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 y See above: Injurious stimulus or inability to adapt l ead to reversible cell injury. If point of irreversibility is reachednecrosis. Types of Cell Death y  Apoptosis: o Usually a regulated, controlled process o Plays a role in embryogenesis  o A method of controlled cell population o Programmed cell death o Necessary for maturation of cell development y Necr osis: o Always pathologic the result of irreversible injury o Numerous causes o The sum of all mor  phologi c  c hanges occ urr ing aft er  cell d eat h o Types:  Coagulative (most common)  Liquefactive  Caseous: combination of liquefactive and coagulative necrosis  Fat necrosis  Gangrenous necrosis: combination of liquefactive and coagulative necrosis Coagulative Necrosis y Cells basic outline is preserved, but not nucleus. y Homogeneous, glassy eosinophlic appearance due to loss of cytoplasmic RNA (basophilic) and glycogen (granular) y Nucleus may show pyknosis, karyloysis, or karyorrhexis (definitions from last lecture) Subject: Pathology Topic: Cell Injury and Death 2 & Cell Growth Lecturer: Dr. Luis Cruz Date of Lecture: 06/14/2011 Transcriptionist: CELLOmapas Editor: kChristel Paok Pages: 17    S    Y    2    0    1    1      2    0    1    2

Cell Death 2 Cell Growth

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