BROEGELMANN RESEARCH LABORATORY · The Autoimmunity and Mucosal Immunobiology Research Group (AMIR) - 10 - 4. Scientific activity COMPLETED THESIS IN 2010 WITH CONTRIBUTIONS FROM

BROEGELMANN RESEARCH LABORATORY

The Gade Institute

University of Bergen

ANNUAL REPORT

2010

The Autoimmunity and Mucosal Immunobiology Research Group (AMIR)

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Mailing address: Broegelmann Research Laboratory The Gade Institute The Laboratory Bldg, 5th floor N-5021 Bergen, Norway Tel: +47-55974648 or 55974649 Fax: +47-55975817 E-mail: [email protected] or [email protected] http://www.uib.no/Broegelmann/ http://www.uib.no/Broegelmann/brsi/index.html


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1. The Year in Review 2. Administration - Personnel - Scientists Administration Technical and administrative personnel Postdoctoral fellows Visiting scientists Trainees 3. Teaching Postgraduate teaching Guestlectures 4. Scientific Activity Completed doctoral theses Aims of research Collaborating institutions Major projects Collaborating projects Publications 5. Editorial Activities – Scandinavian Journal of Immunology 6. Lectures – Seminars - Other activity


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1. The Year in Review 2010 has been another exciting year for the Broegelmann Research Laboratory and its staff. In particular, since the Laboratory was awarded a prize for the best research environment by the Western Norway Regional Health Authority in 2009 and the monetary part of this prize was used in 2010 for a study visit for the whole staff to Karolinska Institutet, Stockholm, Sweden. Furthermore, Jonsson was awarded the Distinguished Scientist Award by the International Association of Dental Research. The Laboratory has continued to bond its place in the top league of international laboratories investigating systemic autoimmune diseases with a focus on Sjögren’s syndrome. This year the Laboratory has been visited by international guests – professor Ammon Peck, University of Florida who spent 2 weeks, one PhD trainee – Irena Berglova DDS from Department of Clinical Immunology and Allergology, Faculty Hospital Hradec Králové, Czech Republic, and two medical students – Maria Giulia Disanto from the University of Siena, Italy, and Linn Tønder from Semmelweis Egyetem, Budapest, Hungary. Professor Jonsson’s standing in the field of Sjögren’s syndrome research was recognized by invitations to give a number of keynote lectures and/or chair scientific sessions worldwide (Vienna, Austria; Tallinn, Estonia; Göteborg, Sweden; London, UK). The Vienna lecture concerned the Norwegian PhD training program i medicine. Laboratory members were invited to speak at other national and international meetings or author articles and/or chapters in scientific publications/books. The Laboratory has published extensively this year in major international journals. The breadth of the Laboratory’s approach to study autoimmunity and mucosal immunity is reflected in the diversity of fields in which publications have appeared, including Immunology, Biomedicine, and Rheumatology. Our Editorial Office for Scandinavian Journal of Immunology has received continuous attention by obtaining a steady influx and increase of manuscripts in 2010. The impact factor for Scandinavian Journal of Immunology has continued to increase after launch of electronic submission and handling of manuscripts was set to Feb 1, 2006 through http://mc.manuscriptcentral.com/sji. The Laboratory has a track record of success in obtaining international funding (EU, NATO). In 2009 we obtained a major grant from the Norwegian Research Council (GLOBVAC-program). Our grant support from the Western Norway Regional Health Authority continued in 2010. A major challenge will be to establish modern and up to date laboratory equipment and infra-structure. This is essential for being eligible and competitive for additional funding. 2010 has also been a productive year for cementing and establishing translational clinical and scientific collaborations. As an initiative to further increase the Laboratory’s activity, interaction and integration, for the Research School Program at the University of Bergen “The Bergen Research School in Inflammation (BRSI)” has established 5 separate research courses/seminars (HUIMM901-905), among those an advanced 3 day lecture workshop at Voss with highly renowned international speakers. The Day of Immunology was also successfully organized in 2010, with a program on Vaccines. The Laboratory has a number of ongoing research projects including:

