1

CHAPTER 20

CELLULAR COMMUNITIES: TISSUES, STEM CELLS, AND CANCER

( 2009 Garland Science Publishing

Extracellular Matrix and Connective Tissues

20-1Both multicellular plants and animals have _____________________.

(a)cells capable of locomotion(b)cells with cell walls(c)a cytoskeleton composed of actin filaments, microtubules, and intermediate filaments(d)tissues composed of multiple different cell types20-2For each of the following sentences, fill in the blanks with the best word or phrase selected from the list below. Not all words or phrases will be used; use each word or phrase only once.Plants are sedentary and thus their cells have different needs from those of cells found in motile animals. For example, in plant cells, __________________ generates the turgor pressure that drives cell growth. Plants have cell walls, but cell growth is possible in the developing tissue because the __________________ cell walls are expandable. The __________________ cell walls are deposited once growth has stopped, and can be specially adapted to their function. Fibers made from __________________ (the most abundant organic macromolecule on Earth) are found in plant cell walls, and provide tensile strength. In woody tissues, the __________________ in the cell walls makes the tissue more rigid and waterproof. The deposition of the cell wall is directed by the __________________ cytoskeleton.celluloseligninsecondarycollagenmembranousmicrotubuleepidermisosmosistertiarynuclearlaminactinpectinprimary20-3Which of the following statements about plant cell walls is true?

(a)The microtubule cytoskeleton directs the orientation in which cellulose is deposited in the cell wall.

(b)The molecular components of the cell wall are the same in all plant tissues.

(c)Because plant cell walls are rigid, they are not deposited until the cell has stopped growing.

(d)The cellulose found in cell walls is produced as a precursor molecule in the cell and delivered to the extracellular space by exocytosis.

20-4Indicate the direction in which the plant cell shown in Figure Q20-4 is most likely to grow. The black lines indicate the direction of the cellulose microfibrils around the cell. Explain your answer.

Figure Q20-4

20-5Which of the following molecules are not found in plants?(a)cellulose

(b)lignin

(c)collagen

(d)pectin

20-6Indicate whether the following molecules are found in plants, animals, or both.A.intermediate filamentsB.cell wallsC.microtubulesD.celluloseE.collagen20-7Which of the following statements about animal connective tissues is true?

(a)Enzymes embedded in the plasma membrane synthesize the collagen in the extracellular matrix extracellularly.

(b)In connective tissue, the intermediate filaments within the cells are important for carrying the mechanical load.

(c)Cells can attach to a collagen matrix by using fibronectin, an integral membrane protein.

(d)Proteoglycans can resist compression in the extracellular matrix.

20-8A major distinction between the connective tissues in an animal and other main tissue types such as epithelium, nervous tissue, or muscle is _______________.

(a)the ability of connective tissue cells such as fibroblasts to change shape(b)the amount of extracellular matrix in connective tissues(c)the ability of connective tissues to withstand mechanical stresses(d)the numerous connections that connective tissue cells make with each other20-9What are the main structures providing tensile strength in the following?

A.animal connective tissueB.animal epidermisC.plant cell walls20-10Do you agree or disagree with the following statement? Explain your answer.Like many other extracellular proteins, newly synthesized collagen molecules undergo post-translational processing inside the cell to convert them into their mature form; they are then secreted and self-assemble into fibrils in the extracellular space.20-11Fibroblasts organize the collagen of the extracellular matrix by ______________.

(a)cutting and rejoining the fibrils(b)processing procollagen into collagen(c)twisting fibrils together to make ropelike fibers(d)pulling the collagen into sheets or cables after it has been secreted20-12Match the four lettered lines in Figure Q20-12 with the appropriate numbered label.

Figure Q20-121. integrin

2. actin

3. collagen

4. fibronectin

20-13Which of the following statements about integrins is false?(a)Integrins use adaptor proteins to interact with the microtubule cytoskeleton.(b)Integrins can switch to an activated state by binding to an extracellular matrix molecule.(c)Integrins can switch to an activated state by binding to an intracellular protein.(d)An activated integrin molecule takes on an extended conformation.20-14Proteoglycans in the extracellular matrix of animal tissues ________________.

