btm.gujarat.gov.inhuman protein manufactured in bacteria by Genentech, In c. A synthetic, recombinant gene was used to clone a protein for the first time. 1978 Genentech, Inc. and

Editorial Message

Creation of wealth capital, human resource, employment generation, are, natural and much needed output from any sector. The societal relevance of Biotechnology can be realized if new products and technologies are driven by engine of business, and made available to human society.

Growth of sector is measured by business intensity. And investment and turn overs are barometer of business. And lot is happening in Gujarat in Biotechnology!

The state is witnessing promising growth, in terms of number of new Biotech companies, higher scale of investments and of course, notable contributions to overall Biotech turn over. Recent event of Vibrant Gujarat - Global investor summit 2013, provided a reflection of the same. Nearly 72 MoUs were signed by industries, covering various sectors. It included strategic partnership as well.

The continuing trend of investment in biotechnology sector in 2013, confirms the gradual emergence of Gujarat, as important destination for Biotech investment. Despite the global slowdown, commissioning of 38 biotech projects, with completed investment of Rs. 1457 crores, committed investment of Rs. 270 crores in 46 ongoing projects, provides a promising sign of growth of biotech business in Gujarat. This growth has provided additional employment to 1570 technical people.

It is time to sit up and take note. It is also the time to ponder and prepare ourselves to sustain this growth and even better it.

Akshay K. Saxena, IFS Mission Director GSBTM

Research Centre Food Testing Laboratory JAU JUNAGADH

National level food adulteration, quality testing and research facility of JAU Food Testing Laboratory at Junagadh Agricultural University (JAU), Junagadh (Gujarat) is serving community by doing quality work in the fields of food quality. This facility is a joint venture of JAU, Ministry of Food Processing Industries (MFPI), ICAR (New Delhi) and Gujarat Agro Industries Corporation with Good Laboratory Practice - GLP standards and has been accredited by the National Accreditation Board for Testing Calibration Laboratories (NABL).

This laboratory is providing professional interface to public and private sectors. In a due period of time this laboratory has become an authentic agency for Quality Control (QC)/ Quality Assurance (QA). It was established with objectives to meet food Quality Control for fresh farm product, processed food, organic products, Genetically Modified (GM) foods, packed food certification, COA report for the export of farm products, detect the food adulterations, an assay of food toxins and to provide analytical backup to the research related to food and agricultural sciences.

Farmers, traders, industrialists and those carrying out agriculture related activities are expected to get international level benefit from this laboratory

facilities which conducts tests and analysis on various parameters of all types of food items and analysis of agricultural products.

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Different cells of Food Testing Laboratory Separation Cell for extraction and purification of phytochemicals from agricultural plant and herb samples including Amino acid profiling, solvent extraction, caffeine determination, impurity profiling, Histamine estimation, oil extraction, percent salt determination, estimation of volatile components, Alcohol estimation, freeze drying of different components, separation and estimation of organic components. This cell is facilitated by instrumentation like Scoville heat unit, surface plasmon resonance, Protein scanner, HPLC, Solvent extractor, Spot picker and Digester and Glutein analyser. GFQC Cell to provide professional service of Quality Control & Quality Assurance to help and promote Agri-product export through analytical balkne and providing analytical support to agro processing industries. Services includes analysis of texture, adulteration, animal feed, allergens testing, Vitamins, grain and gram products, dairy and milk product, flour and baking products, Fats and Oils, Proximate, Molasses products, spices, oilseeds and oilseed products, meat and poultry products and dietary supplements.

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Microbial Cell, similar to GSFQ cell, having excellent facilities of Scanning Electron Microscope (SEM), Micro-manipulator, Flow-Cytometer, BOD Analyser, Laminar Air Flow, Lyophilizer to provide professional services for identification and mass production of beneficial microorganisms, production and isolation of useful metabolites and other component through mass producing microbes, qualitative and quantitative estimation of surface microbes present on fruits, vegetables and soil, development of efficient strain for production of Bio fertilizer, Bio pesticides, various enzymes, antibiotics, vitamins, to develop new method for eradication of microbes present on surface of food and developing the easy and rapid method for detection and quantification of toxin present in food which causes food borne diseases. Element Cell targeting fruitfulness of soil and safety of water. The services includes qualitative and quantitative analysis of soil for different elements as well as water for different pesticide residues, different types of elements and also analysis of fertilizer and manure. Facilities includes ICPMS, XRF, and FTIR, CHNS analyser, Micro kjeldahl unit and VA analyser. Biotech Cell targeting Genetic manipulation of crops for stress resistance, Molecular level interventions in functional genes for quality improvement, Modification of metabolic pathways for useful secondary metabolites, GMO’s for important phytochemicals, bio-diesels & natural pigments. Services of this cell includes Isolation and purification of DNA and RNA, Phylogenetic analysis through molecular marker, Total DNA isolation from soil and water, Gene sequencing, ELISA test for mycotoxin, ELISA test for GMO’s, PCR based analysis for GMO’s, Genotypic barcoding, Regulation of gene expression, Operating and manipulation at individual microbes at different level for various aspects by micromanipulator. Adorned with Whole genome sequencer, Genome sequencer, Capillary sequencer, Micro manipulator, Capillary electrophoresis, RT PCR. MS/MS Cell promote agricultural export, organic farming, Food safety and natural resource management with LCMS, GCMS facilities. Services includes trace level determination of pesticide in food, feed, agricultural products and inputs, natural resource i.e. soil, water and air appraisal for pesticides, organic farm product testing, trace level appraisal of heavy metals and other toxic elements, food profiling (determination of residual pesticide in foods).

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Nanotech Cell focuses on nanotechnology in marine products like imparting nanomolecules for disease diagnosis, fertility improvement through nanoenzymology, yield improvement through nano-neutraceutical delivery, nanotechnology in post-harvest technology including control of Carbon Monoxide (CO), Carbon Dioxide (CO2) in fermented food, contamination indicators by nanosensors, Nano-silicon films in packaging Bioananlytical nanobiosensors like early disease diagnosis, Early plant nutrient deficiency diagnosis, Nutrient bioavailability diagnosis and toxin diagnosis. Proteomics Cell’s primary objective is proteomics study translating genome information into useful biological insight, to find better solutions for challenges in food production, medicine and environmental management. Protein separation, identification, quantification, sequence analysis and Protein modification are the services provided by this cell.

Training Cell provides vocational and regular training, project work up to Post Graduation (PG) level studies as well as training to professionals and Government nominees. Key features of the training courses are DNA isolation, purification and quantification from plant, application of markers in Agriculture and Marker Assisted selection, Gene Sequencing, disease diagnosis, Gene cloning, Plant transformation, Genotyping, Gene Expression Profiling, Microbial Biotechnology and Genome informatics.

1977

The Age of biotechnology arrives with "somatostatin" - a human growth hormone-releasing inhibitory factor, the first human protein manufactured in bacteria by Genentech, Inc. A synthetic, recombinant gene was used to clone a protein for the first time.

1978

Genentech, Inc. and The City of Hope National Medical Center announce the successful laboratory production of human insulin using recombinant DNA technology. Hutchinson and Edgell show it is possible to introduce specific mutations at specific sites in a DNA molecule.

1979

Sir Walter Bodmer suggests a way of using DNA technology to find gene markers to show up specific genetic diseases and their carriers. John Baxter reports cloning the gene for human growth hormone.

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Once upon a time in Biotechnology

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Techno Views DSIR- Department of scientific and industrial research

Encouraging Biotechnology research in private industries Establishing DSIR recognized research facilities: An eligibility and gateway for funding

INTRODUCTION

Biotech business is driven by industries. The number and size of industries govern the industrial output and industrial growth. The size of industry also follows a evolutionary pathway. Every industry starts as small unit and gradually expands, on the strength of its product and business strategy.

