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Cell Death and Cancer. SNC2D. First a bit more cell division…. How do prokaryotes d ivide? Do all eukaryotes divide their cells using mitosis? Do all cells divide at the same speed? What factors affect mitosis? How do cells die?. 1. Binary Fission. - PowerPoint PPT Presentation
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Cell Death and CancerSNC2D
First a bit more cell division…How do prokaryotes divide?Do all eukaryotes divide their
cells using mitosis?Do all cells divide at the same
speed?What factors affect mitosis?
How do cells die?
1. Binary Fission◦ Type of cell division used by
prokaryotes (bacteria)
2. BuddingAsexual reproduction in which a
new organism develops from an outgrowth or bud on another one
3. Regeneration the process of restoration, and
growth after damage
4. FragmentationA form of asexual
reproduction where an organism is split into fragments and each fragment develops into mature, fully grown individuals which are clones of the original organism
What other factors impact mitosis?◦Altitude, antibiotics…◦Can you think of any others?
Chemotherapy Radiation Sunlight
How do Cells die?NecrosisDeath due to unexpected and
accidental cell damage.This is an unregulated cell death.Causes: toxins, radiation, trauma, lack
of oxygen due to the blockage of blood flow.
How do Cells die?ApoptosisA cell also dies as a normal part of the
functioning of healthy multicellular organisms.This is a regulated, or controlled, cell death
of cells that are no longer useful.Apoptosis also removes cells that have lost
their ability to perform efficiently.
ApoptosisThe material of the cell is recycled
by the body.
Comparison
Apoptosis Videoshttp://www.youtube.com/watch?v
=7WRkY8q_F3k
http://www.youtube.com/watch?v=gYWUTBM8tTo
Cell Lifespans Cells do not live forever. They can only divide a certain
number of times until they receive a message or instructions to die. Cell division is necessary for cells to be replaced after they die.
In your body, 3 billion cells die every minute.
We undergo cell division as part of regeneration, a process essential for repairing damaged tissue.
Why do we age?◦ Not entirely sure◦ as cells die, they are not replaced or just not as quickly. This
results in changes to the structure and function of major body systems.
What happens when damage to a cell impairs its ability to commit apoptosis and it divides and divides and divides?CANCER
Cancer Cancer = uncontrolled cell
divisionCaused by changes in the
genes controlling cell divisionloss of a cell’s ability to
undergo apoptosis (“immortal”)◦On/off switch is broken◦Continually reproducing= Tumour
CancerIn small groups
◦ – Compare Normal Cells to Cancer Cells
Normal Cells Cancer CellsMake exact copies of themselvesthrough mitosis
Make exact copies of themselvesthrough mitosis
Reproduce for about 50-60 celldivisions
Do not stop reproducing
Stick together to form masses of cells as appropriate
Do not stick to other cellsBehave independently
Self-destruct when too old or too damaged
May move to another location of the body
Review: The cell cycle has four phases and controls cell division
Cell Cycle Checkpoints There are three checkpoints in
the cell cycle◦ G1-S transition◦ G2-M transition◦ Exit M phase transition
Checkpoints are where the cell assesses whether conditions are favorable for cell division.
When the environment is not favorable (for example, when the cell’s DNA is damaged), a protein called p53 can stop the cell cycle and cause the cell to die.
When the proteins that regulate the cell cycle are mutated or absent, cells can divide controllably, leading to cancer.
Tumor suppressors and oncogenesMutations in oncogenes and
tumor suppressor genes can lead to cancer
http://science.education.nih.gov/supplements/nih1/cancer/activities/activity2_animations.htm◦(animation #5)
Cell Cycle CheckpointsA cell should remain in
interphase and not divide if…◦Signals from surrounding cells tell
the cell not to divide◦There are not enough nutrients in
the cell◦The DNA has not yet been replicated◦The DNA is damaged
These checkpoints are regulated by special proteins like p53
Microscopic Appearance of Cancer Cells
DefinitionsTumour:
◦A mass of cells resulting from rapid cell growth
Benign:◦Tumours that stay confined in a small
area, causing little damageMalignant:
◦Dangerous tumours that break away and move to other areas of the body.
• Metastasize• Spread of
cancer
Causes of CancerMutation:
◦Random changes that can occur when DNA is replicated
Carcinogen:◦Any environmental factor that can
cause a mutation
Videos on Cancerhttp://www.youtube.com/watch?v
=j_wRpa2b5XIhttp
://www.youtube.com/watch?v=8n0ijZpYXwo
http://www.pbs.org/wgbh/nova/body/how-cancer-grows.html
ANDI – Inserted DNA
Monkey with green glow protein from a jellyfish inserted into its DNA.
TgCat1 - Green Glow CatsThese GM cats
carry:◦ Green fluorescent
protein (GFP) gene◦ and an extra
monkey gene, called TRIMCyp, which protects rhesus macaques from infection by feline immunodeficiency virus or FIV – responsible for cat AIDS
Glow in the dark dog with an on/off switch!
The switch is a chemical trigger Give the dog an antibiotic along with food, she’ll
start to glow under UV light Tegon was cloned and in the process her genes
were modified to instruct her cells to react to an antibiotic by glowing
This research will help find cures to diseases (like Alzheimer's and Parkinson's) that are common to both dogs and humans
Want one?She costs $3 million.
Curious Cloning…Random In 2008 an American
couple paid more than $150,000 to have their late pet dog cloned