cardrdiac surgeon

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Stella Maris Novitzky (wife) DOB: September 18, 1947

Michael Novitzky (son) DOB: May 25, 1980

Peter Novitzky (son) DOB: January 15, 1983

Alexei Novitzky (son) DOB: March 11, 1984

Revised: December, 2009

POST GRADUATE TRAINING

M.D. Degree: La Plata School of Medicine, La Plata, Buenos Aires, Argentina, graduated in 1969.

Rotating Internship: July 1969 to June 1970, La Plata, Buenos Aires, Argentina.

Straight Surgical Intern: June 15, 1970 to June 14, 1971, Vancouver General Hospital, Vancouver, Canada (University of British Columbia).

Resident in General Surgery: July 1, 1971, to June 30, 1972, Vancouver GeneralHospital (University of British Columbia).

Tutor in Anatomy: October 1972 to June 1973, University of La Plata Medical School, Buenos Aires, Argentina.

Resident in Surgery: June 1973, to April 30, 1974, Hospital Regional, ComodoroRivadavia, Argentina.

Chief Resident in General Surgery: May 1, 1974 to April 30, 1975, Hospital Regional, Comodoro 0Rivadavia, Argentina.



Full-time Specialist in General Surgery: May 1, 1975 to December 15, 1976, Hospital Regional, Comodoro Rivadavia, Argentina.

Resident in Cardiothoracic Surgery: January 1, 1977 to December 30, 1977, National and Pelonomi Hospitals, Republic of South Africa (University of the Orange Free State)

Resident in Cardiac Surgery: February 1, 1978 to August 31, 1981, Groote SchuurHospital and Red Cross War Memorial Children's Hospital, Republic of South Africa (University of Cape Town). The training at the University of the Orange FreeState was a combined program of cardiac and thoracic surgery, supervised by Professor Johannes Meyer. During the training at the University of Cape Town, sixmonths were dedicated to thoracic surgery and the remaining time to cardiovascular surgery. This was directly supervised by Professor Christiaan N. Barnard.

In 1981, I was appointed specialist in cardiac surgery at Groote Schuur Hospitaland Red Cross War Memorial Children's Hospital in Cape Town, South Africa. This appointment was held until January 1987. During this period, I was actively involved in adult and pediatric cardiac surgery, with main emphasis in the fieldof heart transplantation. Part of my duties included the training of residents,participation in ward rounds, tutorials, and supervising a group of researchersstudying of the effects of brain-death on the heart and its effects on the metabolism of the body as a whole.

From February 4, 1987, until October 1990, I was a member of the heart transplantation team at the Oklahoma Transplantation Institute, Baptist Medical Center, Oklahoma City, Oklahoma.

Since November 1990, I have been working as an Associate Professor at the University of South Florida in the Department of Cardiothoracic Surgery in Tampa, Florida.

As of July 1998, I have been promoted and received tenure as a full Professor atthe University of South Florida in the Department of Cardiothoracic Surgery inTampa, Florida.

DEGREES

Graduated as a medical doctor from the La Plata School of Medicine, La Plata, Buenos Aires, Argentina, June 1969.

ECFMG: February 1970FLEX: December 1990

Fellow of the Argentine College of Surgeons registered as specialist in GeneralSurgery: 1975 (by examination)

Fellow of the College of Medicine of South Africa registered as a specialist inCardiothoracic Surgery (FCS) with the South African Medical and Dental Council:1982 (by examination)

PhD from the University from Cape Town June 2008, for the development of the scientific management of the brain dead organ donor (Hormonal Therapy)



DISSERTATION

1. PhD for the dissertation submitted to the University of Cape Town aPathophysiological Effects of Brain Death on Potential Donor Organs, and the Introductionof a New Method of Donor Management. June 2008

2. Patent in development. USF patenting office has approved the concept of high dose Esmolol administration during cardiopulmonary bypass in patients withhigh risk for surgery. The FDA a" IND application as well as the IRB protocol are in progress. 2007

PROFESSIONAL LICENSURE

Argentine College of Medicine 1969

Argentine College of Surgeons 1975

South African Medical and Dental Council 1982Specialist in Cardiothoracic Surgery 1982

Oklahoma State Board of Medical Examiners 1985Specialist in Cardiothoracic SurgeryLicense #15634

Florida Teaching Certificate 1991

License #ME 0061367

LANGUAGES

I am fluent in reading, writing and speaking in English, Spanish and Russian.

AWARDS AND PRIZES

President's Award of the International Society for Heart Transplantation for thepaper: "Electrocardiographic, hemodynamic and endocrine changes occurring during experimental brain-death in the Chacma baboon", in collaboration with W. Wicomb, A. Rose, R. Fraser, D. Cooper, and C.N. Barnard, 1984.

First prizewinner for the presentation of the poster entitled "Diagnosis of acut



e cardiac rejection using radio nuclide scanning techniques", presented at the biannual meeting of the South African Cardiac Society with the participation of Professor M. Iturralde, 1986.

SCHOLARSHIPS

During my medical training, I was initially a junior tutor of anatomy, and aftergraduation during the rotating internship, I became a lecturer of anatomy withthe Anatomy Department, La Plata Medical School, Buenos Aires, Argentina, 1965-1970.

CLINICAL WORK

During the years of training in general surgery, I was exposed to all surgical specialties on a rotation basis during the first two years.

As Chief Resident, I was in charge of the Department of General Surgery, being responsible for all the emergency operations and permanently on call for trauma calls. During this year, I performed all -types of major general surgical proced

ures.

As Resident in Cardiothoracic Surgery, I was guided by Professor C.N. Barnard inthe field of cardiovascular surgery. My primary responsibilities were initially in the care of patients and, during the last two years, performing all types of adult cardiac operations and pediatric cardiac surgery.

From the beginning, my duty was especially dedicated to the care of donors for heart transplantation. After one year, I took over the post-operative managementof patients who had undergone a heart transplant.

I performed my first heterotopic heart transplant as a fellow at Groote Schuur Hospital.

In September 1982, I was appointed by Professor C.N. Barnard as a specialist incharge of the Heart Transplant Unit and full-time Fellow at the Cardiac ResearchLaboratory for one year. During that period, I developed a non-invasive technique for the diagnosis of acute cardiac rejection using radionuclide-scanning methods, first in animals and then afterwards applied the technique to human cardiac transplantation, which was widely used at the University of Cape Town.

From January 1984 to the present, I have continued my research activities. At the Heart Transplant Unit in Cape Town, I worked approximately 50% in the laboratory where I embarked on the experimental study of brain-death in baboons and pig

s looking at the effects on the myocardium and the hemodynamic and endocrine deterioration following brain-death. The metabolic studies in brain-dead animals and patients confirmed that aerobic metabolism is inhibited. Explaining one of the mechanisms participating in the graft dysfunction after organ transplantation.

Based on this work, I developed the "hormonal therapy for brain-dead organ donors", showing its beneficial effect.

As a result of this research, I found that by administering Triiodothyronine (T3



), the metabolic dysfunction is fully corrected prior to organ transplantation.Currently, this therapeutic modality is used widely in the rescue of unstable brain-dead organ donors.

Together with Dr. W.N. Wicomb, I was involved in myocardial preservation in a portable unit, achieving successful preservation of the myocardium over a period of 48 hours, followed by orthotopic transplantation of the hearts of Chacma baboons with excellent survival of the animals.

In immunosuppressed Chacma baboons, I performed using cardiopulmonary bypass, anen bloc heart and lung transplantation finding that the lungs are actively rejected while minimal histological changes occur in the transplanted hearts. Thisis in contraindication to previous reports in which it was stated that the heartand lungs are rejected simultaneously. This work was published in the Annals of Thoracic Surgery.

In September 1982, I was in charge of the Department of Heart Transplantation, working in close collaboration with Professor Christiaan N. Barnard, and later with B. Reichart and D.K.C. Cooper, performing personally a total of 55 heart transplants, of which 8 were retransplantations (1 for irreversible acute rejectionand 7 were for chronic rejection). In 2 patients, the recipient heart was resected (previousheteroptoic heart transplants), and a heart was implanted in orthotopic position, leaving these patients with two transplanted hearts. During this period, 12 h

eart and lung transplants were performed in Groote Schuur Hospital, in which I participated actively in the surgical procedures, resecting the donor heart and lung block and performing a heart and lung transplant in a patient with primary pulmonary hypertension.

In 1987, as a member of the Oklahoma Transplantation Institute, I became co-director of research and director or organ procurement. While in this position, I have been involved in 77 procedures, including heart and heart-lung transplants.

