8/6/2019 CF poster

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Exercise correlates of pulmonary function inExercise correlates of pulmonary function inpaediatric patients with cystic fibrosispaediatric patients with cystic fibrosisSara ThompsonSara Thompson 11, Jane Schneiderman, Jane Schneiderman 11, Donna Wilkes, Donna Wilkes 11, Felix Ratjen, Felix Ratjen 11, Greg D. Wells, Greg D. Wells 1,21,2

11The Hospital For Sick Children, Toronto, Canada,The Hospital For Sick Children, Toronto, Canada, 22Faculty of Physical Education and Health, University of Toronto, CanadaFaculty of Physical Education and Health, University of Toronto, Canada

The standard measure of lung health in CF patients isForced expiratory volume in 1 second (FEV1). Peak

aerobic fitness (VO2peak ) has been linked to lung function

and has been the traditional fitness assessment in thepaediatric population.

While aerobic metabolism has been found to be impairedin CF1, it has been suggested that anaerobic fitness andmuscle strength and power are affected by CF as well1,2 .However equivocal results have been found in this area ofstudy, and the relationship between these parameters anddisease status (FEV1) remains unclear.

Introduction Results

These results suggest that anaerobic fitness and upperbody strength, but not lower body power, may be usefulindicators of lung function in children with CF.

Interestingly, peak aerobic power was not found to becorrelated to lung function in this study. This implies thatother parameters of fitness might be better tools for theassessment of physical performance as it relates tolung health in this population.

Conclusions

Methods Simple fitness tests such as hand grip strength andanaerobic cycle tests may be effective in predicting lunghealth in clinics that do not have the facility to conductmore technical aerobic fitness tests.

Physical activity programs that include anaerobic andstrength training could be implemented for thispopulation. Including this variety of training could havesignificant health benefits while avoiding the monotonyof exclusively aerobic programs2.

Implications

FEV1 (% predicted)

PeakPower(watts)

FEV1 (% predicted))

Handgripstrength(kg)

FEV1 (% predicted)

VerticalJump(cm)

References

1.Wells, G.D., Wilkes ,D.L., Schneiderman, J.E., Rayner, T., Elmi, M., Selvadurai,H,. Dell, S.D., Noseworthy, M.D., Ratjen, F., Tein, I., Coates, A.L. Skeletalmuscle metabolism in cystic fibrosis and primary ciliary dyskinesia. PediatrRes. 2011 Jan;69(1):40-5.

2.Wilkes, D.L., Schneiderman, J.E., Nguyen, T., Heale, L., Moola, F., Ratjen, F.,Coates, A.L., Wells, G.D. Exercise and physical activity in children withcystic fibrosis. Paediatr Respir Rev. 2009 Sep;10(3):105-9. Epub 2009 Jul21. Review.

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1. 16 Children between the ages of 7-18 yrs were tested duringtheir regular CF clinic visits as follows:Pulmonary function was measured according to standardspirometric techniquesVO2peak was calculated using an electrically braked cycle

ergometerAnaerobic capacity for 10- and 30- second trials was measuredusing an isokinetic cycle ergometerUpper body muscle strength was measured using a handgripdynamometer and lower body muscle power was assessed byvertical jump height

2. Correlational analyses were performed and all variables werecompared to FEV1.

FEV1 was significantlycorrelated to anaerobicfitness (60 Hz)

FEV1 (% predicted))

PeakPow

er(watts)

FEV1 was significantlycorrelated to upper bodymuscle strength

r=0.51, p=0.04

FEV1 was not correlated

to lower body musclepower

r=0.03, p=0.91

FEV1 (% predicted)

VO2p

eak

(ml/kg/min)

FEV1 was not correlated to

maximal aerobic capacity

r=0.27, p=0.33

r=0.66, p=0.01