BIOTECHNOLOGY INDUSTRIES: RESEARCH AND INNOVATION DRIVEN

Biotechnology industries are capital intensive and research driven. Innovations in product development, processes, technology, refining the existing procedures, can lead to multiplier effect. However, Biotech research is costly and capital intensive. At the same time, it is required to give cutting edge options. Hence R & D is must for every biotechnology company. While big cash rich companies, have sufficient resources and especially dedicated funds for undertaking research, the problem, lies with small and medium scale companies who do not have financial resources for investing in research.

SMALL AND MEDIUM SCALE INDUSTRIES: PART OF VALUE CHAIN

In the pyramid of industries, the large base is constituted by small and medium scale industries. The large base provides probabilities of evolution of smaller companies to grow into bigger ones. The large base also provides big service base to bigger industries. It also provides options and large scale collaborations for various set of roles. It forms essential part of value chain.

RELEVANCE OF RESEARCH FOR SMALL AND MEDIUM SCALE BIOTECH INDUSTRIES

Big industries have resources for manufacturing, production, marketing etc. and small / medium companies cannot compete with them. Hence innovation and research, niche areas, are key for these industries. This also provides business models for them wherein product/ technology, processes developed can be used for revenue flow through technology selling, licencing and collaborative or business partnership etc. For small and medium scale companies, research can provide access to new products, processes, which it can sell or produce at any stage of development depending upon its business strategy or product value.

ISSUES FOR INVESTMENT IN RESEARCH

However, research in biotechnology is capital intensive, time taking and high risk and is not always a bankable project. Capital availability becomes the issue and small and medium industries, with this crunch do not invest in research though they are keen and need for their business sustenance. Government realizes the position of small and medium scale industries in value chain. Government also realizes that innovation and research by industries, is suffering due to these reasons.

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GOVERNMENT SUPPORT FOR FACILITATING RESEARCH IN PRIVATE INDUSTRIES

The innovation driven biotech sector needs essential investment and pursuit of research & developmental activities. To enable private industries, to undertake research& development, government is providing easy capital availability through various programs. These include SBIRI, BIG, TDB, and NMTILI. This support is provided by DST, DBT, ICAR, TDB, and various other organizations. The support includes in the form of grant, loan, rebate, exemptions. These programs provide financial support for undertaking research independently, or in partnership with academic institutes, developing proof of concept, validating proof of concept, pilot level scaling up. It also supports developing ancillary research infrastructure (equipment), by providing exemption in customs and excise duties. It also provides rebate on investment done in research by providing income tax concession. In brief it provides big spectrum of financial support needed at various stages of application based research.

DSIR RECOGNIZED RESEARCH CENTERS: AN ELIGIBILITY FOR FINANCIAL SUPPORT

However, to seek the advantage of all such schemes and programs, essential eligibility is to establish research facilities and seek recognition from department of Scientific and industrial research (DSIR). Presently 59 industries are having DSIR recognized centres in Gujarat.

RELEVANCE OF THIS PROGRAM FOR GUJARAT BIOTECH INDUSTRIES

Gujarat has are number of small and medium scale industries in biotech sector. Many new start-ups have been added. These units need to be innovation and research driven. And this is possible if these units undertake dedicated research, for incremental improvement, new product, new process development, innovative product etc. And this can be possible by taking maximum advantage of funds which are available under various central government schemes / programs.

It is in this respect that small and medium scale industries can take the advantage of this fund availability. However, the first and foremost step is to seek DSIR recognition.

GSBTM: A FACILITATING AGENCY

GSBTM, is state nodal agency. It has mandate for promoting the development of biotechnology in the state. It is working on key enabling factors of biotechnology- Policy development, developing research and business infrastructure, supporting research and innovation, Human resource development, developing biotechnology business and entrepreneurship, networking, awareness generation and information dissemination. GSBTM has been addressing each of this issue through specific program and initiative. Apart from supporting through state level program, GSBTM is also playing facilitation role by enabling the stakeholder with information about policy, program and financial support available at national level.

DEVELOPING RESEARCH CULTURE IN BIOTECH INDUSTRIES FOR GUJARAT

Biotech business sector will be driven by small and medium scale industries through application based research. And hence to facilitate research in biotech industries of Gujarat, GSBTM is

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facilitating through key interventions. Encouraging the biotech industries of Gujarat, to establish research facilities, duly recognized by DSIR, GoI, is essential and first step in this direction. This will provide access to national funding for undertaking research by biotech industries of Gujarat. This has to be followed by developing high quality application based innovative projects which can develop a pipeline of products / process/ technologies for small scale and medium scale industries in life science & biotechnology. The ultimate aim is to develop research culture and base in small and medium scale biotech industries which can be source and platform for new business, revenue models and partnerships and growth of the sector.

MAIN FEATURES OF DSIR SCHEME

The Department of Scientific & Industrial Research (DSIR) is operating a scheme for granting recognition & registration to in-house R&D units established by corporate industry. Companies seeking recognition to their in-house R&D units should be engaged in manufacture or production or in rendering technical services. Companies engaged in contract research and also those engaged in research only at present but have plans to start manufacture at a later date are also eligible for the recognition.

The department provides, on a selective basis, partial financial support in the form of grants-in-aid to research, development, design and engineering of the small and medium scale industry. The primary endeavour of DSIR is to promote R&D by the industries, support a larger cross section of small and medium industrial units to develop state-of-the art globally competitive technologies of high commercial potential, catalyze faster commercialization of lab-scale R&D, strengthen industrial consultancy & technology management capabilities and establish user friendly information network to facilitate scientific and industrial research in the country.

The in-house R&D units applying for recognition to DSIR are expected to be engaged in innovative research & development activities related to the line of business of the firm, such as, development of new technologies, design & engineering, process/product/design improvements, developing new methods of analysis & testing; research for increased efficiency in use of resources, such as, capital equipment, materials & energy; pollution control, effluent treatment & recycling of waste products or any other areas of research.

FISCAL INCENTIVES AND SUPPORT MEASURES

There are number of fiscal incentives and other support measures aimed at promoting R&D in industry and also at encouraging the utilisation of locally available R&D options for industrial development. Some of them are as follows:

• 100% write off of revenue expenditure on R&D; (Section 35(1)(i) of IT Act). • 100% write off of capital expenditure on R&D in the year the expenditure is incurred ;( Section

35(1) (iv) of IT Act). • Weighted tax deduction @175% (to the sponsor) for payments made to approved national

laboratories, universities and IITs or a specified person, with a specific direction that the said sum shall be used for scientific research under a programme. (Section 35(2AA) of the IT Act).

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• Weighted tax deduction @200% on expenditure (other than land & buildings) incurred on approved in-house R&D facilities of companies engaged in the business of bio-technology or in any business of manufacture or production of any article or thing, not being an article or thing specified in the list of the Eleventh Schedule. [Expenditure on scientific research in relation to drugs and pharmaceuticals, includes expenditure incurred on clinical drug trials, obtaining approvals from any regulatory authority under any Central, State or Provincial Act and filing an application for a patent under the Patents Act, 1970 (39 of 1970). (Section 35(2AB) of the IT Act.)]

• Accelerated depreciation allowance for investment on plant and machinery, made on the basis of indigenous technology (Rule 5(2) of IT Rules, 1962). INCENTIVES BASED ON INDIRECT TAXES

• Customs duty exemption to in-house R&D units established by corporate companies, other than a Hospital for capital equipment and consumables needed for R&D. (Notification No.24/2007-customs, dated 01 March, 2007 as amended from time to time).

• Central excise duty exemption to in-house R&D units established by corporate companies, other than a Hospital for capital equipment and consumables needed for R&D. (Notification No.16/2007-central excise, dated 01 March, 2007 as amended from time to time).

• Central excise duty waiver for 3 years on goods designed and developed by a wholly owned Indian company and patented in any two countries out of: India, USA, Japan and any one country of European Union (Notification No.15/96-CE dated July 23, 1996, amended vide Notification No.13/99-CE dated 28 February, 1999).