From 1990 to December 1995, I held the title of Acting Chief of Cardiothoracic Surgery at the James A. Haley Veterans' Hospital. On January 1, 1996, I became t

he formal Chief of Cardiothoracic Surgery performing the majority of open heartsurgeries. I am also involved in Thoracic Surgery coverage whenever required and provide surgical stand by for all PTCA elective or emergent.

At Tampa General Hospital, Tampa, Florida, I am a member of the Heart TransplantTeam. I perform open heart surgery and provide coverage for the Thoracic Trauma Service.

From July to present, I have performed over 1,000 total myocardial revascularizations not using the heart-lung machine. This is a new re-introduction of old technology. However, with the advent of beta-blockers and special retractors, I am able to do a coronary bypass on any epicardial artery. This technique has been performed only in one other institution in the United States.

APPOINTMENTS

Professor, Department of Cardiothoracic Surgery, University of South Florida, Tampa, Florida, August 1998 to March 30 2009.



Cardiothoracic Surgeon, Surgical Service, James A. Haley Veterans' Hospital, Tampa, Florida.

Acting Chief, Cardiothoracic Surgery, Surgical Service, James A. Haley Veterans'Hospital, Tampa, Florida, 1990-1995.

Chief, Cardiothoracic Surgery, Surgical Service, James A. Haley Veterans' Hospital, Tampa, Florida, January 1996 to January 2001.

Cardiothoracic Surgeon, Department of Surgery, H. Lee Moffitt Cancer Center, Tampa, Florida.

Council Member of the American Society of Transplant Surgeons, Thoracic Organ Transplantation Section, Chicago, Illinois.

Director Transplant Research at Tampa Transplant Institute, from October 1st, 2009 to date

PREVIOUS RESEARCH

The potential applications of Triiodothyronine therapy following acute myocardial ischemic events were further examined in conditions exhibiting the euthyroid sick syndrome.

Experimental work was performed at the Veterinary School at the Oklahoma State University in Stillwater and the Oklahoma Medical Research Foundation. The mainemphasis of this research was to examine the effects of Triiodothyronine in thereversal of myocardial dysfunction in the following conditions: 1) stunned Myocardium, 2) recovery of the cardiac function following catecholamine infusion, and 3) myocardial depression following cardiopulmonary bypass.

Currently, we are looking at the effect of T3 pretreatment in rats with heart fa

ilure, observing a significant cardiac recovery and response to beta agonists.Control rats, after six weeks of heart failure, no longer respond to beta agonists. This may become of relevance mainly in open heart surgery or following PTCA's.

I have been acting as a Consult to SmithKline Beecham Pharmaceuticals for the development of protocols related to T3 in experimental and clinical applications in non-thyroid diseases.

The FDA has issued an IND number for the use of T3 in non-thyroid diseases. A randomized blinded study was done in Oklahoma in patients undergoing coronary artery grafts on cardiopulmonary bypass.

Recently, a fully funded study has been completed (Protocol TS-107). In this study using transesophageal echocardiography, we examined the effects of T3 in patients undergoing open heart surgery in a randomized, prospective blinded study.This was done in collaboration with Dr. Hector Fontanet (Cardiology Department).

We administered open T3 to high-risk heart patients with an estimated mortalityof 15-50%, (using a mathematical model developed by Dr. Parsonnet from Beth Israel Hospital, New Jersey), observing a significant death rate reduction by 60%.



At the James A. Haley Veterans' Hospital, I was the Primary Investigator for a VA Cooperative Study entitled, "Urgent Revascularization in Unstable Angina".In addition, I was Co-Investigator in the following research protocols:

1) Leukocyte & Platelet Activation During Cardiac BypassSurgery: Phase II2) Staging of Non-Small Cell Lung Carcinoma by DiagnosticImaging with Immuraid CEA3) Diagnosis of Myocardial Viability: Outcomes and Costs inChronic Heart Disease4) What is the Effect of Increasing F102 on the Distribution of Alveolar Ventilation and Perfusion in Patients After Cardiac Operations?5) Can Dobutamine Stress Echocardiography Predict Recovery ofContractile Function of Viable Myocardium?

I was a Primary Investigator at the Baptist Medical Center for the use of the "Thoratec" ventricular assist device for the rescue of the myocardium following open heart surgery and as a bridge to transplantation. I implanted the device in apatient who survived 70 days with its support (one of the longest ventricular assist device supported patients in the USA), and was thereafter successfully transplanted.

CURRENT CLINICAL RESEARCH

I am Co-Chairman with Dr. Fred Grover on a VA grant (10.6 million dollars) for acooperative study aOutcomes Following Myocardial Revascularization: On and OffCardiopulmonary Bypassa, which was performed in 18 Veteran Medical Centers.

We have completed the randomization and one year follow up for the Cooperative study CSP 517. Preparation of the main manuscript on the study findings has beeninitiated.

I am the senior author of the primary manuscript of the study CSP 517 entitled:

Outcomes Following Non-Emergent Coronary Artery Bypass Graft Procedures:Revascularization Off versus On Bypass (ROOBY) Trial Findings. NEJM

Multiple manuscripts will follow the primary paper, I estimate that at least twenty relevant papers will be published in prestigious journals and multiple meeting presentations will follow.

Also, I am reviewer for selected articles for the following journals: 1) Annalsof Thoracic Surgery, 2) Transplantation, and 3) The Journal of heart and Lung Transplantation.

MEMBERSHIP IN MEDICAL SOCIETIES

1984 - International Society for Heart and Lung Transplantation

1987 - Fellow of the American College of Cardiology (F.A.C.C.)

1990 - The American Society of Transplant Surgeons

1992 - The Society of Organ Sharing



1993 - American Medical Association

1993 - Florida Medical Association

1993 - The Society of Thoracic Surgeons

1994 - Hillsborough County Medical Association

1994 - Association of VA Surgeons

1995 - Florida Physicians Association

1996 - Florida Society of Thoracic & Cardiovascular Surgeons

2001 - Honorary Member: The Argentinean Cardiothoracic Surgical Society 2007 - Member of Editorial Board of Argentinean Journal of CT Surgery

External examiner of a dissertation for a PhD degree, University of Oslo: Safe introduction of myocardial revascularization without cardiopulmonary bypass.January 2010.

PRESENTATIONS AT MAJOR MEETINGS

1. NOVITZKY, HELLMAN, COOPER, HASSOULAS, BARNARD, ITURRALDE Radionuclide assessment of heteroptoic heart transplants. Presented to the South African Cardiac Society, September 1982.

2. COOPER, WICOMB, BOYDT, LANZA, NOVITZKY, HASSOULAS, BARNARD. Orthotopic and heteroptoic heart transplantation: Aspects of the Cape Town experience. Presented to the Transplantation Society, Brighton 1982.

3. NOVITZKY, WICOMB, COOPER, ROSE, FRASER, BARNARD. Presidentas Award: Presented to the International Society for Heart Transplantation, 1984.

4. NOVITZKY, COOPER, WICOMB, REICHART. Hemodynamic changes, myocardial injury,and pulmonary edema induced by Sympathetic activity during the development of br

ain-death in the baboon. Presented to a Symposium on Organ Procurement, Detroit1985.

5. NOVITZKY, COOPER, WICOMB, REICHART. Improved function of stored hearts following hormonal therapy after brain-death in pigs. Presented to the European Society for Organ Transplantation, Munich 1985.

6. NOVITZKY, COOPER, WICOMB, REICHART. Brain-death induced hemodynamic changesresulting in cardiac and pulmonary injury in the baboon. Paper presented to theEuropean Society for Organ Transplantation, Munich 1985.



7. NOVITZKY D, WICOMB WN, COOPER DKC, REICHART B. Evidence of myocardial and renal function recovery following hormonal treatment after brain-death. Presentedto the Southern African Transplantation Society, Ceres 1985, and to a Symposium on Organ Procurement, Detroit 1985.

8. NOVITZKY D. Presented a new approach in the management of brain-dead organ donors at Hospital Broussais, Cardiovascular Surgery Department, Paris, France 1985.

9. NOVITZKY D, ROSE AG, COOPER DKC, REICHART B. Histopathologic changes at thesite of endomyocardial biopsy: Potential for confusion with acute rejection. Poster presented to the International Society for Heart Transplantation, New York1986.

10. NOVITZKY D. Speaker at the Lisbon Transplant Society Annual Meeting on aTheCape Town Experience of Heart Transplantationa, 1986.

