CELADA, Franco - CV 12-9-2008 - New York Universityimmsimteam.med.nyu.edu/files/immsimteam/u5/CELADA...CURRICULUM VITAE Name: FRANCO CELADA, M.D., Ph.D. Home Address: 345 East 12th

CURRICULUM VITAE Name: FRANCO CELADA, M.D., Ph.D. Home Address: 345 East 12th Street, Apartment 15 New York, NY 10003

Phone: (212) 353-8308

Office Address: NYU Hospital for Joint Diseases Department of Rheumatology 301 East 17th Street, 16th Floor New York, NY 10003

Phone: (212) 598-6507 Fax: (212) 598-6168 Email: [email protected]

Place of Birth: Milano, Italy Citizenship: Italy. U.S.A. Status: Permanent Resident Alien EDUCATION 1945-49 High School, Liceo Classico Gonzaga, Milano. 1950-56 Faculty of Medicine, University of Milano. 1956-59 Post-doctoral training, University of Milano (Medical Clinic). DEGREES 1956 Medical Doctor, University of Milano. 1961 Specialist in Internal Medicine, University of Milano. 1966 Docent in Immunology (Ph.D.), Karolinska Institutet, Stockholm. 1967 "Libero Docente" in Immunology, Rome, Ministry of Education. POSITIONS 2007-present Research Professor of Medicine, New York University School of Medicine, New

York, NY, USA. 1987-present Senior Immunologist, NYU Hospital for Joint Diseases, New York, NY, USA. 1996-2007 Professor of Pathology (Adjunct), NYU School of Medicine, New York, NY, USA 1987-1996 Professor of Pathology, NYU School of Medicine, New York, NY, USA 1986 Visiting Professor, Department of Microbiology, Mount Sinai Medical Center, New

York, NY, USA. 1982-87 Coordinator, Italian Ph.D. program in Immunological Sciences (Dottorato di

Ricerca in Scienze Immunologiche). 1976-2006 Professor of Immunology, University of Genova and Director, Transplantation

Immunology Service, Hospital San Martino, Genova, Italy. 1975 Visiting Professor, UCLA, Departments of Biological Chemistry and of

Bacteriology, Los Angeles, CA. 1971 Director of Research, C.N.R. (Italian Research Council) and Head, Immunology

Section, Laboratory of Cell Biology, Rome, Italy. 1970 Guest Investigator, Dept. de Biologie Moleculaire, Institut Pasteur, Paris.

Franco Celada, M.D., Ph.D. CURRICULUM VITAE Page 2

POSITIONS - continued

1969-1972 Associate Professor, then, Full Professor in Immunology, Karolinska Institutet. (On leave, 1972)

1969 Personal Research Position in Immunology at Karolinska Institutet (Forskardocent). 1968 Research position in Immunology of the Swedish Medical Research Council

(Forskartjanst i immunologi). 1968 Docent at the Karolinska Institutet (E.O. Docenttjanst, icke amnesbundet). 1967 Visiting Associate Professor, Department of Biological and Medical Sciences, Brown

University, Providence, RI, USA (6 months). 1966 Guest Investigator at the Karolinska Institutet, supported by the Swedish Cancer Society 1962-1964 Assistant Professor, University of Torino, Italy (Institute of Medical Genetics). SCHOLARSHIPS AND FELLOWSHIPS 1955 Scholarship of the French Government to work at the Institut Pasteur, Paris (4 months). 1959 NIH International Post-doctoral Fellowship, to work at the Oak Ridge National

Laboratory (renewed, 1960). 1964 Eleanor Roosevelt Fellowship awarded by UICC, to work at the Karolinska Institutet,

Stockholm. 1970 Foreign-Exchange Fellowship of the DGRST (Délégation Générale pour la Recherche

Scientifique et Technique) to work at the Institut Pasteur, Paris. 1975 Fellowship of the Italo-American Medical Education Foundation (10 months). 1986 NATO Senior Fellowship, to work at the Mount Sinai Medical Center, New York. PRE-DOCTORAL RESEARCH EXPERIENCE 1954-1956 Intern student, Istituto di Clinica Medica, University of Milano (Director: Prof. Luigi

Villa). Physico-chemical characteristics of leukemic DNA. (Supervisor: Dr. E. Polli). 1955 Chercheur benevole, Institut Pasteur, Paris Service de chimie microbienne. (Director:

Pierre Grabar). Antigens of human leukocytes by gel immunodiffusion. (Supervisor: Maxime Seligmann).

POST-DOCTORAL RESEARCH AND PROFESSIONAL EXPERIENCE 1957 Investigator at the Istituto Sieroterapico Milanese, Milano, Dept. of Prof. R. Ceppellini.

Anti-DNA antibodies in serum from patients with systemic lupus. 1959-1961 Post-doctoral fellow at the Oak Ridge National Laboratory, Oak Ridge, Tennessee,

USA, Radiation Immunology Group (Group Leader: Takashi Makinodan). - Quantitation of the homograft reaction by "in vivo culture" system of lymphoid cells - Purification and assay of transplantation antigens. - Differential radiosensitivity of homograft rejecting and antibody-forming cells. - Immunogenetics of male antigen in mice. 1962-1964 Institute of Medical Genetics of the University of Torino, Italy (Director: Prof. R.

Ceppellini). Study of leukocyte antigens as an approach to transplantation in man. 1964-1967 Department of Tumor Biology, Karolinska Institutet, Stockholm (Director: Prof. George

Klein). - Kinetics of immunological memory: evidence for a biphasic decay.

- Linear transmission of specificity and heavy chain class in spleen colonies of repopulated mice.

- Evidence of cell cooperation in the adoptive response to soluble antigens; maturation of avidity.


POST-DOCTORAL RESEARCH AND PROFESSIONAL EXPERIENCE - continued

1967 Division of Biological and Medical Sciences, Brown University, Providence, RI. - Interaction of wild type anti-ß-galactosidase antibody with a Z gene product of an E.

coli mutant ß-galactosidase of resulting in enzyme activation.

1967-1970 Department of Tumor Biology, Karolinska Institutet. Mechanisms of activation of defective enzymes by antibody. Competition among different antigenic determinants on the same protein molecular. Presence of viral antigens on functional antibody-forming cells in Moloney leukemia virus infected mice.

1970 Department of Molecular Biology of the Pasteur Institut (Director: Prof. Jacques Monod). Antibody as an allosteric effector: facilitation of Omega complementation in ß-galactosidase of E. coli.

1971 Laboratorio di Biologia Cellulare, Rome, Italy. Conformational activities of antibodies on enzyme antigens. Cell cooperation in vivo and in vitro in anti-ß-galactosidase response. Enzyme-immunoassay of tumor specific antigens.

1975-1976 Departments of Biological Chemistry and Bacteriology, UCLA. Antigenic-immunogenic "map" of the ß-galactosidase molecule, utilizing mutant gene products and fragments obtained by chemical cleavage: definition of quaternary conformation-dependent and of cryptic sequential epitopes. Mechanisms of alpha-complementation and of antibody-induced conformational changes.

1977-2006 Department of Immunology, University of Genova, Transplantation Immunology Service, Hospital S. Martino, Genova. Organization of a Basic and Applied Immunology laboratory (Staff: 4 M.D.s, 8 Ph.D.s, 5 Technicians, 5 Students), including HLA typing and immune complexes determination. Research: measure of circulating immune complexes in serum of patients by a new immunoenzymatic methods. Mechanism of ab-mediated conformational changes, by means of monoclonal enzyme activating antibodies. T cell clones and difference of repertoire between T and B cells. Demonstration of preferential help by individual T and B cell clones depending on the topology of "T" and "B" epitopes in a protein antigen. Human B cell clones, antigen specific and stimulated by alloreactive T cells. Human monoclonal antibodies anti-tetanus and anti-Dr. specificities obtained by EBV transformation and cellular hybridization of anti-graft sensitized B cells.

1986 Mount Sinai Medical Center. Targeting of T cytotoxic cells on selected antigens by means of bi-specific antibodies produced by hybrid-hybridomas. Anti-idiotype as internal image of a conformation-dependent epitope of ß-galactosidase.

1988-present NYU-Hospital for Joint Diseases. T cell help for anti-idiotype and anti-interstitial image responses. Effect of CD4-gp120 binding on processing and on the fine specificity of the antibody response. Development, in association with Dr. Philip Seiden of IBM, of a computer model of the immune system based on cellular automata, capable of simulating the humoral and cellular immune response and performing in machina experiments.