• Exemption from customs duty on imports made for R&D projects funded byGovernment in industry. (Notification No.50/96-Customs dated 23 July 1996).

• Goods specified in List-28 (comprising of analytical and specialty equipment) for use in pharmaceutical and biotechnology sector allowed to be imported duty free {notification No. 26/2003-Customs dated 1 March 2003 (entry substituted at S. No. 248 of the table in the said notification)} Subject to conditions mentioned in the notifications. LIKELY OUTCOME

Having DSIR recognized research facilities in private industries, provides access to funding for research to private industries, by different department of Government of India like department of Science & technology (DST), Department of Biotechnology (DBT), Agriculture department and their various organizations- Indian Council of Agriculture Research (ICAR), Indian Council of medical research (ICMR), Technology Development Board (TDB), through their various ongoing schemes.

GSBTM

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Bio Entrepreneur Mr. Janak Sheth

Mr. Janak Sheth Managing Director Century Pharmaceuticals Ltd 406, World Trade Center, Sayajiganj, Vadodara, India Phone No. : +91-0265-2361581 / 2361978 / 2362509 Email Id : [email protected]; [email protected] Websites : www.centurypharma.com;

www.centurypharmavadodara.com Century Pharmaceuticals Limited is a Bulk Drug Manufacturing Plant was set up in the year 1980 at GIDC Halol, Gujarat, India. Currently we are manufacturing API’s such as Oxytetracycline Salts, Chloramphenicol Salts, Erythromycin Salts, Acenocoumarol, Fluticasone Propionate and Fluphenazine Deaconate. Plant was ISO-2008 certified unit and upgraded to meet with USFDA requirements. We are engaged both in domestic and export market. Century Pharmaceuticals Ltd. holds a strong presence in the growing domestic Indian market. Century's commitment of providing high quality goods in a timely manner at a competitive rate remains its strength. To develop, manufacture, and sell cGMP Active Pharmaceutical Ingredients, and finished Veterinary products. To work on developing new biotech products that will improve the quality of human life. We have a sharp focus on giving value added services to our customers cost effectively. Century Pharmaceuticals Ltd was established in 1982 and now limited Liability Company. We have established the Israeli Biotech Research Collaboration in 2007. We used get continuous support from the GVFL with following visions To develop, manufacture, and market cGMP APIs, Veterinary, and innovative biotech products.

New therapeutic products New direction in cost effective process development

To create value for all our customers, partners, and employees while applying environmentally safe and socially responsible business practices.

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Awards and recognition ‘A1’ SME company by Dun and Bradstreet Fair Business Practices (Indian Council for Fair Businesses) Gold Medal for excellence in Business Practices (Switzerland) Excellence award for Exports (Indian council for Small & Medium size exporters) Excellence for Innovation, Quality, Productivity, Management (IES, India) Gold Award from Lockheed Martin for best innovation in Biotech technology, August

2007 Govt. recognized R & D unit by DSIR 2008. WHO GMP facility 2012 by Gujarat state FDA, India

CPL Biotech Research Division CPL Biotech Research division drug discovery and development was initiated in 2007 and we are committed to discover and develop the biotech drugs Century recognizes the role of Biotechnology as the future of the pharmaceutical industry in enhancing the specificity and effectiveness of drugs, improving lifestyle quality and working on unmet needs of the industry. The company is involved with the creation of significant biotechnology research capabilities in the area of targeted human therapeutic proteins. Currently research work is focused

on a novel product which can cure Asthma and Allergy patients and also work on mastocytosis and Basophilic leukaemia. The candidate biological molecule has reached preclinical stage of development. We expect to start human phase-1 clinical trial in 2015. We were expecting our molecule leads to few patents on process development and Investigational biological drug filing in India. We were the first organizations as SME to start new business model as research boutique. We have

obtained funding support from DBT, Govt. of India to develop this project under SBRI. Now our focus has broadened to marine biotechnology on Drug discovery projects. As you all know the entire world is talking about the green synthesis of molecules for pharmaceutical manufacturing and formulation. The exploration of plants and their products have been explored worldwide for the treatment of many diseases. Nowadays the exploration of algal derivatives has been recent focus on discovery of Phlorotannins for the treatment of many disease. We are trying to partner with scientific research

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organization like ICAR who had already involved in the marine algal research. In this aspect we have been evaluated to take two major research proposals. 1) To identify and develop a process for the use of Indian algal sp for the extraction of Bio diesel. 2) To study different Phlorotannins in the treatment of cancer and inflammation In brief we will be identifying the algal sp for the pilot scale that is dedicated to the growth and development of high-quality algae oil and biomass products. Our goal is to achieve commercial production capabilities and establish a distribution network of algae co-products and by-products. We are also involved in undertaking contract research and analytical development of Recombinant proteins, strain improvement, process development for Biotechnology companies. Recently we have transferred a technology from DRDO ‘Bio digester’- Environmentally friendly cost effective way to treat waste. The discharge of untreated wastewater on economically important natural resources such as rivers and seas, and their ecosystems leads to their destruction. The inadequate handling and disposal of sewage lead to health problems. Household sewage generated causes serious pollution of surface and ground waters. The present on-site systems of sewage disposal do not provide much in the way of treatment. The extremely high cost of high tech systems (activated sludge, oxidation ditches etc.) to find out the need for alternative energy sources.

The Nobel Prize in Physiology or Medicine 2012

"For the discovery that mature cells can be reprogrammed to become pluripotent"

Sir John B. Gurdon

Gurdon Institute, Cambridge, United Kingdom

Shinya Yamanaka

Kyoto University, Kyoto, Japan,

Gladstone Institutes, San Francisco, CA, USA

The Nobel Prize in Chemistry 2012

"For studies of G-protein-coupled receptors"

Robert J. Lefkowitz

Howard Hughes Medical Institute, Duke University Medical Center,

Durham, NC, USA

Brian K. Kobilka

Stanford University School of Medicine, Stanford, CA, USA

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Bio Business AURA Herbal Textile Ltd.

A company involved in producing herbal textiles and dyes is a dream venture of Arun

Baid and Sonal Baid, driven by love for the environment and defines passion to work for it. Their aim is to offer options to each and every user to choose a herbal dyed textile over chemical dyed one, with no limitations to design, quantity, and quality. It was established in year 2001 for environment and social reasons.

The ‘Aura’ company is involved in an innovative process of producing herbal textiles and dyes inspired by ancient AYURVEDIC process which could help in preventing GLOBAL WARMING and POLLUTION related to textiles as well as help in impeding pollution and harm caused by regularly dyed textiles. Certified organic fabrics, textiles and yarns are used as the raw material. Dyeing, weaving, printing all is done under keen supervision to maintain quality standards. Dyeing of fabrics up to 120" width has been achieved. Even lengths of up to 1000 meters in different fabrics like voiles, poplins, twills, flannels, corduroys, denims, knits, silks is now achieved at Aura. Aura Herbal Textiles Ltd has beautiful colour palette of earthy shades & various prints ensuring no waste is generated. All the solid & liquid waste is used as manure & irrigating their farms. ORGANIC COTTON

Cotton production uses more chemicals per unit area than any other crop and accounts to a total of 25% of the world's pesticides. The chemicals used in the processing of cotton also pollute the air and surface waters and also causes skin irritation. Organic cotton is grown using methods and materials that have low impact on the environment. Organic production

system replenishes and maintains soil fertility, reduces the use of toxic and persistent pesticides and fertilizers, and builds biologically diverse agriculture. Third-party certification organizations verify that organic producers use only methods and materials allowed in organic production. BENEFITS OF ORGANIC TEXTILE Organic clothing can help reduce exposure to allergens and other irritants and give a comfortable feeling. Manual farming and organic practices have a lower carbon footprint as the entire process consumes less fuel and energy and emits fewer greenhouse gases compared to chemical textiles. Not grown from genetically modified cottonseed. Grown using natural pesticides and fertilizers, no chemical - synthetic pesticides used. Eco-friendly processing that does not compromise workers' health and helps reduce water and electric use and toxic runoff. Strict testing ensures the absence of contaminants like nickel, lead, formaldehyde, amines, pesticides and heavy metals. People with allergies and chemical sensitivity especially benefit from organic cotton clothing, as conventional cotton may retain harmful toxic residues. Even if you don't have sensitive skin, organic cotton will just feel better against your skin. Children are at greater risk for pesticide-related health problems than adults. Millions of children in the US

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receive up to 35% of their estimated lifetime dose of some carcinogenic pesticides by age five through food, contaminated drinking water, household use, and pesticide drift. HERBAL DYEING GARMENTS

The leading product of a company is organic cloth. It is treated by colour that has been extracted from herbs in eco-friendly processes. The herbs, used in process, are renowned for their medicinal values. Aura offers innovations with large scale manufacturing on a varied range of cloth with several shades and prints with authenticity.

