Embed Size (px)
Citation preview
You must know
• The three stages of cell signaling.
• The function of G protein-coupled receptors. (This is a type of cell signaling.)
The Three Stages of Cell Signaling
• Cells receiving signals undergo three processes– Reception– Transduction– Response
© 2014 Pearson Education, Inc.
Figure 5.20-1
EXTRACELLULARFLUID Plasma membrane
Reception
Receptor
SignalingMolecule A.K.A. ligand
CYTOPLASM
© 2014 Pearson Education, Inc.
The ligand is specific to the receptor
Plasma membrane protein
Figure 5.20-2
EXTRACELLULARFLUID
CYTOPLASM
Plasma membrane
Reception Transduction
Relay molecules
Receptor
Signalingmolecule
© 2014 Pearson Education, Inc.
EXTRACELLULARFLUID
CYTOPLASM
Plasma membrane
ResponseReception Transduction
Relay molecules
Activation
Receptor
Signalingmolecule
© 2014 Pearson Education, Inc.
The response may be almost any imaginable cellular activity…
Receptors in the Plasma Membrane
• There are two main types of membrane receptors– G protein-coupled receptors– Ligand-gated ion channels
Plasma membrane
Receptor
CYTOPLASM
Plasma membrane protein
hydrophilicsignaling molecule
Importance of G protein-coupled receptors
• Nearly 1,000 different types that we know of.
• Nearly 60% of all medicines influence G protein-coupled receptors.
• Involved in:– Embryonic development– Senses of smell– Sense of taste– Maintaining homeostasis!
• Ex. Cholera, whooping cough, and botulism are caused by toxins that interfere with G protein-coupled receptors.
• Video: https://www.youtube.com/watch?v=V_0EcUr_txk
1. The G protein is “off” because it is bound to GDP. (GDP is similar to ADP)
Signal (ligand)
Receptor
G protein in “off” conformation
2. The ligand binds to the receptor.
Signal (ligand)
Receptor
G protein in “off” conformation
3. The ligand binding to the receptor cause the receptor to change shape.
Signal (ligand)
Receptor
G protein in “off” conformation
4. The receptor changing shape is a switch that activates its G protein. The G protein releases the GDP molecule that kept it in an inactive state and binds to GTP instead.
Signal (ligand)
5. When GTP is attached, the G protein becomes activated and splits into two parts.
Signal (ligand)
Receptor
G protein in “off” conformation
6. One part of the “split” G protein activates a nearby enzyme that is embedded in the plasma membrane. The activated enzyme catalyzes the production of second messengers. The second messengers are small signaling molecules that diffuse rapidly to spread the signal throughout the cell and elicit a cellular response.
Signal (ligand)
Receptor
G protein in “off” conformation
Cellular response
Activatedenzyme
SecondMessengers
