CARMINES, Pamela K. PAMELA K. C · Project Period: 09/30/02 - 07/31/05. Total Direct Costs $587,000. Principal Investigator. Impact of Glucose on Calcium Signaling in Cultured Renal

CARMINES, Pamela K.

UNMC Format CV page 1 10/30/2017

PAMELA K. CARMINES

HOME ADDRESS 15806 Curtis Avenue Omaha, NE 68116-4044

CAMPUS ADDRESS Department of Cellular & Integrative Physiology University of Nebraska College of Medicine 985850 Nebraska Medical Center Omaha, NE 68198-5850 Phone: (402) 559-9343 FAX: (402) 559-4438 E-mail: [email protected] Office locations: DRC 6046 and ARS 2004A

PLACE OF BIRTH Hampton, VA

EDUCATION Aug 1977 – June 1982 Ph.D. in Physiology (Minor: Life Sciences) Indiana University, Indianapolis, IN Dissertation: Role of angiotensin in the vascular response to chronic renal

tubular obstruction

Aug 1973 – May 1977 B.S. in Chemistry & Biology, Cum Laude Longwood College (now Longwood University), Farmville, VA

POST-DEGREE TRAINING June 1982 – Oct 1984 Postdoctoral Fellow (Advisor: L. Gabriel Navar, Ph.D.) Cardiovascular Research & Training Center, Nephrology Research & Training

Center, and Department of Physiology & Biophysics University of Alabama at Birmingham

CONTINUING EDUCATION TRAINING Jan 2017 ELAM Alumni Professional Development Workshop Drexel University College of Medicine

July 2016 How to Teach & Advise on Career Development Topics for the Next Generation of Biomedical Sciences

NIH Office of Intramural Training & Education

Oct 2015 Making the Leadership Leap UNMC Faculty Development

Sept 2015 – Mar 2016 Digital Campus: Apple Professional Development Training UNMC / Apple

CARMINES, Pamela K.


June 2012 – Apr 2013 Hedwig van Ameringen Executive Leadership in Academic Medicine® (ELAM) Program for Women

Drexel University College of Medicine

Oct 2010 – May 2011 The Management Series UNMC Human Resources / Organizational Development Office

Apr 2010 Search Engine Optimization and Other Online Strategies for Effective Student Recruiting

Peterson’s Recruitment Services (Webinar)

Apr 2005 Effective Testing: Writing Multiple-Choice Questions UNMC Center for Continuing Education

Feb 2005 Dealing with Students Experiencing Academic or Clinical Performance Problems UNMC Center for Continuing Education

ADMINISTRATIVE APPOINTMENTS January 2018 – Executive Associate Dean for Graduate Studies University of Nebraska Medical Center

July 2015 – present Vice Chair, Promotion & Tenure Committee College of Medicine, University of Nebraska Medical Center

July 2013 – Dec 2017 Assistant Dean for Graduate Studies University of Nebraska Medical Center

Sept 2010 – present Vice Chair for Graduate Education, Department of Cellular & Integrative Physiology

College of Medicine, University of Nebraska Medical Center

ACADEMIC APPOINTMENTS July 1997 – present Professor, Department of Cellular & Integrative Physiology (formerly

Physiology & Biophysics) University of Nebraska College of Medicine

July 1993 – June 1997 Associate Professor (tenured 07/1995), Department of Physiology & Biophysics University of Nebraska College of Medicine

Oct 1988 – June 1993 Assistant Professor, Department of Physiology (tenure approved, effective 07/1993)

Tulane University School of Medicine

May 1986 – Sept 1988 Research Assistant Professor, Department of Physiology & Biophysics Scientist II, Nephrology Research & Training Center University of Alabama at Birmingham

Oct 1984 – Apr 1986 Research Instructor, Department of Physiology & Biophysics Scientist I, Nephrology Research & Training Center University of Alabama at Birmingham

CERTIFICATIONS AND LICENSES – None

CARMINES, Pamela K.


GRANT/CONTRACT SUPPORT

PLANNED APPLICATIONS – None

PENDING SUPPORT – None

CURRENT SUPPORT

Scientific and Editorial Consultant. Jennifer S. Pollock/University of Alabama at Birmingham. Total contract period: 04/01/2016 - 03/31/2020. Total Direct Costs: Fee for Service (up to $50,000 total). Contractor.

Neuro-Circulatory Function in Chronic Heart Failure. Project 3: The Chemoreflex in Heart Failure. National Institutes of Health (5 P01 HL062222). Total Project Period: 09/01/2015 - 07/31/2020. Total Direct Costs $5,389,990 (Project 3 = $1,214,885). Consultant. (H.D. Schultz, P.I.; I.H Zucker, Program Director)

PREVIOUS SUPPORT Mitochondrial Redox Systems in Neurogenic Hypertension. National Institutes of Health (1 R01 HL103942).

Total Project Period: 07/01/10 - 06/30/15. Total Direct Costs $1,250,000. Co-Investigator, 5% effort. (M.C. Zimmerman, P.I.)

Impact of ROMK Channel Inhibition on Renal Arteriolar Function. Merck & Co. Total Project Period: 06/13/2013 - 12/31/2014. Total Direct Costs $81,863. Principal Investigator.

Renal Complications of Diabetes using Murine Models. UNMC College of Medicine and Vice Chancellor for Research. Total Project Period: 7/27/2012 - 06/30/2013. Total Direct Costs $100,000. Principal Investigator.

Tyrosine Kinases in Renal Vasoconstrictor Signaling. National Institutes of Health (5 R01 DK071152). Total Project Period: 01/18/06 - 12/31/11. Total Direct Costs $987,326. Principal Investigator.

Tyrosine Kinases in Renal Vasoconstrictor Signaling (ARRA supplement). National Institutes of Health (3 R01 DK071152-04S1). Total Project Period: 09/22/09 - 08/31/11. Total Direct Costs $66,519. Principal Investigator.

Oxidative Stress and Potassium Channel Dysfunction in the Renal Afferent Arteriole during Diabetes (Predoctoral Fellowship). American Heart Association. Total Project Period: 01/01/2009 - 12/31/2010. Total Direct Costs $52,000. Sponsor (C.M. Troncoso Brindeiro, P.I.)

Renal Microvascular Smooth Muscle and Reactive Oxygen Species in T1D. UNMC College of Medicine Research Grant Award. Total Project Period 04/01/08 - 03/31/10. Total Direct Costs $30,000. Principal Investigator.

Tyrosine Kinases in Renal Vasoconstrictor Signaling. National Institutes of Health (R01 DK071152; Research Supplement to Promote Diversity in Health-Related Research to support C.M. Troncoso Brindeiro). Total Project Period: 01/01/07 - 12/31/08. Total Direct Costs $55,042. Principal Investigator.

Impact of Puberty on the Kidney in Diabetes. National Institutes of Health (R01 DK59869). Total Project Period: 08/01/01 - 07/31/07. Total Direct Costs $1,125,000. Co-Investigator (P.H. Lane, P.I.)

EGFR and Src Family Tyrosine Kinases in AngII-induced Contraction of the Renal Preglomerular Microvasculature. American Heart Association Heartland Affiliate (0555644Z). Total Project Period: 07/01/05 - 06/30/07. Total Direct Costs $130,000. Principal Investigator. (Relinquished 12/31/05 due to overlap with DK071152)

CARMINES, Pamela K.


Cerebral Microcirculation during Alcohol Consumption. National Institutes of Health (R01 AA011288). Total Project Period: 05/01/05 - 04/30/09. Total Direct Costs $875,000. Co-Investigator during yr 1 (W.G. Mayhan, P.I.)

Tyrosine Kinases in Renal Vasoconstrictor Signaling. UNMC College of Medicine Research Grant Award (Dean’s Indirect Cost Program/”New” Research Grant). Total Project Period 02/15/05 - 02/14/06. Total Direct Costs $30,000. Principal Investigator.

Cerebrovascular Disease in Type 1 Diabetes. National Institutes of Health (R01 HL079587). Total Project Period: 09/30/04 - 08/31/08. Total Direct Costs $1,000,000. Co-Investigator during yr 1 (W.G. Mayhan, P.I.)

Poly(ADP-ribose) polymerase-mediated endothelial dysfunction in high fat-induced Type 2 diabetes. National Kidney Foundation of Nebraska. Total Project Period 07/01/04 - 06/30/05. Total Direct Costs $5,000. Co-Investigator (B.J. Padanilam, P.I.)

Renal Cortical Oxidative & Nitrosative Stress in IDDM. National Institutes of Health (R21 DK063416). Total Project Period: 09/30/02 - 07/31/05. Total Direct Costs $587,000. Principal Investigator.

Impact of Glucose on Calcium Signaling in Cultured Renal Arteriolar Smooth Muscle Cells. National Kidney Foundation of Nebraska. Total Project Period: 07/01/01 - 06/30/02. Total Direct Costs $5,000. Principal Investigator.

Oxidative Stress in the Renal Cortex during Diabetes Mellitus (Seed Grant). UNMC Department of Physiology & Biophysics. Total Project Period: 04/15/01 - 06/30/01. Total Direct Costs $15,000. Principal Investigator.

Ion Channels in Diabetic Complications. Project 1 – Deranged Electromechanical Coupling in the Renal Microvasculature during Diabetic Hyperfiltration. UNMC College of Medicine Dean’s Indirect Cost Return Grant. Total Project Period: 03/01/01 - 02/28/03. Total Direct Costs $150,000 (Project 1 =$18,000). Program Coordinator & Principal Investigator of Project 1.

Volume Regulation in Diabetes: Intrarenal Mechanisms. National Institutes of Health (R01 HL48023). Total Project Period: 05/01/99 - 04/30/04. Total Direct Costs $447,669. Co-Investigator (K.P. Patel, P.I.)

Hormonal Influences on the Renal Microvasculature. National Institutes of Health (R01 DK39202 09-13). Total Project Period: 08/01/98 - 07/31/04. Total Direct Costs $588,935. Principal Investigator.

Volume Regulation in Diabetes: Intrarenal Mechanisms. Juvenile Diabetes Foundation International. Total Project Period: 07/01/98 - 06/30/00. Total Direct Costs $181,818. Consultant (K.P. Patel, P.I.) Declined (alternative to HL48023).

Renal Microvascular Angiotensin II / Nitric Oxide Interactions in Diabetes Mellitus. Juvenile Diabetes Foundation International (197008). Total Project Period 09/01/97 - 12/31/99. Total Direct Costs $174,004. Principal Investigator.

Renal Microvascular Angiotensin II / Nitric Oxide Interactions in Diabetes Mellitus. Nebraska Affiliate, American Heart Association. Total Project Period 07/01/97 - 06/30/99. Total Direct Costs $40,000. Principal Investigator. Declined (alternative to JDF #197008).