AWARDS AND HONORS

2005 Honorary Member, Societe Royale de Sciences de Liège


SCIENTIFIC SOCIETIES AND INTERNATIONAL ORGANIZATIONS Scandinavian Society of Immunology (1967). Group of Cooperation in Immunology (Italy), 1972-1986

(Founder, President, Member of the Organizing Committee, Vice-President). Federation of the Italian Immunological Societies, member of the Committee (1982-1986). EMBO (European Molecular Biology Organization), 1974 – present.

EMBO, Member of the Courses and Workshops Committee, 1976-82. Italian Society of Biophysics and Molecular Biology, 1976. Organizer of the Immunology Club of Genova, 1977-1982. IUIS (International Union of Immunological Societies)

Chairman of Education Committee (1986-1993). American Association of Immunologists (AAI) (1989 – present) European Association for Higher Education in Biotechnology (HEduBT),

Secretary General (1994 – 2000). MAJOR COMMITTEE ASSIGNMENTS 1976–1982 Member, EMBO Courses and Workshops Committee 1986–1993 Chairman, Education Committee, International Union of Immunological Societies (IUIS) 1994–2000 Founder and Secretary General, European Doctorate in Biotechnology 2001–2004 Coordinator, European Strategic Action on Biotechnology Ethics (Bio-T-ethics) 2005–2008 Coordinator of Bio-T-Ethics action extended to 16 European Union Members EDITORIAL BOARDS The Journal of the Reticuloendothelial Society, Associate Editor, 1967. Immunochemistry, member of the Advisory Board, 1976. Scandinavian Journal of Immunology, member of Editorial Board, 1972. Immunology Letter, Editor, 1979. European Journal of Immunology, member of Editorial Board, 1982. Immunologia Clinica e Sperimentale, member of Editorial Board, 1984. International Reviews of Immunology, member of Editorial Board, 1985. EMBO Journal, member of Editorial Board, 1990-present. APPLIED RESEARCH ACHIEVEMENTS 1978 Application of the "probe complex" (enzyme-anti-enzyme) to the routine determination of

circulating immune complexes at the Hospital San Martino (Genoa). 1979-1983 Translation of the probe complex competitive method into a line of commercial kits by

Farmitalia Carlo Erba, SpA, through an applied research cooperative program of the Italian Research Council, a) to measure Circulating Immune Complexes (CIC) using several recognition units and b) to measure the serum capacity of solubilizing complexes (ICSC).

1985-1986 Development for Biodata SpA of a homogenous immunoassay using bi-specific hybrid monoclonal antibodies endowed with the capacity of protecting the signal molecule, ß-galactosidase, from heat denaturation (with G. Görög).

1989-1995 Development (with Philip Seiden of IBM Watson Research Center) of a computer model of the immune system (IMMSIM) based on cellular automata.


MAJOR RESEARCH INTERESTS / HIGHLIGHTS

Autoimmunity: anti DNA antibodies in Lupus patients (1957)

Cellular/Humoral response: Differential radiosensivity in adoptive transfer (1960)

Transplantation: - measure of immunogenicity of allogeneic grafts (1961) - discovery of syngeneic barrier (1966)

Memory: - two-speed decay of humoral memory (1967) - kinetic poof of cellular cooperation in antibodies response (1967)

Conformation: antibodies anti wild-type activate mutant enzyme by restoring original conformation (1986)

AIDS: modulation of CD4-gp120 binding by antibodies influencing conformation (1988)

Cell Cooperation: T help shown to be independent of fine antibody specificity (1965)

Computational Immunology: Construction of IMMSIM, a discrete model based on cellular automata (1992)

Theoretical Immunology: modeling affinity maturation and hypermutation (1992)

Theoretical Immunology: crossreactivity and plasticity of antiviral memory (2003) TEACHING EXPERIENCE (selected)

1962-1964 Lectures in the Courses of General Biology and Medical Genetics, University of Torino, Italy. (Course Director: R. Ceppellini)

1964-1972 Principles of Immunology, in the Course of Microbiology I and II, Stockholm University (Course Director: G. Bertani).

1967 Special topics of Immunology, IAE Postgraduate course of radiation immunology, Buenos Aires, Argentina (Course Director: E.E. Capalbo).

1969 One-week of Immunology, part of the Course of Pathology, University of Trieste, Italy (Director: F. Rossi).

1970 Member of the organizing committee, European Molecular Biology Organization (EMBO) Course of Cellular Immunology, Wenner Gren Institute, Stockholm.

1972 Lecturer, EMBO Training Course of Enzyme Immunochemical Methodology, Villejuif (Paris).

1973 Faculty, Practical Course in Immunochemistry, organized by the Group of Cooperation in Immunology, Naples, September 17-25 (Course Director: S. Zappacosta).

1975 Faculty, Course of Tumor Immunology, organized by the Group of Cooperation in Immunology, Milan, February 2-16 (Course Director: G. Della Porta).

1975 Faculty, Advanced EMBO Course on Immunochemistry of the cell membrane, Ravello, July 23-29 (Course directors: S. Zappacosta and P. Comoglio).

1976 Leader (with V.N. Schumaker) of Graduate Seminar Course: "Conformational changes accompanying immune complex formation" (UCLA, Chem. 251B).

1976-2006 Official Course of Immunology (yearly), University of Genoa. 1979 Organizer (with A. Siccardi), the first EMBO Lecture Course, Basic Immunology,

Pavia. 1980 Faculty, EMBO Practical Course of Cellular Immunology, Uppsala, Sweden. 1982 Organizer (with A. Siccardi, A. Clivio and U. Ugazio) of the second EMBO Lecture

Course, Basic Immunology, Pavia, Italy


TEACHING EXPERIENCE - continued

1985 Organizer (with A. Siccardi) of the third EMBO Lecture Course, Basic Immunology, Pavia, Italy.

1988 Organizer of IUIS International Course on Basic and Clinical Immunology, Poiana Brasov (Romania) May 12-19.

1988 Faculty, FEBS International School of Immunology, Ionian Village, Greece, September 18-29, 1988.

1989-1996 Faculty member, Graduate Immunology Course, Department of Pathology, New York University, New York, N.Y.

1989 Organizer of IUIS-WHO Advanced Course in Immunology, New Delhi, India, November 14-25.

1990 Organizer of IUIS-WHO-SAREC Advanced Course in Immunology, San Jose, Costa Rica, November 12-23.

1991 Director (with B. Pernis) of the NATO Advanced Study Institute "T Lymphocytes: Structure, Functions, Choices," Porto Conte, Sardinia, Italy, September 15-26.

1992 Faculty, Winter Advanced Course for Immunology and Infectious Disease, Hong Kong, February 7-10.

1992 Faculty, VIIth Course of the International School of the History of Biological Sciences, Ischia, Italy, June 16-22.

1993 Faculty and Scientific Organizing Committee, IUIS-SRP Course "Fundamental Immunology and Its Applications to the Study of Schistosomiasis," Sharm-el-Sheikh, Egypt, January 30-February 11, 1993.

MEETINGS & CONFERENCES (selected)

1978 Organizer, Symposium on Monoclonal Antibodies, Napoli (Meeting of the Society for Biophysics and Molecular Biology).

1980 Scientific Advisor, EMBO Workshop "Immunologic aspects of nuclear components," S. Margherita, Genoa.

1981 Organizer, Symposium "Developmental aspects of immunology," Napoli, Castel dell'Ovo (SIBRES Meeting).

1981 Organizer (with E. Sercarz and V.N. Schumaker) of the EMBO Workshop "Protein conformation as immunological Signal," October 1-4, Portovenere, La Spezia, Italy.

1980-1981 Organizer, The Italian Workshop of Immune Complexes. S. Vincent, May 1981 and Rome, October 1981.

1983 Chairman of workshop "Structural basis of antigenic epitopes for triggering T- and B-cells," 5th International Congress of Immunology, Kyoto, Japan.

1983 Organizer, Symposium Immunogenetics of Human MHC, Crotona, Italy. 1986 Organizer (with C. Bona and M. Zanetti) of the Symposium "Idiotypes and Diseases,"

May 7-9, Venice, Italy. 1986 Chairman (with R.W. Chestnut) of the workshop "Antigen Processing and Presentation

by B-Cells," 6th International Congress of Immunology, July 6-11, Toronto, Canada. 1986 Organizer (with E.E. Sercarz, N.A. Mitchison and T. Tada) of the NATO Workshop on

"The Semiotics of Cellular Communication in the Immune System" September 9-12, Il Ciocco, Lucca, Italy.