HERBAL DYEING PROCESS The process of herbal dyeing was developed through extensive research during the age-old dyeing methods practiced since the days of the Indus civilization. The process of herbal dyeing starts with the grey cloth passing through several stages of treatment before it becomes colourful and ready to wear. During this entire treatment only natural processes are used. Fabrics & Yarns used are certified organic cotton, natural cotton, silk, wool, linen, jute, hemp etc. and their natural blends. Desizing The washing of processed greige cloth starts with removing sizing, gums and oils used in the course of weaving by washing with natural mineral-rich water and sea salts. Bleaching Fabrics are exposed to direct sunlight, use of a natural grass base and animal manure starts the bleaching process.

Mordanting To make the colors bright and fast natural mordents such as Myrballams, rubhabsleaves, oils, minerals, alum, iron Vat etc are used. We do not use heavy metal mordents like copper, chrome, zinc, tin etc.

Dyeing Aura uses only medicinally rich herbs, plant material, minerals & oils like, turmeric, Myraballam, castor oil, sea salt etc., for dyeing fabric or yarn. We have aspired to achieve and retain the medicinal qualities of the herbs by immersing the plant material directly in the dye bath for the same reason.

Finishing In Herbal Dyeing, finishing is done by sprinkling pure water on the cloth and then stretching under pressure, using hand rolls, aloe vera, castor oil etc.,

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Recycling Plant Solid and liquid waste is separated through the process of filtration and used for farming purposes as manure & watering the fields.

PRODUCTS Herbal dyed organic products are soft in feel and will have more strength than conventional in comparison. These products are Bio Compostable: by using these products you will make contribution to the betterment of your lifestyle and environment. The herbal colours are extremely therapeutic to eye, mind and body. All of the herbs have therapeutic uses as botanicals (herbs), or as homeopathic (diluted), or as nutritional supplements (minerals). It is extra smooth and good for transpiration.

Organic T – Shirt Organic Shirt Organic Undergarment Organic Spa Organic Fabrics Organic Bags Organic Scarf

Aura company looks at futuristic world where every user may enthusiastically choose herbal dyed fabric without compromising on design, quantity or quality. Thus company is accomplishing this dream through Global Organic Textile Standard certified processes. To add to this company practices of recycling the solid as well as liquid waste produced. This not only allows it to be the producers of fabric that is completely eco-friendly, but makes the process a reflection of our belief: We live and dye naturally…

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Bio Academia Navsari Agriculture University

The Navsari Agricultural University (NAU) was commenced with a college of Agriculture established in 1965, widespread in 400 hectares, located on the historic road of Dandi March. The Univesity aims to create Excellence in Research, Education and Extension activities in south Gujarat and to carry out research in the frontier areas of Agricultural sciences and to contribute towards the advancement of knowledge and alleviation of Problems related to Agriculture. NAU is an autonomous body engaged in Under Graduate (UG), Post Graduate (PG) and Doctorate Teaching, Research and extension of Agriculture and allied science, with well-established Agri-Business Centre. Apart from the teaching, university takes research challenges to improve overall productivity of the mandated crops of south Gujarat and to lift socioeconomic status of the peasant farmers.

Realizing the importance of recently developing field of biotechnology and after the boom of BT cotton the Navsari Agricultural University had initiated the research and teaching activities in Biotechnology. The NAU has started post graduate teaching courses in Biotechnology at ASPEE college of Horticulture and forestry and NM College of Agriculture at Navsari Campus, and Integrated M.Sc. course in Agricultural Biotechnology and Certificate course to impart training to women in

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plant tissue culture at Gujarat Agricultural Biotechnology Institute, Surat. Currently, 4 academic programs are being executed by NAU in the field of Biotechnology: Integrated M. Sc. course in Agricultural Biotechnology, M. Sc. course in Plant molecular Biology and Biotechnology, Ph.D in Biotechnology and also a certificate course to impart training to women in plant tissue culture. The Agriculture Biotechnology program is anchored around the research subjects in which NAU faculty members are specialized, such as Plant Tissue Culture, Plant Biotechnology, Functional Genomics, Plant Molecular Biology, Microbiology, Environmental Biotechnology, Genetic Engineering and Bioinformatics. The program is intended to provide the student both theoretical and practical knowledge and strictly follows the ICAR guidelines for their course curriculum.

M. Sc. (Plant Molecular Biology and Biotechnology) It is four semester’s program based upon coordinated courses for the B.Sc. (Agriculture) students, whereas for the student from basic science faculties it encompass six semester programme. The basic science students have to study intensive two semester pre-requisite course of 30 credits in agriculture. The remaining four semesters students will be taught different basic and advanced courses in Biotechnology, which together requires 55 credits spreading over two years. The program is intended to provide both theoretical and practical knowledge to the students. The Master thesis work is the final part of the program and is based on 20 credits independent novel research work. Ph. D. (Plant Molecular Biology and Biotechnology) It is six semester’s program based upon coordinated courses for the M. Sc. (Agril.) students, whereas for the student from basic science faculties it encompass eight semester programme. The basic science students have to study the intensive two semester’s pre-requisite as for the M. Sc. Students enrolled from basic science. The remaining six semesters students will be taught different basic and advanced courses in Biotechnology, which together requires 75 credits spreading over three years. The Doctoral thesis work is the final part of the program and is based on 45 credits independent novel research work.

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Research Projects (Students of other university) With the aim of development of trained man power in the field of Biotechnology, these department offer special facilities for dissertations and training to the students of other biotechnology colleges, especially south and middle Gujarat. The department provides opportunity to students from other university to conduct their dissertation work under guidance of universities excellent faculties for the duration of 3 months. At present the intake capacity for dissertation is ten. The training programme for one month is also provided by the department. The fees for dissertation and training in Plant Molecular Biology and Biotechnology are Rs. 30,000 and Rs. 10,000 respectively, whereas for the training in tissue culture Rs. 5,000 only. The aim is to provide them sufficient experience and proficiency in the methodology of biological research, to enable them to carry out independent research. Integrated M. Sc. (Agricultural Biotechnology) Realizing the increasing importance of Biotechnology in Agriculture the Navsari Agricultural University had established Gujarat Agricultural Biotechnology Institute (GABI) and initiated the integrated M. Sc. Course in Agricultural Biotechnology under the College of Agriculture Biotechnology, Surat. The integrated Master programme is first of its kind in India. The programme has intake capacity of 50 students for Five years (10 semesters) and total credits of 233. During their course work students will be taught intensively courses of basic agriculture for first two semesters. During the third and fourth semester the Basic and fundamental courses on Biochemistry, Molecular biology and Biotechnology will be covered. In Fifth to Eight semester the advance courses on biotechnology will be taught. In last year students will undergo one month Job Training and 30 credits of research work in the field of Agriculture Biotechnology.