- Translational studies in autoimmunity; autoantibodies and biomarkers - Functional genomics and genetic basis of the autoimmune exocrinopathy (human/murine) - Influenza and mucosal immunity - Dendritic cells and tumor vaccines

Roland Jonsson Head, Broegelmann Research Laboratory


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2. Administration - personnel - scientists The Broegelmann Research Laboratory (BRL) is an immunology research unit with a focus on Autoimmunity and Mucosal Immunobiology at the University of Bergen and Haukeland University Hospital. The Laboratory was initiated in 1957 after a donation to the University of Bergen and is co-localized and integrated with the Department of Microbiology and Immunology, the Gade Institute. Internationally the unit is one of the leading groups on Experimental, Clinical and Genetic Studies of Sjögren´s syndrome and currently holds a EU funded Marie Curie Training Site. A broad repertoire of molecular and cellular methods in immunology and molecular biology has been established. The core financial support comes from the Broegelmann Foundation. Other major funding agencies have been EU (six contracts – five as coordinator), the Research Council of Norway (“miljøstøtte”), Western Norway Regional Health Authority, the Foundation Health and Rehabilitation, and more recently the Strategic Research Program at Helse Bergen, GLOBVAC/The Research Council of Norway, Bergen Forskningsstiftelse og Kreftforeningen. Between 1962 and 2010 BRL has contributed to the finalization of >60 PhD/doctoral and ≈20 Master degrees. BFL has been the organizer of three international immunology meetings in Bergen 1997, 2001 and 2002. Since 1999 the unit was one of three Editorial offices for the Scandinavian Journal of Immunology with Prof R. Jonsson as Editor-in-Chief. Since 2006, the major activity of the Journal is localized to Bergen. RESEARCH AREAS:

The research activity at BRL has been devoted to the following areas: inflammation and autoimmunity; molecular medicine; functional genomics; mucosal immunity; immunopathology; tumor immunology.

HEAD OF LABORATORY (from 1991): Roland Jonsson DMD, PhD Professor of medicine (The Broegelmann Chair in Immunology) Director Bergen Research School in Inflammation TECHNICAL/ADMINISTRATIVE PERSONNEL:

Kate Frøland (100% adm [70% BFL/UiB, 30% SJI]) Marianne Eidsheim (100% BFL/UiB) Kjerstin Jacobsen (100% UiB) Dagny Ann Sandnes (80% UiB) Marie Karlsen (100% UiB)

SENIOR RESEARCH/POSTDOCTORAL FELLOWS: Silke Appel PhD (cellular/molecular immunology) Oddmund Bakke PhD, (prof II) (cellular/molecular immunology) Karl A. Brokstad PhD (molecular immunology/cell biology) Nicolas Delaleu PhD (immunology, systems biology) Arnt-Ove Hovden PhD (cellular/molecular immunology) VISITING SCIENTISTS: Maria Giulia Disanto, Italy Medical student Linn Tønder, Hungary Medical student Irena Berglova, DDS, Czech Rep. PhD trainee Ammon Peck PhD, USA Visiting professor