Renal Microvascular Angiotensin II / Nitric Oxide Interactions in Diabetes Mellitus. American Diabetes Association. Total Project Period 07/01/97 - 06/30/00. Total Direct Costs $130,803. Principal Investigator. Declined (alternative to JDF #197008).

CARMINES, Pamela K.


Cardiovascular Research Center. Project III – Microvascular Regulation in Chronic Heart Failure. UNMC College of Medicine Dean’s Indirect Cost Return Grant. Total Project Period: 06/30/97 - 06/29/00. Total Direct Costs $15,000. Co-Investigator (W.G. Mayhan, P.I.)

Noradrenergic Influences on Renal Function in Heart Failure. American Heart Association (96006840). Total Project Period: 07/01/96 - 06/31/00. Total Direct Costs $120,000. Co-Investigator (K.P. Patel, P.I.)

Circulatory Control in Heart Failure. Project II – Mechanisms of Abnormal Microvascular Regulation in Chronic Heart Failure. UNMC Interactive Seed Grant (INT-07-02-97). Total Project Period: 06/01/96 - 06/30/98. Total Direct Costs $9,367. Co-Investigator (W.G. Mayhan, P.I.)

Potassium Channel Modulation of Renal Microvascular Function (Undergraduate Research Fellowship for Joseph P. Bast). American Heart Association - Nebraska Affiliate (96-SF-02). Total Project Period: 06/01/96 - 08/31/96. Total Direct Costs $1,500. Sponsor.

Renal Arteriolar Intracellular Calcium Signaling during the Hyperfiltration Stage of Diabetes Mellitus. Juvenile Diabetes Foundation International - Robert A. & Renee Belfer Fund Research Grant (194113). Total Project Period: 09/01/94 - 12/31/96. Total Direct Costs $76,774. Principal Investigator.

Renal Arteriolar Intracellular Calcium Signaling during the Hyperfiltration Stage of Diabetes Mellitus. Nebraska Affiliate, American Heart Association Total Project Period 07/01/94 - 06/30/96. Total Direct Costs $40,000. Principal Investigator. Declined (alternative to JDF #194113).

Hormonal Influences on the Renal Microvasculature. National Institutes of Health (R01 DK39202 04-08). Total Project Period: 08/01/92 - 07/31/98. Total Direct Costs $421,446. Principal Investigator.

Pathophysiology of Intracellular Ca2+ Homeostasis (Equipment Grant - Imaging upgrade of quantitative fluorescence microscopy facility). Louisiana Educational Quality Support Fund (LEQSF[1992-93]-ENH-TR-35). Total Direct Costs $44,475. Co-Principal Investigator.

Determinants of Renal Arteriolar Angiotensin Responsiveness. American Heart Association (910709). Total Project Period: 07/01/91 - 06/30/95. Total Direct Costs $120,000. Principal Investigator.

Renal Microvascular Derangements in Diabetes Mellitus. American Diabetes Association. Total Project Period 07/01/91 - 06/30/94. Total Direct Costs $80,000. Principal Investigator.

Use of Isolated Perfused Afferent and Efferent Arterioles for Study of Calcium Access Pathways Evoked by Angiotensin. Biomedical Research Support Grant. Total Project Period: 11/01/90 - 06/30/92. Total Direct Costs $7,500. Principal Investigator.

Intrarenal Mechanisms Controlling Microvascular Dynamics (Established Investigator Award). American Heart Association (900235). Total Project Period: 07/01/90 - 06/30/95. Total Direct Costs $175,000 (salary only). Principal Investigator.

Microscope-Based Digital Photometry System for Quantitative Fluorescence Analysis of Intracellular Signaling Events (Equipment Grant). Tulane University Interdisciplinary Program in Molecular & Cellular Biology. Total Direct Costs $49,843. Principal Investigator.

Microvascular Control of Juxtamedullary Nephron Function (FIRST Award). National Institutes of Health (R29 DK39202 01-03). Total Project Period: 09/01/87 - 08/31/91. Total Direct Costs $191,192. Principal Investigator.

Microvascular Control of Juxtamedullary Nephron Function (New Investigator Award). National Institutes of Health (R23 DK36115 01-02). Total Project Period 09/23/85 - 08/31/87. Total Direct Costs $68,892. Principal Investigator.

CARMINES, Pamela K.


STUDY SECTIONS

AD HOC REVIEWER 2017 Advancing a Healthier Wisconsin (AHW) Endowment 2011 Medical Research Council (United Kingdom) 2000 Veterans Administration Nephrology Merit Review 1998 NIH Cardiovascular & Renal (CVB) Study Section 1995 Veterans Administration Nephrology Merit Review 1995 National Science Foundation 1992 NOAA Undersea Research Program 1991-1993 Veterans Administration Nephrology Merit Review 1988-1989 Veterans Administration Nephrology Merit Review

SPECIAL STUDY SECTIONS 2011, 2012 NIH Heart, Lung, and Blood Program Special Emphasis Panel (Program Project Grant

reviews) 2008 Chair, NIH Hypertension & Microcirculation Special Emphasis Panel ZRG1 CVS-N 02 2006 Chair, NIH Renal & Urological Sciences-B Special Emphasis Panel ZRG1 RUS-B 02 2005 NIH Heart, Lung, and Blood Program Special Emphasis Panel (Program Project Grant

review) 2002 University of Michigan Diabetes Research & Training Center Young Investigator

Grants 1993 NIH Clinical Sciences Ad Hoc Review Section SSS-L (M7)

REGULAR STUDY SECTIONS Ad Hoc Member:

2010 NIH Cell and Molecular Biology of the Kidney (CMBK) Study Section 2005 NIH Vascular Cell and Molecular Biology (VCMB) Study Section 2003 NIH General Medicine B (GMB) Study Section 1994 National Kidney Foundation of Michigan

Regular Member: 2012-2014 American Heart Association Vascular Biology & Blood Pressure BSc2 Peer Review

Study Group 2006-2009 American Heart Association Vascular Biology & Blood Pressure Regulation I Peer

Review Study Group 1999 National Kidney Foundation of Nebraska 1995-1998 Veterans Administration Merit Review Board for Nephrology 1995-1998 American Heart Association Cardio-Renal Peer Review Study Group 1992-1993 American Heart Association – Louisiana Affiliate 1991-1992 American Heart Association Southern Region Peer Review Board 1989 American Heart Association – Louisiana Affiliate

CARMINES, Pamela K.


PATENTS – None

OTHER APPOINTMENTS OR POSITIONS – None

CONSULTING POSITIONS

EXTERNAL REVIEWER 2018 Academic Program Review Team, Physiological Sciences Graduate Interdisciplinary

Program, University of Arizona 2009 Program Project Grant (David M. Pollock, P.I), Medical College of Georgia

REVIEWER FOR JOURNALS

American Journal of Nephrology American Journal of Physiology: Cell Physiology American Journal of Physiology: Heart and Circulatory Physiology American Journal of Physiology: Renal Physiology American Journal of Physiology: Regulatory, Integrative and Comparative Physiology Frontiers in Physiology Hypertension Journal of Physiology Kidney International PLoS-One

EDITORIAL BOARDS 2013-present Editorial Reviews Board, American Journal of Physiology: Renal Physiology 2009-2013 American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2007-2010 Editorial Reviews Board, American Journal of Physiology: Renal Physiology 2001-2014 Hypertension 2001-2007 Associate Editor, American Journal of Physiology: Renal Physiology 1999-2001 American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 1998-2001 Editor, Council Newsletter; American Heart Association Council on Kidney in

Cardiovascular Disease 1993-1995 American Journal of Physiology: Renal Fluid and Electrolyte Physiology 1993 Hypertension Supplement: Proceedings of the Inter-American Society of

Hypertension

MILITARY SERVICE – None

HONORS AND AWARDS 2015 Fellow (inaugural class), American Physiological Society 2012-2013 Fellow, Hedwig van Ameringen Executive Leadership in Academic Medicine® (ELAM)

Program for Women 2011 UNMC Outstanding Teacher Award (awarded by the Faculty Senate)

CARMINES, Pamela K.


2004 Fellow, American Society of Nephrology 2003 Golden Apple Award, American Medical Student Association (UNMC Chapter) 2001 Alumni Achievement Award, Longwood College 1996 Young Scholars Award, American Society of Hypertension 1993 International Congress of Physiological Sciences Travel Award 1993 Finalist, Young Investigator Award, Inter-American Society of Hypertension 1993 Who's Who of American Women (18th Edition) 1992 Young Scientist Award, Sigma Xi (Tulane Chapter) 1992 Fellow, American Heart Association Council for High Blood Pressure Research 1990-1995 Established Investigator, American Heart Association 1990 Who's Who of American Women (17th Edition) 1990 American Society of Nephrology Travel Award (to attend International Congress of

Nephrology) 1987 American Society of Nephrology Travel Award (to attend International Congress of

Nephrology) 1986 American Men and Women of Science 1984 International Society of Nephrology Travel Award 1984 Sigma Xi 1981 Award for Excellence in Renal Research, American Physiological Society

MEMBERSHIPS AND OFFICES IN PROFESSIONAL SOCIETIES

SOCIETY MEMBERSHIPS − American Heart Association

Council on Kidney in Cardiovascular Disease; Hypertension Council − American Physiological Society

1° affiliation: Renal Section 2° affiliation: Water & Electrolyte Homeostasis Section

− American Society of Nephrology

ELECTED OFFICES IN PROFESSIONAL SOCIETIES 2012-2015 Councillor, American Physiological Society 2005-2008 Chair, Renal Section of the American Physiological Society 1999-2002 President-Elect / President / Past President, Nebraska Physiological Society 1998-1999 Councilor, Nebraska Physiological Society 1995-1999 Executive Committee, American Heart Association Council on Kidney in

Cardiovascular Disease 1995-1998 Councilor, Women in Nephrology 1991-1994 Treasurer, Renal Section of the American Physiological Society

COMMITTEE SERVICE FOR PROFESSIONAL SOCIETIES Alabama Kidney Foundation

1986-1988 Board of Medical Advisors

CARMINES, Pamela K.


