Caltech Coursera - Drugs&Brain_report_posting 8 Feb 2013

7/29/2019 Caltech Coursera - Drugs&Brain_report_posting 8 Feb 2013

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Drugs and the Brain on Coursera

(December 2012 J anuary 2013, including 2-week break)

Report as of 8 February 2013

2012 California Institute of Technology

ays a er e ea ne or e as quz

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Initial weeks: concepts and tools

miniLectures 1-12: Introduction to neuroscience,drugs as chemicals with access to the brain,

receptors as proteins,proteins as possible drugs,

study of the nervous system,dose-response relations, and electrophysiology

Week 2 Drugs Activate & Block Ion Channels (mL 13 -16)

SynapsesNa+ K+

Week 2 Drugs Act on G protein pathways (mL 17 -21)G

Week 3: Drugs Act on Transporters (mL 22, 23)

E

Week 3 Recreational Drugs (mL 24-26)

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Later weeks: neural diseases

Omitted:

opioid addiction, cocaine addiction, alcohol addiction

Week 4: Drugs for Neurodegenerative DiseasesAlzheimers (mL 32 -34)

Parkinsons (35 -39)

M3-M4 loop

H+ +

BiP

Omitted: amyotrophic lateral sclerosisPERK

IRE1

Week 5: Drugs for Psychiatric DiseasesMajor Depressive Disorder (mL 40-44)

Bipolar Disorder (mL 45-47)

-Omitted:

anxiety disorder, borderline personality disorder

Other omissions: migraine, details on epilepsy 3


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Instructional materials

52 miniLectures10 hours 3 minutes of total material

~60 GB of raw recordings, including WebcamTotal of ~ 420 Powerpoint slidesEach miniLecture has 2 3 embedded questions

ac o e ve wee s as one s an a one quz, ~ ques ons.Estimated work load, 4-6 h/wk

Overall, equivalent to ~ 4 Caltech units.

Recommended textbook(Nestler, Hyman & Malenka Molecular Neuropharmacology)

,

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Summary numbers of students

4450 students took all 5 quizzes with a passing grade ( > 70%) and will receiveStatements of Accomplishment

9100 students logged in to the Web site in a typical week during the 2nd half

64,000 remained registered during the final week of lectures,67,800 registered at the peak

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40%

30%

35%egreesearne y u e n s

(some students may have interpreted the question, highest degree earned)

20%

25%

Ages: 13 to 83

10%

15%

fellowships or grants fromscientific or medical

agencies

0%


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Argentina

0.3%

Bangladesh

0.3%

Bosnia&Herzegovina0.1%

Belgium

0.3% Belarus

0.3% Bulgaria

0.5%

China

CostaRica0.2%

Croatia

0.6%

Taiwan

Romania

1.2%

Thailand

0.2% Egypt

0.6%

Malaysia

0.6%

>75Countries

Australia

2.9%Brazil

5.2%

Cambodia

0.0%

Canada

3.8%

0.6%

Colombia

1.4%

Cyprus

0.1%

CzechRepublic

Slovakia

0.3%

SouthAfrica0.5%

Switzerland

0.2%

Spain

6.2%

.notlisted

5.4%

0.7%Denmark

0.2%

Ecuador

0.2%France

1.2%Germany

Venezuela

0.2%

Russia

3.0%

Singapore

1.9%

2.6%1.8%

HongKongSAR0.8%

Hungary

0.3%India

3.9%

Indonesia

0.3%

Iran

0.3%Ireland

0.5%Israel

0.4%

Italy

1.2%

Japan

0.3%

Macedonia

0.2%

ex co

1.7%

Netherlands

1.1%

New Zealand0.5%

Pakistan

0.6%Peru

0.5%

Portugal

2.8%

USA

31.9%

0.8%Poland

1.2%

Se r a

0.6%

Sweden0.2%

Switzerland

0.3%

Turkey

0.5%Ukraine

0.8%

UK

4.9%


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10,000

15,000

ingquiz Students submitting quizzes

5,000

ntssubmit

0

1 2 3 4 5Stude

Quiz #

30,000

35,000

,

rs

Students viewing video miniLectures

15,000

20,000

25,000

iqueviewe

4450 passed5,000

10,000U

8

0 10 20 30 40 50 60

miniLecture #


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Grades

Statistic # of students

Total users graded 61,120

Users who meet distinction criteria (>99% score) 1140

Users who meet normal criteria 3310

Users who did not meet any criteria 56,695

Pass

100%

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Communications

920,000 individual views of the miniLectures~ 1014 bytes streamed

25,420 unique users submitted embedded video quizzes,6. .

Discussion forums, a vibrant online community:Study groups in 20 countries & 13 languages;Fact -checking (mistakes) in lectures;Technical problems;

General discussion on lectures & materials;Quiz feedback. Self-policing on revealing answers;Molecular modeling software.

1049 threads,

o a pos s2136 unique users174,000 total views

Students organized a Facebook group and a Twitter feed

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Connection with Bi/CNS 150, Introduction to Neuroscience.Henry Lester and Ralph Adolphs

Route to Bi/CNS 150 extra credit:

a. Enroll for the course.

c. Pass the course. Should be quite easy.

d. Contribute to the forums with technical and scientific explanations.

. .

Result: at least 1/3 grade (i. e., B+ to A-). Retroactive, will not destroy the curve.

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Documents

Caltech Coursera - Drugs&Brain_report_posting 8 Feb 2013