11. NOVITZKY D, COOPER DKC, REICHART B. The values of hormonal therapy in improving organ viability in the transplant donor. Presented to the TransplantationSociety, Helsinki, and to the Society of Thoracic and Cardiovascular Surgeonsof Great Britain and Ireland, Edinburgh 1986.

12. BECERRA E, COOPER DKC, NOVITZKY D, REICHART B. Are there indications for et

eroptoic heart transplantations today? Presented to the Transplantation Society, Helsinki, and to the Society of Thoracic and Cardiovascular Surgeons of GreatBritain and Ireland, Edinburgh 1986.

13. NOVITZKY D, COOPER DKC, BRINK J. REICHART B. Sequential second and third heart transplants in patients with previous heterotopic heart allografts. Presented to the South African Cardiac Society, Sun City 1986.

14. NOVITZKY D, COOPER DKC, MORRELL D, ISAACS S. Brain-death, triiodothyronine(T3) depletion, and inhibition of oxidative phosphorylation-relevance to management of organ donors. Presented to the European Society for organ transplantation, Gothenburg 1987.

15. REICHART BA, NOVITZKY D, COOPER DKC, CUNNINGHAM MS, ROSE AG. Successful orthotopic heart-lung transplantation in the baboon after 5 hours cold ischemia with cardioplegia and Collinsa solution. Presented to the International Society for Heart Transplantation, New York 1986, and Southern African Transplantation Society, Berg-en-Dal 1987.

16. REICHART BA, HUMAN PA, ROSE AG, NOVITZKY D, COOPER DKC. Is pulmonary ischemia a factor in the reperfusion response? An experimental study in the Chacma baboon. Presented to the International Society for Heart Transplantation, New Orleans 1987, and Southern African Transplantation Society, Berg-en-Dal 1987.

17. NOVITZKY D, COOPER DKC, ZUDHI H. The physiological management of cardiac transplant donors and recipients using triiodothyronine (T3). Presented as a pos

ter at an International Organ Transplant Forum in honor of Dr. T.E. Starzl, Pittsburgh 1987.

18. NOVITZKY D, COOPER DKC, WICOMB WN. Pathophysiology of brain-death in the experimental animal - extracranial aspects: Endocrine changes and metabolic responses. Presented at the Fourth Annual Christiaan N. Barnard Symposium, OklahomaCity 1987.

19. NOVITZKY D, COOPER DKC. Hormonal therapy of the potential donor: Results of hormonal herapy in human brain-dead potential organ donors. Presented at the



Fourth Annual Christiaan N. Barnard Symposium, Oklahoma City 1987.

20. NOVITZKY D, COOPER DKC, ZUHDI N. Hormonal therapy to the cardiac recipient:Triiodothyronine therapy in the cardiac transplant recipient. Presented at theFourth AnnualChristiaan N. Barnard Symposium, Oklahoma City 1987. 21. NOVITZKY D, COOPER DKC. The value of triiodothyronine (T3) in the rescue ofa failing heart following valve replacement. Presented to the Society of Thoracic Surgeons at the 23rd Annual Meeting, Toronto, Canada 1987.

22. REICHART B, REICHENSPURNER H, ODELL JA, COOPER DKC, NOVITZKY D, ROSE AG, KLINNER W. Initial experience in heart and lung transplantation. Presented at theAnnual Symposium of the Texas Heart Institute, October 1987.

23. REICHENSPURNER H, ODELL JA, COOPER DKC, NOVITZKY D, HUMAN PA, BARNARD CN, REICHART B. Twenty years of heart transplantation at Cape Town University. Presented at the Annual Symposium of the Texas Heart Institute, October 1987.

24. NOVITZKY D, COOPER DKC, BARTON C, GREER A, CHAFFIN J, ZUHDI N. Triiodothyronine (T3) as an inotropic agent following open heart surgery. Presented at the C. Walton Lillehei Surgical Symposium, Minneapolis 1988.

25. NOVITZKY D, COOPER DKC, HUMAN PA, REICHART B, ZUHDI N. Triiodothyronine therapy for heart donor and recipient. Presented to the International Society for

Heart Transplantation, Los Angeles 1988.

26. NOVITZKY D, HORAK A, COOPER DKC, ROSE AG. Electrocardiographic and histopathologic changes developing during experimental brain-death in the baboon. Presented as a poster to the Transplantation Society, Sydney 1988.

27. COLLINS GM, WICOMB WN, NOVITZKY D, COOPER DKC, HILL JD. Early extranucleareffect of triiodothyronine (T3) on tissue slices: Relevance to organ donor viability. Presented as a poster to the Transplantation Society, Sydney 1988.

28. NOVITZKY D, COOPER DKC, CHAFFIN JS, GREER AE, DEBAULT LE, ZUHDI N. Improvedcardiac allograft function following triiodothyronine (T3) therapy to both donor and recipient. Presented to the American Society of Transplant Surgeons, Chica

go 1989.

29. NOVITZKY D. Case presentations on: (I) prolonged bi-ventricular assist support as a bridge to transplantation, and (ii) bi-ventricular assist device usedin the successful rescue of a transplanted heart, Thoratec Assist Device Investigatoras Meeting, Boston 1989.

30. NOVITZKY D. Presented aNew trends and strategies in the management and diagnosis of acute cardiac rejectiona to the International Society for Heart Transplantation, Colorado Springs 1989.

31. NOVITZKY D. Presented (I) the euthyroid sick syndrome, facts, and fallacieson triiodothyronine replacement therapy, and (ii) experimental and early clinic

al application of triiodothyronine following cardiopulmonary bypass, Oklahoma Medical ll Research Foundation, National Institutes of Health raining Grant Meeting, 1989.

32. NOVITZKY D. The Euthyroid sick syndrome and Triiodothyronine and the reversal of myocardial dysfunction. Presented at Grand Rounds, University of South Florida, April 15, 1991.

33. NOVITZKY D. Triiodothyronine therapy and reversal of renal graft dysfunction following brain death and dopamine support. Abstract submitted at the Interna



tional Symposium on Acute Renal Failure, continuing Education Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, October 2-4, 1991.

34. NOVITZKY D. Euthyroid sick syndrome, brain-death and donor organ quality -evidence for the benefit of hormonal therapy in organ donor management. Abstract submitted at the Fifth International Symposium, Endocrinology in Anesthesia and Critical Care Medicine, October 15-26, 1991, Berlin, Germany.

35. NOVITZKY D. Cardiopulmonary bypass, myocardial dysfunction, reversal by iodothyronine therapy. Presented at Grand Rounds, University of South Florida, Department of Surgery, November 18, 1991.

36. NOVITZKY D. Current world-wide results of thoracic transplantation. Presented at Groote Schuur Hospital, Cape Town, South Africa in commemoration of the 25th Anniversary of the first human heart transplant, 1992.

37. NOVITZKY D. Cardiac implications of brain-death. Presented at Florida Hospital Translife, Orlando 1992.

38. NOVITZKY D. Presented a poster entitled, aThe impact of Triiodothyronine (T3) therapy in high risk patients undergoing open heart surgery, at the 15h Annua

l Meeting of the Society of Cardiovascular Anesthesiologists, San Diego, April 27, 1993.

39. NOVITZKY D. The surgical aspects of intrathoracic organ transplantation. Presented at TheFavaloro Foundation, Buenos Aires, Argentina, June 11, 1993.

40. NOVITZKY D. Hormonal Therapy in Cardiac Surgery. Honorary Lecture at III International Symposium on Heart Transplantation, Cordoba, Spain, May 13-14, 1994.

41. MCKEOWN P, CONANT P, NOVITZKY D, CINTRON G, FONTANET H. Surgical managementof thrombosed single A-V valve. GSM, Royal Australasian College of Surgeons,May 1994.

42. NOVITZKY D, FONTANET H, SNYDER M, COBLIO N, MCKEOWN P, SMITH D, PARSONNET V.The impact of Triiodothyronine (T3) Therapy in the Survival of High Risk Patients Undergoing Open Heart Surgery. Paper presented at The Western Thoracic Surgical Association, Squaw Creek, California, June 22-25, 1994.

43. NOVITZKY D. Presentation at the 75th Annual Meeting of the American Association of Thoracic Surgeons, Boston, Mass., April 23-26, 1995.

44. NOVITZKY D, FONTANET H, SMITH D, COLBIO N. The Role of Triiodothyronine inHigh Risk patients Undergoing Open Heart Surgery. Presented during the plenarysession of the 19th Annual Association of VA Surgeons Meeting in Pittsburgh, Pennsylvania, April 30 - May 3, 1995.