American Heart Association (AHA) − National Center

2007-2010 Research Committee • Policy & Evaluation Subcommittee, 2007-2010 • Multidisciplinary & Collaborative Approaches Working Group, 2008

− Heartland Affiliate 2003-2007 Research Committee

− Nebraska Affiliate 1996-1998 Research Committee

− Council on Kidney in Cardiovascular Disease 2007-2015 Leadership Committee

• AHA Research Committee Liaison, 2007-2010 • At-Large Member, 2010-2015

1999-2001 Communications Committee (Chair) 1995-1999 Executive Committee 1995-1999 Budget Committee 1996-1998 Nominating Advisory Group

− Hypertension Council (formerly Council for High Blood Pressure Research) 2014-2015 Leadership Committee 2009-2015 Awards Committee

• Chair, 2014-2015 • Vice-Chair, 2011-2014

2006-2008 Fall Conference Program Committee 1993-1996 Scientific Sessions Program Committee

American Physiological Society (APS) 2016-2017 Membership & FAPS (Fellows of the American Physiological Society) Committee 2015 Task Force: “Strategic Planning Survey” 2014-2017 Sage, Renal Section Steering Committee 2012-2015 Membership Committee (APS Council Liaison) 2011-2012 Task Force: “Enhancing Opportunities for Scientific Interaction and Exchange” 2011 Strategic Planning Retreat 2008-2015 APS Council

• Councillor, 2012-2015 • Ex officio (SAC Chair), 2008-2011

2005-2011 Section Advisory Committee • Chair, 2008-2011

2005-2006 Nominating Committee 2005 Strategic Planning Retreat 2000-2002 Committee on Committees 1999-2002 Renal Section Steering Committee 1997-1999 Membership Committee

CARMINES, Pamela K.


1996 Renal Section Awards Committee 1991-1994 Renal Section Steering Committee 1992 Renal Section Awards Committee 1991 Mentor, APS/NIDDK Minority Travel Award Fellows Program

American Society of Nephrology 2017-2019 Publications Committee 2014-2016 Communications Committee

Inter-American Society of Hypertension 1993 Publication Committee

National Kidney Foundation of Nebraska 2001-2006 Bylaws & Policies Committee

• Chair, 2005-2006 2000-2006 Board of Directors 2000-2001 Cadillac Invitational Organizing Committee 1996-2005 Medical & Scientific Advisory Committee

• Chair, 2003-2005

Nebraska Kidney Association 2011-2014 Medical & Scientific Advisory Committee 2008-2009 Bylaws & Policies Committee

Nebraska Physiological Society (NPS) 1998-2002 NPS Council

• Past-President, 2001-2002 • President, 2000-2001 • President-elect, 1999-2000 • Councillor, 1998-1999

UNMC Alumni Association – Graduate Studies Engagement Council 2013-present Board of Directors

Women in Nephrology 1996-1998 Professional Referrals Committee 1995-1998 Executive Council

SCIENTIFIC MEETING ORGANIZATION AND ABSTRACT REVIEW 2015-2017 Poster Reviewer, Nebraska Physiological Society 2011-2014 Abstract Reviewer, American Heart Association High Blood Pressure Research

Scientific Sessions 2011 Abstract Reviewer, American Society of Nephrology 2008-2010 Executive Committee, 2010 FASEB Summer Research Conference on “Renal

Hemodynamics: Mechanisms to Understand Disease” 2006-2008 Abstract Reviewer, American Heart Association High Blood Pressure Research

Scientific Sessions

CARMINES, Pamela K.


2006 Abstract Reviewer, American Society of Nephrology 2005-2007 Organizing Committee, 2007 FASEB Summer Research Conference on “Renal

Hemodynamics: Biomolecular Control Mechanisms Integrating Vascular and Tubular Function”

2005 Abstract Reviewer, American Heart Association High Blood Pressure Research Scientific Sessions

2004 Abstract Reviewer, American Society of Nephrology 1999 Abstract Judge, Midwest Student Medical Research Forum 1997 Abstract Reviewer, American Society of Nephrology 1997 Abstract Reviewer, American Heart Association High Blood Pressure Research

Scientific Sessions 1996-1997 Abstract Judge, Midwest Student Medical Research Forum 1994-1995 Abstract Reviewer, American Heart Association Scientific Sessions 1994 Abstract Judge, Midwest Student Medical Research Forum 1993 Abstract Reviewer, American Society of Nephrology

UNIVERSITY COMMITTEE ASSIGNMENTS

TULANE UNIVERSITY Department of Physiology:

1991-1993 Graduate Education Committee

Tulane Medical Center: 1993 Search Committee, Director of the Vivarium 1990-1993 Institutional Animal Care and Use Committee 1990 Shaffer Award Selection Committee

UNIVERSITY OF NEBRASKA Department of Cellular & Integrative Physiology (formerly Physiology & Biophysics):

2011-2012 Departmental Advisory Committee 2006 Ad Hoc Committee for Revising/Restructuring CIP 814 (Scientific Writing) 2000-2005 Reward & Recognition Committee 1999-2005 Promotion & Tenure Committee 1998-1999 Faculty Search Committee 1997 Promotion & Tenure Committee 1995 Faculty Search Committee 1995 Promotion & Tenure Committee 1993-present Cellular & Integrative Physiology Graduate Committee

• Chair, 2002-present 1993-present Director, Quantitative Fluorescence Microscopy Facility

College of Medicine: 2016-2019 Faculty Grievance Committee

CARMINES, Pamela K.


2015-present Vice Chair, Promotion & Continuous Appointments (Tenure) Committee 2014-2015 Promotion & Tenure Guidelines Review Committee 2014-2015 Pathology & Microbiology Department Review Committee 2011-2014 A. Ross McIntyre Award Selection Committee 2004-2005 LCME Self-Study Task Force Subcommittee on Medical Students 2004 Search Committee, Chair of the Department of Psychiatry 2003-2009 Faculty Grievance Committee 2003 Search Committee, Dean of the College of Medicine 1998-2004 Selection Committee, UNMC Endocrine Society Student Achievement Award 1998-1999 Ad Hoc Committee on Post-Tenure Review 1997-2003 Promotion & Continuous Appointments (Tenure) Committee 1997-1998 Class of 1962 Basic Science Outstanding Teacher Award Committee 1997-1998 LCME Self-Study Task Force on Graduate Basic Science Education & Research 1997 Biomedical Sciences Graduate Program, Cardiovascular Biology Steering Committee 1995-1996 Curriculum Oversight Committee

University of Nebraska Medical Center: 2017-present Graduate Studies Representative (Alternate), Education Council 2017-present iEXCEL Project Prioritization Work Group 2016-2018 Mentoring Committee 2016-present Academic Affairs Education and Faculty Leadership Council 2016 Search Committee, Associate Director (Director of Application Services), IT Services 2016-present Chair, Purdue Pharma Scholars Committee 2015-2016 Writing Center Task Force 2015 UNMC / Nebraska Medicine Organization Values Team 2014-2016 NCA-HLC Accreditation Team: Mission 2013-present Board of Directors, UNMC Alumni Association Graduate Studies Engagement Council 2013 Graduate Studies Task Force on Collecting Appropriate Metrics for Training Grants 2013 Graduate Studies Chapter Organizational Committee, UNMC Alumni Association 2012-2014 International Ambassador Committee 2012-2013 Chair, Graduate Studies Task Force on Improving Alumni & External Relations 2012 Cardiovascular Institute Think Tank 2011-2014 Science Literacy Think Tank 2006 Task Force on Vendors for Electronic Submission of NIH Grants 2003 Ad Hoc Committee on Single Cell Fluorescence Imaging Facility for the Durham

Research Center 2002-present Graduate Council 1999 Laboratory Systems Design Committee for the Durham Research Center 1998-1999 Ad Hoc Committee on Postdoctoral Fellow Status & Benefits 1998 Search Committee, Director of Molecular Genetics 1996-1998 Confocal Core Facility Advisory Committee

CARMINES, Pamela K.


1994-1996 Professional Conduct Committee 1993-1996 Research Council

University of Nebraska at Omaha: 1998 Faculty Search Committee, Department of Biology

University of Nebraska (System-wide): 2014 -2015 External Review Team, M.A. degree in Critical & Creative Thinking (UNO College of

Arts and Sciences) 2012-present UNMC representative, Executive Graduate Council 2011-2014 Selection Committee, Outstanding Research & Creative Activity Award 2001 Elected member, Executive Graduate Council

PRESENTATIONS

INVITED PRESENTATIONS AT REGIONAL, NATIONAL AND INTERNATIONAL MEETINGS:

2016 Council of Graduate Schools Workshop: Supporting Students’ Writing and Degree Completion. Challenges and successes in introducing dissertation boot camps at an academic medical center.

2012 EB2012/American Physiological Society Symposium: Regulation of Water and Electrolyte Balance in Diabetic Nephropathy. Mechanisms of diabetes-associated glomerular hyperfiltration.

2010 FASEB Summer Research Conference: Renal Hemodynamics – Mechanisms to Understand Disease. Potassium channels in afferent arterioles: Impact on arteriolar tone and role in the arteriolar dysfunction accompanying diabetes.

2007 FASEB Summer Research Conference: Renal Hemodynamics – Biomolecular Control Mechanisms Integrating Vascular and Tubular Function. Is oxidative stress responsible for altered electromechanical coupling in afferent arteriole during type 1 diabetes?

2005 XXXV Annual Congress of Physiological Sciences (Satellite Meeting): Coordinating Hemodynamic, Filtration and Reabsorptive Functions of the Kidney. Tyrosine kinase involvement in renal arteriolar vasoconstrictor responses

2004 FASEB Summer Research Conference: Renal Microcirculatory and Tubular Dynamics – Molecules to Man. Involvement of tyrosine kinases in renal microvascular responses to AngII

2001 FASEB Summer Research Conference: Renal Microcirculatory Hemodynamics – Molecular, Cellular, Physiologic, Clinical and Integrative Mechanisms. Oxidative stress and the renal arteriolar impact of NO in diabetes

2001 EB2001/American Physiological Society Symposium (Co-Chair): The Early Impact of Diabetic Hyperglycemia on Renal and Cardiovascular Function. Onset of diabetes alters renal preglomerular electromechanical coupling

2000 Jackson Cardiovascular-Renal Meeting. Disrupted electromechanical coupling in the renal microvasculature during glomerular hyperfiltration

1998 American Physiological Society Conference: Endothelial Regulation of Vascular Tone – Molecular to Integrative Physiology. Nitric oxide-dependent mechanisms in diabetic nephropathy

CARMINES, Pamela K.