1988 Chairman (with T. Lehner) of the workshop on "T-B Cell Cooperation," Ninth European Immunology Meeting, Roma, September 14-17.


MEETINGS - continued

1989 Chairman (with E. Simpson) of the workshop "Immunodominance," UCLA Symposium on Immunogenicity, Steamboat Springs, Colorado, January 21-28.

1989 Chairman (with S. Buus) of the workshop "Antigen Processing and Presentation," International Congress of Immunology, Berlin, July 28-August 3.

1998 IEEE (Institute of Electrical and Electronics Engineers) International Conference on Systems, Man and Cybernetics (SMC 98), San Diego, CA

1999 Istituto Alti Studi Galileo (IASG) Meeting 1999: "Outstanding problems in science and complexity." Arcetri (Florence), Italy.

1999 The Science of Complexity. SAFI School, University of Pavia, Italy. 2/24/99. "The Complex Immune System"

1999 Immunotechnology Workshop on Antibody Technology. Pontignano (Siena, Italy). April 25-27, 1999. "Cooperation-competition between humoral and cellular responses"


STUDENTS & FELLOWS TRAINED BY FRANCO CELADA Name Contact Present Position Birgitta Asjo 1966 Stockholm Sweden Professor, Univ. of Bergen Claudio Franceschi 1968 Stockholm, Sweden Professor, Univ. of Bologna Alberto Macario 1969 Stockholm, Sweden Professor SUNY Albany, NY Everly Conway de Macario 1969 Stockholm, Sweden School Public Health, SUNY, NY Roberto Tosi 1970 Rome, Italy Director of Laboratory Roberto Revoltella 1971 Roma, Italy Professor, Univ. of Padova Roberto Accolla 1973 Roma, Italy Prof. of Pathology,Univ.of Varese Oreste Acuto 1974 Roma, Italy Lab Director, Institut Pasteur Massimo Romani 1974 Roma, Italy Lab Director, Genoa Cancer Institute Annalisa Kunkl 1977 Genova, Italy Lab Director, Hosp. S.Martino, Genoa Fabrizio Manca 1977 Genova, Italy Director of Research, Gaslini Institute, Genoa, Italy Anna Rubartelli 1979 Genova, Italy Lab Director, Genoa Cancer Institute Antonio Lanzavecchia 1979 Genova, Italy Director, Inst. for Research in Biomedicine Bellinzona, Switzerland Paolo Casali 1983 Genova, Italy Director, Center for Immunology Research University of California – Irvine Michele Bezzi 1993 Genova, Italy Accenture Technology Lab. Antipolies, France Brynja Kohler 1995 New York, NY Researcher, Univ. of Utah Claudia Calcagno 2000 New York, NY PhD Student, Computational Biology,

Mount Sinai School of Medicine, NY Dario Ghersi 2000 New York, NY PhD Student, Computational Biology,

Mount Sinai School of Medicine, NY


Yiming Cheng 2007 New York, NY Researcher, School of Medicine, New York University, NY

MENTORS & COLLABORATORS

Name Contact

Pierre Grabar 1955 Institut Pasteur Paris, France Takashi Makinodan 1960 National Laboratory, Oak Ridge, Tennessee Ruggero Ceppellini 1963 University of Torino, Italy George Klein 1965 Karolinska Institute, Stockholm, Sweden Hans Wigzell 1967 Karolinska Institute, Stockholm, Sweden Boris Rotman 1968 Brown University, Providence, RI Sven Britton 1969 Karolinska Institute, Stockholm, Sweden Jacques Monod 1970 Institut Pasteur, Paris, France Roberto Strom 1973 University La Sapienza Roma, Italy Irving Zabin 1975 UCLA, Los Angeles, CA Eli Sercarz 1976 UCLA, Los Angeles, CA Constantin Bona 1985 Mount Sinai School of Medicine, New York, NY Philip Seiden 1992 IBM New York, NY Stefano Ruffo 1995 University of Firenze, Italy Liisa Selin 2002 University of Massachusetts Worcester, MA


RECENT FUNDING RECORD IN THE U.S. (as Principal Investigator) NIH 1R01 AI 054455/04-06 $256,000 dir/year 08/25/2006 – 08/31/2010 “To model crossreacting T memory of virus-infected mice” NIH 1R01 AI 054455/01-03 $307,464/year 9/15/2003 – 12/31/2005 “To model crossreacting T memory of virus infected mice” CAAT $29,000 USD 2/1/1999 – 1/31/2001 (Center for Alternatives to Animal Testing, Johns Hopkins University) “Experiments Using a Computer Model of the Immune System” CAAT $30,000 USD 2/1/1997 – 1/31/1999 (Center for Alternatives to Animal Testing, Johns Hopkins University) “Experiments Using a Computer Model of the Immune System” NIH 1 R01 AI 42262-01 $138,075/year 01/01/1998-12/31/2000 “Modelling cell mediated responses in the computer” NIH 2R01 AI 33660-04 A1 $233,562 dir/year 12/01/1996 – 11/30/1999 “Computer simulation for immunological experiments” Aaron Diamond Foundation ~$150,000 / year ~1991–1994 This 3-year grant funded a study of a monoclonal antibody recognizing HIV gp120 and influencing its binding to CD4. American Foundation for AIDS Research (AmFAR) ~$40,000 ~1990 Grant No. 000964-7-R9 (In memory of Ralph J. Eppensteiner) This 1-year grant funded a study of the influence upon the conformation of HIV gp120, and its binding to CD4, by antibodies that exert effects on conformation. NIH R01 AI28194 ~$150,000 / year ~1987–1990 This 3-year grant funded a study of the influence upon the conformation of HIV gp120, and its binding to CD4, by antibodies that exert effects on conformation Council for Tobacco Research 2298 ~$40,000 / year ~1985–1988 This 3-year grant funded a study of influence upon epitope conformation by antibodies


BIBLIOGRAPHY Original Peer-Reviewed Reports: 1. SEMENZA G, DI MAIORCA GP, CELADA F, POLLI E: A proposito di alcune caratteristiche

fisio-chimiche degli acidi desossinucleici provenienti da cellule normali e patologiche di varie specie. Boll. Soc. Ital. Ematol. 2:346, 1954.

2. BUSSI L, COLOMBO B, BOESI S, CELADA F: Particolare comportamento ematologico in

seguito a terapìa prednisonica in un soggetto affetto da leucemia linfatica cronica. Boll. Soc. Ital. Ematol. 4:263, 1956.

3. POLLI E, CELADA F: Alcuni aspetti immunologici delle leucemie sperimentali ed umane.

Rivista di Emoterapìa ed Immunoematologìa 4:351, 1957. 4. POLLI E, CELADA F, CEPPELLINI R: A proposito di un fattore serico del Lupus Eritematoso,

reagente con l'acido desossipentosonucleico. Boll. Inst. Sieroterapico Milanese 36:577, 1957. 5. CEPPELLINI R, POLLI E, CELADA F: A DNA-reacting factor in serum of a patient with lupus

erythematosus diffusus. Proc. Soc. Exp. Biol. Med. 96:572, 1957. 6. FASOLI A, CELADA F, MANZOCCHI L: Ipoproteinemia di alto grado ed an asarca da

gastropatia cronica con ipertrofia gigante della mucosa e perdita di proteine plasmatiche nel lume gastrico. Arch. Patol. e Clinica Medica 37:107, 1960.

7. CELADA F, MAKINODAN T: A new model to study hematopoietic transplantation antigens.

J. Immunol. 86:638-645, 1961. 8. CELADA F, RAMOS A: Passive cutaneous anaphylaxis in mice and chickens. Proc. Soc. Exp.

Biol. Med. 108:129-133, 1961. 9. CELADA F, ANDERSON NG, MAKINODAN T: Solubilization and purification of

homologous transplantation antigens in the mouse. Radiat. Res. 14:455, 1961. 10. CELADA F, WELSHONS WJ: Demonstration of F1 hybrid antiparent immunological reaction.