(a)chiefly provide tensile strength(b)allow cartilage to resist compression(c)are linked to microtubules through the plasma membrane(d)are polysaccharides composed of glucose subunits20-15Which of the following statements is false?(a)Proteoglycans can act as filters to regulate which molecules pass through the extracellular medium.(b)The negative charge associated with proteoglycans attracts cations, which cause water to be sucked into the extracellular matrix.(c)Proteoglycans are a major component of compact connective tissues but are relatively unimportant in watery tissues such as the jellylike substance in the interior of the eye.(d)Glycosaminoglycans are components of proteoglycan.Epithelial Sheets and Cell Junctions

20-16For each of the following sentences, fill in the blanks with the best word or phrase selected from the list below. Not all words or phrases will be used; use each word or phrase only once.

__________________ join the intermediate filaments in one cell to those in the neighboring cell. __________________ anchor intermediate filaments in a cell to the extracellular matrix. __________________ involve cadherin connections between neighboring cells and are anchorage sites for actin filaments. __________________ permit the passage of small molecules from one cell to its adjacent cell. __________________ prevent the leakage of molecules between adjacent cells.adherens junctionsgap junctionshighway junctionsdesmosomeshemidesmosomestight junctions20-17Label the five different types of cellcell junction shown in Figure Q21-17, and identify the apical and basal surfaces of the epithelium.

Figure Q20-17

20-18Match the molecules (list 1) with the cell structures in which they are involved (list 2). A cell structure may be listed more or less than once.

20-19A basal lamina ______________________.

(a)is a thin layer of connective tissue cells and matrix underlying an epithelium

(b)is a thin layer of extracellular matrix underlying an epithelium

(c)is attached to the apical surface of an epithelium

(d)separates epithelial cells from each other

20-20Tight junctions ______________________.

(a)allow small water-soluble molecules to pass from cell to cell

(b)interact with the intermediate filaments inside the cell

(c)are formed from claudins and occludins

(d)are found in cells in connective tissues

20-21Adherens junctions ______________________.

(a)can be used to bend epithelial sheets into tubes

(b)are most often found at the basal surface of cells

(c)are found only in adult tissues

(d)involve fibronectin and integrin interactions

20-22At desmosomes, cadherin molecules are connected to ________________.

(a)actin filaments

(b)intermediate filaments

(c)microtubules

(d)gap junctions

20-23Hemidesmosomes are important for ______________________.

(a)tubulation of epithelial sheets

(b)linkages to glycosaminoglycans

(c)forming the basal lamina

(d)attaching epithelial cells to the extracellular matrix

20-24Which of the following statements about gap junctions is false?

(a)Gap junctions are made of connexons.

(b)Molecules up to 1000 daltons in molecular weight can move across gap junctions.

(c)Because gap junctions do not allow ions to pass through, they are not used for electrically coupling cells.

(d)Gap junctions can close in response to extracellular signals.

20-25Which type of junction involves a connection to the actin cytoskeleton?

(a)adherens junctions

(b)desmosomes

(c)tight junctions

(d)gap junctions

20-26Which type of junction contributes the most to the polarization of epithelial cells?

(a)adherens junctions

(b)desmosomes

(c)tight junctions

(d)gap junctions

20-27Cadherins ______________________.

(a)are used to transfer proteins from one cell to another

(b)mediate cellcell attachments through homophilic interactions

(c)are abundant in the plant cell wall

(d)bind to collagen fibrils

20-28Plasmodesmata ______________________.

(a)permit small molecules to pass from one cell to another

(b)are found only in animal cells

(c)are closed by the neurotransmitter dopamine

(d)provide tensile strength

Tissue Maintenance and Renewal

20-29Match the appropriate cell type found in the mammalian skin with the best description of its function.

20-30Name the three key mechanisms important for maintaining the organization of cells into tissues.

20-31Place the following in order of their replacement times, from shortest to longest.

A.epidermal cell

B.nerve cell

C.bone matrix

D.red blood cell

E.cell lining the gut

20-32Cells that are terminally differentiated ______________________.

(a)will undergo apoptosis within a few days

(b)can no longer undergo cell division

(c)are unable to move

(d)no longer produce RNAs

20-33An adult hemopoietic stem cell found in the bone marrow ______________________.