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TRAINEES: Rheumatological immunology Principal supervisor(s) Elisabeth Sivy Nginamau MD, doctoral degree trainee Jonsson Petra Vogelsang MSc, doctoral degree trainee Appel/Jonsson Ewa Szyszko MSc, doctoral degree trainee Skarstein/Brokstad/Jonsson Karstein Halvorsen MD, doctoral degree trainee Bolstad/Brun/Appel Tove Ragna Reksten MPharm, doctoral degree trainee Brokstad/Jonsson MV Roman Volchenkov MD, doctoral degree trainee Appel/Jonsson/Hansen Lara Aqrawi MSc, doctoral degree student Brokstad/Skarstein Tumor immunology Lene Frøyen Sandvik MD, doctoral degree trainee Appel/Nilsen/Jonsson Florian Sprater MSc, doctoral degree trainee Appel/Hovden/Niere Master students Magne Olsen – 2009/2010 Appel/Hovden Særoppgaver Anna Ellingsen Appel Glenn André Opland Appel Anna Totland Lunestad Appell Inger Helene Salvesen Jonsson Anette Hole Blakstad Jonsson Affiliated with Broegelmann Research Laboratory (doctoral/master degree studies): Carla Olsnes Msc, Dept of ENT, UoB Aarstad ADDITIONAL SCIENTISTS/KEY-COLLABORATORS AFFILIATED WITH THE LABORATORY AND WITH E.G. SUPERVISION FUNCTIONS PLUS JOINT PUBLICATIONS: Assoc Professor Torbjørn Hansen (immunology) Post-doc Malin V. Jonsson DMD, PhD (clinical immunology/rheumatology) Senior scientist Stephanie Le Hellard PhD, (medical genetics) Professor Lars Bø MD, PhD, Inst of Clinical Medicine Professor Anne Isine Bolstad DMD, PhD, Inst of Clinical Dentistry Professor Johan G. Brun, Inst of Internal Medicine Professor Kathrine Skarstein, Sect for Pathology, The Gade Institute Professor Hans-Jørgen Aarstad, Department of Otolaryngology/Head & Neck Surgery, Inst of Surgery


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3. Teaching POSTGRADUATE TEACHING Continuously during the spring and fall semesters a seminar series in immunology was conducted

every week with presentations from research fellows or invited speakers. On a weekly basis seminars were given related to research areas of the students/trainees (project-meetings). Guest lectures are an important part of intellectual stimulation. The scientists were teaching immunological techniques, autoimmunity, mucosal immunity and oral medicine in postgraduate courses and at other invited situations both at national and international gatherings.

The followining courses have been provided by the Bergen Research School in Inflammation (BRSI): HUIMM 901 (2 students); HUIMM 902 (2 students); HUIMM 903/303 (3 students); and HUIMM 904/304 (5 students).

Immunologiens dag2010

Auditorium 1 i BB-Bygget (Jonas Lies vei 91, rett ved Haukeland sykehus)Sted:

Tid: Torsdag 29. april kl 1000-1500

Tema: Vaksiner

Kl 1000 Åpning

Kl 1015 Vaksinasjon mot årlig og pandemisk influensa ved Rebecca Cox,

Kl 1055 Adjuvans i vaksiner - bruk og virkemåte ved Kristian Lie, GlaxoSmithKline

Kl 1135 Lunsj

Kl 1300 Utfordringer ved utvikling av effektive vaksiner til fisk ved Edel Anne Norderhus,

Kl 1355 HIV-vaksine - problemer og utfordringer ved Birgitta Åsjö, Gades institutt, UiB

Møtet er åpent og tilpasset for alle interesserte!

Immunologiens dag er et verdensomspennende prosjekt som tar sikte på å bringe forskningsnyheter fra immunologi ut til et interessert publikum.

Kl 1435 Paneldiskusjon

Kl 1220 Vaksinasjonsprogrammet - hvem bestemmer? ved Hanne Nøkleby,

Bergen Branch av Norsk selskap for immunologi, Broegelmanns forskningslaboratorium og Forskerskolen i inflammasjon arrangerer:

Kl 1340 Kaffepause

ved Stener Kvinnsland, Haukeland Sykehus

Influensasenteret, Gades institutt

Folkehelseinstituttet

PHARMAQ


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GUESTLECTURES AND VISITORS AT BRL 12/5 "The 14th Broegelmann Lecture" by Professor Stig Frøland, MD, PhD

Oslo University Hospital, Oslo, Norway " Virus and lymphocytes - a personal experience of the origin and development of the HIV/AIDS pandemic”

13/10 2nd Bergen meeting NSI Bergen branch.


