Cells4Life TransplantsYear Treatment Centre Medical condition Sample provided Recipient2012 Imperial Trust, UK Blood disorder Whole blood Sibling2012 Duke University, USA Cerebral injury Whole blood

Sufficient for two treatments - further cord blood remains in storage

Donor

2013 Imperial Trust, UK Leukaemia Whole blood Sibling2014 Guy’s & St Thomas’ UK Patient Specific

TherapyCord tissue Sibling

2015 Duke University, UK Acquired brain injury

Whole blood10 ml released, majority of cord blood remains in storage

Donor

SUMMER 2015

Cells4LifeUPDATE

Read more about Dr. Joanne Kurtzberg and the clinical trials for brain injury at Duke University inside. >>>

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What’s inside:> Introducing +PROTECT

> Stem cells : First therapy approved by EU

> The Baby Show : Birmingham NEC

Cells4Life releases sample for treatment of brain injury.

In February 2015 we released just 10ml (2 x 5ml vials) for a customer for the treatment of an acquired brain injury - the family still have more portions in storage should they need follow up treatment for perhaps different therapy – an opportunity available to them because they stored whole cord blood with our Platinum Service.

PROTECT is a unique insurance policy that helps to ease the financial burden should you ever need to use your stem cells – it could even cover the cost to source and retrieve additional stem cells should you need them.

Key Features

Up to £250,000 of cover with +PROTECT towards your stem cell treatment related expenses including £30,000 of post treatment recovery costs

Reimbursement of costs for global search, transportation and purchase of alternative stem cells from any suitable source (including cord blood, bone marrow & peripheral blood) if needed

Over 80 conditions included

Abilty to extend the cover to include parents and siblings

Summer 2015

Of course, we all hope you never need to use your child’s stem cells for a life-threatening condition but what if you did? The costs of treatment and recovery could be significant.

This is why Cells4Life is delighted to be the first private cord blood bank in the UK to offer a unique insurance policy to accompany stem cell storage.

REFER A FRIEND... AND BOTH GET £50!If you refer a friend or family member to Cells4Life then you could both be in line for a reward when they take one of our services. We offer a £50 voucher to both you and your friend as a way of saying thank-you and welcome!

Visit www.cells4life.co.uk/referral

Find out more at www.cells4life.co.uk/cells4life-insurance

the experts in stem cell processing...

Acute Leukaemias- Acute Lymphoblastic Leukaemia (ALL)- Acute Myelogenous Leukaemia (AML)- Acute Biphenotypic Leukaemia- Acute Undifferentiated LeukaemiaChronic Leukaemias- Chronic Myelogenous Leukaemia (CML)- Chronic Lymphocytic Leukaemia (CLL)- Juvenile Chronic Myelogenous Leukaemia (JCML)- Juvenile Myelomonocytic Leukaemia (JMML)Myelodysplastic Syndromes- Myelodysplastic Syndrome (MDS)- Refractory Anaemia (RA)- Refractory Anaemia with Ringed Sideroblasts (RARS)- Refractory Anaemia with Excess Blasts (RAEB)- Refractory Anaemia with Excess Blast in Transformation (RAEB-T)- Chronic Myelomonocytic Leukaemia (CMML)Haematopoietic Cell Disorders- Aplastic Anaemia (Severe)- Congenital Dyserythropoietic Anaemia- Fanconi Anaemia- Paroxysmal Nocturnal Haemoglobinuria (PNH)- Pure Red Cell Aplasia- Acute Myelofibrosis- Agnogenic Myeloid Metaplasia (Myelofibrosis)Lymphoproliferative Disorders- Non-Hodgkin’s Lymphoma- Hodgkin’s DiseasesPhagocyte Disorders- Chediak-Higashi Syndrome- Chronic Granulomatous DiseasePlasma Cell Disorders- Multiple Myeloma- Plasma Cell Leukaemia- Waldenstrom’s MacroglobulinemiaOther Malignancies- Ewing Sarcoma- Neuroblastoma- Testicular CancerInherited Platelet Abnormalities- Amegakaryocytosis / Congenital ThrombocytopeniaInherited Haemoglobinopathies- Thalassaemia- Sickle cell disease

Inherited Metabolic Disorders - Aspartylglucosaminuria - Adrenoleukodystrophy - Alpha-mannosidosis - Congenital Erythropoietic Porphyria - Fucosidosis - Gangliosidosis - Gaucher’s Disease - Hunter Syndrome - Hurler Syndrome - Hurler-Scheie Syndrome - I-cell Disease - Infantile Ceroid Lipofuscinosis - Krabbe Disease - Lesch-Nyhan Syndrome - Metachromatic Leukodystrophy - Maroteaux-Lamy Syndrome - Morquio Syndrome - Mucopolysaccharidosis - Niemann-Pick Disease - Sandhoff Disease - Sanfilippo Disease - Sialidosis - Tay Sachs Disease - Wolman Disease Histiocytic Disorders - Familial Erythrophagocytic Lymphohistiocytosis - Histiocytosis-X - Haemophagocytosis Inherited Immune System Disorders - Ataxia-Telangiectasia - Kostmann Syndrome - Myelokathexis - Leukocyte Adhesion Deficiency - DiGeorge Syndrome - Bare Lymphocyte Syndrome - Omenn Syndrome - Severe Combined Immunodeficiency (SCID) - SCID with Adenosine Deaminase Deficiency - SCID with absence of T & B Cells - SCID with absence of T Cells, Normal B Cell - Common Variable Immunodeficiency - Wiskott-Aldrich Syndrome

Listed Medical ConditionsThe following list specifies medical conditions where a haematopoietic stem cell transplant is a fully approved treatment and for which cover would be provided if this is recommended as the best treatment option for the Insured person.