1998 FASEB Summer Research Conference: Renal Hemodynamics – Integration of Endothelial, Epithelial and Vascular Control Mechanisms. Electromechanical coupling in renal arterioles

1996 American Society of Hypertension Plenary Session: Young Scholar Award Lectures. Disparate vascular smooth muscle activation mechanisms in renal afferent and efferent arterioles

1995 FASEB Summer Research Conference: Renal Hemodynamics – Vascular Biology of the Renal Circulation. Role of tubuloglomerular feedback in juxtamedullary afferent arteriolar vasoconstrictor responses

1993 International Congress of Physiological Sciences Symposium: Interactive Paracrine Mechanisms Regulating Renal Microvascular Function. Modulation of the vasoconstrictor influences of angiotensin II on renal arterioles

1992 FASEB Summer Research Conference: Renal Hemodynamics – Interactions with Endothelial and Epithelial Systems. Control of cytosolic [Ca2+] in renal arterioles: Implications for angiotensin II-induced vasoconstriction

1991 American Physiological Society Symposium: Hormonal Signal Transduction and Regulation of Vascular Smooth Muscle. Multiple intrarenal angiotensin actions and modes of coupling

1990 American Society of Nephrology Basic Science Symposium: Control of the Renal Microvasculature. Microvascular regulatory mechanisms revealed through analysis of juxtamedullary nephron function

1990 International Congress of Nephrology Satellite Symposium: The Juxtaglomerular Apparatus and the Tubuloglomerular Feedback Mechanism. Determinants of renal microvascular autoregulatory behavior in normal and hypertensive rats

1990 FASEB Symposium (Chair): Control of the Renal Microvasculature by Vasoactive Peptides. Influences of angiotensin II on the pre- and postglomerular vasculature of juxtamedullary nephrons from rat kidney

1989 FASEB Summer Research Conference: Renal Hemodynamics – Integrative and Cellular Control Mechanisms. Autoregulatory and angiotensin-induced microvascular responses of in vitro perfused juxtamedullary nephrons

1986 FASEB Symposium: Direct Assessment of Renal Microcirculatory Dynamics. The blood-perfused juxtamedullary nephron preparation: videometric study of renal microvascular function

INVITED SEMINAR PRESENTATIONS (at institutions outside of UNMC)

2016 Linköping University (Sweden), Department of Medical and Health Sciences / Division of Drug Research.

2012 Merck & Co., Department of Cardiovascular Diseases.

2010 Mount Sinai School of Medicine, Department of Medicine / Renal Division.

2010 Tulane University School of Medicine, Department of Physiology.

2008 University of Mississippi Medical Center, Department of Physiology.

2008 Virginia Commonwealth University School of Medicine, Department of Pharmacology & Toxicology.

CARMINES, Pamela K.


2007 University of North Carolina-Chapel Hill School of Medicine, Department of Cell & Molecular Physiology.

2006 Georgetown University, Department of Medicine / Division of Nephrology.

2005 Indiana University School of Medicine, Department of Cellular & Integrative Physiology.

2004 University of Louisville, Department of Physiology & Biophysics.

2004 Tulane University Health Science Center Department of Physiology and LSU Health Sciences Center Department of Physiology.

2003 University of Arizona College of Medicine, Department of Physiology.

2002 Medical College of Georgia, Department of Physiology.

2001 University of North Texas Health Science Center in Fort Worth, Department of Integrative Physiology.

2000 Tulane University School of Medicine, Department of Physiology.

1999 Medical College of Wisconsin, Department of Physiology.

1997 University of Calgary, Smooth Muscle Research Group.

1997 University of Nebraska at Omaha, Department of Biology.

1996 Medical College of Georgia, Vascular Biology Center.

1995 Tulane University School of Medicine, Departments of Physiology, Pediatrics, and Medicine.

1994 University of North Dakota, Department of Physiology.

1994 Creighton University, Departments of Pharmacology and Biomedical Sciences.

1993 University Hospital Utrecht, Division of Nephrology.

1992 Henry Ford Hospital, Division of Hypertension & Vascular Research.

1988 University of Louisville, Department of Physiology. PUBLICATIONS

ARTICLES PUBLISHED IN SCHOLARLY JOURNALS Original Research Communications: *contributed equally to the work

1. De Miguel C, Hamrick WC, Hobbs JL, Pollock DM, Carmines PK, Pollock JS. Endothelin receptor-specific control of endoplasmic reticulum stress and apoptosis in the kidney. Sci Rep 7: 43152, 2017. (PMCID: PMC5322462)

2. Saleh MA, De Miguel C, Stevens DI, Carmines PK, Pollock DM, Pollock JS. Free radical scavenging decreases endothelin-1 excretion and glomerular permeability during type 1 diabetes. Physiol Rep 4: e13055, 2016. (PMCID: PMC5210388)

3. De Miguel C*, Foster JM*, Carmines PK, Pollock JS. Interaction between NO synthase and NADPH oxidase in control of sodium transport by the renal thick ascending limb during diabetes. Acta Physiol (Oxf.) 209: 148-155, 2013. (PMCID: PMC3880686)

CARMINES, Pamela K.


Editorial focusing on this paper: Hansell P. NADPH-oxidase-driven oxidative stress during experimental diabetes offsets NO-mediated regulation of renal medullary sodium transport. A potential treatment modality during type 1 diabetes? Acta Physiol (Oxf.) 209: 94, 2013.

4. Irsik DL, Carmines PK, Lane PH. Classical estrogen receptors and ERα splice variants in the mouse. PLoS ONE 8(8): e70926, 2013. (PMCID: PMC3733772)

5. Ishii N, Carmines PK, Yokoba M, Imaizumi H, Ichikawa T, Ikenaga H, Kodera Y, Oh-Ishi M, Aoki Y, Maeda T, Takenaka T, Katagiri M. Angiotensin-converting enzyme inhibition curbs tyrosine nitration of mitochondrial proteins in the renal cortex during the early stage of diabetes mellitus in rats. Clin Sci (Lond.) 124: 543–552, 2013. (PMCID: PMC3540783)

6. Troncoso Brindeiro CM, Lane PH, Carmines PK. Tempol prevents altered K+ channel regulation of afferent arteriolar tone in diabetic rat kidney. Hypertension 59: 657-664, 2012. (PMCID: PMC3339563)

7. Yang J, Pollock JS, Carmines PK. NADPH oxidase and PKC contribute to increased Na transport by the thick ascending limb during type 1 diabetes. Hypertension 59: 431-436, 2012. (PMCID: PMC4169139)

8. Yang J, Lane PH, Pollock JS, Carmines PK. Protein kinase C-dependent NAD(P)H oxidase activation induced by type 1 diabetes in renal medullary thick ascending limb. Hypertension 55: 468-473, 2010. (PMCID: PMC4586163)

9. Yang J, Lane PH, Pollock JS, Carmines PK. PKC-dependent superoxide production by the renal medullary thick ascending limb from diabetic rats. Am J Physiol Renal Physiol 297: F1220-1228, 2009. (PMID: 19741016)

10. Foster JM, Carmines PK, Pollock JS. PP2B-dependent NO production in the medullary thick ascending limb during diabetes. Am J Physiol Renal Physiol 297: F471-F480, 2009. (PMCID: PMC2724259)

11. Troncoso Brindeiro CM, Fallet RW, Lane PH, Carmines PK. Potassium channel contributions to afferent arteriolar tone in normal and diabetic rat kidney. Am J Physiol Renal Physiol 296: F171-F178, 2008. (PMCID: PMC2494504)

12. Langer WJ, Devish K, Carmines PK, Lane PH. Prepubertal onset of diabetes prevents expression of renal cortical connective tissue growth factor. Pediatric Nephrol 23: 275-283, 2008. (PMID: 18030501)

13. Sun J, Devish K, Langer WJ, Carmines PK, Lane PH. Testosterone treatment promotes tubular damage in experimental diabetes in pre-pubertal rats. Am J Physiol Renal Physiol. 292: F1681-F1690, 2007. (PMID: 17311907)

14. Sasser JM, Sullivan JC, Hobbs JL, Yamamoto T, Pollock DM, Carmines PK, Pollock JS. Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanism. J Am Soc Nephrol 18: 143-154, 2007. (PMCID: PMC2579758)

15. Ishii N, Ikenaga H, Carmines PK, Takada N, Okazaki T, Nagai T, Maeda T, Aoki Y, Saruta T, Katagiri M. Impact of angiotensin-converting enzyme inhibition on renal cortical nitrotyrosine content during increased extracellular glucose concentration. Clin Biochem 39: 633-639, 2006.

16. Che Q, Carmines PK. Src family kinase involvement in rat preglomerular microvascular contractile and [Ca2+]i responses to ANG II. Am J Physiol Renal Physiol 288: F658-F664, 2005. (PMCID: PMC2570959)

17. Fallet RW, Ikenaga H, Bast JP, Carmines PK. Relative contributions of Ca2+ mobilization and influx in renal arteriolar contractile responses to arginine vasopressin. Am J Physiol Renal Physiol 288: F545-F551, 2005. (PMCID: PMC2579747)

CARMINES, Pamela K.


18. Lee DL, Sasser JM, Hobbs JL, Boriskie A, Pollock DM, Carmines PK, Pollock JS. Posttranslational regulation of NO synthase activity in the renal medulla of diabetic rats. Am J Physiol Renal Physiol 288: F82-F90, 2005. (PMCID: PMC2570967)

19. Ishii N, Ikenaga H, Carmines PK, Aoki Y, Ogawa Z, Saruta T, Suga T. High glucose augments arginase activity and nitric oxide production in the renal cortex. Metabolism 53: 868-874, 2004.

20. Pluznick JL, Wei P, Carmines PK, Sansom SC. Renal fluid and electrolyte handling in BKCa-β1–/– mice. Am J Physiol Renal Physiol 284: F1274-F1279, 2003.

21. Che Q, Carmines PK. Angiotensin II triggers EGFR tyrosine kinase-dependent Ca2+ influx in afferent arterioles. Hypertension 40: 700-706, 2002.

22. Ishii N*, Fujiwara K*, Patel KP, Lane PH, Carmines PK. Renal cortical nitric oxide synthase activity during maturational growth in the rat. Pediatric Nephrol 17: 591-596, 2002.

23. Harrison-Bernard LM, Imig JD, Carmines PK. Renal AT1 receptor protein expression during the early stage of diabetes mellitus in the rat. Int J Experimental Diab Res 3: 97-108, 2002. (PMCID: PMC2478573)

24. Ishii N, Patel KP, Lane PH, Taylor T, Bian K, Murad F, Pollock JS, Carmines PK. Nitric oxide synthesis and oxidative stress in the renal cortex of rats with diabetes mellitus. J Am Soc Nephrol 12: 1630-1639, 2001.

25. Patel KP, Carmines PK. Renal interstitial hydrostatic pressure and sodium excretion during acute volume expansion in diabetic rats. Am J Physiol Regul Integr Comp Physiol 281: R239-R245, 2001.

