By Matthew Morgan, Andrew Lomanto, Taylor Stauffer

Cystic Fibrosis

http://www.kiwifamilies.co.nz/Topics/Support+Groups/Illness/Cystic+Fibrosis.html

What is Cystic Fibrosis

-A hereditary disorder

-Makes glands secrete a sticky mucus which clods the pancreas, liver, and intestines .

-Infection of the lungs

http://www.nlm.nih.gov/medlineplus/ency/imagepages/18135.htm

Cystic Fibrosis Inheritance

Both parents can carry the geneOccurs right after birthChild has 25% chance of getting Cystic

Fibrosis if both parents are heterozygous carriers and 50% of being a carrier

Abnormal recessive geneBoth parents need to be carriers in order

for the off spring to inherit Cystic Fibrosis

Cystic Fibrosis Inheritance Punnet Square

http://www.csupomona.edu/~biology/bio110/inherit/genes.html

Cystic Fibrosis Frequency

1/25 of all Caucasians carry this disease

http://www.greatstrides.com.au/images/nebulisertreatment.jpg

http://breathe4tomorrow.org/wp-content/uploads/2008/12/alexus.jpg

Symptoms and Effects

- Very salty skin- Frequent coughing- Wheezing- Impaired growth (due to lack of

nutrition) - Greasy feces

Symptoms Effects

-Because of sticky mucus, the pancreas is clogged, which impairs digestive enzyme flow to intestines, which minimizes the patient, potential to digest food and harvest nutrients-Sticky mucus also creates a layer around the lungs makes it harder for patient to breath, especially during cardio activates -Average life expectancy of persons with Cystic Fibrosis: about 30 years

http://www.exposay.com/weeman-the-world-premiere-of-jackass-number-two/p/4630/65/

How is it Diagnosed?Usually discovered in early childhoodSimple procedure, where the patient is

tested for excessive levels of sodium chloride in their sweat

http://www.baynews9.com/article/news/2011/january/192524/New-hope-for-people-living-with-cystic-fibrosis

How is this Disease Treated?It is possible to extract the pancreas, to

overcome the lack of digestive enzyme flowDaily back slapping is in order, because it

helps break up the mucus. Gene Therapy- It is possible to inject a

normal, healthier gene into the patient. This therapy has had high hopes from scientists, but has shown no positive results yet.

Currently, there are a few known antibiotics that have proven to increase one’s life expectancy

Is There a Cure?

There is no known cure, but scientists everywhere are striving to produce one for this disease. There is a foundation for this disease, which raises money for aid to the current patients, and for finding a cure in the near future

SMaRT TherapyA type of gene therapy, which takes

advantage of the need to remove introns. This makes a functional mrna, so genes will continue to reduce possibility of the patient’s child getting the disease

Works Consulted “About Cystic Fibrosis.” Cystic Fibrosis Foundation. Cystic Fibrosis Foundation,

n.d. Web. 28 Jan. 2011. <http://www.cff.org//>.

“Cystic Fibrosis.” Encyclopedia of Genetics. Ed. Don P. Dawson. Vol. 1. Pasadena, CA: Salem Press Inc., 2004. 195-198. Print.

“Cystic Fibrosis.” Genetic Science Learning Center. Learn Genetics , 28 Jan. 2011. Web. 28 Jan. 2011. <http://learn.genetics.utah.edu/////ex.html>.

Jacoby, David R., and Robert M. Youngson. “Cystic Fibrosis.” Encyclopedia of Famliy Health. Ed. Joyce Tavolacci. Vol. 4. Tarrytown, NY: Marshall Cavendish, 2005. 448. Print.

“What is Cystic Fibrosis.” TOBI. TOBI, 2011. Web. 28 Jan. 2011. <http://www.tobitime.com/// cystic_fibrosis.jsp?utm_medium=cpc&utm_content=about+cystic+fibrosis&utm_source=MSN&utm_campaign=Tobi_Unbr anded_2.25.10>.