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Nick Golding Challenges and opportunities of large- scale automated disease risk mapping

Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

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Page 1: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

Nick Golding

Challenges and opportunities of large-

scale automated disease risk mapping

Page 2: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,
Page 3: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,
Page 4: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,
Page 5: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,
Page 6: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,
Page 7: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

expert panel

data triage

modelling

Genbank

occurrence data

risk map

Page 8: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

modelling

data on many diseases

many risk maps

Page 9: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

challenges

accurate models with poor data expressing uncertainty ‘one size fits all’ model

Page 10: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

share information between diseases find general rules where to sample next? develop new methods

opportunities

Page 11: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

Bhatt et al. (2013) Nature

sparse, presence-only data

Page 12: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

species distribution modelling

function of environment (fundamental niche) require pseudo-absence data

Page 13: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

problems with PO-SDM

assumes fundamental niche is key - communicable diseases? assumes equilibrium - emerging diseases? discards spatial info - disease control?

Page 14: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

Gaussian process SDM

Page 15: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,
Page 16: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

add prior knowledge (mean function) marginalise uncertainty from polygon occurrences efficient (Laplace approximation) extendable (spatial models ++)

advantages

Page 17: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

compositional kernels

Duvenaud et al. (2013) arXiv

Page 18: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

movement models

Page 19: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

movement models

Page 20: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

movement models

Page 21: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

human population predicted movement

movement models

Page 22: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

environmental spatial

movement all

Page 23: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

biotic interactions

interactions between diseases (e.g. LF / malaria?) or with control measures convolved GPs

Page 24: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,
Page 25: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

polygon occurrence data

Page 26: Challenges and opportunities of large- scale automated disease … · 2015-12-04 · Monica F. Myersl, Dylan B. George2 and Peter W. Gethingl Ispatial Ecology and Epidemiology Group,

prevent regression dilution