Proc. Nat. Acad. Sci. USA 48:326, 1962. 11. CELADA F, CARTER RR: The radiosensitive nature of homograft-rejecting and agglutinin-

forming capacities of isolated spleen cells. J. Immunol. 89:161, 1962. 12. CELADA F, WELSHONS WJ: An immunogenetic analysis of the male antigen in mice utilizing

animals with an exceptional chromosome constitution. Genetics 48:139, 1963. 13. CEPPELLINI R, CELADA F, MATTIUZ PL, ZANALDA A: Study of the possible correlation

between blood antigens and histocompatibility in man. I. Production of leucoagglutinins by repeated transfusions from one donor. Ann. N.Y. Acad. Sci. 120:335, 1964.


14. CELADA F: Transplantation of antibody forming cells in mice of the same strain. Study of an age dependent, radiosensitive barrier. The Swedish Cancer Society Yearbook 1964/65, p. 282 (Engl. edition).

15. CELADA F, WIGZELL H: Immune responses in spleen colonies. I. Clonal distribution of

haemolytic plaque-forming cells. Immunology 10:231, 1966. 16. CELADA F, WIGZELL H: Immune responses in spleen colonies. II. Clonal assortment of 19-S

and 7-S producing cells in mice reacting against two antigens. Immunology 11:453, 1966. 17. CELADA F: Quantitative studies of the adoptive immunological memory in mice. I. An age-

dependent barrier to syngeneic transplantation. J. Exp. Med. 124:1, 1966. 18. CELADA F: Studies on the homograft reactivity and transmission ofimmunological information

by adoptive transfer and in vivo cloning of lymphoid cells. Dept. of Tumor Biology, Karolinska Institutet Medical School, Stockholm, 1966.

19. CELADA F: Quantitative studies of the adoptive immunological memory in mice. II. Linear

transmission of cellular memory. J. Exp. Med. 125:199, 1967. 20. CELADA F, ROTMAN B: A fluorochromatic test for immunocytotoxicity against tumor

cells and leukocytes in agarose plates. Proc. Nat. Acad. Sci. 57:630, 1967. 21. CELADA F, KLEIN G: Autonomy of H-2 genes in individual immunocytes. Nature 215:1136, 1967. 22. BRITTON S, CELADA F: Immunogenicity of human serum albumin: Decay in the normal

mouse. Immunology 14:503, 1968. 23. ROTMAN B, CELADA F: Formation of ß-D-galactosidase mediate by specific antibody in a

soluble extract of E. coli containing a defective z gene product. Proc. Nat. Acad. Sci. USA 60:660, 1968.

24. CELADA F, SCHMIDT D, STROM R: Determination of avidity of anti-albumin antibodies in

the mouse. Influence of the number of cells transferred on the quality of the secondary adoptive response. Immunology 17:189, 1969.

25. CELADA F: Activation of a defective E. coli ß-galactosidase by antibodies: characteristics of

the antigenic determinant involved (Abstract). Acta Pathol. Microbiol. Scand., 1969. 26. CELADA F, ÅSJÖ B, KLEIN G: The presence of Moloney virus-induced antigen on antibody-

producing cells. Clin. Exp. Immunol. 6:317, 1970. 27. CELADA F: Tumor-specific antigen appearance on normal cells during intermediate steps of

viral carcinogenesis. Boll. Ist. Sieroter. Milanese 50:176, 1971. 28. CELADA F, ELLIS G, BODLUND K, ROTMAN B: Antibody-mediated activation of a

defective ß-D-galactosidase. II. Immunological relationship between the normal and the defective enzyme. J. Exp. Med. 134:751, 1971.


29. STROM R, GANDINI ATTARDI D, FORSEN S, TURINI P, CELADA F, ANTONINI E: The activation of ß-galactosidase by bivalent and monovalent cations. Transient and steady-state studies. Eur. J. Biochem. 23:118, 1971.

30. CELADA F: The cellular basis of immunological memory. Progr. Allergy 15:223-267, 1971. 31. MACARIO AJL, CONWAY de MACARIO E, FRANCESCHI C, CELADA F: Maturation of

the immune response in vitro. Focal fluctuation and changes in affinity of anti- ß-D-galactosidase activating-antibody. J. Exp. Med. 136:353, 1972.

32. CELADA F, STROM R: Antibody-induced conformational changes in proteins. Quart. Rev.

Biophysics 5:395, 1972. 33. MACARIO AJL, CONWAY de MACARIO E, CELADA F: An immunoenzymatic system to

study in vitro immune responses. Synthesis of antibodies directed toward different ß-D-galactosidase determinants in lymph node fragments cultures. Immunology 24:237, 1973.

34. MACARIO AJL, CONWAY de MACARIO E, CELADA F: Rabbit memory cells are not

restricted to the affinity of circulating antibodies. Nature New Biology 241:22, 1973. 35. CELADA F, MACARIO AJL, CONWAY de MACARIO E: Enzyme activation by antibodies:

A method to determine the binding constant of the activating antibody towards one determinant of E. coli ß-D-galactosidase. Immunochemistry 10:797, 1973.

36. TOSI R, CELADA F: Influence of antiserum avidity on inhibition reactions. Immunology

27:941-951, 1974. 37. CELADA F, RADOJKOVIC J, STROM R: Antibody-mediated activation of ß-galactosidase

mutants and complementary fragments. J. de Chimie Physique 71:1007, 1974. 38. CELADA F, ULLMANN A, MONOD J: An immunological study of complementary fragments

of ß-galactosidase. Biochemistry 13:5543, 1974. 39. STROM R, CELADA F: Antibody-induced conformational changes in enzymes. Acta Vitam.

Enzymol. (Milano), 28:276, 1974. 40. ANDERSSON B, CELADA F, ÅSJÖ B: Studies on high and low dose paralysis. Eur. J.

Immunol. 4:788-793, 1974. 41. MILLER A, DE LUCA D, CELADA F, SERCARZ E: Patterned antigen-binding cells of

multiple specificity. Adv. Exp. Med. Biol. 66:343-348 (1976). 42. CELADA F, NATALI PG, RADOJKOVIC J: An in vitro immunoenzymatic assay of tumor

antigens in the mouse using ß-D-galactosidase. J. Immunol. 117:904-910, 1976. 43. COMOGLIO S, CELADA F: An immuno-enzymatic assay of cortisol using E. coli ß-

galactosidase as label. J. Immunol. Methods 10:161-170, 1976.


44. ACCOLLA R, CELADA F: Antibody-mediated activation of a deletion-mutant ß-galactosidase defective in the α region. FEBS Letters 67:299-302, 1976.

45. ISETTA AM, MINGHETTI A, RADOJKOVIC J, VASILE C, CELADA F: Affinity and

specificity of penicillin-antibody interaction determined by an enzyme (E. coli ß-galactosidase) immunoassay. Eur. J. Immunol. 6:737-742, 1976.

46. BRAKE AJ, CELADA F, FOWLER AV, ZABIN I: An immunochemical aid to sequence

determination of proteins. Anal. Biochem. 80:108-115, 1977. 47. CONWAY de MACARIO E, MACARIO AJL, TOSI RM, CELADA F, LANDUCCI TOSI S:

Long-term antibody synthesis in vitro. Immunology 35:341-352, 1978. 48. ACCOLLA RS, CELADA F: Immune response against the B-galactosidase enzyme of E. coli at

precursor cell level. I. Analysis of the secondary repertoire in Balb/c mice. Eur. J. Immunol. 8:688-692, 1978.

49. CELADA F, FOWLER AV, ZABIN I: Probes of ß-galactosidase structure with antibodies.

Reaction of anti-peptide antibodies against native enzyme. Biochemistry, 17:5156, 1978. 50. CELADA F, ZABIN I: A dimer-dimer binding region in ß-galactosidase. Biochemistry 18:404,

1979. 51. MANCA F, MIGLIORINI P, BOMBARDIERI S, CELADA F: An enzymatically active

antigen-antibody probe to measure circulating immune complexes by competition. I. Use of E. coli ß-galactosidase in the probe and of bovine conglutinin as the complex-binding reagent. Clin. Immunol. Immunopathol. 16:131-141, 1980.

52. VALBONESI M, GARELLI S, MOSCONI L, MANCA F, CANTARELLA S, CELADA F:

Patients with high titers of circulating immune complexes are most likely to benefit from plasmapheresis treatment. Intl. J. Artifical Organs 4:234-237, 1981.