45. NOVITZKY D, FONTANET H, SMITH D, COBLIO N. Improving Efficiency in CardiacSurgery Practice. A joint conference with the Department of Veterans Affairs Office of Quality Management and the Cardiac Surgery Consultants Committee of theVACO Surgical Service, Keystone, Colorado, August 24-26, 1995.

46. NOVITZKY D, FONTANET H, SMITH D, COBLIO N. aNovel Actions of Thyroid Hormonea, at the International Endocrinology Congress, Toronto, Canada, September 10,1995.



47. NOVITZKY D. aManagement of the High Risk Cardiac Surgery Patient and Surgical Alternatives in the Technically Difficult Patienta, Cardiovascular Symposiumin Ponce, Puerto Rico, September 22-23, 1995.

48. NOVITZKY D. aThe Impact of T3 on Survival in High Risk Cardiac Surgery Patientsa. Presentation at Emory University Division of Cardio-thoracic Anesthesiology Annual Postgraduate Course, Cardiopulmonary Bypass in the 90as VI, Atlanta, Georgia, September 6-8, 1996.

49. NOVITZKY D, SMITH D, FONTANET H. aT3, A New Therapeutic Modality in Open Heart Surgerya. Presented at the 45th International Congress of the European Society for Cardiovascular Surgery Symposium, Benice, Italy, September 15-18, 1996.

50. NOVITZKY D, PERRY RW, FONTANET HL, SMITH DB. aMitral Valve Replacement, A bench Approacha. Accepted for presentation at the VIIIth Annual Cardiac and General Thoracic Surgery Update, Rio Mar, Puerto Rico, December 4-7, 1996.

51. NOVITZKY D. aThe Impact of T3 on Survival in High Risk Cardial Surgery Patientsa. Presented at the 19th Annual Meeting of the Society of Cardiovascular Anesthesiologists, Baltimore, Maryland, May 10-14, 1997.

52. NOVITZKY D. aAlternatives to Organ Transplantationa. Presented at the Annual Symposium of the International Society for Organ Sharing, Washington, D.C., July 1997.

53. NOVITZKY D. aDonor Management: The State of the Arta. Presented at the International Society of Transplant Coordinators, Washington, D.C., July 1997.

54. NOVITZKY D. aDetrimental Effects of Brain Death in the Organ Donora. Presented at the Annual Symposium of the International Society for Organ Sharing, Washington, D.C., July 1997.

55. NOVITZKY D. aAdvances in Cardiac Surgery. Minimally Invasive Coronary Surgery and Total Myocardial Revascularization Off Cardiopulmonary Bypass & The Management of End Stage Heart Failure: Partial Left Ventriculectomya. Presented asymposium at the Tampa General Hospital in conjunction with the University of South Florida College of Medicine, Tampa, Florida, February 6-7, 1998.

56. NOVITZKY D. aTotal Myocardial Revascularization Without Cardiopulmonary Bypassa. Presented at the Florida Society of Thoracic and Cardiovascular Surgeons31st Annual Meeting, Naples, Florida, February 20-22, 1998.

57. NOVITZKY D. aClinical Outcome After aOff-Pumpa Surgerya and aLeft Ventricular Remodeling forthe Treatment of End Stage Heart Failurea. Presented at the Cardiovascular Interventions a98 Third Annual Symposium at the Tampa ConventionCenter, Tampa, Florida, February 26-28, 1998.

58. NOVITZKY D. aTotal Myocardial Revascularization Without Cardiopulmonary Bypassa. Presented at CARDIOSTIM 98, 11th International Congress, Nice Acropolis, French Riviera, FRANCE June 17-20, 1998.

59. NOVITZKY D. aTotal Myocardial Revascularization Without Cardiopulmonary Bypassa. Poster presentation presented at the International Society for MinimallyInvasive Cardiac Surgery (ISMICS), Minneapolis, Minnesota June 25-27, 1998.

60. NOVITZKY D. aResults of Myocardial Revascularization Without Cardiopulmonar



y Bypassa. Invited Guest Speaker. Presented at the Advanced Laparoscopy Training Center (ALTC) during the Minimally Invasive Cardiac Surgery Course, Marietta,Georgia July 17-18, 1998.

61. NOVITZKY D. aTotal Myocardial Revascularization Off Cardiopulmonary Bypass& Minimally Invasive Coronary Surgerya. The 2nd Symposium presented at The Tampa General Hospital in conjunction with the University of South Florida College of Medicine and the James A. Haley Veterans Administration Hospital, Tampa, Florida, October 9, 1998

62. NOVITZKY D. aCoronary Surgery Without the Heart Lung Machinea. Presented at the International Society of Cardiothoracic Surgeons, 8th World Congress. Houston, Texas, November 1-4, 1998.

63. NOVITZKY D. aBrain Monitoring During Hypotensive Anesthesia for MyocardialRevascularization Without Cardiopulmonary Bypassa. Presented at the Magic of Minimally Invasive Cardiac & Thoracic Surgery: A Comprehensive Training Program.Jointly sponsored by The University of Cincinnati & The Endo-Surgery Institute,Cincinnati, Ohio. November 13-14, 1998.

64. NOVITZKY D. aCoronary Surgery Off Cardiopulmonary Bypass: A Reviewa, Presented at Yale University for Grand Rounds, New Haven, Connecticut. December 1-2,1998.

65. NOVITZKY D. aNew Trends of Myocardial Revascularizationa. Guest Speaker atthe Scientific Forum VIII: On Cardiology and Cardiovascular Surgery in Belo Horizonte, Brazil. Performed Live Surgery at this symposium. December 11-13, 1998.

66. NOVITZKY D. aLive Surgery Telecast from the James A. Haley VA Hospital (Tampa, FL) to San Antonio, Texas. A Case of Myocardial Revascularization Off Cardiopulmonary Bypass - The USF Experiencea Presented at the 35th Annual Meeting of the Society of Thoracic Surgeons, San Antonio, Texas. January 22-27, 1999.

67. NOVITZKY D. aInternational Symposium of Total Myocardial Revascularizationa. Presented at the Tampa General Hospital in conjunction with the University of

South Florida and the James A. Haley Veterans Administration Hospital, Tampa, Florida. March 19-20, 1999.

68. NOVITZKY D. aChairman of Donor Management, Organ Preservation, Organ Distribution Sessiona. Conducted at the 19th Annual Meeting and Scientific Sessions International Society for Heart and Lung Transplantation. April 21-24, 1999.

69. NOVITZKY D. aInvited Guest Speaker at the University of Guayaquil in Ecuador, South America. Performing (2) Live Surgeries at this meeting. June 17-20, 1999.

70. NOVITZKY D. aInvited Guest Speaker at the 1st Japanese Symposium on Myocardial Revascularization Off Cardiopulmonary Bypass, Tokyo, Japan. Performed Live

Surgery at this meeting. July 2-6, 1999.

71. NOVITZKY D. aInvited Guesta to return to the University of Guayaquil in Ecuador, South America or the dedication of the hospital. July 28-31, 1999.

72. NOVITZKY D. Invited Guest Speaker for aBack to the Future: On Pump, Off Pump Coronary Artery Surgery for the New Millenniuma at the Buffalo General Hospital, Buffalo, New York. August 12-15, 1999.

73. NOVITZKY D. Invited Guest Speaker for aEsperiencia de 20 Anox en Trasplante



s Cardiacos and Experiencia con Cirugia Coronaria Sin CEC at the VIII Meeting ofCardiovascular Surgeons in Tucuman, Argentina, September 2-4, 1999.

74. NOVITZKY D. aInternational Symposium of Total Myocardial Revascularizationa. Presented at The Tampa General Hospital in conjunction with the University ofSouth Florida and the James A. Haley Veterans Administration Hospital, Tampa, Florida. March 17-18, 2000.

75. NOVITZKY D. aMinimally Invasive Cardiac Surgery (MICS) II: Outcomes, Innovations and Future Directionsa. Invited Guest Speaker on the topic of aCNS Monitoring in High-Risk OPCAB Patientsa in Key West, Florida. May 28, 2000.

76. NOVITZKY D. a3rd Annual International Symposium of Total Myocardial Revascularizationa. Presented at The Tampa General Hospital in conjunction with the University of South Florida and the James A. Haley Veterans Administration Hospital, Tampa, Florida. March 16-17, 2001.

77. NOVITZKY D. aCoronary Artery Surgery on a Beating Heart Symposiuma. Presented in Havana, Cuba. April 20-23, 2001.

78. NOVITZKY D. Invited guest speaker for aInterventional Cardiology & Cardiovascular Surgery Updatea in conjunction with the University of South Florida andthe University at Sea Program. May 13-20, 2001.