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4. Scientific activity COMPLETED THESIS IN 2010 WITH CONTRIBUTIONS FROM BRL: Vogelsang P: Dendritic cells in Sjögren’s syndrome; degree of philosophiae doctor (PhD), thesis defence May 28, 2010. Supervisors: Silke Appel, Roland Jonsson Szyszko EA: Characterization of long-lived plasma cells in primary Sjögren’s syndrome; degree of philosophiae doctor (PhD), thesis defence Dec 19, 2010. Supervisors: Kathrine Skarstein, Karl Brokstad, Roland Jonsson Master theses Magne Henrik Olsen: Bromelain in combination with components of the cytokine cocktail as a maturation stimuus for dendritic cells, thesis defense 16.06.2010; supervisors: Appel/Hovden


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SPECIFIC AIMS OF THE RESEARCH AT BRL: The laboratory targets its efforts within the fields of autoimmunity, mucosal immunity, immunopathology and tumour immunology. The work is directed towards basic immunological questions incl. genetics associated with rheumatic diseases and mucosal immunity as well as clinical immunological topics. Furthermore, these topics are also assessed in experimental systems. The laboratory work is performed with immunomorphological and functional immunological techniques at both cellular and molecular levels in human and murine tissues, sera, and secretions as well as in tissue- and cell-cultures. Specific areas of interest are summarized below: • AUTOIMMUNITY Autoimmune reactions are of central importance in the etiology of many somatic diseases. Different tissues can be affected in different ways but a common denominator is a chronic inflammation, which can result in tissue damage and accompanying loss of function. Our aim is to study disease mechanisms in connective tissue diseases (Sjögren's syndrome and rheumatoid arthritis) with special reference to exocrine gland and joint tissue. For this purpose we combine studies in both human and murine systems, which hopefully will help us in elucidating pathogenic mechanisms and more recently the genetic background as a basis for better diagnosis and therapy. The immunological aspect is concerned with cellular and molecular characterization of lesions, quantification of humoral and cellular immune responses against endogenous and exogenous antigens, as well as attempts at immunomodulation. Special attention is given to programed cell death (apoptosis) in relation to the chronic inflammatory disorders (Sjögren's syndrome, rheumatoid arthritis, adult periodontitis). • MUCOSAL IMMUNITY Mucous membranes constitute important defense mechanisms for the body and contain important humoral effector functions via the humoral immune system. A change in the regulation of immunity can however give rise to undesirable side effects which may result in tissue lesions in mucous membranes of the oral cavity, the gastro-intestine, the vagina, the lungs, the exocrine glands etc. Furthermore, the body is normally confronted with the first antigen contact/stimulation through the mucous membranes. Our aim is to study antigen presentation in mucous membranes and to characterize defense mechanisms and pathological immunological situations. Knowledge obtained within this field is of particular importance for better diagnostic and preventive/treatment measures e.g. vaccines. • TUMOR IMMUNOLOGY The immune system obviously has an important role in the development of malignant tumors. Our interests within this are: role of dendritic cells, T cells, macrophages, cytokines and apoptosis incl. regulating molecules in tumor development. The scientific activity at BRL is concentrated much on an international profile with a vast network. Internationally BRL has kept and established contact with more than 10 foreign research institutions, mainly in Sweden, other European countries, Australia and USA. The work is characterized by "crossing" scientific fields aiming both towards clinical and basic research, laying the ground for truly translational medicine.


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COLLABORATION IS ESTABLISHED WITH THE FOLLOWING LOCAL RESEARCH INSTITUTIONS: University of Bergen – Haukeland University Hospital A. Department of Microbiology and Immunology, Sections for immunology, bacteriology and

virology, The Gade Institute B. Section of Rheumatology, Institute of Medicine C. Department of Otolaryngology/Head & Neck Surgery D. Centre for Clinical Molecular Medicine/Dept of Medical Genetics E. Department of Neurology, Inst of Clinical Medicine F. Department of Pathology and Oral Pathology, The Gade Institute H. In addition, collaboration (joint grants/publications and/or sharing of

reagents/materials) is established with the following laboratories/institutions: 1. Experimental rheumatic disease in murine models (R. Holmdahl, Dept of Medical Inflammation