26. Fallet RW, Bast JP, Fujiwara K, Ishii N, Sansom SC, Carmines PK. Influence of Ca2+-activated K+ channels on rat renal arteriolar responses to depolarizing agonists. Am J Physiol Renal Physiol 280: F583-F591, 2001. (PMCID: PMC2570964)

27. Carmines PK, Fallet RW, Che Q, Fujiwara K. Tyrosine kinase involvement in renal arteriolar constrictor responses to angiotensin II. Hypertension 37: 569-573, 2001. (PMCID: PMC2570962)

28. Sansom SC, Ma R, Carmines PK, Hall DA. Regulation of Ca2+-activated K+ channels by multifunctional Ca2+/calmodulin-dependent protein kinase. Am J Physiol Renal Physiol 279: F283-F288, 2000.

29. Ikenaga H, Bast JP, Fallet RW, Carmines PK. Exaggerated impact of ATP-sensitive K+ channels on afferent arteriolar diameter in diabetes mellitus. J Am Soc Nephrol 11: 1199-1207, 2000. (PMCID: PMC2572213)

30. Ma R, Smith S, Johnson MA, Carmines PK, Sansom SC. Store-operated Ca channels in human glomerular mesangial cells. Am J Physiol Renal Physiol 278: F954-F961, 2000.

31. Patel KP, Zhang K, Carmines PK. Norepinephrine turnover in peripheral tissues of rats with heart failure. Am J Physiol Regul Integr Comp Physiol 278: R556-R562, 2000.

32. Schoonmaker GC, Fallet RW, Carmines PK. Superoxide anion curbs nitric oxide modulation of afferent arteriolar ANG II responsiveness in diabetes mellitus. Am J Physiol Renal Physiol 278: F302-F309, 2000.

33. Hall DA, Carmines PK, Sansom SC. Dihydropyridine-sensitive Ca2+ channels in human glomerular mesangial cells. Am J Physiol Renal Physiol 278: F97-F103, 2000.

34. Carmines PK, Ohishi K. Renal arteriolar contractile responses to angiotensin II in rats with poorly controlled diabetes mellitus. Clin Exp Pharmacol Physiol 26: 877-882, 1999.

35. Ikenaga H, Ishii N, Didion SP, Zhang K, Cornish KG, Patel KP, Mayhan WG, Carmines PK. Suppressed impact of nitric oxide on renal arteriolar function in rats with chronic heart failure. Am J Physiol Renal Physiol 276: F79-F87, 1999.

CARMINES, Pamela K.


36. Didion SP, Carmines PK, Ikenaga H, Mayhan WG. Enhanced constrictor responses of skeletal muscle arterioles during chronic myocardial infarction. Am J Physiol Heart Circ Physiol 273: H1502-H1508, 1997.

37. Carmines PK, Ohishi K, Ikenaga H. Functional impairment of renal afferent arteriolar voltage-gated calcium channels in rats with diabetes mellitus. J Clin Invest 98: 2564-2571, 1996. (PMCID: PMC507714)

38. Fowler BC, Carmines PK, Nelson LD, Bell PD. Characterization of sodium-calcium exchange in rabbit renal arterioles. Kidney Int 50: 1856-1862, 1996.

39. Patel KP, Zhang PL, Carmines PK. Neural influences on renal responses to acute volume expansion in rats with heart failure. Am J Physiol Heart Circ Physiol 271: H1441-H1448, 1996.

40. Ikenaga H, Fallet RW, Carmines PK. Basal nitric oxide production curtails arteriolar vasoconstrictor responses to ANG II in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 271: F365-F373, 1996.

41. Ikenaga H, Fallet RW, Carmines PK. Contribution of tubuloglomerular feedback to renal arteriolar angiotensin II responsiveness. Kidney Int 49: 34-39, 1996.

42. Harrison-Bernard LM, Carmines PK. Impact of cyclo-oxygenase blockade on juxtamedullary microvascular responses to angiotensin II in rat kidney. Clin Exp Pharmacol Physiol 22: 732-738, 1995.

43. Ohishi K, Carmines PK. Superoxide dismutase restores the influence of nitric oxide on renal arterioles in diabetes mellitus. J Am Soc Nephrol 5: 1559-1566, 1995.

44. Carmines PK. Segment-specific effect of chloride channel blockade on rat renal arteriolar contractile responses to angiotensin II. Am J Hypertens 8: 90-94, 1995.

45. Takenaka T, Harrison-Bernard LM, Inscho EW, Carmines PK, Navar LG. Autoregulation of afferent arteriolar blood flow in juxtamedullary nephrons. Am J Physiol Renal Fluid Electrolyte Physiol 267: F879-F887, 1994.

46. Harrison-Bernard LM, Carmines PK. Juxtamedullary microvascular responses to arginine vasopressin in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 267: F249-F256, 1994.

47. Ohishi K, Okwueze MI, Vari RC, Carmines PK. Juxtamedullary microvascular dysfunction during the hyperfiltration stage of diabetes mellitus. Am J Physiol Renal Fluid Electrolyte Physiol 267: F99-F105, 1994.

48. Carmines PK, Inscho EW. Renal arteriolar angiotensin responses during varied adenosine receptor activation. Hypertension 23, Suppl I: I114-I119, 1994.

49. Carmines PK, Fowler BC, Bell PD. Segmentally distinct effects of depolarization on intracellular [Ca2+] in renal arterioles. Am J Physiol Renal Fluid Electrolyte Physiol 265: F677-F685, 1993.

50. Barbee RW, Harrison-Bernard LM, Carmines PK. Microvascular effects of atrial natriuretic peptide in rat cremaster. Peptides 13: 1181-1185, 1992.

51. Ohishi K, Carmines PK, Inscho EW, Navar LG. EDRF-angiotensin II interactions in rat juxtamedullary afferent and efferent arterioles. Am J Physiol Renal Fluid Electrolyte Physiol 263: F900-F906, 1992.

52. Ortenberg JM, Cook AK, Inscho EW, Carmines PK. Attenuated afferent arteriolar response to acetylcholine in Goldblatt hypertension. Hypertension 19: 785-789, 1992.

53. Carmines PK, Inscho EW. Perfusate composition modulates in vitro renal microvascular pressure responsiveness in a segment-specific manner. Microvasc Res 43: 347-351, 1992.

54. Inscho EW, Carmines PK, Navar LG. Juxtamedullary afferent arteriolar responses to P1 and P2 purinergic stimulation. Hypertension 17: 1033-1037, 1991.

CARMINES, Pamela K.


55. Navar LG, Inscho EW, Ibarrola M, Carmines PK. Communication between the macula densa cells and the afferent arteriole. Kidney Int 39, Suppl 32: S78-S82, 1991.

56. Inscho EW, Carmines PK, Navar LG. Prostaglandin influences on afferent arteriolar responses to vasoconstrictor agonists. Am J Physiol Renal Fluid Electrolyte Physiol 259: F157-F163, 1990.

57. Inscho EW, Carmines PK, Cook AK, Navar LG. Afferent arteriolar responsiveness to altered perfusion pressure in renal hypertension. Hypertension 15: 748-752, 1990.

58. Carmines PK, Inscho EW, Gensure RC. Arterial pressure effects on preglomerular microvasculature of juxtamedullary nephrons. Am J Physiol Renal Fluid Electrolyte Physiol 258: F94-F102, 1990.

59. Carmines PK, Navar LG. Disparate effects of Ca channel blockade on afferent and efferent arteriolar responses to ANG II. Am J Physiol Renal Fluid Electrolyte Physiol 256: F1015-F1020, 1989.

60. Veldkamp PJ, Carmines PK, Inscho EW, Navar LG. Direct evaluation of the microvascular actions of ANP in juxtamedullary nephrons. Am J Physiol Renal Fluid Electrolyte Physiol 254: F440-F444, 1988.

61. Carmines PK, Perry MD, Hazelrig JB, Navar LG. Effects of preglomerular and postglomerular vascular resistance alterations on filtration fraction. Kidney Int 31, Suppl 20: S229-S232, 1987.

62. Carmines PK, Morrison TK, Navar LG. Angiotensin II effects on microvascular diameters of in vitro blood-perfused juxtamedullary nephrons. Am J Physiol Renal Fluid Electrolyte Physiol 251: F610-F618, 1986.

63. Casellas D, Carmines PK, Navar LG. Microvascular reactivity of in vitro blood perfused juxtamedullary nephrons from rats. Kidney Int 28: 752-759, 1985.

64. Carmines PK, Bell PD, Roman RJ, Work J, Navar LG. Prostaglandins in the sodium excretory response to altered renal arterial pressure in dogs. Am J Physiol Renal Fluid Electrolyte Physiol 248: F8-F14, 1985.

65. Rosivall L, Carmines PK, Navar LG. Effects of renal arterial angiotensin I infusion on glomerular dynamics in sodium replete dogs. Kidney Int 26: 263-268, 1984.

66. Carmines PK, Rosivall L, Till MF, Navar LG. Renal hemodynamic effects of captopril in anesthetized sodium-restricted dogs: Relative contributions of prostaglandin stimulation and suppressed angiotensin activity. Renal Physiol 6: 281-287, 1983.

67. Carmines PK, Tanner GA. Angiotensin in the hemodynamic response to chronic nephron obstruction. Am J Physiol Renal Fluid Electrolyte Physiol 245: F75-F82, 1983.

68. Carmines PK, Tanner GA. Effect of albumin microinfusion on proximal tubular pressure. Renal Physiol 5: 85-87, 1982.

69. Tanner GA, Carmines PK, Kinter WB. Excretion of phenol red by the Necturus kidney. Am J Physiol Renal Fluid Electrolyte Physiol 236: F442-F447, 1979.

Editorial Focus Articles, Invited Commentaries, etc.:

1. Carmines PK, Lynch RM. Changes in APS sectional programming for EB2011: Expanded programming and meeting-within-a-meeting structure. Physiologist 53: 137 & 140, 2010.

2. Sands JM, Carmines PK. Cardio-renal research advances: Glimpses of the future. Am Heart Assoc Science News 02/22/2010. (http://www.informz.net/heart/archives/archive_950593.html)

3. Peti-Peterdi J, Navar LG, Bell PD, Casellas D, Carmines PK, Inscho EW, Oparil S. A true champion of Hungarian kidney research and nephrology education – Tribute to László Rosivall. Acta Physiol Hung 96: 375-382, 2009.

http://www.informz.net/heart/archives/archive_950593.html

CARMINES, Pamela K.


4. Carmines PK. The Letters to Our Daughters Project (invited contributor): Committees and the flip side of sexism. 05/14/2009. (http://isisthescientist.com/2009/05/14/the_letters_to_our_daughters_p_62/#more-462) (∼3,200 views during the 1st week after appearing online)

5. Pollock JS, Carmines PK. Diabetic nephropathy: nitric oxide and renal medullary hypoxia. Am J Physiol Renal Physiol 294: F28-F29, 2008. PMID: 18003855

6. Pollock JS, Carmines PK. NOS3 regulation: Renal tubular epithelial cells are not simply large endothelial cells. Hypertension 47: 19-21, 2006.