79 NOVITZKY D. Invited guest speaker at the aBaltic Sea Cardiothoracic Conferencea. Presented in Gdansk, Poland. May 29-June 4, 2001.

80 NOVITZKY D. a2nd International Workshop on Complete Myocardial Revascularization withoutCardiopulmonary Bypassa. Presented in Buenos Aires, Argentina. August 10, 2001.

81 NOVITZKY D. aCardiac Grand Roundsa. Invited guest speaker on aOff Pump By-Pass Cardiac Surgery in 2001a. Presented at Tampa General Hospital, Tampa, Florida. September 5, 2001.

82. NOVITZKY D. Invited guest speaker at the a2nd International Taller of HeartFailure and Intrathoracic Organs Transplantation Meetinga. Presented in Havana,

Cuba. November 5-8, 2001.

83. NOVITZKY D. a5th Annual International Symposium of Total Myocardial Revascularizationa. Presented at The Tampa General Hospital in conjunction with the University of South Florida and the James A. Haley Veterans Administration Hospital, Tampa, Florida. March 15-16, 2002.

84. NOVITZKY D. Invited guest speaker at the a3rd International Taller of HeartFailure and Intrathoracic Organs Transplantation Meetinga. Presented in Havana,Cuba. March 25-29, 2002.

85. NOVITZKY D. Invited guest speaker at the aOff-Pump Coronary Surgery Symposiuma. Presented in Hong Kong. April 8-9, 2002.

86. NOVITZKY D. Invited guest speaker at the a2nd Annual National VA Surgery Symposiuma. Presented in Alexandria, Virginia. May 22-24, 2002.

87. NOVITZKY D. Presenter at the a5th Annual Meeting of the International Society for Minimally Invasive Cardiac Surgerya. Presented in New York, New York. June20-23, 2002.

88. NOVITZKY D. Invited guest speaker and moderator at the aInternational Society for Heart and Lung Transplantation 4th Fall Educationa. Presented in Cambrid



ge, England. September 15-17, 2002.

89 NOVITZKY D. Course Director for the a6th Annual International Symposium of Total Myocardial Revascularization Without Cardiopulmonary Bypassa. Presented at The Tampa General Hospital in conjunction with the University of South Florida,the James A. Haley Veterans Administration Hospital, Tampa, Florida, and the University of Miami School of Medicine. August 29-30, 2003.

90. NOVITZKY D. Invited guest participant at the aAnnual Chilean Society of Cardiology & Cardiovascular Surgery Meetinga. Presented in Vina del Mar, Chile. December 9-12, 2003.

91. NOVITZKY D. Invited guest speaker at the aCanadian Forum on Medical Management to Maximize Donor Organ Potentiala. Presented in Mont Tremblant, Quebec. February 23-25, 2004.

92. NOVITZKY D. Invited guest faculty at the a10th Annual CTT Meeting 2004a. Presented in Miami Beach, Florida. March 10-13, 2004.

93. NOVITZKY D. Invited guest participant at the aOutcomes Key West Meetinga. Presenting in Key West, Florida. May 19-23, 2004.

94. NOVITZKY D. Invited guest speaker at the aBolivian Society of Thoracic & Cardiovascular Surgery Meetinga. Presented in Cochabamba, Bolivia. September 16-18,

2004.

95. NOVITZKY D. Speaker at the aDSMV Meeting: Veteranas Administration Review ofCooperative Study #517a. Presented in Baltimore, Maryland. April 19, 2005.

96. NOVITZKY D. Reducing the Risk of Myocardial Revascularization: Relevance ofMultimodal Brain Monitoring Semin Cardiothorac Vasc Anesth.2005; 9: 131-137

97. NOVITZKY D. Invited guest speaker at the Thomas E. Starzl Transplantation Institute Grand Rounds a" aHeart Transplantation: Donor Organ Managementa. Presented in Pittsburgh, Pennsylvania. September 23, 2005.

98. NOVITZKY D. aCardiology Crisp Grand Roundsa. Invited guest speaker on aHear

t Transplant Overviewa. Presented at Tampa General Hospital, Tampa, Florida. February 15, 2006.

99 NOVITZKY D. ISHLT chair at adonor research managementa Boston, Massachusetts.May 2008

100. NOVITZKY D. Invited guest speaker at the aASTa annual meeting, Orlando Florida, May 2008

BOOKS

1. Heart Transplantation - The Present Status of Orthotopic and HeterotopicHeart Transplantation, edited by Cooper, DKC and Lanza, RP, MTP PressLimited, Lancaster, 1984.

Personal Contributions:

Chapter 8, Pages 103-108. Surgical techniques of orthotopic and heterotopicheart transplantation. NOVITZKY D, COOPER DKC.

Chapter 9, Pages 129-146. Immediate post-operative care and maintenance



immunosuppressive therapy. COOPER DKC, NOVITZKY D.

Chapter 12, Pages 177-194. Diagnosis and management of acute rejection.COOPER, DKC, NOVITZKY D.

Chapter 21, Pages 321-340. Transplantation of the heart and both lungs.NOVITZKY D, COOPER DKC.

2. Hormonal Therapy - A New Concept in the Management of Organ Donors,edited by COOPER DKC, NOVITZKY D, ZUHDI N. (Proceedings of the FourthAnnual Christiaan N. Barnard Symposium, December 4, 1987). Published as anedition of Transplantation Proceedings, October 1988.


1. COOPER DKC, NOVITZKY D, WICOMB WN. Pathophysiology of brain-death in the experimental animal: Extracranial aspects: (i) Hemodynamicand electrocardiographic responses.

2. ROSE AG, NOVITZKY D, COOPER DKC. Pathophysiology of brain-deathin the experimental animal: Extracranial aspects: (ii) Myocardial andpulmonary histopathological changes.

3. NOVITZKY D, COOPER DKC, WICOMB WN. Pathophysiology of brain-death in the experimental animal: Extracranial aspects: (iii) Endocrinechanges and metabolic responses.

4. WICOMB WN, COOPER DKC, NOVITZKY D. Added effects of organ (heart) storage following brain-death in the experimental animal.

5. COOPER DKC, NOVITZKY D, WICOMB WN. Hormonal therapy in thebrain-dead experimental animal.

6. WICOMB WN, NOVITZKY D, COOPER DKC. Effects of hormonal therapy on subsequentorgan (kidney) storage in the experimental

animal.

7. NOVITZKY D, COOPER DKC. Results of hormonal therapy in humanbrain-dead potential organ donors.

8. NOVITZKY D, COOPER DKC, ZUHDI N. T3 Therapy in the cardiactransplant recipient.

9. Transplantation and Replacement of Thoracic Organs. COOPER DKC,NOVITZKY D (Eds.). Kluwer Academic, Lancaster, UK 1990.

Personal Contributions in the Following Chapters:

SECTION I: Orthotopic and Heterotopic Heart Transplantation.

Chapter 6 - COOPER DKC, NOVITZKY D. Selection and management ofthe donor.

Chapter 10 - COOPER DKC, NOVITZKY D. Surgical technique of orthotopicheart transplantation.

Chapter 11 - NOVITZKY D, COOPER DKC. Surgical technique of heterotopic heart transplantation.



Chapter 14 - NOVITZKY D, COOPER DKC. Immunobiology of allograft destruction.

Chapter 16 - COOPER DKC, NOVITZKY D. Diagnosis and management of acuterejection.

Chapter 20 - COOPER DKC, NOVITZKY D. Retransplantation.

SECTION II: Transplantation of the Heart and Both Lungs.

Chapter 35 - HAVERICH A, NOVITZKY D, COOPER DKC. Selection of donor;excision and storage of the donor organs.

Chapter 37 - NOVITZKY D, COOPER DKC. Surgical technique of recipientoperation.

4. Organ Donation, Procurement and Preservation of Vascularized Organs,Kluwer Academic Publishers, The Netherlands, 1994.


Chapter 5 - NOVITZKY D. Special Problems in Donor Maintenance, issues of Triiodothyronine in cardiac recovery (In press).

5. Procurement, Preservation and Allocation of Vascularized Organs,Kluwer Academic Publishers, The Netherlands, 1997


Chapter 8 - NOVITZKY D. Donor conditioning in organ procurement, pp. 59-68, 1997.

6. Organ Procurement & Preservation,Klintmalm & Levy, Landes Bioscience Vademecum Publishers, U.S.A. 1998


Chapter 3 - NOVITZKY D. Physiologic Consequences of Brain Death, pp. 3168,1997.

