By: Kristin IzzoPreceptors:Elizabeth Koustis, MS, RDPamela Jessup, MS, RD

WADE PARK NUTRITION CLINIC

Askari, F., Rashidkhani, B., Hekmatdoost, A. Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patients. Nutrition Research. 2014; 34:143-148.

CITATION

What do we know about Cinnamon?Previous research - Type 2 Diabetes

Insulin resistance, HbA1c, FBG, lipid profiles3

Supplementation daily of 1g, 1.5g, and 6g 2,3,4

NAFLDHighest cause for hepatic injuryCurrent therapies: alter insulin resistance and reduce oxidative stress

BACKGROUND

Typical therapy includes:1. Modulating insulin resistance2. Reducing oxidative stress

Goal:Determine if daily supplementation of 1.5g of cinnamon will provide therapeutic effects NAFLD characteristics?

OBJECTIVE

Randomized double blinded, placebo-controlled trial

Two parallel groupsControl and treatment

SupplementsPrepared by third party

Cinnamon v wheat flour

DESIGN

Inclusion:NAFLD diagnosis past 6 months50 patients enrolled

Ages 20-65Exclusion:

Alcohol or drug abuse, chemotherapy, other liver disease, biliary disease, autoimmune disease, cancer, pregnant/lactating, diabetic, metformin, hyperlipidemia, HTN, Vit E, or use of hepatotoxic drugs last 6 months

Tehran, Iran

PARTICIPANTS/SETTING

GroupsTreatment:

Cinnamon capsules at 750mg each x2/day Control:

Placebo x2/dayTime Period

12 weeks

INTERVENTION

Blood Sampling – at baseline and 12 weeksFBG, serum insulin, insulin resistance and sensitivity

Lipid ProfileLiver EnzymesHs-CRP

AnthropometricsDiet and physical activity survey

MEASURES

Nutritionist 4 software Dietary information

SPSS software Qualitative and quantitative data

Student’s and paired t-tests Compare variables between the groups

ANCOVA Eliminate confounding factors

Sample size Power of 80%, calculated 21 patients

P < 0.05 => statistical significance

STATISTICAL ANALYSIS

RESULTS

P <0.05

After 12 weeks of 1.5g supplementation/day… Cinnamon exhibited an effect on reducing insulin

resistance and positively modified lipid profile.

CONCLUSIONS

Go Cinnamon!

What do we tell the Veterans? Not a cure Implement gradually to avoid risk of unknown adverse

effects Affordable

Home spice v supplementFor RDs

Listen to our patients Maintain current understanding of hot topics

PRACTICAL APPLICATION

1. Askari, F., Rashidkhani, B., Hekmatdoost, A. Cinnamon may have therapeutic benefits on l ipid profile, l iver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty l iver disease patients. Nutrition Research . 2014; 34:143-148.

2. Crawford, P. Effectiveness of Cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22(5):507-12

3. Jamal, AR. Effects of cinnamon on blood glucose and lipids levels in diabetic patients (Type1). Afr J Biochem Res 2009;3(5):181-4

4. Vanschoonbeek, K. et al. Cinnamon supplementation does improve glycemic control in postmenopausal type 2 diabetes patients. J Nutr 2006;136(4):977-80

REFERENCES