7. Carmines PK. Book Review — Bucket Diagrams: A Problem-Solving Approach to Renal Physiology by Janssen HF. Physiologist 38: 73-74, 1995.

Invited Reviews:

1. Carmines PK. Mechanisms of altered renal microvascular function in type 1 diabetes: potential contribution to end organ damage. Curr Vasc Pharmacol 12: 781-787, 2014. (PMID: 24066931)

2. Carmines PK. The renal vascular response to diabetes. Curr Opin Nephrol Hypertens 19: 85-90, 2010. (PMCID: PMC2886724)

3. Carmines PK, Fujiwara K. Altered electromechanical coupling in the renal microvasculature during the early stage of diabetes mellitus. Clin Exp Pharmacol Physiol 29: 143-148, 2002. (PMCID: PMC2570963)

4. Casellas D, Carmines PK. Control of the renal microcirculation: cellular and integrative perspectives. Curr Opin Nephrol Hypertens 5: 57-63, 1996.

5. Carmines PK, Mitchell KD, Navar LG. Effects of calcium antagonists on renal hemodynamics and glomerular function. Kidney Int 41, Suppl 36: S43-S48, 1992.

6. Roman RJ, Carmines PK, Loutzenhiser R, Conger JD. Direct studies on the control of the renal microcirculation. J Am Soc Nephrol 2: 136-149, 1991.

7. Carmines PK, Inscho EW, Ortenberg JM, Cook AK. Determinants of renal microvascular autoregulatory behavior in normal and hypertensive rats. Kidney Int 39, Suppl 32: S89-S93, 1991.

8. Carmines PK, Fleming JT. Control of the renal microvasculature by vasoactive peptides. FASEB J 4: 3300-3309, 1990.

9. Casellas D, Carmines PK, Dupont M, Redon P, Moore LC. Arteriolar renin and vascular effects of angiotensin II in juxtamedullary nephrons. Kidney Int 38, Suppl 30: S60-S64, 1990.

10. Navar LG, Carmines PK, Huang W-C, Mitchell KD. The tubular effects of angiotensin II. Kidney Int 31, Suppl 20: S81−S88, 1987.

11. Navar LG, Paul RV, Carmines PK, Chou C-L, Marsh DJ. Intrarenal mechanisms mediating pressure natriuresis: role of angiotensin and prostaglandins. Federation Proc 45: 2885-2891, 1986.

12. Navar LG, Gilmore JP, Joyner WL, Steinhausen M, Edwards RM, Casellas D, Carmines PK, Zimmerhackl LB, Yokota SD. Direct assessment of renal microcirculatory dynamics. Federation Proc 45: 2851-2861, 1986.

13. Navar LG, Rosivall L, Carmines PK, Oparil S. Effects of locally formed angiotensin II on renal hemodynamics. Federation Proc 45: 1448-1453, 1986.

14. Carmines PK, Casellas D, Navar LG. Control of renal hemodynamics by intrarenal mechanisms. Contr Nephrology 41: 1-9, 1984.

http://isisthescientist.com/2009/05/14/the_letters_to_our_daughters_p_62/#more-462

CARMINES, Pamela K.


ARTICLES ACCEPTED FOR PUBLICATION – None

ARTICLES SUBMITTED FOR PUBLICATION

1. Irsik DL, Romero-Aleshire MJ, Chavez EM, Fallet RW, Brooks HL, Carmines PK, Lane PH. Renoprotective impact of estrogen receptor α and its splice variants in female mice with type 1 diabetes. Am J Physiol Renal Physiol (F-00231-2017; Submitted 4/29/2017; In Revision)

BOOKS – None

CHAPTERS IN BOOKS 1. Carmines PK, Bast JP, Ishii N. Altered renal microvascular function in early diabetes. In: Contemporary

Diabetes — The Diabetic Kidney, edited by Cortes P and Mogensen CE. Totowa, NJ: Humana Press. 2006, p. 23-36.

2. Carmines PK. Angiotensin II regulation of the renal circulation. In: The Renal Circulation, edited by Anderson WP, Evans RG, and Stevenson KM. Stamford, CT: JAI Press, 2000, p. 191-205.

3. Navar LG, Carmines PK, Mitchell KD. Renal circulation. In: Textbook of Nephrology (3rd Edition), edited by Massry SG and Glassock RJ. Baltimore: Williams & Wilkins, 1995, p. 41-53.

4. Navar LG, Carmines PK, Mitchell KD, Bell PD. Role of intracellular calcium in the regulation of renal hemodynamics. In: Nephrology, edited by Hatano M. Tokyo: Springer-Verlag, 1991, p. 718-730.

5. Navar LG, Carmines PK, Paul RV. Renal circulation. In: Textbook of Nephrology (2nd Edition), edited by Massry SG and Glassock RJ. Baltimore: Williams & Wilkins, 1989, p. 43-53.

6. Navar LG, Carmines PK, Thomas CE, Mitchell KD. Critical issues bearing on the mediation of renal autoregulation by the tubuloglomerular feedback mechanism. In: The Juxtaglomerular Apparatus, edited by Persson AEG and Boberg U. Amsterdam: Elsevier, 1988, p. 373-386.

BOOKS OR JOURNALS EDITED 1. Associate Editor, American Journal of Physiology Renal Physiology, 2001-2007.

ABSTRACTS AND PRELIMINARY COMMUNICATIONS (141 total; listed are the most recent abstracts of work not yet published in full; *peer-reviewed selection process)

1. Ishii N, Ichioka T, Imoto A, Kurosaki Y, Carmines PK, Ikenaga H, Kodera Y, Yokoba M, Tsukushi T, Obata S, Suzuki H, Ichikawa T, Takenaka T, Katagiri M. Urinary mitochondrial proteins relevant to renal cortical damaged mitochondrial degradation during the normoalbuminuric stage of diabetes mellitus. J Am Soc Nephrol 28 (Abstract Supplement): 1022-1023, 2017.

2. *Carmines PK, Zhou X, Dajee M, Sullivan K, Walsh SP, Pasternak A. Impact of renal outer medullary potassium channel inhibition on afferent arteriolar tone in kidneys from rats with Type 1 diabetes. Hypertension 70 (Suppl. 1): A068, 2017.

3. *Yamada Y, Kurosaki Y, Carmines PK, Tsukushi T, Imoto A, Ichikawa T, Yokoba M, Ikenaga H, Aoki Y, Takenaka T, Ichikawa T, Katagiri M, Ishii N. Angiotensin II-dependent oxidative stress and increased hypoxia-inducible factor-1α expression in the renal cortex during the normoalbuminuric stage of diabetic mellitus in the rat. Clin Chem 60: S56-S57, 2014.

4. *Kurosaki Y, Yamada Y, Carmines PK, Tsukushi T, Imoto A, Ichikawa T, Yokoba M, Obata S, Ikenaga H, Aoki Y, Takenaka T, Ichikawa T, Katagiri M, Ishii N. The contribution of angiotensin II-dependent

CARMINES, Pamela K.


oxidative stress to megalin expression in the renal cortex during the normoalbuminuric stage of diabetes mellitus in the rat. Clin Chem 60: S55-S56, 2014.

5. *Ishii N, Kurosaki Y, Yamada Y, Carmines PK, Tsukushi T, Imoto A, Ichikawa T, Yokoba M, Suzuki H, Ikenaga H, Aoki Y, Takenaka T, Ichikawa T, Katagiri M. Impact of angiotensin II receptor blockade on the renal cortical tissue renin-angiotensin system during the normoalbuminuric stage of diabetic mellitus in the rat. Clin Chem 60: S65, 2014.

6. Irsik DL, Fallet RW, Adun E, Chavez E, Brooks HL, Carmines PK, Lane PH. ERα66 contributes to early diabetic renal disease in mice. FASEB J 27: 702.12, 2013.

7. Edenfield LA, De Miguel C, Musall BC, Harrison DG, Carmines PK, Pollock JS. Thick ascending limb-specific NOS1 knockout reduces urinary osmolality in type 1 diabetes. FASEB J 27: 910.12, 2013.

8. Irsik DL, Fallet RW, Carmines PK, Lane PH. The full-length estrogen receptor ERα66 mediates ERK activation and downregulation of ERα36 and ERβ expression in kidneys of female diabetic mice. FASEB J 26: 1096.9, 2012.

9. Yang J, Lane PH, Pollock JS, Carmines PK. Mitochondrial PKC, NAD(P)H oxidase and superoxide anion in the renal medullary thick ascending limb during type 1 diabetes. FASEB J 25: 664.12, 2011.

10. Wu S, Langer WJ, Lane PH, Carmines PK. Phospholipase C isoform expression in rat renal preglomerular microvascular smooth muscle cells. FASEB J 22: 761.10, 2008.

11. Carmines PK, Fallet RW, Pollock JS. Effect of H2O2 on afferent arteriolar diameter in normal rat kidney. FASEB J 19: A1145, 2005.

12. Bast JP, Singaravelu K, Ehlers CJ, Fallet RW, Carmines PK. Impaired renal preglomerular responses to depolarization in diabetes: potential roles of extracellular glucose and oxidative stress. FASEB J 18: A293, 2004.

13. Che Q, Carmines PK. Angiotensin II and H2O2 rapidly activate c-Src in renal preglomerular vascular smooth muscle cells. FASEB J 17: A923-924, 2003.

14. Carmines PK, Fallet RW, Sasser JM, Pollock JS. NOS-independent influence of Hsp90 activity on afferent arteriolar diameter. FASEB J 17: A920, 2003.

15. *Carmines PK, Fallet RW, Roscow J, Sasser JM, Pollock JS. Renal cortical Hsp90 and its impact on NOS activity and afferent arteriolar tone are diminished in diabetes mellitus. J Am Soc Nephrol 13: 532A, 2002.

16. *Pollock JS, Roscow J, Sasser JM, Fallet RW, Carmines PK. Diabetes mellitus reduces renal cortical Hsp90 and its influence on NOS activity and arteriolar tone. Hypertension 40: 421-422, 2002.

17. Fujiwara K, Ma R, Sansom SC, Carmines PK. Epidermal growth factor provokes tyrosine kinase-dependent stimulation of Ca2+-activated K+ channels in human glomerular mesangial cells. FASEB J 15: A142, 2001.

18. Maier J, Carmines PK, Patel KP. Exercise training improves urine flow and sodium excretory responses to acute volume expansion in diabetic rats. FASEB J 14: A671, 2000.