Research, Karolinska Institutet, Sweden) 2. Genetic studies in Sjögren´s syndrome and Potential viral etiology of autoantibody (Ro) production

(J. Harley, Arthritis and Immunology Program, Oklahoma Medical Research Foundation, OK, USA)

3. Anti-Ro and anti-La antibody studies (M. Wahren, Centre for Molecular Medicine, Department of Rheumatology, Karolinska Institute, Stockholm, Sverige)

4. Human/murine Ro and La antigens, aquaporins and muscarinic receptors (T. Gordon, Tissue Typing and Immunogenetics, Flinders University Hospital, Adelaide, Australia)

5. Muscarinic receptors and autoimmunity (Ammon B. Peck, University of Gainesville, FL, USA) 6. Characterization of early and covert stages of Sjögren’s syndrome in an experimental model of the

disease using integrative bioinformatics and network analyses (Ammon B. Peck, University of Gainesville, FL, USA)

7. Clinic/Epidemiology of inflammatory rheumatic disease (R. Omdal, Section for Clinical Immunology, Stavanger Hospital)

8. Experimental model of Sjögren's syndrome (Hal Scofield, Arthritis and Immunology Program, Oklahoma Medical Research Foundation, OK, USA)

9. Integrins and matrix biology (Donald Gullberg, Section for Physiology, Institute of Biomedicine, UoB)

10. Design of tumor specific immunotherapies (Hans-Jørgen Aarstad, Dept of Otolaryngology/Head & Neck Surgery, Haukeland University Hospital)

11. The Swedish-Norwegian Sjögren’s Consortium with major partners at Univ o Uppsala (Gunnel Nordmark, Lars Rönnblom), Karolinska Institute (Marie Wahren-Herlenius), Lund/Malmö Univ Hospital (Elke Theander), etc.


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MAJOR PROJECTS - 2010 Antigen induced immune modulation and autoimmunity – Nicolas Delaleu et al. Characterization of the altered homeostasis in the salivary glands prior to the

onset of Sjögren’s syndrome – Nicolas Delaleu et al. Role of dendritic cells in primary and experimental Sjögren’s syndrome - Silke

Appel et al. Use of dendritic cells in immunotherapy – Silke Appel, Arnt-Ove Hovden et al. B cells, autoantigens and autoantibodies in Sjögren’s syndrome – Karl Brokstad et

al. Autoimmunity and lymphoid neogenesis – Malin V. Jonsson et al. The genetics of Sjögren´s syndrome; identification of susceptibility genes and

global gene expression studies - Anne Isine Bolstad, Silke Appel et al.

Influenza and mucosal immunobiology – Karl Brokstad et al. Toll like receptors and B cells – Torbjørn Hansen et al. OTHER COLLABORATIVE PROJECTS: • Relations between immune functions/cytokines, psychological status and cancer

development (Heimdal/Aarstad) • B-cell activity (anti-p24 and anti-gp120) in tonsils and peripheral blood from

humans with HIV infection (Voltersvik) • Immune mediators in connection with removal of amalgam restorations

(Björkman)


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PUBLICATIONS from the LABORATORY in 2010

Brokstad KA, Cox RJ. Influensa: sykdommen. Medisinsk informasjon; Influensa (ed: Fretheim A.) MEDLEX 2010 (24, 10-1) 8-9. ISSN 0801-4612, ISBN 978-82-7841-630-3.

