Brochure Pierre Fabre in France 09-15-2014

A companythat is committedto its roots and that projects itselfeverywhere in the world.

This is the guiding principle of our development,

and why we now operate in 130 countries throughout

the world. We give France, the company’s country

of origin, priority for research and manufacturing

activities (prescription drugs, health care and

dermo-cosmetics).

A company that strives to encourage partnership,

combined with a global vision and a relentless drive

to innovate.

A company that has always been inspired by its

origins, and therefore deliberately has decided to

expand internationally while staying true to its roots.

This is the commitment that ensures our development.

This is why France, and its southwestern region,

remain the company’s natural homeland.

Pierre Fabre:Missions and ValuesOur Mission p. 16

Innovation: A Driving Force p. 18

Investing and Producing in France p. 10

The Pierre Fabre Foundation p. 12

Pierre Fabre Locationsin France Combining Heritage and Aesthetics p. 16

Roger Taillibert,

the Architect of Pierre Fabre’s Humanism p. 17

Pierre Fabre in Castres p. 19

Pierre Fabre in the Tarn p. 31

Pierre Fabre in the Midi-Pyrénées p. 47

Pierre Fabre in Southwestern France p. 57

Pierre Fabre in France p. 69

Pierre Fabre worldwide p. 77

Pierre Fabre : Mission and Values

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We take care of human beings as a whole, in all their diversity.

In order to do this, we design and deve-lop innovative solutions that contribute to people’s well-being, from health to beauty. We achieve this by cooperating with health care professionals, our trusted partners worldwide; by constantly drawing inspira-tion from nature and plants; and by placing pharmaceutical ethics at the very heart of our operations.

Originally a retail pharmacist, Pierre Fabre

decided to shift his retail mission to an

industrial scale, providing a comprehen-

sive response to the therapeutic needs and

well-being of patients.

As a result of this philosophy, the company

has developed a large portfolio of complemen-

tary activities, from prescription medication

(oncology, neuropsychiatry, dermatology, and

women’s health) to dermo-cosmetic products

(Avène, Klorane, Ducray, A-Derma, Galénic,

René Furterer, Darrow, Glytone, and Elancyl

brands), as well as pharmacy medication (Drill,

Elgydium, etc.) and natural health remedies

(Naturactive).

Convinced that the 250,000 known fl owering

plants and some that are yet to be discovered

are treasure troves for health and beauty, Pierre

Fabre has made research on plant substances

a major focus of its activities. The objective of

this research is to develop active ingredients

for health care and dermo-cosmetic purposes.

This fi rm belief has led the company to go to

great lengths to highlight the natural heritage of

its various sites, which are replete with carefully

maintained gardens and green spaces.

The Pierre Fabre Group has an annualturnover of 2 billion euros.International operations represent 56% of overall turnover.

Our mission

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Le Carla Domain in Castres >

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Every year, Pierre Fabre allocates approxi-mately 20% of its pharmaceutical revenue to research and development activities.

Our research centers that employ nearly

1,100 people are all located in France: in

Castres (neuropsychiatry), Toulouse (onco-

logy, dermatology and dermo-cosmetics),

and Saint-Julien-en-Genevois (cancer-fi ghting

biotechnology).

Nearly 80% of our research and development

employees are located in the Midi-Pyrénées

(Toulouse) region.

R&D is organized around 3 priority areas:

> Oncology

> Neuropsychiatry

> Dermatology

Pierre Fabre works in close partnership with a

number of public research bodies (INSERM,

CNRS, Paris VI, etc.). For the past 10 years,

Pierre Fabre has maintained a joint Research

and Service Unit with the CNRS.

This joint team is based at the Pierre Fabre

Research and Development Center at the

Toulouse Oncopole life science campus, and

aims to develop medications that target epige-

netic gene regulation in cancer.