WTTC (Women Tissue Culture Training Centre) Increasing importance of women labour in agriculture and with the aim of improving the women livelihood, the NAU has already initiated the WTTC (Women Tissue Culture Training Centre) with an intake capacity of 10 at GABI, Surat. The WTTC offer Six month certificate training course to women in plant tissue culture. The objective of WTTC is to provide trained women employees for tissue culture industries and also to improve the technical soundness of women’s in tissue culture by that empowered the women.

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Each lab at NAU is well equipped with infrastructural facilities required for a research Laboratories. Apart from academics NAU is actively involved in research in the area of Value addition, Quality of the food product, Disposal of the Agri-waste, Bio fertilizers and Bio pesticides, Plant cell and Molecular Biology, Bioinformatics. Moreover, it has projects from different organizations such as ICAR, Gujarat Government, DBT, GSBTM, etc. Each research lab has highly qualified and knowledgeable scientists who guide as well as pursue research in the different areas of their interests.

Instrumentation Facilities Apart from the dedicated infrastructure facilities, University has Central Instrumental Lab with analytical instruments, Biotechnology Lab equipped with basic research facilities viz., 2DE, Real Time PCR and DNA Sequencer, Imaging Facilities, HPLC, GC-MS, NMR, FTIR, Nitrogen analyser, HPTLC, Dark Room, Green house Facility and bioprocess lab is equipped with 1.5 lts fermented. Other amenities available with the university is central library with internet facilities, Guest house (Both A/c and Non A/c) for more than 200 guests, Auditorium to accommodate 700 audience, Conference halls, etc.

Central Library Since, 2004 more than 500 research papers and many farmers’ recommendations from NAU have been published. Hence, Navsari Agricultural University is on the path of progress towards research in the area of Agricultural and allied sciences and could be the best destination for aspiring graduate and post graduate students. Detailed information’s regarding admission, research and extension activities, achievements could be gathered from our website (www.nau.in).

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BT Spotlight

BT Spotlight

Vibrant Gujarat 2013 – A glowing story of Biotechnology sector

A ROUND TABLE MEET OF BIOTCHNOLOGY –INVESTOR, ORGANIZED BY GSBTM Knowledge based economy commands socio-economic progress and biotechnology is one of the fastest growing sector and has emerged as a tool of promise and potential. India, figuring 12th in global ranking and 3rd in Asia Pacific, is poised to become preferable destination for BT investments. Each state, with its characteristic strength, is projecting India at global forum. Gujarat state has proven its potential share in boosting nation.

Government of Gujarat, in conformity with national efforts, has been organizing Vibrant Gujarat: Global Investor Summit every two years, for bringing the enormous investment potential in Gujarat and to accelerate the rate of FDI and domestic investment in Gujarat and thereby in India.

Biotechnology has been identified as a prospective sector for investment in Gujarat, during Vibrant Gujarat events conducted earlier. The successful summits have given boost and encouragement to the sector. In conformity with spirit of collaboration and facilitating partnerships, GSBTM organized a Round Table meet of Biotechnology investors on 11th January, 2013 at Cambay grand, Ahmedabad. It was done as part of Vibrant Gujarat 2013 and around 100 participants representing 45 biotechnology companies were present on this occasion.

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BT Spotlight

The key objective of Round Table meet was to provide a networking opportunity to biotech industries, from Gujarat who have been investing in the sector in the state. The program became inspiring by the presence of Shri Ravi Saxena, IAS, Additional Chief Secretary, Department of science & technology, Government of Gujarat. He shared his views on Biotechnology sector of Gujarat. Apart from pointing out the initiatives from state government and nodal agency GSBTM, in area of biotechnology, he stressed the need of strong participation of industries in holistic development of biotechnology.

The program included curtain raiser from Mission Director GSBTM. He made presentation covering the status of biotechnology in Gujarat, various initiatives, the achievement and salient impact. He briefly touched upon the issues which need discussion and consideration, participation from stakeholders. The program also saw presentation from 5-6 biotech companies, representing start up, research based established ones, etc.

There was a dedicated discussion on Gujarat focusing on “Government Initiatives and Investors perspective”. Mission director suggested the biotech industries of Gujarat to create a forum for interaction. He emphasized the need research and innovation and requested the industries to invest in application based research as well as to participate whole heartedly in GSBTM operated programs like skill development, entrepreneurship and technology transfer, to name a few. He also advised the companies to take advantage of various schemes of Government of India.

After the discussion session the program went forward by distribution program of Investment intention certificates to those companies who have committed their investment in Gujarat. It is noticeable that around 53 biotech companies have committed Rs. 1800 crores in coming five years in Gujarat which includes approx. investment of Rs. 564.75 crores, committed by 18 companies including seven in agriculture, three in healthcare & marine biotechnology each, two in industrial biotechnology and bio-services each and one in food biotechnology for starting their new operations in Biotechnology in Gujarat, Approx. investment of Rs. 1247.88 crores is committed by 32 companies for undertaking the expansion of their existing operations in biotechnology in Gujarat. Along with it around seventeen different companies, institute, and organizations have also entered into strategic partnership with GSBTM including National Innovation Council, Griffith University, Jawaharlal Nehru Tropical Botanical Garden & Genetic Research institute and Birla Institute of Scientific Research.

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BT Spotlight

BT Spotlight

One of the most encouraging aspects is the increasing investment by smaller companies. There are 20 companies who have committed an investment between Rs. 1-5 crores. This is sign of growth of biotechnology in Gujarat, it also provides a wider base of smaller industries which form the value chain and potential to grow or become feeder platform for bigger companies. Considering the investment of around Rs. 300 crores have been done upto year 2000, investment of around Rs. 200 crores, has been done in the period between 2000 to 2006, the trend of investment commitments in biotechnology from 2007-2011, reflect increasing trend. Of the committed investments from VBGs of 2003, 2005, 2007 & 2009, 2011, around, Rs. 1700 crores has been completed while around Rs. 2400 crores is under implementation to lead state and country to the brightest horizons.

2013 Post Doctoral Fellowship, Rajiv Gandhi Centre for Biotechnology, India Applications are invited by Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram for Post Doctoral fellowship 2013 for research in venous diseases. This fellowship is supported by the Dr N. Radhakrishnan Foundation for Research on Venous Diseases with a purpose of providing advanced research training in “cutting edge” areas of venous disease research.

Eligibility Criteria: Applicants should hold a Ph.D. degree in Life Science or M.D. degree in Modern Medicine and a good academic record.The applicants should preferably be below the age of 35 years (40 years in case of women candidates).

Deadline: Friday, April 19, 2013; Further Information: http://rgcb.res.in/jobs.html

College of Science International Scholarship 2013

Post Graduate The College of Science has a small number of postgraduate scholarships available to new non-UK/EU students from China, India and Nigeria Eligibility Criteria: Scholarships are available only to new postgraduate applicants who are non-UK/EU categorized students from China, India and Nigeria

Deadline: 01st July, 2013; Further Information: www.swansea.ac.uk

Scholarships

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BT News

Teva Pharma, P&G (Procter & Gamble) sets up OTC plant in Gujarat Israel-based Teva Pharmaceuticals, an $18 billion generic drug maker will set up OTC medicine facility in Gujarat in collaboration with Procter & Gamble. Teva Global Operations, Executive Vice President, Strategy and Operation, Eran Katz, said "The multipurpose plant in India will support the growing demand for our non-prescription health care products across Asia. The Sanand facility will be a critical component of PGT Healthcare, Teva's international partnership and joint venture with Procter & Gamble." Teva Pharm India Pvt. Ltd expects completion of construction of the plant in two years. Aanand agriculture university (AAU) to introduce first probiotic of India. AAU signed MoU for commercialization of the probiotic Lactobacillus helveticus (MTCC: 5463) with Thiruvanthampuram based Dr baboo’s food science and Biotachnology Private Limited (kerala firm) run by a managing director Dr. Baboo Nair of a kerala firm who is also an alumnus of AAU . It will be proved a better alternative to the imported probiotic strains from Denmark.