Brokstad KA, Cox RJ. Influensa: viruset. Medisinsk informasjon; Influensa (ed: Fretheim A.) MEDLEX 2010 (24, 10-1) 10-11. ISSN 0801-4612, ISBN 978-82-7841-630-3. Bucci C, Bakke O, Progida C. Rab7b and receptors trafficking. Commun Integr Biol. 2010 Sep–Oct; 3(5): 401–404. Carracedo S, Barczyk M, Popova S, Aumailley M, Jonsson R, Eckes B, Gullberg D. The fibroblast integrin a11b1 is induced in a mechanosensitive manner dependent on activin A and regulates myofibroblast differentiation. J Biol Chem, 2010 Apr 2;285(14):10434-45. Cobb BL, Fei Y, Jonsson R, Bolstad AI, Brun JG, Rischmueller M, Lester SE, Witte T, Illei G, Brennan M, Bowman S, Moser KL, Harley JB, Sawalha AH. Genetic association between methyl-CpG-binding protein 2 (MECP2) and primary Sjögren’s syndrome. Ann Rheum Dis, 2010 Sep;69(9):1731-2. Delaleu N, Manoussakis MN, Moutsopoulos HM, Jonsson R. Pathogenesis: emphasis on dry mouth and the role of salivary glands. In: Sjögren’s syndrome; pathogenesis and therapy, Fox R, ed. In press. Geitung JT, Jonsson MV. Imaging technology in Sjögren’s syndrome – non-invasive evaluation of the salivary glands. In: Sjögren’s syndrome; pathogenesis and therapy. Fox R, ed. In press. Hovden AO, Appel S. The first dendritic cell-based therapeutic cancer vaccine is approved by the FDA. Scand J Immunol 2010 Dec; 72(6):554. Husebye H, Aune MH, Stenvik J, Samstad E, Skjeldal F, Halaas O, Nilsen NJ, Stenmark H, Latz E, Lien E, Mollnes TE, Bakke O, Espevik T. The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes. Immunity. 2010 Oct 29;33(4):583-967. Jonsson MV, Delaleu N, Marthinussen MC, Jonsson R. Oral and dental manifestations in Sjögren’s syndrome. Current approaches to diagnostics and therapy. In: Sjögren’s syndrome; pathogenesis and therapy. Fox R, ed. In press. Jonsson R, Olofsson J. Autoimmune disorders, lymphoproliferation and granulomatous inflammation. In: Diseases of the salivary glands. Bradley & Guntias-Lichius, eds. In press. Jonsson R, Skarstein K, Jonsson MV. Histopathology and glandular biopsies in Sjögren’s syndrome. In: Sjögren’s syndrome; pathogenesis and therapy. Fox R, ed. In press.


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Jonsson R, Brun JG. Sjögren’s syndrome. In: ENCYCLOPEDIA OF LIFE SCIENCES 2010, John Wiley & Sons, Ltd: Chichester http://www.els.net/ [DOI: 10.1002/9780470015902.a0002149.pub2] (Featured article) Landsverk OJ, Barois N, Gregers TF, Bakke O. Invariant chain increases the half-life of MHC II by delaying endosomal maturation. Immunol Cell Biol. 2010 Nov 30. [Epub ahead of print] Låg M, Rodionov D, Øvrevik J, Bakke O, Schwarze PE, Refsnes M. Cadmium-induced inflammatory responses in cells relevant for lung toxicity: Expression and release of cytokines in fibroblasts, epithelial cells and macrophages. Toxicol Lett, 2010 April 1,193 (3), 252-260. Nordmark G, Kristjansdottir G, Theander E, Appel S, Eriksson P, Vasaitis L, Kvarnström M, Delaleu N, Lundmark P, Lundmark A, Sjöwall C, Brun JG, Jonsson MV, Harboe E, Gøransson L, Söderkvist P, Padyukov L, Eloranta M-L, Alm G, Baecklund E, Wahren-Herlenius M, Omdal R, Rönnblom L, Jonsson R, Syvänen A-C. Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren’s syndrome. Genes and Immunity, Epub 2010 Sep 23. Progida C, Cogli L, Piro F, De Luca A, Bakke O, Bucci C. Rab7b controls trafficking from endosomes to the TGN. J Cell Sci, 2010 May 1;123(Pt 9):1480-91. Seror R, Mariette X, Bowman S, Baron G, Gottenberg JE, Boostma H, Theander E, Tzioufas A, Vitali C, Ravaud P; European League Against Rheumatism Sjögren's Task Force. Accurate detection of changes in disease activity in primary Sjögren's syndrome by the European League Against Rheumatism Sjögren's Syndrome Disease Activity Index. Arthritis Care Res (Hoboken). 2010 Apr;62(4):551-8. Seror R, Ravaud P, Bowman SJ, Baron G, Tzioufas A, Theander E, Gottenberg JE, Bootsma H, Mariette X, Vitali C; EULAR Sjögren's Task Force. EULAR Sjogren's syndrome disease activity index: development of a consensus systemic disease activity index for primary Sjogren's syndrome. Ann Rheum Dis. 2010 Jun;69(6):1103-9. Vogelsang P, Brun JG, Oijordsbakken G, Skarstein K, Jonsson R, Appell S. Patients with primary Sjögren´s syndrome (pSS) have significantly reduced amounts of pDC and mDC2 in peripheral blood. Ann Rheum Dis,. 2010 Jun;69(6):1235-8. Walseng E, Furuta K, Bosch B, Weih KA, Matsuki Y, Bakke O, Ishido S, Roche PA. Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20465-70. Wegner CS, Malerød L, Pedersen NM, Progida C, Bakke O, Stenmark H, Brech A. Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5. Histochem Cell Biol, 2010 Jan;133(1):41-55.


