Case 3

• 30 year old woman• Visiting friend from out of province. Found

deceased in bed• Some ethanol ingestion, but no drug use,

reported evening prior • History of hypertension, no medications

• At autopsy:– Cardiomegaly (550 grams) and left ventricular

hypertrophy (2.0 cm)– Arteriolonephrosclerosis

Case 4

• 6 year old boy• Presented to hospital with 2 hours of vomiting• Vtach and hypotension during investigations,

cardiac arrest• One week history occasional headaches and

two day history intermittent chest pain• No known medical or family history

Chromogranin

Inhibin

Synaptophysin

S100

Case 5

• 23 day old infant female• Presented with abnormal respirations and

became unresponsive • Transported to IWK, never regained

consciousness• Approximately 8 hours presentation to death• Normal pregnancy and delivery, previously

healthy

• At autopsy:– Well nourished and normally developed– No injuries– Subarachnoid staining, vascular congestion and

petechial hemorrhages, markedly friable parenchyma

• Neuropathology consultation:– Purulent exudate parieto-occipital region– Perivascular cuffing monocytes and neutrophils,

focal endothelialitis– Gram positive cocci, not paired

• Blood culture (post mortem):– Streptococcus agalactiae, no other growth

• Mother GBS positive on prenatal screening• No antibiotics given at delivery

Case 6

• 32 year old woman• Witnessed sudden collapse• No known medical history