(a)will occasionally produce epidermal cells when necessary

(b)can produce only red blood cells

(c)can undergo self-renewing divisions for the lifetime of a healthy animal

(d)will express all the same transcription factors as those found in an unfertilized egg

20-34Mouse embryonic stem (ES) cells ______________________.

(a)can only be produced through therapeutic cloning

(b)can give rise to all tissues and cell types in the body except germ cells

(c)can be implanted in foster mothers to produce cloned cows and other animals

(d)come from the inner cell mass of early embryos

20-35How do reproductive cloning and therapeutic cloning differ?

(a)The DNA in the nucleus of cells produced for therapeutic cloning is genetically identical to the donor genome, whereas in cells produced for reproductive cloning it is not.

(b)Reproductive cloning requires a supply of fertilized donor egg cells, whereas therapeutic cloning requires unfertilized egg cells.

(c)Therapeutic cloning requires nuclear transplantation, whereas reproductive cloning does not.

(d)Embryos are placed into foster mothers during reproductive cloning but not during therapeutic cloning.

20-36Induced pluripotent stem (iPS) cells ______________________.

(a)are created by the expression of a set of key genes in cells derived from adult tissues so that these cells can differentiate into a variety of cell types(b)require a supply of donor egg cells, such as embryonic stem cells(c)can differentiate into a greater variety of adult tissues than embryonic stem cells(d)are created by nuclear transplantation20-37A stem cell divides into two daughter cells. One of the daughter cells goes on to become a terminally differentiated cell. What is the typical fate of the other daughter cell?

20-38Your friend is a pioneer in ES cell research. In her research, she uses an ES cell line that originated from an inbred strain of laboratory mice called FG426. She has just figured out methods that allow her to grow an entire liver from an ES cell and has successfully grown 10 livers. She demonstrates that the newly grown livers are functional by successfully transplanting one of the new livers into a FG426 laboratory mouse.

You are particularly excited about this, because you have a sick pet mouse, Squeaky. You are very attached to Squeaky, as you found him when you were out camping in New Hampshire. Unfortunately, Squeaky has developed liver disease and will not live much longer without a liver transplant. After you see your friend on TV talking about her new method for growing mouse livers, you immediately grab your cell phone to ask her whether Squeaky could have one of the newly grown livers. Just as you are about to dial your friend, you remember something you learned in cell biology and realize that instead, you should ask your friend about possibly using therapeutic cloning for Squeakys benefit.

A.Why do you think that one of the newly grown livers may not work in Squeaky?

B.Explain why therapeutic cloning would solve this problem.

Cancer

20-39A malignant tumor is more dangerous than a benign tumor because ______________________.

(a)its cells are proliferating faster

(b)it causes neighboring cells to mutate

(c)its cells attack and phagocytose neighboring normal tissue cells

(d)its cells invade other tissues

20-40Which of the following statements about cancer is false?(a)Viruses cause some cancers.(b)Tobacco use is responsible for more than 20% of all cancer deaths.(c)A mutation in even a single cancer-critical gene is sufficient to convert a normal cell into a cancer cell.(d)Chemical carcinogens cause cancer by changing the nucleotide sequence of DNA.20-41Cancer is a disease of enhanced proliferation and cell survival. DNA repair mechanisms are normally important for cell survival. When a cell senses DNA damage, the cell cycle is inhibited until the damage is fixed. Given the importance of DNA repair mechanisms, how can their failure can lead to the production of cancer cells with a competitive advantage over normal cells?20-42Which of the following genetic changes cannot convert a proto-oncogene into an oncogene?

(a)A mutation that introduces a stop codon immediately after the codon for the initiator methionine.

(b)A mutation within the coding sequence that makes the protein hyperactive.

(c)An amplification of the number of copies of the proto-oncogene, causing overproduction of the normal protein.

(d)A mutation in the promoter of the proto-oncogene, causing the normal protein to be transcribed and translated at an abnormally high level.

20-43Which of the following statements about tumor suppressor genes is false?

(a)Gene amplification of a tumor suppressor gene is less dangerous than gene amplification of a proto-oncogene.

(b)Cells with one functional copy of a tumor suppressor gene will usually proliferate faster than normal cells.

(c)Inactivation of tumor suppressor genes leads to enhanced cell survival and proliferation.