19. Bast JP, Carmines PK. Diabetes mellitus curtails the Ca2+ influx response to depolarization of isolated preglomerular microvascular smooth muscle cells. FASEB J 14: A136, 2000.

PUBLISHED AUDIOVISUAL OR COMPUTER-BASED EDUCATIONAL MATERIALS AND COMPUTER SOFTWARE –None

PUBLISHED CONTINUING EDUCATION MATERIALS – None

CARMINES, Pamela K.


ARTICLES IN PREPARATION 1. De Miguel C, Sedaka R, Sonnenberger M, Abad A, Jin C, Carmines PK, Pollock DM, Pollock JS.

Tauroursodeoxycholic acid (TUDCA) prevents high salt-induced renal damage in ETB deficient rats in a blood pressure-independent manner.

2. Irsik DL, Fallet RW, Lane PH, Carmines PK. Impact of estrogen receptor α on renal structure and function in male mice with Type 1 diabetes. Physiol Reports

3. Yang J, Lane PH, Pollock JS, Carmines PK. Mitochondrial PKC, NADPH oxidase and superoxide production in the rat renal medullary thick ascending limb during type 1 diabetes. Physiol Reports

4. Wu S, Langer WJ, Fallet RW, Lane PH, Carmines PK. Phospholipase C isoform expression in renal preglomerular microvascular smooth muscle cells. Can J Physiol Pharmacol

5. Bast JP, Fang Q, Singaravelu K, Lane PH, Carmines PK. Extracellular glucose and oxidative stress contribute to impaired renal preglomerular responses to depolarization in diabetes.

TEACHING ACTIVITIES (all courses are graduate level, except where noted)

LECTURES IN TEAM-TAUGHT COURSES AT UNMC 2018- COM Training Physicians of Tomorrow: Renal (M-ID 507; 6 lectures @ 1 hr each; 6

contact hours annually) Body Fluid Distribution Basic Renal Processes Glomerular Ultrafiltration Renal Hemodynamics Reabsorption & Secretion Quantifying Renal Function 2017 Cardiopulmonary Function in Health & Disease (CIP/IPMM 916; 1 lecture @ 2 hrs; 2

contact hours) Microvascular Pathophysiology

2017 Fundamentals of Receptors & Cell Signaling (IPBS 803; 2 lectures @ 2 hr each; 4 contact hours annually)

Introduction to Cell Signaling Calcium Signaling

2017-present Graduate Physiology I (IPMM 801; 10 asynchronous lectures @ 1 hr each; 1 synchronous lecture @ 1 hr each; 11 contact hours annually)

Renal Physiology Block 2016 Fundamentals of Receptors & Cell Signaling (IPBS 803; 2 lectures @ 1 hr each; 2

contact hours annually) Introduction to Cell Signaling Calcium Signaling

2016 (summer) Cell Signaling (BRTP 824; 2 asynchronous lectures @ 1 hr each; 2 contact hours) Introduction to Cell Signaling Calcium Signaling

CARMINES, Pamela K.


2016-2017 Function of the Human Body Core (M-ID 590; 11 lectures @ 1 hr each; 11 contact hours annually)

Renal Physiology Block 2016 Physiology & Pathophysiology of the Kidney (CIP 930; 1 lecture + 1 journal club @ 1

hr each; 2 contact hours) Diabetic Nephropathy & Progression of Renal Disease

2015-present Graduate Medical Education Core Curriculum Lecture Series for Division of Nephrology fellows & residents (2 lectures @ 1 hr each; 2 contact hours annually)

2014 Physiology & Pathophysiology of the Kidney (CIP 930; 1 lecture + 1 journal club @ 1 hr each; 2 contact hours)

Diabetic Nephropathy & Progression of Renal Disease 2012-2016 Scientific Writing (CIP 814; 1 lecture @ 1 hr, each fall & spring semester; 2 contact

hours annually) Best Practices & Common Errors in Writing Fellowship Proposals

2012-2014 Scientific Writing (CIP 814; Fall semester; small group leader responsible for critiquing weekly writing assignments for 2-4 students; 14 contact hours annually)

2012-2013 Function of the Human Body Core (M-ID 590; 11 lectures @ 1 hr each; 11 contact hours annually)

Renal Physiology Block 2012 Redox Biology in Human Disease (CIP 922; 1 lecture + 1 journal club @ 1 hr each; 2

contact hours) Reactive Oxygen Species in Diabetes Mellitus

2012 Physiology & Pathophysiology of the Kidney (CIP 930; 3 lectures @ 2 hr each; 6 contact hours)

Review of Renal Function – Salt & Water Balance Disorders of Water Balance – Hyponatremia & Hypernatremia Progression of Chronic Renal Failure – Diabetic Nephropathy

2010 Redox Biology in Human Disease (CIP 922; 1 lecture + 1 journal club @ 1 hr each; 2 contact hours)

Reactive Oxygen Species in Diabetes Mellitus 2010 Physiology & Pathophysiology of the Kidney (CIP 930; 3 lectures @ 2 hr each; 6

contact hours) Experimental Techniques in Renal Physiology Glomerular Permeability Barrier Renal Vascular Function

2008-2009 Scientific Writing (CIP 814; 1 lecture @ 1.5 hr; 1.5 contact hours annually) Using PowerPoint and Inserting Figures into Word Documents

2008 Physiology & Pathophysiology of the Kidney (CIP 930; 2 lectures @ 2 hr each) Experimental Techniques in Renal Physiology Regulation of Renal Hemodynamics

2006, 2007, 2009, 2011 Graduate Medical Education Core Curriculum Lecture Series for Division of Nephrology fellows & residents (1-4 lectures annually @ 1 hr each; average 2.5 contact hours annually)

CARMINES, Pamela K.


2006 Physiology & Pathophysiology of the Kidney (CIP 930; 4 lectures @ 2 hr each; 8 contact hours)

Renal Na & H2O Transport Mechanisms Matching Vascular and Tubular Function Countercurrent Multiplication & Exchange Mechanisms Neurohumoral Regulation of Arterial Pressure

2003-2009 Function of the Human Body Core (M-ID 590; 9-11 lectures @ 1 hr each; average 10 contact hours annually)

Renal Physiology Block 2003 Advanced Renal Physiology (PHYS 930; 3 lectures @ 2 hr each; 6 contact hours)

Review of Renal Na & H2O Transport Mechanisms Classical Methods in Renal Physiology Renal Complications of Diabetes Mellitus

2002-2016 Cell Signaling (BRTP 824; 2 lectures @ 1 hr each fall, except 2008 & 2010; 2 contact hours annually)

Overview of Extracellular Signaling and/or Ca2+ as an Intracellular Messenger 2000 Advanced Renal Physiology (PHYS 930; 2 lectures @ 2 hr each; 4 contact hours)

Angiotensin II Regulation of Sodium Excretion Involvement of Renal Hemodynamics in the Control of Sodium Excretion

1996 Advanced Renal Physiology (PHYS 930, 2 hrs of lecture; 2 contact hours) Review of Renal Na & H2O Transport Mechanisms

1994-2002 Intermediate Physiology (PHYS 306/606/806; 9-11 lectures @ 1 hr each; average 10 contact hours annually)

Renal Physiology Block 1994 Advanced Cardiovascular Physiology: Microcirculation (PHYS 916; 6 lectures @ 2 hr

each; 12 contact hours) 1994 Graduate Physiology (PHYS 801, 5 lectures @ 1 hr each; 10 contact hours)

Body Fluid Compartments Renal Anatomy & Methodology Renal Circulation Glomerular Filtration Proximal Tubule Function

COURSE DIRECTOR OR CO-DIRECTOR DUTIES AT UNMC 2017 Course Director: Fundamentals of Receptors & Cell Signaling (IPBS 803; 2 cr). 2016 Course Director: Fundamentals of Receptors & Cell Signaling (IPBS 803; 1 cr). 2016-present Director, Dissertation Boot Camp (offered twice annually; August & January) 2015-present Director, Professional Development Lunch & Learn Series for Graduate Students and

Postdoctoral Fellows (offered monthly during the fall & spring semesters) 2014 Co-Director w/LD Bilek: Seminar (MSIA 970, 1 cr) 2012 Co-Director w/BJ Padanilam: Physiology & Pathophysiology of the Kidney (CIP 930; 2

cr) 2011-2012 Course Director: Graduate Physiology Recitation (CIP 807, 1 cr)

CARMINES, Pamela K.


2010 Co-Director w/BJ Padanilam: Physiology & Pathophysiology of the Kidney (CIP 930; 2 cr)

2006 Course Director: Physiology & Pathophysiology of the Kidney (CIP 930; 2 cr) 2002-2016 Co-Director (coordinating 75% of course content): Cell Signaling (BRTP 824; 3 cr) 1996 Course Director: Advanced Renal Physiology (PHYS 930; 2 cr) 1994 Co-Director w/WG Mayhan: Advanced Cardiovascular Physiology: Microcirculation

(PHYS 916; 2 cr)

COURSES TAUGHT SOLO AT UNMC – None

GRADUATE STUDENT SUPERVISION Predoctoral/medical student research rotations:

Summer 2009 Nancy Y. Hong (Medical Student) Summer 2007 Sara E. Brostrom (Medical Student) Spring 2007 Sanjib Chowdhury (Cellular & Integrative Physiology) Spring 2006 Jing Yang (Cellular & Integrative Physiology) Spring 2006 Carmen M. Troncoso Brindeiro (Biomedical Research Training Program) Fall 2005 Sheng Wu (Cellular & Integrative Physiology) Spring 2004 N. Susanne Montagne (Biomedical Research Training Program) Fall 2003 Kurinji Singaravelu (Physiology & Biophysics) Fall 2003 Kishor Devalaraja-Narashimha (Physiology & Biophysics) Spring 2003 Erin Myers (Biomedical Research Training Program) Summers 2001-2002 Joseph P. Bast (Medical Student – Honors Thesis) Spring 2000 Qi Che (Physiology & Biophysics) Summer 1997 Gwynn C. Schoonmaker (Medical Student) Summers 1996-1998 Joseph P. Bast (Undergraduate Student) Summer 1991 Joseph M. Ortenberg (Medical Student)

Predoctoral trainees (current position): †co-advisor w/L.G. Navar; *co-advisor w/P.H. Lane

2011-2013 * Debra L. Irsik – Ph.D. 2013 (Postdoctoral Research Fellow; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA)

2006-2010 Jing Yang – Ph.D. 2010 (Postdoctoral Research Associate; Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX)

2006-2010 Carmen M. Troncoso Brindeiro – Ph.D. 2010 (Adjunct Professor; Biological Sciences, River Valley Community College, Claremont, NH)

2006-2008 Sheng Wu – M.S. 2008 (current position unknown) 2004-2005 N. Susanne Montagne – M.S. 2006 (Certified Massage Therapist & Registered Yoga

Instructor; Kurmaraja Massage & Bodywork at Benson Healing Massage, Omaha, NE)

2000-2004 Qi Che – Ph.D. 2004 (Nephrologist; Chabot Nephrology Group, San Francisco, CA) 2003-2004 Joseph P. Bast – M.D. with Honors Thesis 2004 (Nephrologist; Omaha Nephrology PC,

Omaha, NE)

CARMINES, Pamela K.


