and infectious organisms• internal factors – inherited mutations, hormones, disease
Treatments for Cancer:• surgery, radiation, chemotherapy, hormones, and immunotherapy
carcinogen – any substance known to produce or promote the development of cancer
* radiation – uses radiation to kill cancer cells in a specific region* chemotherapy – uses drugs to kill actively dividing cells
- both of these also kill healthy cells