Pierre Fabre combines pharmaceutical and

dermo-cosmetic research, thus creating

innovative bridges between these two com-

plementary areas. Over the years, a wealth

of transversal expertise has been developed

in areas such as dermatology, plant research,

and natural ingredient properties.

Innovation: a driving force

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Three scientifi c centers of excellence:

The Pierre Fabre Research

and Development Center (Toulouse Oncopole),

the Pierre Fabre Immunology Center

(Saint-Julien-en-Genevois),

and the Pierre Fabre Research Center

for Neuropsychiatry (Castres - Péraudel)

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Pierre Fabre has 10,000 employees, more than two-thirds of which are located in France.

Nearly 2,700 of our employees are based in

the French department of Tarn (Midi-Pyrénées

region), where our laboratories were foun-

ded. Pierre Fabre is in fact the number one

employer in (Midi-Pyrénées region) this depart-

ment. The company is also the second largest

private employer in the Midi-Pyrénées region.

95% of all products sold by Pierre Fabre are

made in France. Health care and pharmaceu-

tical production is located in Gien, Château-

Renard (Loiret), Pau (Pyrénées Atlantiques),

Aignan (Gers) and Cahors (Lot). Dermo-cos-

metic production is located in Soual (Tarn),

Mazamet (Tarn) and Avène (Hérault).

2,300 employees work in our plants in France.

By focusing its R&D investments in France,

the Group helps to create research centers of

international caliber. In order to recruit and

retain th best researchers in the country.

Pierre Fabre invests signifi cantly in France every year.

Recent investments:

> 2010 - The opening of the Research and

Development Center at the Oncopole

campus in Toulouse: 40,000 m2 of labora-

tories and offi ce space, and 550 on-site

employees.

> 2012 - The extension of the Soual dermo-

cosmetic production plant to 13,500 m2.

> The construction of a 3,300 m2 biotech-

nology unit for monoclonal antibodies on

our Saint-Julien-en-Genevois research site.

Investing and producingin France

An experimental High Environmental Quality approach (“Haute Qualité Environnementale”) has been implemented

in the Soual production site extension

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In 2008, Mr. Pierre Fabre donated the majority of its stake in the company to the Pierre Fabre Foundation, a government-recognized public-interest foundation. He completed his donation in 2013 by making the Foundation his sole legatee.The Foundation is the Group’s majority shareholder, a fi rst in France.

The Pierre Fabre Foundation

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Théron Périé: The Pierre Fabre Foundation head offi ce in Castres.

The Foundation is the majority shareholder of Pierre Fabre Laboratories.

Pierre Fabre has been serving health care

for over 50 years. The Foundation continues this work,

helping to strengthen public health programs in several

developing countries in Africa and southeast Asia.

It is a foundation under French law, and is recognized

as being of public interest.

The Pierre Fabre Foundation plays a decisive

role in the governance of the Pierre Fabre

Group and is instrumental to its long term

continuity. As the majority shareholder (86%)

of Pierre Fabre Laboratories, the Pierre Fabre

Foundation is the only French non-profi t

organization to own a large industrial com-

pany. This means that potential profi t to be

distributed by Pierre Fabre Laboratories in

the form of dividends is primarily paid to the

Foundation, in order to enable it to fulfi ll its

general interest mission. However, although

the Foundation is the company’s majority

shareholder, it is not directly involved in its

operational management.

The Foundation is dedicated to fulfi lling the

objectives specifi ed in its statutes, and

remains impartial, independent and wholly

committed to its mission, that is to improve

access to quality medication and care in the

least developed and developing countries.

Pierre Fabre Locations in France

For over 50 years, the company’s continued development has been

combined with an ambitious geographic strategy, inspired by the Group’s

values.

Pierre Fabre has always strived to keep corporate units personal and

manageable, to help employees work in the best possible conditions.

Pierre Fabre has sought fi rm integration in its local economic fabric, and

has thus often chosen locations in mid-sized towns and even in rural

areas (Gaillac, Mazamet, Soual, Saint-Julien-en-Genevois, Château-Re-

nard and Lavaur). The company has always aimed to combine its own

corporate growth with regional growth.