(d)Individuals with only one functional copy of a tumor suppressor gene are more prone to cancer than individuals with two functional copies of a tumor suppressor gene.

20-44A certain mutation in the receptor for epidermal growth factor (EGF) causes the mutated receptor protein to send a positive signal along the associated intracellular signaling pathway even when the EGF ligand is not bound to it. This signal leads to abnormal cell proliferation in the absence of growth factor. On the basis of this information, would you class the gene for the EGF receptor as a tumor suppressor gene or a potential oncogene? Explain your answer.

20-45Ras is a GTP-binding protein that is often defective in cancer cells. A signal from a growth factor through a receptor tyrosine kinase often stimulates normal cells to divide. When the receptor tyrosine kinase binds the growth factor, Ras is stimulated to bind GTP. Ras in turn activates proteins that promote cell proliferation. A common mutation in cancerous cells causes Ras to behave as though it were bound to GTP all the time.

A.Why is this mutation advantageous to cancerous cells?

B.Your friend decides that the signaling pathway involving the Ras protein is a good target for drug design, because the Ras protein is often defective in cancer cells. Your friend designs a drug that will turn off the receptor tyrosine kinase by preventing it from dimerizing. Do you think that this drug will affect cells that have a defective Ras protein that acts as if it were always bound to GTP? Why or why not?

20-46People who inherit one copy of the Rb (retinoblastoma) gene that is normal and one copy that is mutatedthat is, people who are heterozygous for Rbhave a greatly increased risk of cancer.

Given this information, do you agree or disagree with the following statement? Explain your answer.

The Rb mutation must have a dominant effect, which means that it must result in an increase in Rb function. Thus, Rb in its mutant form must be an oncogene.

20-47Figure Q20-47 shows a sequence of mutations that might underlie the development of colorectal cancer. Explain why the loss of p53 is advantageous to cancerous cells.

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 uuid:CB05872B6BC711DE913FA96064445201 uuid:CB05872C6BC711DE913FA96064445201 uuid:CB05872A6BC711DE913FA96064445201 uuid:CB0587296BC711DE913FA96064445201 209.999994 297.000002 Millimeters 1 False True Black Default Swatch Group 0 C=0 M=0 Y=0 K=0 CMYK PROCESS 0.000000 0.000000 0.000000 0.000000 C=0 M=0 Y=0 K=100 CMYK PROCESS 0.000000 0.000000 0.000000 100.000000 New Color Swatch CMYK PROCESS 39.999996 0.000000 80.000000 0.000000 New Color Swatch 2 CMYK PROCESS 18.000000 0.000000 47.000004 0.000000 New Color Swatch 3 CMYK PROCESS 0.000000 0.000000 100.000000 0.000000 New Color Swatch 4 CMYK PROCESS 0.000000 0.000000 50.000000 0.000000 New Color Swatch 5 CMYK PROCESS 100.000000 0.000000 0.000000 0.000000 New Color Swatch 6 CMYK PROCESS 50.000000 0.000000 0.000000 0.000000 New Color Swatch 7 CMYK PROCESS 30.000002 0.000000 0.000000 0.000000 New Color Swatch 8 CMYK PROCESS 0.000000 100.000000 100.000000 0.000000 New Color Swatch 9 CMYK PROCESS 0.000000 47.000004 42.999996 0.000000 New Color Swatch 10 CMYK PROCESS 0.000000 38.000000 19.999998 0.000000 New Color Swatch 11 CMYK PROCESS 0.000000 55.000000 60.000004 50.000000 New Color Swatch 12 CMYK PROCESS 30.000002 42.999996 47.000004 0.000000 New Color Swatch 13 CMYK PROCESS 6.000000 0.000000 6.000000 14.999998 New Color Swatch 14 CMYK PROCESS 6.000000 0.000000 6.000000 47.000004 New Color Swatch 15 CMYK PROCESS 0.000000 47.000004 100.000000 7.999998 New Color Swatch 16 CMYK PROCESS 100.000000 0.000000 80.000000 26.999998 New Color Swatch 17 CMYK PROCESS 0.000000 34.000004 91.000000 0.000000 New Color Swatch 18 CMYK PROCESS 0.000000 30.000002 50.000000 0.000000 New Color Swatch 19 CMYK PROCESS 100.000000 72.000000 0.000000 0.000000 New Color Swatch 20 CMYK PROCESS 50.000000 36.000000 0.000000 0.000000 New Color Swatch 21 CMYK PROCESS 70.000000 100.000000 0.000000 0.000000 New Color Swatch 22 CMYK PROCESS 35.000004 50.000000 0.000000 0.000000 New Color Swatch 23 CMYK PROCESS 0.000000 100.000000 0.000000 0.000000 New Color Swatch 24 GRAY PROCESS 38 New Color Swatch 25 GRAY PROCESS 76 New Color Swatch 26 GRAY PROCESS 127 New Color Swatch 27 GRAY PROCESS 165 New Color Swatch 28 GRAY PROCESS 204 New Color Swatch 29 GRAY PROCESS 255