7. THE BRAIN-DEAD ORGAN DONORPathophysiology and Management

DIMITRI NOVITZKY, MD, PHD, FCSBook in preparation. 2010



CONTRIBUTIONS TO BOOKS - INVITED ARTICLES

1. COOPER DKC, NOVITZKY D, HASSOULAS J, BARNARD CN. Transplantation of the heart. Brit J Clinic Practice, Vol. 36, pp. 337-345, 1982. Reprinted in the Indian Journal of Thoracic and Cardiovascular Surgery.

2. COOPER DKC, NOVITZKY D, HASSOULAS J, BARNARD CN. Heart transplantation: TheSouth African experience. J Heart Transplant, Vol. 2, 78-84, 1983.

3. NOVITZKY D, SANCHEZ H, BARNARD CN. The significance of femoral pulses in coarctation of the aorta. S Afr Med J, Vol. 65, 755-757, 1983.

4. NOVITZKY D, SANCHEZ H, BARNARD CN. Coarctation of the aorta under one yearof age. S Afr Med J, Vol. 64, 923, 1983.

5. COOPER DKC, NOVITZKY D, REICHART B. The current status of heart and heart-lung transplantation. International Medicine, 5, 2-7, 1985.

6. NOVITZKY D, COOPER DKC, BARNARD CN. The surgical technique of heterotopic heart transplantation. Chapter in Cardiac Surgery - a loose-leaf workbook, an upd

ate service, edited by D. Doty. Yearbook medical publisher, Chicago, 1986.

7. NOVITZKY D, COOPER DKC, BRINK J, REICHART B. Sequential second and thirdAfrican Cardiac Society, Sun City, 1986. J Clin Transplant 5, 57

- 62, 1987.

8. NOVITZKY D, COOPER DKC, BONIASZCZUK J, ROSE AG, SMITH JA, REICHART B. The effect of denervation and acute rejection on left ventricular volumes measured byradionuclide scanning techniques following cardiac transplantation in the Chacmababoon. Sem Nuc Med 28:213-220, 1988.

9. ITURRALDE M, NOVITZKY D, COOPER DKC, ROSE AG, BONIASZCZUK J, SMITH JA, REICHART B, ISAACS S. The role of nuclear cardiology procedures in the evaluation of

cardiac function following heart transplantation. Sem Nuc Med 18, 221-240, 1988.

10. COOPER DKC, NOVITZKY D, WICOMB WN. Improved organ survival from brain-deaddonors. J Acc Emerg Med 5, 17-18, 1988.

11. REICHENSPURNER H, COOPER DKC, ODELL JA, NOVITZKY D, HUMAN PA, VON OPPELL U,BECERRA E, BOEHM DH, ROSE AG, REICHART B. Heart transplantation in Cape Town -a review of 20 years experience. In Assisted Circulation 3, edited by F. Unger.Springer Verlag, Berlin, 1989, pp 425-436.

12. NOVITZKY D, COOPER DKC, BONIASZCZUK J, ISAACS S, ROSE AG, SMITH JI. Acute cardiac rejection by left ventricle volume measurement using radionuclide techniq

ues. J Nuc Med.

13. NOVITZKY D. Selection and management of cardiac allograft donors. CurrentOpinion inCardiology 1996, 11:174-182.

PAPERS ON CLINICAL CARDIOVASCULAR SURGICAL TOPICS



1. BARNARD CN, BARNARD MS, COOPER DKC, CURCIO CA, HASSOULAS J, NOVITZKY D, WOLPOWITZ A. The present status of heterotopic cardiac transplantation. J Thorac Cardiovasc Surg 81:433 -439, 1981.

2. COOPER DKC, HASSOULAS J, NOVITZKY D, BARNARD CN. The results of orthotopic and heterotopic heart transplantation at Groote Schuur Hospital, 1967-1982. J Heart Transplant 1:112-115, 1982.

3. COOPER DKC, FRASER RC, ROSE AG, AYZENBERG O, OILFIELD GS, HASSOULAS J, NOVITZKY D, UYS CH, BARNARD CN. Technique, complications and clinical value of endomyocardial biopsy in patients with heterotopic heart transplants. Thorax 36:727-731, 1982.

4. LOSMAN JG, LEVINE H, CAMPBELL CD, REPLOGLE RL, HASSOULAS J, NOVITZKY D, COOPER DKC, BARNARD CN. Changes in indications for heart transplantation: An additional argument for the preservation of the recipient's own heart. J Thorac Cardiovasc Surg 84: 716-726, 1982.

5. COOPER DKC, NOVITZKY D, HASSOULAS J, BARNARD CN. Transplantation of the Heart. The British Journal of Clinical Practice 36:337-245, 1982.

6. LANZA RP, COOPER DKC, NOVITZKY D, BARNARD CN. Survival after cardiac transplantation (letter to the editor). S Afr Med J 64:1007, 1983.

7. ROSE AG, UYS CJ, NOVITZKY D, COOPER DKC, BARNARD CN. Toxoplasmosis of donorand recipient hearts after heterotopic cardiac transplantation. Arch Pathol LabMed 107: 368-373, 1983.

8. NOVITZKY D, COOPER DKC, BARNARD CN. The surgical technique of heterotopic heart transplantation. Ann Thorac Surg 36:476-482, 1983.

9. COOPER DKC, WICOMB WN, BOYD ST, LANZA RP, NOVITZKY D, HASSOULAS J,BARNARD CN. Orthotopic and heterotopic heart transplantation: Aspects of the Cape Town experience. Presented to the Transplantation Society, Brighton, 1982.Transplant Proc 15:1232-1237, 1983.

10. COOPER DKC, LANZA RP, OLIVER S, FORDER AA, ROSE AG, UYS CJ, NOVITZKY D, BARNARD CN. Infectious complications after heart transplantation. Thorax, 38:822-828, 1983.

11. NOVITZKY D, SANCHEZ HE, BARNARD CN. Coarctation of the aorta in infants under 1 year of age. South African Medical Journal 64:934-936, 1983.

12. SUKKAR AZ, COOPER DKC, DE NOBREGA J, HASSOULAS J, NOVITZKY D, SANCHEZ HE, BARNARD CN. Valve replacement in patients over 70 years of age. S Afr Med J 65:370-373, 1984.

13. NOVITZKY D, COOPER DKC, BARNARD CN. Circulatory assistance with allograft (letter to the editor). Ann Thorac Surg 37:2, 1984.

14. WICOMB WN, COOPER DKC, NOVITZKY D, BARNARD CN. Cardiac transplantation following storage of the donor heart by a portable hypothermic perfusion system. Ann Thorac Surg 37: 232-248, 1984.

15. NOVITZKY D, COOPER DKC, BARNARD CN. Orthotopic heart transplantation in apatient with a heterotopic heart transplant. J Heart Transplant 3:257-259, 1984.



16. VAN VELDHUISEN DB, VAN DEN BERG MP, NOVITZKY D, COOPER DKC. Cyclosporine Ain the management of patients with heart transplants. S Afr Med J 66:557-562,1984.

17. NOVITZKY D, COOPER DKC, BARNARD CN. Reversal of acute rejection by cyclosporine in a heterotopic heart transplant. J Heart Transplant 3:117-120, 1984.

18. NOVITZKY D, BONIASZCUZUK J, COOPER DKC, ISAACS S, ROSE AG, SMITH JA, UYS CG,BARNARD CN, FRASER RC. Prediction of acute cardiac rejection using radionuclide techniques. S Afr Med J 65:5-7, 1984

19. NOVITZKY D, COOPER DKC, ROSE AG, BARNARD CN. The value of recipient heartassistance during severe acute rejection following heterotopic cardiac transplantation. J Cardiovasc Surg 25:287-295, 1984.

20. NOVITZKY D, COOPER DKC, BARNARD CN. Heart transplantation at Groote SchuurHospital using cyclosporine. Poster presented to the International Society forHeart transplantation, New York, 1984. J Heart Transplant 4:17-18, 1984.

21. NOVITZKY D, ROSE AG, MORGAN JA, BARNARD CN. Primary cardiac haemangiomas.A report of 2 cases. S Afr Med J 66:267-270, 1984.

22. NOVITZKY D, SANCHEZ HE, HUMAN D, BARNARD CN. The significance of femoral pu

lses in coarctation of the aorta. S Afr Med J 65:755-757, 1984.