+PROTECT Conditions P1V. PPCDec14

For your peace of mind...• Up to £250,000 of cover towards your stem cell treatment related expenses• Includes £30,000 of cover for non-treatment costs

• Optional £50,000 cover extension for Cerebral Palsy

PROTECT

Insurance

the experts in stem cell processing.

Introducing +PROTECT

Summer 2015

Joanne KurtzbergKurtzberg has been a pioneer in the application of cord blood stem cells for over 20 years. In 1993 she performed the world’s first TWO successful stem cell transplants between unrelated people using umbilical cord blood. Since then her work at Duke has gone on to gain international acclaim as she continues to improve the lives of numerous children who have suffered brain injuries or have cerebral palsy through the cord blood stem cell infusions she administers as part of her clinical trial.

In June 2014, Dr. Kurtzberg was granted $15 million to investigate the application of stem cells for other illnesses including stroke, autism and other brain disorders. Granted by The Marcus Foundation, the money will fund the first two years of a $41 million, 5 year project.

“This research holds the promise of truly transformational discovery, and we are deeply grateful to The Marcus Foundation for making it possible.” Victor Dzau, CEO of Duke University Health System

Stem cells can become any type of tissue in the body and hold huge promise in medicine.

The treatment - Holoclar - is used to treat a rare eye condition that can lead to blindness. It works in around 80% of cases.

The European Medicines Agency (EMA) said the move represented a “major step forward” for the field.

The act of blinking strips cells off the surface of the eye. These are normally replaced by limbal stem cells in order to keep the eye healthy.

Some people, after burns or acid attacks, do not have enough limbal stem cells and the surface of the eye begins to scar. It can eventually lead to blindness.

Restore

Research clinics and specialised centres have been testing a technique to replace the lost stem cells.

A small sample of remaining stem cells are taken, grown into larger numbers in the laboratory and placed back on to the surface of the eye.

The decision by the EMA means the therapy can move beyond a limited research or case-by-case setting and be offered far more widely.

Enrica Alteri, the head of the Human Medicines Evaluation Division at the EMA said: “This recommendation represents a major step forward in delivering new and innovative medicines to patients.”

Prof Chris Mason, from University College London, told the BBC: “This is a therapy that has been done a lot and is very successful, we’ve treated around 20 people at Moorfields hospital.

“This move would enable far more people to access it, you could now prescribe this.”

Source BBC News

Stem cells: First therapy approved by EU

100% match to your child and a possible match to family members

the experts in stem cell processing.

In May 2015 Cells4Life were once again present at The Baby Show at the NEC Birmingham.

The event is a fantastic opportunity for us to meet expectant parents face to face and increase the awareness of cord blood banking and potential benefits.

Last year we met Lisa Whitehead, cord blood banking was something really important to her and her partner:

“We always knew if we were lucky enough to have a child we would want to have their cord blood cells stored in case ever needed for their future. It was extremely important to us as my younger brother suffered from leukaemia aged 28 and if when he had been born this procedure had been performed maybe his blood cells could have been used to help with the treatment of his illness instead of having to go to an unrelated donor for his new bone marrow cells.

The benefits of knowing we have our son’s cord blood cells now stored gives us complete peace of mind: should he ever need to use them for treatment of an illness they are there. That to us is priceless, also we chose cells4life as

they were the only company to store the whole blood from the cord, another important factor to us.

The service we received from our phlebotomist was first class, Jo was always at the end of the phone at the crucial build up to Oliver’s arrival and Jo was extremely professional and very caring during the collection of the cells, after he’d been born, always there when I needed advice and to keep her updated during the pregnancy and due date. It’s been an absolute pleasure to be part of this fantastic company and we have absolute praise for everyone we have dealt with”.

We were delighted that Lisa took time out of her busy life as a mum to come back to the Cells4Life a year later to introduce us to her son.

Cells4Life exclusive partnership with Epsom & St Helier NHS TrustThis new arrangement offers our private banking and also a donation option to be launched later this year.

Epsom & St Helier Trust stated: “The establishment of this service will enable us to offer expectant parents easily accessible advice and information regarding cord blood stem cell collection and storage, at the same time as they are accessing their antenatal care.”

Cells4Life is delighted at the opportunity to create more awareness of cord blood banking and also help towards increasing the stocks of cord blood units on the international register.

The Baby Show: Birmingham NEC

Find out more... www.cells4life.co.uk

Parent’s Guide to Stem Cells

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BANK IT... DON’T BIN IT!Your baby’s umbilical cord

Who would have thought it?

Grow a heart

Mend broken bones

Treat brain damage

One day your baby’s umbilical cord stem cells may do all this and more:

Cells4Life Group LLPUnits 2 & 3 Oak HouseWoodlands Office ParkAlbert Drive, Burgess Hill, RH15 9TN

For all general enquiries please call us:01444 873950Alternatively please email us:enquiry@cells4life.com

Mother Lisa Whitehead and Son with Cells4Life Phlebotomist and Trainer Jo Taylor

Share your Cells4Life story...Whilst we strive to create awareness of cord blood banking, testimonials and real-life stories can be so valuable to other expectant parents researching this service.

Share your Cells4Life experience and if we use your story we will give you One Year’s +PROTECT insurance for your child.

Simply email your story to: mystory@cells4life.com

the experts in stem cell processing.