% &&end XMP packet marker&&[{ai_metadata_stream_123}

/PUT AI11_PDFMark5[/Document1 dict begin /Metadata {ai_metadata_stream_123} defcurrentdict end /BDC AI11_PDFMark5%ADOEndClientInjection: PageSetup End "AI11EPS"%%EndPageSetup1 -1 scale 0 -31.6465 translatepgsv[1 0 0 1 0 0 ]ctgsavenpgsave0 0 mo0 31.6465 li32.3003 31.6465 li32.3003 0 licpclp[1 0 0 1 0 0 ]ct0.25 30.394 mo0.75 31.4946 0.75 31.394 3.0498 31.394 cv5.3501 31.394 22.2505 31.394 22.2505 31.394 cv32.0503 22.2944 li32.0503 20.5942 31.8501 0.594238 31.8501 0.594238 cv31.1499 0.194336 31.7505 0.394531 30.7505 0.294434 cv29.7505 0.194336 9.6499 0.294434 9.6499 0.294434 cv0.25 9.99414 li0.25 30.394 licpfalse sop/0 [/DeviceCMYK] /CSA add_res0 0 0 0.1746 cmykf0.5 lw0 lc0 lj4 ml[] 0 dshtrue sadj0.25 30.394 mo0.75 31.4946 0.75 31.394 3.0498 31.394 cv5.3501 31.394 22.2505 31.394 22.2505 31.394 cv32.0503 22.2944 li32.0503 20.5942 31.8501 0.594238 31.8501 0.594238 cv31.1499 0.194336 31.7505 0.394531 30.7505 0.294434 cv29.7505 0.194336 9.6499 0.294434 9.6499 0.294434 cv0.25 9.99414 li0.25 30.394 licptrue sop0 0 0 1 nzopmsc@31.8501 0.594238 mo31.8501 0.594238 23.6499 9.59424 22.9497 9.79443 cv22.2505 9.99414 21.25 9.99414 21.25 9.99414 cv0.25 9.99414 lifalse sop0 0 0 1 cmyk@22.2505 31.394 mo0.25 31.394 li0.25 9.99414 li22.2505 9.99414 li0 0 0 0.4946 cmykf22.2505 31.394 mo0.25 31.394 li0.25 9.99414 li22.2505 9.99414 litrue sop0 0 0 1 nzopmsc@1 lw8.8501 3.29443 mo9.25 2.89453 9.9502 2.49414 10.8501 2.49414 cv11.75 2.49414 28.9497 2.49414 29.8501 2.49414 cv30.7505 2.49414 31.3501 3.39453 30.7505 3.99414 cv30.1499 4.59424 24.1499 10.9941 23.5503 11.4941 cv22.9497 11.9941 22.5503 12.0942 21.25 12.1943 cv19.9502 12.2944 3.4502 12.1943 2.5498 12.1943 cv1.6499 12.1943 0.75 11.6943 1.5498 10.8945 cv2.3501 10.0942 8.8501 3.29443 8.8501 3.29443 cvcpfalse sop0 0 0 1 cmyk@8.8501 7.39453 mo9.25 6.99414 9.9502 6.59424 10.8501 6.59424 cv11.75 6.59424 28.9497 6.59424 29.8501 6.59424 cv30.7505 6.59424 31.3501 7.49414 30.7505 8.09424 cv30.1499 8.69434 24.1499 15.0942 23.5503 15.5942 cv22.9497 16.0942 22.5503 16.1943 21.25 16.2944 cv19.9502 16.3945 3.4502 16.2944 2.5498 16.2944 cv1.6499 16.2944 0.75 15.7944 1.5498 14.9941 cv2.3501 14.1943 8.8501 7.39453 8.8501 7.39453 cvcp@8.8501 11.4941 mo9.25 11.0942 9.9502 10.6943 10.8501 10.6943 cv11.75 10.6943 