53. ACCOLLA RS, CINÀ R, MONTESORO E, CELADA F: Antibody-mediated activation of

genetically defective E. coli ß-galactosidase enzymes by means of monoclonal antibodies produced by somatic cell hybrids. Proc. Natl. Acad. Sci. USA, 78:2478-2482, 1981.

54. PICCOLELLA E, CENTIS D, CELADA F: Requirement of the immunogen E. coli ß-

galactosidase for the response towards a determinant responsible for antibody-mediated enzyme activation, while antibodies binding some other site can be elicited by mitogen alone. Eur. J. Immunol. 11:286-290, 1981.

55. LANZAVECCHIA A, FERRARINI M, CELADA F: Human T cell lines with antigen specificity

and helper activity. Eur. J. Immunol. 12:468-474, 1982. 56. CELADA F, STROM R: ß-galactosidase: immune recognition of conformation and mechanism

of antibody-induced catalytic activation. Biopolymers 22:465-473, 1983.


57. MIGLIORINI P, TROVATELLO G, CANTARELLA S, MANCA F, BOMBARDIERI S, CELADA F: An enzymatically active antigen-antibody probe to measure circulating immune complexes. II. E. coli ß-galactosidase in the probe and Clq as the recognition unit. J. Immunol. Meth. 59:245-254, 1983.

58. MANCA F, BAROCCI S, KUNKL A, GURRERI G, COSTANTINI M, CELADA F:

Recognition of donor fibroblast antigens by lymphocytes homing in the human grafted kidney. Transplantation 36:670-674, 1983.

59. LANZAVECCHIA A, PARODI B, CELADA F: Activation of human B lymphocytes:

frequency of antigen-specific B cells triggered by alloreactive or by antigen-specific T cell clones. Eur. J. Immunol. 13:733-738, 1983.

60. MIGLIORINI P, RIENTE L, MANCA F, CELADA F, BOMBARDIERI S: Cold-precipitable

immune complexes in collagen diseases: evidence for the coexistence of multiple types of circulating complexes in the same serum. Clin. Immunol. & Immunopathol. 29:129-140, 1983.

61. MANCA F, CAUDA R, LAGHI V, CANTARELLA S, TROVATELLO G, ORTONA L,

CELADA F: Followup of circulating immune complexes in the course of acute viral hepatitis, and correlation with serologically relevant parameters. Hepato-Gastroenterology 31:119-122, 1984.

62. MANCA F, BACIGALUPO A, VAN LINT MT, TROVATELLO G, CANTARELLA S,

FRASSONI F, MARMONT A, CELADA F: Circulating immune complexes in allogeneic marrow graft recipients. Transplantation 36:428-430, 1984.

63. CHIEREGATTI G, MIGLIORINI P, MANCA F, CELADA F: An enzymatically active probe

complex for determination of circulating immune complexes. J. Clin. Immunoassay 7:337-341, 1984.

64. MIGLIORINI P, AIUTI F, BALESTRIERI G, BOMBARDIERI S, CANTARELLA S,

CARBONARA A, CLERICI E, COPPO R, CORDIALI FEI P, D'AMELIO R, DEL GIACCO GS, DI MARIO U, MANCA F, MANNO C, MARCHI M, MASSAI G, NATALI PG, PASSALEVA A, PASTORE A, PASTORE R, ROSSI G, SCHENA FP, TINCANI A, TROVATELLO G, VALESINI G, CELADA F: Comparison of pathologic and normal sera by immune complex determination: five disease groups within 190 samples are discriminated by computer-selected combinations of 13 methods. Clin. Immunol. & Immunopathol. 32:298-315, 1984.

65. MANCA F, KUNKL A, FENOGLIO D, FOWLER A, SERCARZ E, CELADA F: Constraints in

T-B cooperation related to epitope topology on E. coli ß-galactosidase. I. The fine specificity of T cells dictates the fine specificity of antibodies directed to conformation-dependent determinants. Eur. J. Immunol. 15:345-350, 1985.

66. CELADA F, LANZAVECCHIA A: A dramatic representation of immunological cooperative

events. Int. Archs. Allergy Appl. Immun. 76(Suppl.1):28-33, 1985.


67. MANCA F, CAROZZI S, KUNKL A, BAROCCI S, VALENTE U, FONTANA I, CELADA F: Individual sensitivity to cyclosporine in vitro can be detected in kidney failure patients. Transplantation Proc. 17:1265-1267, 1985.

68. MIGLIORINI P, CHIEREGATTI G, TROVATELLO G, CANTARELLA S, FENOGLIO D,

CELADA F: The serum capacity to solubilize immune complexes (ICSC) measured by an enzyme-anti-enzyme complex probe. J. Immunol. Methods 77:119-130, 1985.

69. MANCA F, BAROCCI S, CAROZZI S, VALENTE U, FONTANA I, GURRERI G,

GRIFFANTI F, KUNKL A, CELADA F: Generation of cytotoxic T cell lines from intragraft lymphocytes. I. Donor kidney fibroblasts are recognized as targets by infiltrating cells but not by peripheral blood lymphocytes. Transpl. Proc. 17, 1985.

70. MANCA F, CAROZZI S, KUNKL A, DESSÌ V, VALENTE U, FONTANA I, CELADA F: In

vitro sensitivity to cyclosporine is clonally distributed among alloreactive clones. Transpl. Proc. 17:71, 1985.

71. MANCA F, CICCIARELLI J, CAROZZI S, KUNKL A, BAROCCI S, DESSÌ V, VALENTE U,

CELADA F: Alloreactive precursors are preserved in cyclosporine treated patients. Transpl. Proc. 17:2717-2718, 1985.

72. NOCERA A, LEPRINI A, FONTANA I, ARCURI V, BAROCCI S, DAMIANI G, CELADA F,

VALENTE U: HLA-DR-bearing cells in the human pancreas. Transpl. Proc. 17:144-145, 1985.

73. BAROCCI S, NOCERA A, CAROZZI S, VALENTE U, ARMANI R, DESSÌ V, SANTORO F,

CELADA F: Autoreactive lymphocyte cytotoxic antibodies in kidney transplant patients. Transpl. Proc. 17 (6), 2485-2486, 1985.

74. MANCA F, KUNKL A, CELADA F: Inhibition of the accessory function of murine

macrophages in vitro by cyclosporine. Transplantation 39:644-9, June 1985. 75. NOCERA A, BAROCCI S, VALENTE U, CAROZZI S, BURASTERO S, ZICCA A, DESSÌ V,

CELADA F: In vitro characterization of a donor-specific T cell line established from human lymphocytes homing in a rejected kidney allograft. Transplantation 41:135-138, 1986.

76. MANCA F, CAROZZI S, KUNKL A, BAROCCI S, DESSÌ V, VALENTE U, FONTANA I,

CELADA F: Difference in sensitivity to cyclosporine in vitro of human alloreactive lines and clones. Transplantation 41:199-203, 1986.

77. LEPRINI A, VALENTE U, CELADA F, FONTANA I, BAROCCI S, NOCERA A:

Morphology, cytochemical features, and membrane phenotype of HLA-DR+ interstitial cells in the human pancreas. Pancreas 2:127-35, 1987.

78. ITO M, FREDRICKSON GG, CELADA F, SCHULMAN JL, BONA CA, MORAN TM:

Methods for the selection and growth of antigen-specific cytolytic T lines and clones bearing a defined T cell receptor beta chain marker. J. Immunol. Methods 103:229-27, 1987.


79. KUNKL A, FENOGLIO D, MANCA F, CALTABELLOTTA M, BAROCCI S, CAROZZI S, VALENTE U, GESSAGA M, CELADA F: Cyclosporine sensitivity of human alloreactive T lymphocytes depends on the strength of the allogeneic stimulus. Transplantation Proc. 19:262, 1987,

80. BAROCCI S, NOCERA A, CAROZZI S, LEPRINI A, FONTANA I, ARMANI R, VALENTE

U, LAMPERI S, CELADA F: Identification of autoreactive lymphocytotoxic antibodies in sensitised dialysis and kidney transplant patients. Nephrology, Dialysis, Transplantation 2:266-270, 1987.

81. CELADA F, SERCARZ E: Preferential pairing of T-B specificities in the same antigen: the

concept of directional help. Vaccine 6:94, 1988. 82. MANCA F, FENOGLIO D, KUNKL A, CAMBIAGGI C, SASSO M, CELADA F: Differential

activation of T cell clones stimulated by macrophages exposed to antigen complexed with monoclonal antibodies. J. Immunol. 140:2893-98, 1988.