The Times of India; March 7, 2013

Gold, DNA, Water, Cocktail can work medical wonders. A diagnostic ‘Cocktail’, containing a single drop of Blood, a dribble of water and a dose of DNA powder with Gold particles, Could one day lead to the treatment of the world’s leading diseases. This homegrown brew is being developed by IBBME PhD student Kyryl Zagorovsky and Professor Warren Chan. And study on nanoparticles in particular, the use of Gold particles in sizes so small that they are measured in the nanoscale. He and his group are working on custom –designing nanoparticles to target and illuminate cancer cells and tumors with the potential of one day being able to deliver drugs to cancer cells.

The Economic Times; March 4, 2013

Indian Plant Plays key role in defense against cancer Indian plant compound gedunin attacks p23 co-chaperone helping Hsp-90 in cancer cells. Thus it doesn’t allow mutated protein to last in the cell as Hsp-90 helps mutated to recover normal: C. Patwardhan Georgia regents university cancer center.

The Economic Times; February 18, 2013

Hester Biosciences Launching Biovalent Marek’s disease live vaccine containing HVT and SB1. It has received a WHO-GMP certification for poultry vaccine and a better replacement option to the vaccine imported and that is around 50%.The market for this vaccine is expected to be 300 million. The BGI (Beiging genomics institute) can map any genome. BGI factory in shenzhen is the largest factory for genome mapping run by W jian and Y Huanming since 1999. Around 3000 employees who are under graduate spend their lives mapping genome there. BGI mapped Panda and Liu’s orchid and also does mapping of microbiome more than 1000 from human gut. BGI contributed the most to the Sino-British

22

BT News

Chicken genome Project, Silk worm, First asian diploid genome and also 1% of human genome for the human genome project worldwide.

The economic times; February 16, 2013

International pharma business meet 2013 by “Pharmaceutical export promotion council for India” "International Pharma Business Meet and Exhibition at Ahmedabad, Gujarat from 09th-11th January, 2013 coinciding with Vibrant Gujarat 2013". Excellent opportunity for the Indian Pharma Exporters, particularly SME sector, to meet about 60 prominent Buyers / Drug Regulatory Officials, Government Procurement Agencies of Ten African countries. Quadruple-helix DNA discovery key to fighting cancer “The research indicates that quadruplexes are more likely to occur in genes of cells that are rapidly dividing, such as cancer cells. For us, it strongly supports a new paradigm to be investigated - using these four-stranded structures as targets for personalised treatments in the future,” Balasubramanian said in a statement.

Ahmedabad Mirror; January 22, 2013

DRDO scientists develop death trap to combat mosquitoes. BHOPAL: Scientists at Defence and Research Development Organization (DRDO), Gwalior in Madhya Pradesh, have developed a lethal death trap based on lure and kill strategy to combat dengue transmitting aedes mosquitoes.

Times of India; February 12, 2013

Like Terminator, a liquid that recalls shape (DNA hydrogel) Hydrogels have already been considered for use in drug delivery – the spaces can be filled with drugs that release slowly as gel biodegrades – and as framework for tissue rebuilding. The ability to form gel into desired shape further expands possibilities. For example, a drug-infused gel could be formed to exactly fit the space inside a wound. Dan Luo, professor at Cornell University, and colleagues describe the creation in Nature Nanotechnology.

Ahmedabad Mirror; December 12, 2012 Modified virus kills liver cancer cells Researchers have created a virus that can infect and kill cancerous cells while reducing the size of the tumour. The only side-effects are flu-like symptoms that last a day or two Pexa-Vec “is designed to multiply in and subsequently destroy cancer cells, while at the same time making the patients’ own immune defence system attack cancer cells also,” said Kirn from the biotherapy company Jennerex.

Ahmedabad Mirror; February 12, 2013

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BT Events

Workshop on “Skill Development in Stem Cell Techniques: Basic Training in cell culturing”

Stem cell technology is a fast developing technology in the development era with potential offer solutions incurable disorders and diseases like Cancer, Alzheimer, Organ transplants etc. Stem Cell Technology/Therapy is one such ray of hope in the era of regenerative medicine. In view of the healthcare solutions offered by stem cells, and its relevance

to state of Gujarat, GSBTM is visualizing to develop a platform to enable research, application and use of stem cell technology in the state. The first step towards the same is to generate dedicated skilled manpower in area of stem cell research. Visualizing the thirst and need, GSBTM organized “Skill Development in Stem Cell Techniques: Basic Training in cell culturing” in GSBTM selected training centre in two batches from 11th – 16th March, 2013. 15 participants attended the workshop with plentiful of interest. The programme had direct relevance with the advancement in medical research. The training was conducted at The Gujarat Cancer Research Institute, Ahmedabad and Stem Cure Pvt. Ltd, Ahmedabad. “Trends in Biotechnology” a one day symposium Ahmedabad University. A one day symposium “Trend in Biotechnology” was organised at Ahmedabad University bringing awareness about the application of cutting edge technologies in modern science at 3rd March, 2013 at institute of life sciences, school of sciences and technology, Ahmedabad University. The aim of the symposium was to enable students to upgrade their knowledge with the recent developments in Biotechnology and interact with eminent scientist. The seminar also intended to focus research on Nanobiotechnology and affordable healthcare. The programme has been designed to enable students to upgrade their knowledge with the recent advancement and development in biotechnology and interact with eminent scientists and also to allow them to have an exposure to advanced laboratories. The lecturers introducing advances technology were invited to give a speech on 1) Insilico tools in biological research 2) Nano-Biotechnology and its applications 3) Pharmaceutical biotechnology 4) Molecular diagnostics 5) Biotechnology in health care. The appreciation for this effort truly goes to Dr. Sanjay Singh, Prof. Alok Dhavan and Prof. R. K Goyal and a collective work of the associated people.

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BT Events

Biotechnopreneur™ Camp at Rajkot, Bhavnagar and Gandhidham This office has initiated Biotechnopreneur™ Camp Series in collaboration with Gujarat Venture Finance Limited [GVFL] & Sky Quest Technologies Pvt. Ltd. – as a Knowledge Partner to reach out the Biotech Entrepreneurs of the State. This year same had organized at Rajkot, Bhavnagar & Gandhidham. BTP Camp-Rajkot was organized on 04th January 2013, Friday at Hemu Gadhavi Auditorium, Near Virani High School, Tagore, Main Road, Manhar Plot, Rajkot – 360002 The camp was appreciated with Participants more then 140 (Entrepreneurs, Industry Professionals & Students). Collaborating with Local Associations: 1. Rajkot Engineering Association (REA) 2. Rajkot Chamber of Commerce & Industry (RCCI) 3. Rajkot Management Association (RMA) 4. GIDC Lodhika Industrial Association 5. JCI Silver 2012 6. Shapar Veraval Industrial Association BTP Camp-Bhavnagar was organized on 18th January 2013, Friday at Doctors Hall, Mahila College Circle, Opp. Yashwantrai Natya Gruh, Bhavnagar, Gujarat- 364 004 with appearance of participants more than 100 (Entrepreneurs, Industry Professionals & Students). Collaborating with Local Associations: 1 . Bhavnagar District Chamber of Industries 2 . Bhavnagar Chemical Manufacturers Association 3 . Saurashtra Chamber of Commerce & Industry 4 . Bhavnagar Drug Manufacturers Association 5 . Bhavnagar Plastic Manufacturers Association 6 . Chitra Industries Association 7 . Ship Recycling Industries Association 8 . Bhavnagar University, Head of Departments:

Chemistry, Microbiology. 9 . Biotech & Marine Biotech Department Central

Salt & Marine Chemicals Research Institute. BTP Camp-Gandhidham was organized on 1st February 2013, Friday at Lions Hall, Off Tagore Road, Gandhidham and the Participants enrolled were more than 65+ (Entrepreneurs, Industry Professionals & Students)

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BT Events

Workshop on cost cutting effort to LSD (Lysosomal disorders).