1987-1988 † Peter J. Veldkamp – M.S. 1988 (Associate Professor, Director of Education, and Director of Travel Health; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA)

Awards and honors to predoctoral trainees: Debra L. Irsik

2013 American Physiological Society/NIDDK Minority Travel Fellowship Award (to attend EB2013)

2013 FASEB MARC Travel Award (to attend American Physiological Society Professional Skills Training Course: Writing and Reviewing for Journals)

2012 Caroline tum Suden/Frances Hellebrandt Professional Opportunity Award, American Physiological Society

2011 American Physiological Society Renal Section Featured Topics Speaker Travel Award (to attend EB2011)

Ying Yang 2010 Lee Zucker Featured Student Presentation, Nebraska Physiological Society annual

meeting 2009-2010 UNMC Graduate Studies Research Assistantship 2007 Finalist, Award for Excellence in Renal Research (Predoctoral), American Physiological

Society Carmen M. Troncoso Brindeiro

2010 Alice L. Cummings Award in Physiology (presented to the graduating UNMC student who most clearly demonstrates a commitment to physiology above that required to satisfy degree requirements)

2009-2010 Predoctoral Fellowship, American Heart Association – Midwest Affiliate 2007 2nd Place, Predoctoral Poster Competition, Joint Meeting of the Nebraska & Iowa

Physiological Societies 2007 MARC Poster Presenter Travel Award (to attend FASEB Summer Research Conference

on Renal Hemodynamics) 2007-2008 NIH Research Supplement to Promote Diversity in Health-Related Research (R01

DK701152, years -02 and -03) 2007 Finalist, Award for Excellence in Renal Research (Predoctoral), American Physiological

Society 2007-2010 American Physiological Society/NIDDK Minority Travel Fellowship Award (to attend

EB2007, EB2008, EB2009 & EB2010) 2007 4th Place Award for Best Poster Presentation, Midwest Student Biomedical Research

Forum 2005-2006 UNMC Exceptional Incoming Student Assistantship

Nancy Y. Hong 2009 UNMC Medical Student Summer Research Assistantship

Sheng Wu 2008 American Physiological Society Renal Section Featured Topics Speaker Travel Award

(to attend EB 2008)

CARMINES, Pamela K.


Joseph P. Bast 2004 UNMC Endocrine Society Student Achievement Award (for meritorious endocrine-

related research by a graduating medical student) 2004 Alpha Omega Alpha Senior Thesis Award (highest rated M.D. Honors Thesis as

determined by the Research & Development Committee of the College of Medicine)

2004 Alice L. Cummings Award in Physiology (presented to the graduating UNMC student who most clearly demonstrates a commitment to physiology above that required to satisfy degree requirements)

2004 Finalist, Award for Excellence in Renal Research (Predoctoral), American Physiological Society

2002 Medical Student Summer Research Assistantship, National Kidney Foundation of Nebraska

2001 Finalist, Nebraska Physiological Society Best Poster Competition 2000 Finalist, Award for Excellence in Renal Research (Predoctoral), American Physiological

Society 1996 Undergraduate Student Research Fellowship, American Heart Association – Nebraska

Affiliate Qi Che

2003 Caroline tum Suden/Frances Hellebrandt Professional Opportunity Award, American Physiological Society

2002-2004 Predoctoral Fellowship, American Heart Association – Heartland Affiliate 2002-2003 UNMC Graduate Studies Research Assistantship (Declined; alternative to AHA

Fellowship) 2002 Finalist, Nebraska Physiological Society Student Research Competition 2002 Award for Excellence in Renal Research (Predoctoral), American Physiological Society 2001 Finalist, Nebraska Physiological Society Best Poster Competition

Gwynn C. Schoonmaker 1998 2nd Place, UNMC Manuscript/Oral Presentation Competition, Midwest Student

Biomedical Research Forum 1997 Student Research Scholarship, Nebraska Medical Foundation

Joseph M. Ortenberg 1993 Nicholas DiLuzio Award for Physiology Research by a Medical Student 1991 Merck Sharp & Dohme Award for Excellence in Hypertension Research 1991 Southern Section American Federation for Clinical Research Travel Award 1990 Tulane University BRSG Medical Student Research Fellowship

Peter J. Veldcamp 1987 Award for Excellence in Renal Research, American Physiological Society

Service on graduate student advisory/supervisory committees: − Linköping University (Dissertation Defense Opponent) Stephanie Franzén (Ph.D. 2016; Experimental Renal Medicine)

CARMINES, Pamela K.


− Medical College of Georgia (External Examiner) Jan M. Foster (Ph.D. 2009; Vascular Biology) Jennifer M. Sasser (Ph.D. with Distinction 2005; Pharmacology) − Tulane University Basil G. Hanss (Ph.D. 1993; Physiology)

Robert C. Gensure (M.D., Ph.D. 1993; Physiology) Barbara L. Perrone (M.S. 1992; Physiology)

Martina Okwueze (M.S. 1992; Physiology) − University of Alabama at Birmingham Peter J. Veldkamp (M.S. 1988; Physiology & Biophysics) − University of Calgary (External Examiner) Martina Reslerova, M.D. (Ph.D. 1997; Cardiovascular/Respiratory Sciences) − University of Nebraska Medical Center Bangchen Wang (current M.D./Ph.D. Scholar; Cellular & Integrative Physiology) Yuan Ying (Ph.D. 2016; Cellular & Integrative Physiology) Alicia M. Schiller (Ph.D. 2015; Cellular & Integrative Physiology) Ryan Cornelius (Ph.D. 2014; Cellular & Integrative Physiology) Cassandra Steiner (M.S. 2014; Cellular & Integrative Physiology) Debra L. Irsik (Co-advisor; Ph.D. 2013; Cellular & Integrative Physiology) Puttappa R. Dodmane (Ph.D. 2011; Pharmacology & Experimental Neuroscience) Sarah C. Clayton (Ph.D. 2011; Cellular & Integrative Physiology) Jing Yang, M.D. (Advisor; Ph.D. 2010; Cellular & Integrative Physiology) Carmen M. Troncoso Brindeiro (Advisor; Ph.D. 2010; Cellular & Integrative Physiology) P. Rick Grimm (Ph.D. 2009; Cellular & Integrative Physiology) Kurinji Singaravelu (Ph.D. 2009; Cellular & Integrative Physiology) Kishor Devalaraja-Narashimha (Ph.D. 2008; Cellular & Integrative Physiology) Sheng Wu (Advisor; M.S. 2008; Cellular & Integrative Physiology) Ruth M. Foutz (M.S. 2007; Cellular & Integrative Physiology) N. Susanne Montagne (M.S. 2006; Cellular & Integrative Physiology) Qin Fang, M.D. (Ph.D. 2005; Cellular & Integrative Physiology) Jennifer L. Pluznick (Ph.D. 2005; Cellular & Integrative Physiology) Qi Che, M.D. (Advisor; Ph.D. 2004; Cellular & Integrative Physiology) Jennifer M. Green (M.S. 2002; Physiology & Biophysics) Sean P. Didion (Ph.D. 1998; Physiology & Biophysics) Kun Zhang (Ph.D. 1997; Physiology & Biophysics)

CARMINES, Pamela K.


POSTGRADUATE TRAINEE SUPERVISION Postdoctoral fellows (current position): †co-advisor w/L.G. Navar; *co-advisor w/L.G. Navar & K.D. Mitchell

2007-2008 Deepika Reddy, M.D. (Assistant Professor; Division of Endocrinology & Metabolism, Department of Internal Medicine, University of Utah, Salt Lake City, UT)

2006 Qin Fang, M.D., Ph.D. (Physician/Nephrologist; Dignity Health–St. Rose Dominican Hospital, Las Vegas, NV)

1998-2001 Keiji Fujiwara, M.D., Ph.D. (Physician; Mon-naka Jin Clinic, Japan) 1996-1998 Naohito Ishii, M.A., Ph.D. (Professor; Department of Clinical Chemistry, School of

Allied Health Sciences, Kitasato University, Kanagawa, Japan) 1994-1996 Hideki Ikenaga, M.D., Ph.D. (Chief Physician; Ikenaga Clinic, Tochigi, Japan) 1993-1994 Shari McArdle, Ph.D. (current position unknown) 1992-1993 * Tsuneo Takenaka, M.D., Ph.D. (Physician/Faculty; Department of Nephrology,

Saitama Medical School, Saitama, Japan) 1990-1993 Lisa M. Harrison-Bernard, Ph.D. (Associate Professor; Department of Physiology, LSU

Health Sciences Center, New Orleans, LA) 1990-1993 Kazuhisa Ohishi, M.D., Ph.D. (†1990-1991) (Physician/Faculty; Division of Nephrology

& Rheumatology, Hamamatsu University Medical Center, Hamamatsu, Japan) 1987-1990 † Edward W. Inscho, Ph.D. (Professor, Section of Cardio-Renal Physiology & Medicine,

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL)

Awards and honors to postdoctoral fellows: Keiji Fujiwara

2001 Finalist, Nebraska Physiological Society Best Poster Competition Hideki Ikenaga

1996 Bristol-Myers Squibb Recognition Award for Young Physicians, American Society of Hypertension

1995-1996 Postdoctoral Fellowship, American Heart Association – Nebraska Affiliate 1995 Marion Merrell Dow Award for Excellence in Renal Research (Postdoctoral),

American Physiological Society Kazuhisa Ohishi

1993 Award for Excellence in Renal Research (Postdoctoral), American Physiological Society

1992 Southern Section American Federation for Clinical Research Travel Award Lisa M. Harrison-Bernard

1991-1993 Hoffmann La Roche / National Kidney Foundation Postdoctoral Fellowship

Visiting Scientists: 1992 László Rosivall, M.D., Ph.D., D.Sc.Med.; Semmelweis University, Budapest, Hungary

CONTINUING EDUCATION LECTURES/COURSES GIVEN 2008 Panelist, UNMC Writing Program – Write, Right Now! 2005 Panelist, Faculty Development Workshop – Your Message in 250 Words or Less