23. COOPER DKC, NOVITZKY D, LANZA RP, ROSE AG, WICOMB WN, BARNARD CN.Immunosuppression in the baboon cardiac allograft model: Effects of splenectomy, bolus methylprednisolone, propranolol, high-dose azathioprine, cyclophosphamide, and a nitridazole metabolite. Transplantation 38:299-301, 1984.

24. NOVITZKY D, WICOMB WN, COOPER DKC, ROSE AG, FRASER RC, BARNARD CN.Electrocardiographic, hemodynamic and endocrine changes occurring during experimental brain death in the Chacma baboon. Presented to the International Societyfor Heart Transplantation, New York, 1984 (President's Award). J Heart Transp

lant 4:63-69, 1984.

25. NOVITZKY D, COOPER DKC, LANZA RP, BARNARD CN. Further cardiac transplantproceedings in patients with heterotopic heart transplants. Ann of Thoracic Surg 39:149-154, 1985.

26. COOPER DKC, NOVITZKY D, REICHART B. The current status of heart and heart-lung transplantation. International Medicine 5:2-7, 1985.

27. NOVITZKY D, COOPER DKC, DU TOIT E, OUDSHOORN M, LANGMAN E, JACOBS P. Preformed lymphocytotoxic antibodies disappear following cyclosporine therapy. J Heart Transplant 4:362-363, 1985.

28. NOVITZKY D, COOPER DKC, WICOMB CN, ROSE AG, REICHART B. Transplantation ofthe heart and both lungs: experimental and clinical experience and review of the literature. S Afr Med J 67:575 - 580, 1985.

29. COOPER DKC, CHARLES RG, ROSE AG, FRASER RC, ISAACS S, NOVITZKY D, BARNARD CN. Does the electrocardiogram detect early heart rejection? J Heart Transplant

4:546 - 549, 1985.

30. NOVITZKY D, COOPER DKC, BONIASZCZUK J, ISAACS S, FRASER RC, COMMERFORD PJ, U



YS CH, ROSE AG, SMITH JA, BARNARD CN. The significance of left ventricular volume measurement after heart transplantation using radionuclide techniques. J Heart Transplant 4:206 - 209, 1985.

31. NOVITZKY D, COOPER DKC, BONIASZCZUK J, FRASER RC, ISAACS S, ROSE AG, SMITH J, UYS CJ, BARNARD CN. Prediction of acute cardiac rejection using radionuclidescanning to detect left ventricular volume changes. Transplant Proc 17: 218-220, 1985.

32. WICOMB WN, COOPER DKC, NOVITZKY D. An airlife pump device for low pressureperfusion storage of the isolated heart. Cryobiology 22:401-408, 1985.

33. NOVITZKY D, COOPER DKC, WICOMB WN. A successful method of administering cyclosporin A to the Chacma baboon. S Afr Med J 68:737-739 , 1985.

34. COOPER DKC, WICOMB WN, LANZA RP, NOVITZKY D, ROSE AG, BARNARD CN. Effects of brain death and hypothermic perfusion storage on donor heart function: An experimental study. Presented to the Transplantation Society, Minneapolis, 1984.Transplant Proc 17:231-232, 1985.

35. COOPER DKC, BECERRA E, NOVITZKY D, HORAK A, REICHART B. Surgery in patientswith heart transplants: Anesthetic and operative considerations. S Afr Med J70:137-142, 1986.

36. WICOMB WN, NOVITZKY D, COOPER DKC, ROSE AG. Forty-eight hours hypothermicperfusion storage of pig and baboon hearts. Presented to the South African Transplantation Society, Ceres, 1985. (Abstract in S Afr J Surg 24, 15, 1986). JSurg Research 40:276-284, 1986.

37. COOPER DKC, NOVITZKY D, BECERRA E, REICHART B. Are there indications forheterotopic heart transplantation in 1986? A 2 to 11 year follow-up to 49 consecutive patients undergoing heterotopic heart transplantation. Presented to theSouth African Cardiac Society, Sun City, 1986. The Thoracic and Cardiovasc Surgeon 34:300-304, 1986.

38. BHOOPCHAND A, COOPER DKC, NOVITZKY D, ROSE AG, REICHART B. Regression of Ka

posi's sarcoma after reduction of immunosuppressive therapy in a heart transplant patient. J Heart Transplant 5:461-464, 1986.

39. NOVITZKY D, COOPER DKC, REICHART B. Value of triiodothyronine (T3) therapyto brain-dead potential organ donors. (Letter) J Heart Transplant 5:486-7, 1986.

40. WICOMB WN, COOPER DKC, NOVITZKY D. Impairment of renal slice function following brain death, with reversibility of injury by hormonal therapy. Transplantation 41:29-33, 1986.

41. NOVITZKY D, ROSE AG, COOPER DKC, REICHART B. Interpretation of endomyocardial biopsy after heart transplantation. S Afr Med J 70:789-792, 1986.

42. WICOMB WN, COOPER DKC, LANZA RP, NOVITZKY D, ISAACS S. The effects of braindeath and 24 hour storage by hypothermic perfusion in donor heart function in the pig. J Thorac Cardiovasc Surg 91:896-909, 1986.

43. NOVITZKY D, WICOMB WN, COOPER DKC, ROSE AG, REICHART B. Prevention ofmyocardial injury during brain death by total cardiac sympathectomy in the Chacma baboon. Ann Thorac Surg 41:520-4, 1986.

44. COOPER DKC, NOVITZKY D, ROSE AG, REICHART B. Acute pulmonary rejection prec



edes cardiac rejection following heart-lung transplantation in a primate model.Paper presented to the International Society for Heart transplantation, New York, 1986.

45. NOVITZKY D, COOPER DKC, ROSE AG, REICHART B. Acute isolated pulmonary rejection following transplantation of the heart and both lungs: Experimental and clinical observations. Ann Thorac Surg 42:180-4, 1986.

46. NOVITZKY D, COOPER DKC, WICOMB WN, REICHART B. Hemodynamic changes,myocardial injury, and pulmonary edema induced by sympathetic activity during the development of brain death in the baboon. Presented to a Symposium on Organ Procurement, Detroit, 1985. Transplant Proc 18:609-12, 1986.

47. NOVITZKY D, COOPER DKC, WICOMB WN, REICHART B. Brain death-inducedhemodynamic changes resulting in cardiac pulmonary injury in the baboon. Paperpresented to the European Society for Organ Transplantation, Munich, 1985. Transplant Proc 18:1190-192, 1986.

48. ROSE AG, NOVITZKY D, COOPER DKC, REICHART B. Endomyocardial biopsy sitemorphology: An experimental study in baboons. Arch Pathol Lab Med 110:622-625

, 1986.

49. WICOMB WN, ROSE AG, COOPER DKC, NOVITZKY D. Hemodynamic and myocardial histological and ultrastructural studies on baboons from three to twenty-seven months following autotransplantation of hearts stored by hypothermic perfusion for 24or 48 hours. J Heart Transplant 5:122-9, 1986.

50. NOVITZKY D, WICOMB WN, COOPER DKC, REICHART B. Evidence of myocardial and renal unctional recovery following hormonal treatment after brain death. Presented to the South African Transplantation Society, Ceres, 1985 (Abstract in S Afr

J Surg 24, 50, 1986), and to a Symposium on Organ Procurement, Detroit, 1985.Transplant Proc 18:613-5, 1986.

51. NOVITZKY D, ROSE AG, COOPER DKC, REICHART B. Interpretation of endomyocardial biopsy after heart transplantation. Potentially confusing factors. S Afr Med J 70:789-92, 1986.

52. NOVITZKY D, COOPER DKC, WICOMB WN, REICHART B. Improved function of storedhearts following hormonal therapy after brain death in pigs. Presented to the European Society for Organ Transplantation, Munich, 1985. Transplant Proc 18:1419-21, 1986.

53. NOVITZKY D, ROSE AG, COOPER DKC, REICHART B. Histopathological changes at t

he site of endomyocardial biopsy: Potential for confusion with acute rejection.Poster presented to the International Society for Heart Transplantation, New Y

ork, 1986. J Heart Transplant 5:79-80, 1986.

54. REICHART B, COOPER DKC, NOVITZKY D. The artificial heart - a reality in 1986. Medical Researched Council (SA) News 17:8-9, 1986.

55. COOPER DKC, NOVITZKY D, REICHART B. Current cardiothoracic research projects. Medical Research Council (SA) News 17:5-7, 1986.



56. REICHENSPURNER H, ODELL JA, COOPER DKC, NOVITZKY D, HUMAN PA, VON OPPELL U,BECERRA E, BOEHM DH, ROSE AG, FASOL R, ZILLA P, REICHART B. Twenty years of heart transplantation at Groote Schuur Hospital. J Heart Transplant 6:317-323,1987.