28.9497 10.6943 29.8501 10.6943 cv30.7505 10.6943 31.3501 11.5942 30.7505 12.1943 cv30.1499 12.7944 24.1499 19.1943 23.5503 19.6943 cv22.9497 20.1943 22.5503 20.2944 21.25 20.3945 cv19.9502 20.4946 3.4502 20.3945 2.5498 20.3945 cv1.6499 20.3945 0.75 19.8945 1.5498 19.0942 cv2.3501 18.2944 8.8501 11.4941 8.8501 11.4941 cvcp@8.8501 15.5942 mo9.25 15.1943 9.9502 14.7944 10.8501 14.7944 cv11.75 14.7944 28.9497 14.7944 29.8501 14.7944 cv30.7505 14.7944 31.3501 15.6943 30.7505 16.2944 cv30.1499 16.8945 24.1499 23.2944 23.5503 23.7944 cv22.9497 24.2944 22.5503 24.394 21.25 24.4946 cv19.9502 24.5942 3.4502 24.4946 2.5498 24.4946 cv1.6499 24.4946 0.75 23.9946 1.5498 23.1948 cv2.3501 22.3945 8.8501 15.5942 8.8501 15.5942 cvcp@8.8501 19.6943 mo9.25 19.2944 9.9502 18.8945 10.8501 18.8945 cv11.75 18.8945 28.9497 18.8945 29.8501 18.8945 cv30.7505 18.8945 31.3501 19.7944 30.7505 20.3945 cv30.1499 20.9946 24.1499 27.394 23.5503 27.894 cv22.9497 28.394 22.5503 28.4946 21.25 28.5942 cv19.9502 28.6948 3.4502 28.5942 2.5498 28.5942 cv1.6499 28.5942 0.75 28.0942 1.5498 27.2944 cv2.3501 26.4946 8.8501 19.6943 8.8501 19.6943 cvcp@%ADOBeginClientInjection: EndPageContent "AI11EPS"userdict /annotatepage 2 copy known {get exec}{pop pop} ifelse%ADOEndClientInjection: EndPageContent "AI11EPS"grestoregrestorepgrs%%PageTrailer%ADOBeginClientInjection: PageTrailer Start "AI11EPS"[/EMC AI11_PDFMark5[/NamespacePop AI11_PDFMark5%ADOEndClientInjection: PageTrailer Start "AI11EPS"[[/CSA [/0 ]]] del_resAdobe_AGM_Image/pt gxAdobe_CoolType_Core/pt get execAdobe_AGM_Core/pt gxcurrentdict Adobe_AGM_Utils eq {end} if%%TrailerAdobe_AGM_Image/dt get execAdobe_CoolType_Core/dt get execAdobe_AGM_Core/dt get exec%%EOF%AI9_PrintingDataEnd

userdict /AI9_read_buffer 256 string putuserdict begin/ai9_skip_data{mark{currentfile AI9_read_buffer { readline } stopped{}{not{exit} if(%AI9_PrivateDataEnd) eq{exit} if} ifelse} loopcleartomark} defenduserdict /ai9_skip_data get exec%AI9_PrivateDataBegin%!PS-Adobe-3.0 EPSF-3.0%%Creator: Adobe Illustrator(R) 13.0%%AI8_CreatorVersion: 13.0.2%%For: (Nigel Orme) ()%%Title: (Q20.04.eps)%%CreationDate: 7/6/09 2:02 PM%AI9_DataStream%Gb"-6qf3skPrH3+^iu`,1a,Z).GTL(m'dR;Odsa-g/>FtN>7H["]_:n*g:CDqkDJ%rSi#R!&?'_c#0qbp;SJ;AFgKJ#ojp)S3&q2%kk+\O]5O:sI=(hgIm2\u&iS.UNOO0HI6%/fU]:;Z:Y.7cD3"QO9k\bk6_8&YFI\>1ooXW