The event was sponsored by LSDSS and an event was commenced with the welcome speech of Mr Prasanna Kumar Shirol and the chief lecturer was Dr Jayesh Sheth, Director, Institute of Human Genetics, FRIGE House and Ahmedabad 6th Feb 2013. He gave a speech on the following.

Overview of Lysosomal Storage Disorders: Facts about the disorder Need for government intervention in treatment and management of the disease. Scenario in Gujarat- disease incidence Importance of early detection

The advertisement of workshop was published in Rajasthan Patrika, Herald Young leader, Prabhat and Metro Herald. Finally the entire workshop was ended up with patients’ introduction to the audience furnishing with story of their lives. Biosafety Environment in India and Challenges Ahead, A day-long seminar on biosafety was organized on 7th February, 2013, at ISTA, Ahmedabad, for the biotechnology stakeholders of the state. The seminar began at 10 AM. The seminar was divided into three sessions, where the first session was the Opening Session, immediately followed by the session on the science of biotechnology. The Session named “Genetic Engineering: The Indian Scenario”, talked of the scenario of genetic engineering in the changing socio-economic status of the country, the prime concerns of genetic engineering to the animal and human health and the environment. The post lunch session dealt with

the legal and futuristic issues of biosafety. The Biosafety Needs of India, was discussed by various strata of scientists and industrialists. Following biosafety norms, is becoming mandatory from the quality and legal perspective. It is needed both at research and business development levels. The seminar was organized keeping in mind three very preliminary objectives:

To generate a general awareness about genetic engineering and the nitty-gritties of the rules and regulations

To build a consensus amongst all the biotech stakeholders, about the importance of biosafety in our research endeavours

To generate an environment of making informed choices, in the state, regarding the genetically engineered crops and drugs.

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BT Events

Hands on training on software related to Computer Aided Drug Design (CADD).

CADD was organized on 21st and 22nd January, 2013 at INSTITUTE OF PHARMACY Nirma University Ahmedabad – 382 481. Computer aided drug design is the technology that benifits to the easy drug discovery in the medical field. The processes used by academic and industrial scientists to discover new

drugs has recently experienced a true renaissance with many new and exciting computer aided techniques being developed in the past 5-10 years. Medicinal chemistry has benefited tremendously from the technological advances in the field of Computer Aided Drug Design. The aim of the workshop is to disseminate knowledge about this immensely useful discipline, which accelerates the design of new leads for the life threatening diseases like Cancer, AIDs, Tuberculosis, Leishmania etc. These new tools have had a significant impact on both drug design and discovery in the pharmaceutical industry that helps the scientist in their research work. The workshop introduces concepts through lectures delivered by renowned speakers, discussion regarding envisaged and encountered problems in these and related technologies. The workshop will also include hands-on training on some important computer software for drug design. Attending the workshop will be of great help to budding scientists from various fields as it covers how to effectively put to use the knowledge of different software of drug design.It is an important to know about it and hence Nirma University organized the workshop on it.

“Cancer: From Biologist’s Perspective”. The one day seminar on “Cancer: From Biologist’s Perspective” hosted as a part of National Science Day Celebrations- 2013 at Rustomji Cama Hall, GCRI, Ahmedabad on the 28th February, 2013. The seminar was an effort to bring on a common platform, faculty members and students from all parts of Gujarat to review and discuss “Recent Perspective on Cancer Biology”. The main aim was to create awareness regarding “Career Development in Cancer Biology”. In the beginning of the seminar an inauguration speech was given by Chief Guest: Shri A.K. Saxena (Mission Director, GSBTM, and Gandhinagar) followed by an introductory speech of Dr. Shilin N. Shukla (Hon. Director, GCRI, Ahmedabad) and informative series of speeches by various experts from medical field, industrial field and academic field. The session for the poster presentation was also held after in the next session and Panel discussion was held also and the seminar was ended with award ceremony.

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Bio Bit – Drug Bank

The Drug Bank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information. The database contains 6712 drug entries including 1448 FDA-approved small molecule drugs, 131 FDA-approved biotech (protein/peptide) drugs, 85 nutraceuticals and 5080 experimental drugs. Additionally, 4227 non-redundant protein (i.e. drug target/enzyme/transporter/carrier) sequences are linked to these drug entries. Each Drug Card entry contains more than 150 data fields with half of the information being devoted to drug/chemical data and the other half devoted to drug target or protein data.

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Step 1: Go to the link http://www.drugbank.ca/

Step2: Enter any drug name in the search box.

Step3: list of drug based on your search will appear.

Step 4: click on the Drug Name.

Step5: Detail information about the drug you have selected will appear.

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Step6: You can view all the detail about the drug and structure and you can also be downloaded into Molecular format, SDF and Drug Databases.

Users may query DrugBank in any number of ways. The simple text query (above) supports general text queries of the entire textual component of the database. Clicking on the Browse button (on the DrugBank navigation panel above) generates a tabular synopsis of DrugBank's content. Clicking on a given DrugCard button brings up the full data content for the corresponding drug. A complete explanation of all the DrugCard fields and sources is given here. The PharmaBrowse button allows users to browse through drugs as grouped by their indication. This is particularly useful for pharmacists and physicians, but also for pharmaceutical researchers looking for potential drug leads. The ChemQuery button allows users to draw (using MarvinSketch applet or a ChemSketch applet) or write (SMILES string) a chemical compound and to search DrugBank for chemicals similar or identical to the query compound. The TextQuery button supports a more sophisticated text search (partial word matches, case sensitive, misspellings, etc.) of the text portion of DrugBank. The SeqSearch button allows users to conduct BLASTP (protein) sequence searches of the 18,000 sequences contained in DrugBank. Both single and multiple sequence (i.e. whole proteome) BLAST queries are supported. The Data Extractor button opens an easy-to-use relational query search tool that allows users to select or search over various combinations of subfields. The Data Extractor is the most sophisticated search tool for DrugBank. Users may download selected text components and sequence data from DrugBank and track the latest DrugBank statistics by clicking on the Download button.

Some Important Databases for Drugs Databases PharmGKB The PharmGKB database is a central repository for genetic, genomic, molecular

and cellular phenotype data and clinical information about people who have participated in pharmacogenomics research studies. The data includes, but is not limited to, clinical and basic pharmacokinetic and pharmacogenomic research in the cardiovascular, pulmonary, cancer, pathways, metabolic and transporter domains. Its aim is to aid researchers in understanding how genetic variation among individuals contributes to differences in reactions to drugs. PharmGKB contains searchable data on genes (>20,000), diseases (>3000), drugs (>2500) and pathways (53).

STITCH STITCH ('search tool for interactions of chemicals') is a searchable database that integrates information about interactions from metabolic pathways, crystal structures, binding experiments and drug–target relationships. Text mining and chemical structure similarity is used to predict relations between chemicals The database contains interaction information for over 68 000 different chemicals, including 2200 drugs, and connects them to 1.5 million genes across 373 genomes.

SuperTarget SuperTarget is a database that contains a core dataset of about 7300 drug-target relations of which 4900 interactions have been subjected to a more extensive manual annotation effort. SuperTarget provides tools for 2D drug screening and sequence comparison of the targets. The database contains more than 2500 target proteins, which are annotated with about 7300 relations to 1500 drugs; the vast majority of entries have pointers to the respective literature source. A subset of 775 more extensively annotated drugs is provided separately through the Matador database (Manually Annotated Targets And Drugs Online Resource.

