BURDEN OF DISEASE IN PATIENTS WITH MENOPAUSE IN BRAZIL: RESULTS FROM 2011 NATIONAL HEALTH AND WELLNESS SURVEY (NHWS)

Mould JF1, Fujii RK2, Boulos FC2, Pomerantz D3, Chapnick J3, Sternbach N4, Manfrin DF2

1) Pfizer, Inc., São Paulo, SP, Brazil; 2) Pfizer, Inc., New York, NY, USA3) Kantar Health, Princeton, NJ, USA; 4) Kantar Health, New York, NY, USA

ConclusionsResults from the Brazil NHWS indicate women currentlyexperiencing symptoms of menopause suffer fromimpairment in QOL, work/productivity loss , greater usage ofhealthcare resources and more co-morbidities.Findings indicate there is still an unmet medical need inmenopause patients in Brazil.

References1. brazil.org, Available at: http://www.brazil.org.uk/resources/documents/bs-primary03.pdf; Accessed: 22nd of December

2011. 2. Brazil Demographics profile 2011. Available at: http://www.indexmundi.com/brazil/demographics_profile.html;

Accessed: 22nd of December 2011. 3. Knebel, Patricia for Inforsurhoy, Brazil: The young country is aging. Available at:

http://www.infosurhoy.com/cocoon/saii/xhtml/en_GB/features/saii/features/society/2011/02/23/feature-02; Accessed: 21st of December 2011.

4. imsociety.org, What is Menopause, page 2. Available at: http://www.imsociety.org/downloads/world_menopause_day_2011/gp_booklet_english.pdf; Accessed: 22nd of December 2011.

5. Pinho Neto, Professor João Sabino, Chairman of Department of Gynecology of Federal University of Pernambuco, Brazil, Menopause Perspectives Around The World. Available at: http://www.imsociety.org/menopause_perspectives_around_the_world.php; Accessed: 22nd of December 2011.

6. Kantar Health. December 2011. NATIONAL HEALTH AND WELLNESS SURVEY, 2011 [US]. Princeton, NJ.

IntroductionBrazil is said to be the fifth most populous nation worldwide,with slightly more than one-half of Brazilian adults beingwomen1.One source estimates that the total population will continueto grow at a rate of 1.134% annually2. According to aNational Survey by Household Sampling (PNAD – 2009), theelderly population is growing at nearly triple the rate ofBrazil‘s overall population3. The shift in the average age ofthe Brazilian population is due to a combination of factors: adrop in the annual number of births and various advances inmedicines that help Brazilians live longer.The International Menopause Society (IM Society) states thatmost women become menopausal between the ages of 45and 55 years, with the average age of onset close to 50years4. According to the Brazilian Institute of Geography andStatistics, almost 25% of the Brazilian female population is45 years old or older5.Considering this conditions and estimates, the number ofwomen experiencing menopause is expected to rise aspopulation of Brazil ages and people live longer.

MethodsA total of 12,000 individuals’ (age 18+) self-reported datawere collected from 2011 National Health and WellnessSurvey (NHWS) in Brazil6. QOL was measured by the physicalcomponent score (PCS) and mental component score (MCS)of the Short Form-12 (SF-12) (mean score of 47.2 for generalpopulation). Loss of work/productivity was measured by thevalidated Work Productivity and Activity Impairmentinstrument. Medical resource utilization was measured byhealthcare provider, emergency room visits andhospitalization in the past 6 months.

ObjectivesThis study is aimed to assess co-morbidity, quality of life(QOL), work/productivity loss, and medical resourceutilization in patients with menopause symptoms in Brazil.

ResultsAmong all women, 825 (13.7%) had completed menopauseand 1,016 (16.9%) were currently experiencing symptoms ofmenopause. Average age for women currently experiencingsymptoms of menopause was 49.6 years. Compared to thenon-menopause group, those experiencing symptomsreported more co-morbidities (sleep difficulties 35%,insomnia 33%, depression 29%, high blood pressure 25%,high cholesterol 22%, arrhythmia/cardiac arrhythmia 17%),lower mean PCS scores (47.3 vs. 50.3), more patients visitedgeneral practitioners (56% vs. 49%), and higher meannumber of visits (5.9 vs. 5.1) were observed over the past 6months. Furthermore, those experiencing menopausesymptoms reported greater impairment in daily activity(28%) compared to the non-menopause group (22.7%). Allcomparisons were statistically significant at p< 0.05.

Completed Menopause9.7 M (14%)

(n=825) Currently Experiencing Symptoms of Menopause

11.9 M (17%)(n=1,016)

Total Brazil AdultWomen70.7 M

(n=6,017)

Non-Menopausal 44.9 M (63%)

(n=3,824)

6% of women are not included in this analysis due to being Non-Menopausal & Age 65 + OR Post-Menopausal & Age Less than 40

47,3

56,0

5,9

28,0

50,349,0

5,1

22,7

0,0

10,0

20,0

30,0

40,0

50,0

60,0

PCS scores Visits to general practitioners

Mean number of visits Impairment in daily activity

Comparison between experiencing menopause symptoms groupd and Non-menopause group

Non-menopause group Experiencing menopause symptoms group

p<0.05