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5. EDITORIAL ACTIVITIES – Scandinavian Journal of Immunology Since 1999 BRL has been serving as the central Editorial Office for Scandinavian Journal of Immunology. This activity means a number of international contacts in addition to the reviewing of scientific immunology papers. K. Frøland is part-time employed as Editorial Assistant with responsibilities for contacts with the publisher Blackwell Science, address lists for subscribers, economy etc. Jonsson - Editor-in-Chief: Scandinavian Journal of Immunology (1999 - present) Jonsson - Editorial Board Member/Advisory Editor: Scandinavian Journal of Immunology (1995 - 1999); European Journal of Oral Sciences (1999 - 2005); Scandinavian Journal of Rheumatology (2000 – present); Arthritis & Rheumatism (2000 – 2004); Current Rheumatology Reviews (2004 – present); Up-to-date Rheumatology (2005 – present); Annals of Rheumatic Diseases (2008 – present). Referee: Annals of the Rheumatic Diseases, Arthritis & Rheumatism, Journal of Oral Pathology & Medicine, Journal of Rheumatology, Nature Reviews Rheumatology, Scandinavian Journal of Immunology, Scandinavian Journal of Rheumatology. 6. LECTURES – SEMINARS - OTHER ACTIVITY Roland Jonsson - 2010 Invited speaker: Vienna, Austria; The Norwegian PhD Training Program in Medicine and Health Related Sciences Tallinn, Estonia; Welcoming address – Scandinavian Society for Immunology Göteborg, Sweden; A clinical update on Sjögren’s syndrome London, UK; Immunopathology resulting in hyposalivation Evaluation of research grant proposals: Wellcome Trust The Sjögren’s Syndrome Foundation Appointed vice-chairman, the Gade Institute, with main responsibility for Research, from 2009. Faculty and other volunteering activities – Faculty of Medicine and Dentistry: Leader of committee for Research Education and Training since 2008 Member of steering committee for Basic Course in Medical and Health related topics since 2003 Permanent member of the Faculty Board since 2009 Permanent member of the Faculty Research Committee since 2009 Member of National committee for scientific publication in Rheumatology since 2007 Chairman of National committee for scientific publication in Biomedicine and Immunology since 2010

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BROEGELMANN RESEARCH LABORATORY · The Autoimmunity and Mucosal Immunobiology Research Group (AMIR) - 10 - 4. Scientific activity COMPLETED THESIS IN 2010 WITH CONTRIBUTIONS FROM