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BT Quiz

1) What is the full form of GFP? a) Green Fish Protein b) Green Fluorescent Protein c) Go For Protein d) Glass Of Protein

2) Which enzyme can be used for bioluminescence?

a) Luciferase b) Amylase c) Protease d) Lipase

3) Which biosensor detects analyte by measuring change in current?

a) Amperometic b) Optical c) Calorimetric d) Fluorometric

4) Which enzyme needs to be used to make milk lactose free?

a) Lipase b) Protease c) Amylase d) Lactase

5) Which of the following is property of male sterile plants? a) Inability to produce of enzyme b) Inability to grow c) Inability to reproduce d) Ability to reproduce

6) Which of the following is the protein database? a) NCBI b) KREGG c) PDB d) CLUSTAL W

7) On the solid substrate, which of the following microbe can grow most easily? a) Filamentous Fungi b) Algae c) Bacteria d) Yeast

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BT Quiz

8) Which protein is produced as the by-product of cheese industry? a) Casein b) Whey c) Amylase d) Insulin

9) Which of following genetically modified crop is allowed to be used for cultivation in India? a) Brinjal b) Tomato c) Potato d) Rice

10) Which of the following technology is banned in India, for commercial production of seeds? a) Haploid plants b) Somatic Embryogenesis c) Recombinant DNA Technology d) Terminator Technology

11) Which enzyme causes breakdown of cellulose? a) Cellulase b) Glucose oxidase c) Pectinase d) Ligase

12) Which hormone is needed to prevent Diabetes Type I? a) Bromelain b) Insulin c) Papain d) Ligase

13) What is the full form of PCR? a) Plastic Chain Reactor b) Please Close Room c) Polymeric Chainsaw Reactor d) Polymerase Chain Reaction

14) What is the full form of RAPD? a) Randomly Amplified Polymorphic DNAb) Routinely Amplified Polymorphic DNA c) Rarely Amplified Polymorphic DNA d) None of these

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BT Quiz

15) What is the charge imparted to DNA if it is treated with SDS? a) Neutral b) Zwitterion c) Negative d) Positive

16) Which protein of papaya is important for leather industry? a) Bromelain b) Insulin c) Papain d) Ligase

17) Which of the protein is commercially extracted from tomato? a) Lycopene b) Insulin c) Papain d) Ligase

18) Which pathway is not followed by the bacteria causing gangrene? a) All pathways b) Aerobic pathway c) Anaerobic pathway d) Lactic acid pathway

19) Which enzyme can be used to detect Ecoli in milk? a) Bromelain b) Insulin c) Papain d) Galactosidase

20) Which of the following software can be used to predict the 3D- drug protein interactions? a) Vensim b) Ligand Scout c) CreativeWorks d) Foxlight

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Browse BT

http://www.jove.com/ Journal of Visualized Experiments (JoVE) is a peer reviewed, PubMed indexed journal devoted to the publication of biological, medical, chemical and physical research in a video format. The Journal of Visualized Experiments (JoVE) was established as a new tool in life science publication and communication, with participation of scientists from leading research institutions. JoVE takes advantage of video technology to capture and transmit the multiple facets and intricacies of life science research. Visualization greatly facilitates the understanding and efficient reproduction of both basic and complex experimental techniques, thereby addressing two of the biggest challenges faced by today's life science research community: i) low transparency and poor reproducibility of biological experiments and ii) time and labour-intensive nature of learning new experimental techniques.

http://www.protocol-online.org/prot/Molecular_Biology/ Protocol Online is a database of research protocols in a variety of life science fields. It contains protocols contributed by worldwide researchers as well as links to web protocols hosted by worldwide research labs, biotech companies, and personal web sites. The data is stored in a MySql relational database. Protocol Online also hosts discipline specific discussion forums (BioForum), and provides a free PubMed search and alerting service (PubAlert). This site was created in June 1999 and is maintained by Dr. Long-Cheng Li. In order to better serve the research community, any comments and suggestions that can help improve this site are welcomed.

http://www.microbeworld.org/ Established in 2003, Microbe World is an interactive multimedia educational outreach initiative from the American Society for Microbiology that promotes awareness and understanding of key microbiological issues to adult and youth audiences, and showcases the significance of microbes in our lives. Microbe World has additional value in informing the public about how science works. The various outreach methods feature the process of discovery, historical changes in research, and a variety of scientific careers in industry, academia, and government.

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Browse BT

BT CARTOON

http://psimi.ibioinformatics.org/index.php This portal is designed to integrate information pertaining to cancer researchers in India. This database contains information about scientists along with their educational and professional background, research areas, research achievements and grant support. In addition, contact information of each individual researcher is also provided. DBT will also utilize this portal to announce new research initiatives related to cancers and to list sanctioned grants. The user can find an expert cancer researcher by using this database and consult him/her. Clinicians and Basic researchers can easily team up for research collaborations. It will also help industry to locate a basic researcher or clinicians for industry-academia collaborations. This database will provide a platform for Indian researchers to showcase cancer research in India at an international level.

www.vadlo.com

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BT EXAMINATIONS

TERI UNIVERSITY- 2013 M Sc (Environmental Studies), M Sc (Natural Resources Management), M Sc (Water Resources Management), M Sc (Geoinformatics), M Sc (Plant Biotechnology) Important Dates Commencement of issue of application forms - February Last date for sale of forms - 20th April Last date for receipt of completed application forms - 27th April Date of online Test - 26th May For detail log on http://www.teriuniversity.ac.in

BANASTHALI VIDYAPEETH, BANASTHALI - 2013 M.Sc. Biotechnology Important Dates Commencement of issue of application forms - February Last date for receipt of completed application forms - 05th May Date of Entrance Test - 2nd June For detail log on http://www.banasthali.org/banasthali/admissions/imp.html

PONDICHERRY UNIVERSITY, PONDICHERRY M.Sc.Biotechnology M.Sc.Biochemistry and Molecular biology M.Sc.Microbiology IMPORTANT DATES:- Issue of application form- 7th March Last date for submission of form - 8th April Entrance Tests - 28-29th May For detail log on http://www.pondiuni.edu.in/

JAMIA MILLIA ISLAMIA, NEW DELHI- M.Sc. Biotechnology M.Sc. Biosciences M.Sc. Biochemistry IMPORTANT DATES: Issue of application form -19th March Last date for submission of form - 05th May Entrance Tests - 11th June On the Notice Board of the University and Web-site. For detail log on http://www.jmi.ac.in

AIIMS, NEW DELHI - M.Biotechnology M.Sc. Biochemistry IMPORTANT DATES:- Issue of application form- 11th April Last date for submission of form - 06th May Entrance Tests - 14th July (Saturday) For detail log on http://www.aiims.edu/aiims/events/exams-results.htm

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BT EXAMINATIONS

THAPAR UNIVERSITY, PATIALA- M.Sc.Biotechnology IMPORTANT DATES: Issue of application form- 21th March Last date for submission of form - 04th June Entrance Tests -15th to 20th June For detail log on http://www.thapar.edu HYDERABAD UNIVERSITY - 2013 Plant Biotechnology Animal Biotechnology M.Sc.Biochemistry M.Sc.Molecular Biology IMPORTANT DATES:- Issue of application form- 12th April Last date for submission of form - 06 May Entrance Tests - 01-07th June For detail log on http://www.uohyd.ernet.in/index.php/admissions DEVI AHILYA VISWAVIDYALAYA, INDORE- M.Sc. Biochemistry M.Sc. Life Science M.Sc. Microbiology IMPORTANT DATES:- Issue of application form- 12th May Last date for submission of form - 27th June Entrance Tests - July For detail log on http://www.dauniv.ac.in/

ACBR, DELHI UNIVERSITY Biomedical Sciences IMPORTANT DATES:- Issue of application form- 16th May Last date for submission of form - 10th June Entrance Tests - 2nd July For detail log on http://www.acbrdu.edu/forms.html

DELHI UNIVERSITY South Campus M.Sc.Genetics Department of plant and molecular biology IMPORTANT DATES:- Issue of application form- 23rd May Last date for submission of form - 24th June Entrance Tests - 29th June For detail log on http://www.south.du.ac.in/cms/uploads/MSc_Bulletin_May_23_2011.pdf

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Documents

btm.gujarat.gov.inhuman protein manufactured in bacteria by Genentech, In c. A synthetic, recombinant gene was used to clone a protein for the first time. 1978 Genentech, Inc. and