57. NOVITZKY D, COOPER DKC, BRINK JG, REICHART B. Sequential - second and thirtransplants in patients with heterotopic heart allografts. Clin Transplant 1:57-62, 1987.

58. NOVITZKY D, COOPER DKC, ROSE AG, WICOMB WN, BECERRA E, REICHART B. Early donor heart failure following transplantation from myocardial injury sustained during brain death. Clin Transplant 1:108-13, 1987.

59. REICHART B, BLASCHKE F, COOPER DKC, NOVITZKY D, REICHENSPURNER H, ODELL JA,ROSE AG, KEMKES BM, KLINNER W. Transplantation of the heart and both lungs: Initial experience of twelve operations in ten patients. Clin Transplant 1:231-239, 1987.

60. NOVITZKY D, COOPER DKC, REICHART B. Hemodynamic and metabolic responses tohormonal therapy in brain-dead potential organ donors. Transplantation 43:852- 854, 1987.

61. NOVITZKY D, COOPER DKC, REICHART B. The value of hormonal therapy in improving organ viability in the transplant donor. Presented to the Transplantation S

ociety, Helsinki, and to the Society of Thoracic and Cardiovascular Surgeons ofGreat Britain and Ireland, Edinburgh, Transplant Proc 19:2037-2038, 1987.

62. BECERRA E, COOPER DKC, NOVITZKY D, REICHART B. Are there indications forheterotopic heart transplantation today? Presented to the Transplantation Society, Helsinki, and to the Society of Thoracic and Cardiovascular Surgeons of Great Britain and Ireland, Edinburgh, 1986. Transplant Proc 19:2512-2513, 1987.

63. REICHART B, REICHENSPURNER H, ODELL JA, COOPER DKC, NOVITZKY D, HUMAN PA, VON ODELL U, BECERRA E, BOEHM DH, ROSE AG. Heart transplantation at Groote SchuurHospital, Cape Town - Twenty years experience. S Afr Med J 72:737-739, 1987.

64. NOVITZKY D, COOPER DKC, MORRELL D, ISAACS S. Brain death, triiodothyronine(T3) depletion, and inhibition of oxidative phosphorylation: Relevance to management of organ donors. Transplant Proc 19:4110-1, 1987.

65. WICOMB WN, COOPER DKC, NOVITZKY D. Loss of myocardial viability followinghypothermic perfusion storage from contaminating trace elements in th

e perfusate.Transplantation 45:23-9, 1987.

66. NOVITZKY D, WICOMB WN, COOPER DKC, TJAALGARD MA. Improved cardiac functionfollowing hormonal therapy in brain-dead pigs: Relevance to organ donation. Cr

yobiology24:1-10, 1987.

67. NOVITZKY D, WICOMB WN, ROSE AG, COOPER DKC, REICHART B. Pathophysiology ofpulmonary edema following experimental brain death in the Chacma baboon. Ann Thorac Surg 43:288-94, 1987.

68. NOVITZKY D, COOPER DKC, ROSE AG, REICHART B. Prevention of myocardial injury by pre-treatment with verapamil hydrochloride prior to experimental brain death: Efficacy in a baboon model. Amer J Emerg Med 15:11-18, 1987.



69. NOVITZKY D, COOPER DKC, MORRELL D, ISAACS S. Brain death, triiodothyronine(T3) depletion, and inhibition of oxidative phosphorylation - relevance to management of organ donors. Presented to the European Society for Organ Transplantation, Gothenburg, 1987. Transplant Proc 19:4068-4069, 1987.

70. NOVITZKY D, COOPER DKC, REICHART B. Preservation of organs & acute tubularnecrosis: Procurement and preservations of organs: The value of hormonal therapy in improving organ viability in the transplant donor. Transplant Proc 19:2037-2038, 1987.

71. REICHART BA, HUMAN PA, ROSE AG, NOVITZKY D, COOPER DKC. Is pulmonary ischemia a factor in the reperfusion response? An experimental study in the Chacma baboon. Presented to the International Society for Heart Transplantation, New Orleans, 1987. Berg-en-Dal, 1987. J Heart Transplant 6:238-243, 1987.

72. REICHART BA, NOVITZKY D, COOPER DKC, CUNNINGHAM MS, ROSE AG. Successful orthotopic heart-lung transplantation in the baboon after 5 hours cold ischemia withcardioplegia and Collins' solution. Presented to the International Society forHeart Transplantation, New York, 1986, and South African Transplantation Society, Berg-en-Dal, 1987. J Heart Transplant 6:15-22, 1987.

73. REICHENSPURNER H, ODELL JA, COOPER DKC, NOVITZKY D, ROSE AG, KLINNER W, REICHART B. Initial experience with heart and lung transplantation. Presented tothe 17th Annual Symposium of the Texas Heart Institute, Houston, 1987. Texas Heart Institute Journal 15:3-6, 1988.

74. COOPER DKC, SUMPTER P, NOVITZKY D, CHAFFIN J, GREER AE, BARNARD CN, ZUHDI Assessment and selection of patients for heart transplantation. J Okla State Med Assoc 81:137-140, 1988.

75. COOPER DKC, ROMERO CA, CLARK RM, CHAFFIN JA, GREER AE, NOVITZKY D, BARNARD CN, ZUHDI N. Indications for heterotopic heart transplantation, and report on two patients. J Okla State Med Assoc 81:513-517, 1988.

76. NOVITZKY D, COOPER DKC, ZUHDI N. Triiodothyronine therapy in the cardiac transplant recipients. Presented as a poster at an International Organ TransplantForum in honor of Dr. T.E. Starzl, Pittsburgh, 1987, Transplant Proc 20:65-8,1988.

77. COOPER DK, NOVITZKY D, WICOMB WN. Hemodynamic and electrocardiograhic responses. Trans Proc 20:25-8, 1988.

78. ROSE AG, NOVITZKY D, COOPER DK. Myocardial and pulmonary histopathologicchanges. Trans Proc 20:29-32, 1988.

79. NOVITZKY D, COOPER DK, WICOMB WN. Endocrine changes and metabolic responses. Trans Proc 20:33-8, 1988.

80 WICOMB WN, COOPER DK, NOVITZKY D. Added effects of organ (heart) storage after brain death in the experimental animal. Trans Proc 20:39-43, 1988.

81 COOPER DK, NOVITZKY D, WICOMB WN. Hormonal therapy in the brain-dead experimental animal. Trans Proc 20:51-4, 1988. 82 WICOMB WN, NOVITZKY D, COOPER DK, Effects of hormonal therapy on subsequent organ (kidney) storage in the experimental animal. Trans Proc 20:55-8, 1988.



83 NOVITZKY D, COOPER DK. Results of hormonal therapy in human brain-dead potential organ donors. Trans Proc 20:59-62, 1988.

80. NOVITZKY D, COOPER DKC, BONIASZCZUK J. Prediction of acute cardiac rejection by changes in left ventricular volumes. J Heart Transplant 7:453-455, 1988.

81. COOPER DKC, NOVITZKY D. Thyroid function in human cardiac allograft donors(Letter).Transplantation 45:671-672, 1988.

86. NOVITZKY D, COOPER DKC, HUMAN PA, REICHART B, ZUHDI N. Triiodothyronine therapy for heart donor and recipient. J Heart Transplant 7:370-376, 1988.

87. ROSE AG, NOVITZKY D, PRICE SK. Heterotopic thyroid tissue in the heart.Am J of Cardiovasc Pathol 1:401-404, 1988.

88 Hermann Reichenspurner, MD, John A. Odell, MB, ChB, David K.C. Cooper, MD, DIMITRI NOVITZKY, MD, Alan G. Rose, MB, ChB, Werner Klinner, MD, and Bruno Reichart, MD. Initial Experience with Heart and Lung Transplantation. Tex Heart Inst J. 1988; 15(1): 3a"6

89 NOVITZKY D, HUMAN PA, COOPER DKC. Effect of triiodothyronine (T3) on myocardial high-energy phosphates and lactates following ischemia and cardiopulmonary bypass - An experimental study in baboons. J Thorac Cardiovasc Surg 96:600-607,

1988.

90 NOVITZKY D, COOPER DKC. The physiological management of cardiac transplant donors and recipients using triiodothyronine (T3). Presented as a poster at theInternational Organ Transplant Forum in honor of Dr. T.E. Starzl, Pittsburgh, 1987. Transplant Proc 20:

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