83. MANCA F, FENOGLIO D, KUNKL A, CAMBIAGGI C, LI PIRA G, CELADA F: B cells on

the podium: regulatory roles of surface and secreted immunoglobulins. Immunology Today 9:300-303, 1988.

84. MANCA F, FENOGLIO D, KUNKL A, CALTABELLOTA M, CELADA F: Effect of

clycosporine on the antigen-presenting function of human and murine accessory cells. Transplantation 46:40S-43S (Suppl.), 1988.

85. MANCA F, CAUDA R, LAGHI V, TROVATELLO G, CANTARELLA S, TRESALTI E,

ORTONA L, CELADA F: Detection of parasite related antigens associated with conglutinin binding immune complexes in patients with Schistosoma haematobium. Trans. Royal Soc. Tropical Medicine & Hygiene 82:254-257, 1988.

86. MANCA G, PERFUMO F, VALENTE U, BAROCCI S, CELADA F, GUSMANO R: Inhibition

of factor VIII synthesis by kidney endothelial cells by graft-infiltrating T helper lymphocytes. Transplantation 46:916-918, 1988.

87. GÖRÖG G, GANDOLFI A, PARADISI G, ROLLERI E, KLASEN E, DESSÌ V, STROM

R, CELADA F: Use of bispecific hybrid antibodies for the development of a homogeneous enzyme immunoassay. J. Immunol. Meth. 123:131-140, 1989.

88. VALLE MT, KUNKL A, FENOGLIO D, PERFUMO F, VALENTE U, MANCA F, NOCERA

A, CELADA F: Limiting dilution analysis of alloreactive precursors is more discriminatory than MLR to evaluate functional histocompatibility. Transplantation Proc. 21:685-686, 1989.

89. ITO M, USUBA O, UNKELESS J, SCHREIBER R, CELADA F, BONA CA, MORAN TM:

Sideways killing: the cytolysis of Fc receptor-bearing cells through bridging to cytolytic T lymphocytes by antibodies specific for the T-cell receptor-T3 complex. Scand. J. Immunol. 29:659-669, 1989.


90. CELADA F, CAMBIAGGI C, MACCARI J, BURASTERO S, GREGORY T, PATZER E, PORTER J, MCDANAL C, MATTHEWS T: Antibody raised against sCD4-rgp120 complex recognizes the CD4 moiety and blocks membrane fusion without inhibiting CD4-gp120 binding. J. Exp. Med. 172:1143-1150, 1990.

91. BURASTERO SE, CUTOLO M, DESSÌ V, CELADA F: Monoreactive and polyreactive

rheumatoid factors produced by in vitro Epstein-Barr virus-transformed peripheral blood and synovial B lymphocytes from rheumatoid arthritis patients. Scand. J. Immunol. 32:347-357, 1990.

92. MANCA F, FENOGLIO D, LI PIRA G, KUNKL A, CELADA F: Effect of antigen/antibody

ratio on macrophage uptake, processing and presentation to T cells of antigen complexed with polyclonal antibodies. J. Exp. Med. 173:37-48, 1991.

93. MANCA F, ROSSI G, VALLE MT, LANTERO S, LI PIRA G, FENOGLIO D, DE BRUIN J,

COSTANTINI M, DAMIANI G, BALBI B, CELADA F: Limited clonal heterogeneity of antigen-specific T cells localizing in the pleural space during mycobacterial infection. Infection & Immunity 59:503-513, 1991.

94. CELADA F, SEIDEN PE: A computer model of cellular interactions in the immune system.

Immunology Today 13:56-62, 1992. 95. KUNKL A, FENOGLIO D, MANCA F, LI PIRA G, CAMBIAGGI C, STROM R, CELADA F:

Kinetic immunodominance: Functionally competing antibodies against exposed and cryptic epitopes of E. coli β-galactosidase are produced in time sequence. Intl. Immunol. 4:627-636, 1992.

96. MANCA F, WALKER L, NEWELL A, CELADA F, HABESHAW JA, DALGLEISH AG:

Inhibitory activity of HIV envelope gp120 dominates over its antigenicity for human T cells. Clin. Exp. Immunol. 88:17-22, 1992.

97. SEIDEN PE, CELADA F: A model for simulating cognate recognition and response in the

immune system. J. Theor. Biol. 158:329-357, 1992. 98. MANCA F, SERAVALLI E, VALLE MT, FENOGLIO D, KUNKL A, LI PIRA G, ZOLLA-

PAZNER S, CELADA F: Noncovalent complexes of HIV gp120 with CD4 and/or monoclonal antibodies enhance activation of gp-specific T clones and provide intermolecular help for anti-CD4 antibody production. Intl. Immunol. 5:1109-1117, 1993.

99. MORPURGO D, SERENTHÀ R, SEIDEN PE, CELADA F: Modelling thymic functions in a

cellular automaton. Intl. Immunol. 7:505-516, 1995. 100. KONOPKA K, PRETZER E, SERAVALLI E, CELADA F, DÜZGÜNES N: Differential effects

of a monoclonal antibody to the gp120-CD4 complex on HIV-induced syncytium formation and viral infectivity. J. General Virology 76:669-679, 1995.


101. BURASTERO SE, GAFFI D, LOPALCO L, TAMBUSS G, BORGONOVO B, DE SANTIS C, ABECASIS C, ROBBIONI P, GASPARRI A, LAZZARIN A, CELADA F, SICCARDI AG, BERETTA A: Autoantibodies to CD4 in HIV type 1-exposed seronegative individuals. AIDS Research and Human Retroviruses 12:273 (1996).

102. LEFÉVRE O, SEIDEN PE, CELADA F: Insights into rheumatoid factor production using a

cellular automaton model of the immune system. International Journal of Applied Science and Computations 3:32-47 (1996).

103. CELADA F, SEIDEN PE: Affinity maturation and hypermutation in a simulation of the humoral

immune response. Eur. J. Immunol. 26:1350-1358 (1996). 104. BEZZI M, CELADA F, RUFFO S, SEIDEN PE: The transition between immune and disease

states in a cellular automaton model of clonal immune response. Physica A 245:145-163 (1997).

105. KOHLER B, PUZONE R, SEIDEN P, CELADA F. A systematic approach to vaccine

complexity using an automaton model of the cellular and humoral immune system. Vaccine 19:862-976 (2000).

106. SELIN LK, CORNBERG M, BREHM MA, KIM SK, CALCAGNO C, GHERSI D, PUZONE R,

CELADA F, WELSH RM. CD8 memory T cells: cross-reactivity and heterologous immunity. Semin Immunol. 2004;16:335-347

107. BAHL K, KIM SK, CALCAGNO C, GHERSI D, PUZONE R, CELADA F, SELIN LK,

WELSH RM. IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections. J Immunol;2006;176:4284-4295.

108. CORNBERG M, CHEN AT, WILKINSON LA, BREHM MA, KIM SK, CALCAGNO C,

GHERSI D, PUZONE R, CELADA F, WELSH RM, SELIN LK. Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity. J Clin Invest 2006;116:1443-1456.

109. WUCHERPFENNIG KW, ALLEN PM, CELADA F, COHEN IR, DE BOER R, GARCIA KC, GOLDSTEIN B, GREENSPAN R, HAFLER D, HODGKIN P, HUSEBY ES, KRAKAUER DC, NEMAZEE D, PERELSON AS, PINILLA C, STRONG RK, SERCARZ EE: Polyspecificity of T cell and B cell receptor recognition. Semin Immunol 2007;194):216-224.

110. CHENG Y, GHERSI D, CALCAGNO C, SELIN LK, PUZONE R, CELADA F: A discrete

computer model of the Immune System reveals competitive interactions between the humoral and cellular branch and between cross-reacting memory and naïve responses. Vaccine, in press.

111. CLUTE SC, WATKIN LB, NAUMOV YN, SULLIVAN JL, LUZURIAGA K, WELSH RM,

PUZONE R, CELADA F, SELIN LK. A broad array of cross-eractive T cell receptor structures comprise the private repertoires that recognize Eptein-Barr and influenza A viruses. (Manuscript submitted)


Proceedings of Meetings

1. POLLI E, CELADA F, CEPPELLINI R, BIANCHESI M: In tema di alcuni aspetti immunologici del Lupus Eritematoso sistemico. Dimostrazione di un fattore serico anti-ADN. Atti del II Convivio Internazionale: I più recenti aggiornamenti in tema di malattie del collageno, p. 31, Ganassini, Milano, 1958.

