CellScope: Mobile Microscopy for Disease Diagnosis

Daniel Fletcher

UC Berkeley Bioengineering

NIH

Xdrtb.org

http://www.worldmapper.org/display.php?selected=229

Distribution of malaria cases

http://www.worldmapper.org/display.php?selected=219

Distribution of physicians

http://freelargephotos.com

http://www.hsph.harvard.edu/now/20070928/images/people/tuberculosis.jpghttp://www.sciencedaily.com/images/2008/10/081008151314-large.jpg

Microscopy = gold standard

“…very little living animalcules,very prettily a-moving…”

Antony van Leeuwenhoek(1632-1723)

The first microscopes

http://media.wiley.com/CurrentProtocols/PH/ph1410/ph1410-fig-0003-1-full.jpg

http://img.forministry.com/B/BB/BBA2D614-FA22-4613-958ECA06DFF85CE4/EECBECEF-91B7-45D3-B830587F5F3818C0.jpg

CellScope: Mobile Microscopy

Sample image

Diagnosis

Healthcare worker

Clinical expert

Patient

CellScope: Mobile Microscopy

ABL

Hospital

Malaria Sickle cell Tuberculosis

Disease imaging with CellScope

Automated analysis on the phone

TB score = 9

Electronic record keeping

http://www.tissuepathology.typepad.com

Remote detection of drug-resistant outbreaks

Geo-tagging and epidemiology

Sample image

Diagnosis

Healthcare worker

Clinical expert

Patient

CellScope: Mobile Microscopy

ABL

Hospital

NIH