PAS600: De-risking

biobased products

and technologies

Dan NoakesBusiness Development Manager

CPI

CPI believe in...

Better ...

use of resources and proliferation of bio-based products to stimulate economies and mitigate climate impact.

Innovating...

cleaner, greener, faster, more efficient processes.

Supporting...

enabling technologies to underpin scientific innovation critical to the future success of industrial biotechnology.

‘Valley of Death’: de-risking investment

National Composite Centre

Manufacturing

Technology Centre

Advanced

Manufacturing

Research Centre

Nuclear Advanced

Manufacturing Research

Centre

Warwick

Manufacturing

Group

CPI

Advanced forming

research centre

Funding

BIOPHARMA

FO

RM

ULA

TIO

N

INDUSTRIAL

BIOTECHNOLOGY

BIOENERGY &

BIOREFINERY

INC

RE

AS

ING

CO

ST

RAW

MATERIALS

INT

PROD

CONS

PROD

CPI: Inter/Intra -relationships…

Areas of

technology

overlap

Biomass

Biomass Waste

FEEDSTOCK

Oil, Gas

Chemical Waste

Biocatalysis

Fermentation

PROCESS

Catalysis

Thermal

Green Novel

Green Existing

PRODUCT

Novel

Existing

INDUSTRIAL

BIOTECHNOLOGY

BIOENERGY &

BIOREFINERY

• Alignment to the concept of ‘integrated-

biorefining’ as set out in the SET-plan, EIBI,

Horizon 2020, BRIDGE-PPP and National

Programs.

• Capability to effectively identify and address

bottlenecks to commercialising next generation

products and processes.

CPI will...Align...

technical resource to meet Client needs

Identify...

critical pathways to commercial success

De-risk...

technologies through sound commercial and technical evaluation

CPI technology flow

(Coupled Flow – High value proposition)

Feasibility/POC

Efficient Process

Development

(Tools, enablers &

methodologies)

De-risked

Demonstration at

Scale

(utilising scaled assets)

Manufacturing

CORE SKILLS &

EXPERTISE

CORE

COMPETENCIES

CENTRE FOR PROCESS INNOVATION EARLY STAGE

CLIENTS

LATE STAGE

CLIENTS

CAPITAL

ASSETS

Commercial:

towards success, overcoming barriers

• Scale and reward vs staged investment

• Competitive/eff product – price, capital/energy/carbon

• Market size, dynamics, potential impact

• Regulatory and political landscape – fighting with or against

• Raw material security and stable prices – decouple from oil?

• Certification/labelling/regulator approval – particually for GMO or waste

• Investment risk and future proofing

• Funding R&D to address known knowns/unknowns

Techno-Economics

critical path to optimised, robust business model

• Product vs price point vs purity

• Yield conversion vs process design

optimise pre-processing, Synbio, intensification

• Product vs cost efficient downstream processing

• Waste reduction, secondary products and recycle streams

• Feedstock flexibility and energy self sufficient

• Product quality/repeatability

• Technology robustness and downtime

• Emissions – carbon, odour, effluent

Development Laboratories

DSP matched to plant

scale up units

Up to 15 litre working

volume

Supporting analytical

capability

Chemistry, molecular

biology and process

testing

Pilot Facility

• 10L, 20L, 50L, 750 L fermenters

• Downstream processing

•‘Plug and play’ process

• Solvent suit

Demonstration facility

•‘Plug and play’ process

• Solvent suit

•Continuous distillation

• Wet/dry biomass pre-treatment

• 10,000 L fermenter

• Downstream processing

CPI wish to...

Promote...

better products not from fossil-oil and affordable energy security using alternative feedstocks

Facilitate...

commercialisation of biobased products and integrated technologies for efficient use of resources

Create...

wealth, jobs and inward UK investment.

Platforms to bio-products

• CPI is focusing towards three core capabilities:

‒ Generation of sugars for delivery into fermentation (1)*

‒ Generation of C1 gas for delivery into fermentation (2)*

‒ Fractionation and extraction of products from raw materials

*Includes anaerobic digestion and thermal processing as

part of a bio-refinery model

CPI: De-risking capability

• Program scoping and planning (Roadmapping)

• Engagement of key collaborators in the supply chain

• Process modelling and simulation

• Commercial and techno-economic evaluation

• Gap and risk analysis and mitigation

• life cycle analysis

• Scaled down and scale-up process development and demonstration

Thank you

…questions?