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Center for Population Health Sciences
ANNUAL SYMPOSIUM
October 26, 2015
8 AM – 5 PM
@StanPopHealth
Center for Population Health Sciences
STANFORD POPULATION HEALTH SCIENCES ANNUAL SYMPOSIUM
October 26, 2015
8 AM – 5 PM
Mark R. Cullen, MDDirector
What is Population Health Sciences ?
Development and application of tools integrating clinical, biologic, social and environmental data on large numbers of people to:
Provide evidence for improved health care delivery at the bedside Establish scientific foundations for population level
decision making impacting health of groups Enhance our understanding of the pathways by which
health and disease evolve over the life-course
Stanford Population Health Sciences (PHS) Mission
To fuel the trans-disciplinary work of PHS at Stanford
To provide an academic home for scientists in the core PHS disciplines
To coordinate and enhance training opportunities in PHS and its core disciplines
To serve as a home for community focused research and education in biomedical science in the region
Core Disciplines
Health Services Research
Epidemiology
Informatics and Biostatistics
Demography
Genetics
Environmental Science
Economics, Psychology, Sociology & other Social Sciences
Strategic Plan
Secure a trove of data resources - including access to bio-specimens, populations, and secondary data
Develop a team of professionals and an infrastructure to facilitate the relationships between investigators, trainees and the above assets
Develop resources to support core faculty, post-docs, visiting scholars, seed funds, and incentives for investigators at every career stage
Stanford Center for Population Health Sciences
PhD and MSTraining Seed Grants
Access to Populations, Databases and
Biobanks
Learning Health System
Bioethics Center
Symposia, Seminars, Academic Exchange
Post-docs and Fellows Community
Engagement
Department of BDS and Hub
“Sister” Centers & Institutes:
• IRiSS/RDC• Woods• Genomics• CPOP• SCI• Poverty Center
Clinical Research Informatics
Stanford Center for Clinical Research
BDSISpectrum
Special Populations
Stanford Hospital and Clinics
HRP
Data Sets
ASSETS WORKING GROUPS
Learning Health Systems
& Care Delivery
PHS
Gene -
Environment Interaction
Special Populations
& Rare Diseases
mHealth &
Technologies for Health
First 1000 Days
of Life
Sex & Gender in
HealthResearch
Immigration &
Health
Analytics
Health Disparities: Global
& Domestic
Cohorts
PHS Resources
Community Partnership
Biobank
“Shark Tank” Sessions
Data Curation & Tech Support
PHS Staff
Consultation Services
Grant/IRB Help
MEMBERS
Co-Working Space
Work-Life, Retirement, Disability,
Aging & Cognitive Decline
Wiki Hub – PHS Intranet
PHS Pilot Funds
SphinX
WG X Prizeand more…
Seed Grants
Stanford PHS Data Vault
Large Regional/National Data Children
• CPQCC Neonatal Database• March of Dimes• HCUP – KID• California Perinatal Quality Care
Collaborative• Medi-Cal Seriously Ill Children
Large Regional/National Data
• Optum• Marketscan• CMS• IRiSS – Census Data• Danish Biobank• Alcoa Occupational Cohort• Solano Cohort• HRS/CMS Linked Data• Kaiser Northern California• Stanford Military Data Repository• NHANES Dietary Data• VA Disability • HCUP Nationwide Inpatient Sample
Disease Specific Data
• AIDS Clinical Trials Group data• DAIDS data sets• California Cancer Registry• Ovarian Cancer Assoc. Consortium
Environmental Data
• California Neighborhoods Data System
• Worldwide weather data• Particulate matter• Pesticide use
Global Health Data
• Indian Rail Service • Africa - Demographic and Health
Surveys/ INDEPTH• Singapore Cohort• Taiwan National Insurance • FEWSnet food price datasetStanford Data
• STRIDE• Stanford Cancer
Genetics Research Database
• Stanford Imaging Studies
• Asthma/Allergy Data with samples
Data Set Overview
Dataset Overview: Sampling Frame (n=205)
World
wide
Intern
ational - LM
IC
Intern
ational - Afri
ca
Intern
ational - Asia
LMIC
Intern
ational - Asia
HIC
Intern
ational - Centra
l/South
Americ
an
Scandinavia
National Data
USA
State
-CA
State
- CA/M
ulti
Regional Data
- CA
Regional - Oth
er
Stanfo
rd0
10
20
30
40
50
60
70
80
90
100
Num
ber
of D
atas
ets
(n=2
05)
Dataset Overview: Type of Data Collection (n=228)
Administra
tive/claim
s
Survey
Surveilla
nce/c
laims
EMR
RCT
Registry
Environmenta
l surv
eillance
Genetic data
"Omes"
Biologic sa
mples0
10
20
30
40
50
60
70
80
90
100
Num
ber
of D
atas
ets
(n=2
28)
Dataset Overview: Condition/Disease of Interests (n=62)
Cancer -
All
Cancer -
Breast
Cancer -
Colorecta
l
Cancer -
Ovaria
n
Cancer -
Prosta
te
Cardiac -
Adult
Disease
specifi
c
Menta
l Health
Surgery
/Tra
uma
Brain Tumors
Vector
Weight L
oss0
2
4
6
8
10
12
14
Num
ber
of D
atas
ets
(n=6
2)
Human Assets: Brokering the “chasms”
Resources
Colleagues
Community Partnership
Mentor(s)
Data
Colleagues
Resources
Technical Support
Funding Support
Seed Grants PHS Pilot Funds SphinX WG X Prize Faculty/Post-doc Stipends Visiting Scholars
Pitch an idea!
PHS LeadershipWorking Group Co Chairs
EntrepreneursVenture Capitalists
Up Next . . .
@StanPopHealth
Selected presentations of PHS Data Assets:
• March of Dimes • Women & Gender • Stanford Military Data Repository
• Optum Commercial • Community Health Partners • HIMC Biobank• VA Disability & ACA/Medicaid• Solano Cohort
New concentrations in Epidemiology
Concentration LeaderGlobal Health Luby
Life-course / Social Rehkopf, Leonard
Infectious diseases Parsonnet
Chronic diseases Nelson, Simard
Quantitative methods Sainani
Clinical Research / CER Goodman
Meta-research Ioannidis, Goodman
Cancer / genetic Whittemore
Environmental / Occupational
Cullen
Under considerationLearning Health Systems
Mental health
New programsin Epidemiology
Program LeaderUndergrad co-term (now)
Parsonnet
Joint Epi-Law(in development)
Mello, Goodman
PHS Working Groups
What’s a Challenge?
A study whose result could ideally be achieved within 3 years
Result implies measureable anticipated health impact
Conducted by a team of investigators from, at least two different schools if within SOM, at least one basic and clinical
science
Demonstrable originality in study design or method
Working Group Panels
Panel 1 Moderator: Mark Cullen
• Health Disparities – Global, Domestic | Immigration and Health• Work-Life, Retirement, Disability, Aging & Cognitive Decline• Sex and Gender in Health Research
Panel 2 Moderator: Doug Owens
First 1000 Days of Life Gene-Environment Interaction Special Population & Rare Diseases
Panel 3 Moderator: Lorene Nelson
Learning Health Systems mHealth & other New Technologies for Health Analytics