2. POLLI E, CELADA F: Present status and perspectives of leucocyte desoxyribonucleic acid

antigenicity. Proc. 7th Congr. Europ. Soc. Haematol., London, 1959, p. 482 (part II). 3. MAKINODAN T, CELADA F, CAPALBO EE: An immunological approach to the study of

radiation-induced blood chimeras. Proc. 8th International Congress of Haematology 1960, p. 115, Pan Pacific Press, Tokyo.

4. MAKINODAN T, CAPALBO EE, URSO P, CELADA F, PERKINS EH, ALBRIGHT JF:

Studies on immune reactions in in vivo cultures. Proc. Intern. Symp. on Tissue Transpl., Santiago, 1961, p. 73. Editorial Universitaria, Santiago, 1962.

6. CELADA F, MAKINODAN T: Radiosensitivity of homograft-rejecting and antibody-

synthesizing capacities of isolated cells; its significance to tolerance. Mechanisms of Immunological Tolerance, Proc. Symp. at Liblice, Prague, 1961. Publishing house of the Czechoslovak Academy of Sciences, Prague, 1962, p. 157.

7 CELADA F: Studio comparativo della radiosensibilità di due tipi di risposta immunitaria:

produzione di agglutinine e reazione anti-omotrapianto. Atti del VI Congresso Nazionale di Radiobiologìa Medica, Trieste, p. 55, 1962.

8. CELADA F: Control of amount and affinity of antibody during the response to a protein antigen.

In Nobel Symposium 3: Gamma Globulins, Structure and Control of Biosynthesis, J. Killander (Ed.), Almqvist & Wiksell, Stockholm, 1967, p. 517.

9. CELADA F: The immunologic defense in relation to age. In Thule International Symposium on

Cancer and Aging. Nordiska Bokhandelns Förlag, Stockholm, 1968, p. 97. 10. CELADA F, KLEIN G: Viral antigens on plaque-forming cells in Moloney infected mice

(abstract). The Transplantation Society 2nd International Congress, N.Y., 1968. 11. MACARIO AJL, CONWAY de MACARIO E, CELADA F: Heterogeneity of memory cells in

rabbits producing serum antibodies of high affinity. Third Meeting of the Scandinavian Soc. Immunol. May, 23-27, 1972. Espoo, Finland. Scand. J. Immunol., 1:416, 1972 (Abstract).

12. CELADA F: Concepts and methods in immunology applicable to the control of human fertility.

7th Karolinska Symposium, 1974, pp. 419-435. 13. CELADA F: ß-D-galactosidase as a tool in immunochemistry. In Proceedings of a Symposium

on enzyme-immunoassay, Feldmann C, et al. (Eds.), North Holland, 1976, pp.


14. CELADA F: Enzymo-immuno-assay in perspective. C.R., 3° Colloque du Radioimmunologie, Lyon, 1976, p. 384-386.

15. CASALI P, MANCA F, CELADA F: Riconoscimento e caratterizzazione degli immuno

complessi solubili nei liquidi biologici: lo stato dell'arte. XIV Congresso Nazionale della Soc. Allerg. e Immunol. Clinica (Firenze, 28-30 Nov., 1979). Leonardo Ediz. Scientifiche, Roma.

16. CELADA F, MIGLIORINI P: Italian Workshop on Immune Complexes. Folia Allergol.

Immunol. Clin. 29:93-98, 1982. 17. CELADA F, SIMPSON E: Discussion summary: Immunodominance. In Immunogenicity,

UCLA Symposia, Vol. 113, C.A. Janeway, J. Sprent, E. Sercarz (Eds.), Wiley-Liss, pp. 73-77, 1990.

18. CELADA F, SEIDEN P. Modelling immune cognition. Proceedings, 1998 IEEE International Conference on Systems, Man and Cybernetics (SMC 98), San Diego, CA.

19. PUZONE R, KOHLER B, SEIDEN P, CELADA F. IMMSIM, a simulator of the immune

system's recognition and response, based on cellular automata. Proceedings of IASG Meeting 1999: "Outstanding problems in science and complexity." Istituto Alti Studi Galileo, Arcetri (Florence), Italy, 2001.

Reviews and Educationally Relevant Publications

1. POLLI E, CELADA F: Stato presente e prospettive a proposito della antigenicità del DNA di leucociti. Haematologica Latina 4:1, 1960.

2. BRITTON S, CELADA F: Immunogenicity decay of foreign antigen in the mouse. In

Lymphatic Tissue and Germinal Centers Immune Response, ed. L. Fiore-Donati and M.G. Hanna Jr., Vol. V. Advances in Experimental Medicine and Biology, Plenum Press, 1969.

3. CELADA F, STROM R, BODLUND K: Antibody-mediated activation of a defective ß-D-

galactosidase (AMEF). Characteristics of binding and activation processes. In The Lactose Operon. J.R. Beckwith and D. Zipser, editors. Cold Spring Harbor Laboratories Press, Cold Spring Harbor, N.Y., 1970, p. 291.

4. MACARIO AJL, CONWAY de MACARIO E, FRANCESCHI C, CELADA F: Attempt to

separate antibody-forming clones of different affinity for one antigenic determinant on a macromolecule. In Advances in Experimental Medicine and Biology, Vol. 12 (Morphological and Functional Aspects of Immunity), K. Lindahl-Kiessling, G. Alm and M.G. Hanna, Jr. (Eds), Plenum Press, New York-London, 1971, pp. 365-370.

5. CELADA F, ÅSJÖ B: Dynamics of MLV infection of antibody-forming cells. In International

Virology, p. 135, J.L. Melnick, editor, S. Karger, Basel 1971 (Abstract). 6. CELADA F, ÅSJÖ B: Studies on Moloney leukemia virus infection of antibody-forming cells.

In Virus Tumorigenesis and Immunogenesis. Academic Press, New York & London, 1973, p. 262.


7. CELADA F, ÅSJÖ B: Studies on Moloney leukemia virus infection of antibody-forming cells.

La Ricerca, Vol. III, suppl. 2, p. 75, 1973. 8. CELADA, F: Maturazione della risposta immunitaria. In Lezioni del Corso di Aggiornamento in

immunologìa Clìnica, Roma, 9-14 Aprile, 1973. 9. CELADA F: Hierarchic immunogenicity of protein determinants. In Lecture notes in

biomathematics. Systems theory in immunology proceedings, 1978. Edited by C. Bruni et al., Springer-Verlag, 32:28-36, 1979.

10. FOWLER AV, CELADA F, WELPLY J, ZABIN I: The use of antibodies in protein structure

determination. In Methods in peptide and protein sequence analysis. C. Birr, ed. Elsevier/North-Holland Biomedical Press. 247:256, 1980.

11. CELADA F: La sorveglianza immunologica rivisitata. In Immunologia dei Tumori, Ed. Ercole Sega, pp. 317-329, 1980.

12. LANZAVECCHIA A, SANTINI P, PISCHEDDA F, FERRARINI M, CELADA F: Attivazione

dei linfociti B umani indotta da cloni T antigene-specifici o alloreattivi. In Immunologia - Attualita e Prospettive. I. Pensiero Scientifico Editore, Roma. pp. 184-187, 1983.

13. PARODI B, DESSÌ V, CASALI P, STROM R, CELADA F: Could aggregation of human

immunoglobulins bring about appearance of novel antigen sites? In Protein Conformation as an Immunological Signal, F. Celada, V. Schumaker, E. Sercarz (Eds.), Plenum Press, N.Y. pp. 31-44, 1983.

14. STROM R, RADOJKOVIC J, MINALE P, CELADA F: Is there a preferential pathway for

antibody-mediated enzyme activation? In Protein Conformation as an Immunological Signal. F. Celada, V. Schumaker, E. Sercarz (Eds.), Plenum Press, N.Y. pp. 233-241, 1983.

15. ACCOLLA RS, CINÀ R, MONTESORO E, CELADA F: Antibody-mediated activation of

genetically defective E. coli galactosidase by monoclonal antibodies. In Protein Conformation as an Immunological Signal, F. Celada, V. Schumaker, E. Sercarz (Eds.), Plenum Press, N.Y. pp. 213-216, 1983.

16. ZABIN I, FOWLER AV, CELADA F: Antibodies as probes of protein structure. In Protein

Conformation as an Immunological Signal, F. Celada, V. Schumaker, E. Sercarz (Eds.), Plenum Press, N.Y. pp. 225-231, 1983.

17. TROVATELLO G, CELADA F: Diagnostica del complemento: metodologia e tattica.

Elettromedicali 3, 1983. 18. MANCA F, CELADA F: La situazione immunologica e gli immunocomplessi. In La nuova

prevenzione attiva anisenile (ed. C. Sirtori), Cortina International - Verona. pp. 103-107, 1984.


19. CELADA F, KUNKL A, MANCA F, FENOGLIO D, FOWLER A, KRZYCH U, SERCARZ E: Preferential pairings in T-B encounters utilizing Th cells directed against discrete portions of ß-galactosidase and B cells primed with the native enzyme or a hapten epitope. In Regulation of the Immune System, UCLA Symposia on Molecular and Cellular Biology. Alan R. Liss, New York, 1984.

20. CELADA F, MIGLIORINI P, MANCA F, TROVATELLO G, CANTARELLA S, ROSSI G,

BOMBARDIERI S, BARRA S, CANESI M, GIORDANO D, PARODI A, REBORA A, SABBADINI MG, SALUSCEV P: Quality of immune complexes in systemic lupus. In Recent Advances in Systemic Lupus Erythematosus (eds. P.H. Lambert et al.) Academic Press, 179-193, 1984.

21. CELADA F, TROVATELLO G, MANCA F, MIGLIORINI P: Enzyme immunoassay: immune

complexes. In Methods of Enzymatic Analysis (ed. Bergmeyer), Verlag Chemie, Weinheim (FRG), 10:_______, 1985.

22. CELADA F: La logica della risposta immunitaria. In Le Difese Immunitarie: come l'organismo

riconosce se stesso e il mondo esterno. (F. Celada Ed.) Le Scienze, Milano, pp. 1-15, 1986. 23. CELADA F, STROM R: L'immunochimica: il rapporto antigene-anticorpo. In Le Difese

Immunitarie: come l'organismo riconosce se stesso e il mondo esterno. (F. Celada Ed.) Le Scienze, Milano, pp. 62-72, 1986.

24. CELADA F, MANCA F, MIGLIORINI P, PUCCETTI A, TROVATELLO G: Gli

immunocomplessi circolanti: significato e misura. In Le Difese Immunitarie: come l'organismo riconosce se stesso e il mondo esterno. (F. Celada Ed.) Le Scienze, Milano, pp. 193-198, 1986.

25. CELADA F: Basic principles of antigen-antibody interaction. In Handbook of Experimental

Pharmacology. Vol. 82, Radioimmunoassay in basic and clinical pharmacology. C. Patrono and B.A. Peskar (Eds.). Springer-Verlag, Berlin Heidelberg, Ch. 2, p. 7, 1987.

26. CELADA F, MANCA F: Specific T-B interaction in the response to conformation-dependent

determinants. In Synthetic Vaccines (Ed. R. Arnon) CRC Press, Boca Raton (FL), Vol. 1, p. 117, 1987.

27. CELADA F, SERCARZ E: The induction of memory and its implications for vaccine design. In

Immunogenicity of Protein Antigens: Repertoire and Regulation, CRC Press, Inc., Vol. 1, p. 75, 1987.

28. CELADA F, KUNKL A, FENOGLIO D, MANCA F: Selective cooperation between T and B

clones specific for the same macromolecular antigen: does antibody specificity influence antigen processing? In Processing and Presentation of Antigens, B. Pernis, S.C. Silverstein and H.J. Vogel, eds. Academic Press, Inc., New York, N.Y., pp. 235-45, 1988.

29. CELADA F: In search of T-cell help for the internal image of the antigen. In Theoretical

Immunology, Part Two, SFI Studies in the Sciences of Complexity. Editor, A.S. Perelson. Addison-Wesley Publishing Company, pp. 233-45, 1988.


30. CELADA F: Does the human mind use a logic of signs developed by lymphocytes 108 years

ago? In The Semiotics of Cellular Communication in the Immune System, F. Celada, N.A. Mitchison, E.E. Sercarz, T. Tada (Eds), Springer Verlag, Berlin and Heidelberg, 1988.

31. CELADA F: Bricolage in cellular immunity. Intl. Rev. Immunol. 4:107-194, 1989. 32. ADORINI L, BARNABA V, BONA C, CELADA F, LANZAVECCHIA A, SERCARZ E,

SUCIU-FOCA N, WEKERLE H: New perspectives on immunointervention in autoimmune diseases. Immunology Today, 11:383-386, 1990.

33. REVILLARD J-P, CELADA F: Guidelines for the Ph.D. degree in immunology. Immunology

Today 13:367-373, 1992. 34. CELADA F, SEIDEN PE: Teaching immunology: A Montessori approach using a computer

model of the immune system. In T Lymphocytes: Structure, Functions, Choices (F. Celada and B. Pernis, eds.), NATO ASI Series, Vol. A 233. Plenum Press, New York and London, pp. 215-225, 1992.

35. SEIDEN PE, CELADA F: A simulation of the humoral immune system. In Theoretical

Immunology, NATO ASI Series, Vol. H 66 (A.S. Perelson and G. Weisbuch, eds.), Springer Verlag, Berlin and Heidelberg, 1992.

36. CELADA F: Computer modeling of the immune system: who are the "fruitori?" In Theoretical

Immunology, NATO ASI Series, Vol. H 66 (A.S. Perelson and G. Weisbuch, eds.), Springer Verlag, Berlin and Heidelberg, 1992, pp. 3-13.

37. CELADA F: Eurodoctorate in Biotechnology: Idea and Feasibility. Year Immunol., Vol. 7, pp.

1-4, Karger, Basel, 1993. 38. BEHN U, CELADA F, SEIDEN P. Computer modelling in immunology. In Frontiers of LIfe

Enciclopedia Italiana (Roma) and Academic Press, 1998. 39. CELADA F. The immune system, and why modelling it makes sense. In Dynamical Modelling

in Biotechnologies, Bagnoli F, Lio P, Ruffo S (eds.) World Scientific Textbooks, 1998. 40. CELADA F. Immunology: A complex system. Rivista di Biologia 91:307-310 (1998). 41. PUZONE R, KOHLER B, SEIDEN P, CELADA F. A discrete model of cellular humoral

response. In Theoretical and Practical Issues on Cellular Automata (S Bandini, T Worsch, eds) Springer, London: 2000; 117-125.

42. BEHN U, CELADA F, SEIDEN P. Computer modeling in immunology. In Frontiers of Life,

Vol. II, Part 2: The Immunological System (Lanzavecchia A, Malissen B, Sitia R, eds) Academic Press, London, 2001;611-630.


Books

1. Franco Celada (Editor). Metodi dell'Immunochimica. Boringhieri, Milano, 1975.

2. Franco Celada, Verne N. Schumaker and Eli E. Sercarz (Editors). Protein Conformation as an Immunological Signal. Plenum Press, New York and London, 1983.

3. Franco Celada. Le Difese Immunitarie: come l'organismo riconosce se stesso e il mondo esterno. Le Scienze SpA., Editore, Milano, 1986.

4. Franco Celada, N.A. Mitchison, E.E. Sercarz, T. Tada (Editors). The Semiotics of Cellular Communication in the Immune System. Springer Verlag, Berlin and Heidelberg, 1988.

5. Franco Celada (Guest Editor). Non-Conventional T Cytotoxicities, Vol. 4, No. 2, Intl. Reviews of Immunology. Harwood Academic Publishers, 1989.

6. Franco Celada (Editor). Il Sistema Immunitario (Le Scienze quaderno 55). Le Scienze S.p.A., Milano, 1990.

7. Franco Celada and Benvenuto Pernis (Editors). T Lymphocytes: Structure, Functions, Choices. NATO A.S.I. Series, Vol. A233. Plenum Press, New York and London, 1992.

8. Franco Celada (Editor). Il Nuovo Immunologia. Le Scienze S.p.A., Milano, 1992.

Documents

CELADA, Franco - CV 12-9-2008 - New York Universityimmsimteam.med.nyu.edu/files/immsimteam/u5/CELADA...CURRICULUM VITAE Name: FRANCO CELADA, M.D., Ph.D. Home Address: 345 East 12th