Our focus on local integration also refl ects our concern about preserving

and enhancing heritage. Our locations are often noteworthy in terms of

industrial, cultural (Sorèze) or family (Castres for example) heritage. We

are committed to keep this heritage alive. Even our most modern loca-

tions, such as the Toulouse Oncopole Research and Development Center

and Les Cauquillous head offi ce in Lavaur, are part of the history and

geography of their host locations.

Through the way it discretely tames its surrounding nature, the com-pany conveys its founding values: aesthetics, rigor, heritage preser-vation and humanism.

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Les Cauquillous, the head offi ce of the dermo-cosmetics division: a successful synthesis

of nature and technological innovation.

Sorèze Abbey School, Pierre Fabre University.

Combining Heritageand Aesthetics

Pierre Fabre entrusted the design of its

most iconic buildings to Roger Taillibert,

member of the Institut de France, and

President of the Académie des Beaux

Arts. More than anyone else, he was

able to skillfully and boldly embody the

company’s identity.

Roger Taillibert is an undisputed

concrete shell specialist. Throughout

his entire career, he relentlessly perfec-

ted this technique to serve high-quality form and function. He freed the

medium of its rigidity, lending it newfound fl exibility and fl uidity. The space

and light that his concepts incorporate symbolize a beacon of hope for

life and good health.

Roger Taillibert is the architect behind stadiums such as the Parc des

Princes in Paris, the Olympic Stadium of Montreal, the Khalifa International

Stadium in Qatar, and the International Sports Complex of Luxemburg.

Pierre Fabre considers that this architect has supported and followed the

Group’s development with ever-renewed inspiration. He designed the

very fi rst Research Center in Péraudel and the Group’s very fi rst factory in

Soual. He later created the Research Center in Saint Julien-en-Genevois,

the Distribution Center in Ussel, the dermo-cosmetics head offi ce named

Les Cauquillous in Lavaur, and most recently the Research and Develop-

ment Center at the Oncopole in Toulouse.

Roger Taillibert has succeeded in creating a harmonious architectu-ral language that expresses the company’s values of humanism and generosity.

Roger TaillibertThe Architect of Pierre Fabre’s Humanism

Pierre Fabre in Castres

LévezouLa Chartreuse

Le Carla

LévezouLa ChaCha trtreuse

Le Carla

La Michonne

Théron-Perié

Lacaze-Basse

Le Causse

Bagatelle

Les Fontaines

Le Sidobre

Péraudel JeanMoulin

Miredames

Activities

> Corporate communications and public

relations teams

> Showroom displaying all

of the Group’s products

> Reception of the Group’s partners

and visitors

History

Built in 1875 by Eugene Fau, a textile manu-

facturer in Castres, the domain was later

acquired by the Liebersac family, who lived

in Paris. It was a Liebersac family tradition

to spend summers at Le Carla. In 1968, Le

Carla Domain was transferred to the Refor-

med Church of France, and divided into

3 plots.

Mr. Pierre Fabre acquired the 3 plots in 1971,

and thereby could recreate the original estate.

Le Carla Domain houses the head offi ce of the Pierre Fabre Chairmanship. It is a place for meetings that fosters communication, where the Group’s

partnerships are usually concluded.

Pierre Fabre has installed a 14 rooms hotel and a restaurant on-site, which enables the company to host the Group’s various visitors on a daily basis.

Le Carla Domain also includes the company showroom, which displays all of the Group’s product ranges and brands.

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Le CarlaChairmanship of Pierre Fabre LaboratoriesBurlats

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This Basque-inspired house in the center of Castres was built in a hundred-year-old park by the Lasbordes family, textile manufacturers. Acquired by

Mr. Pierre Fabre in 1974, the home now houses the Group’s General Management offi ces.

La MichonneGeneral Management of the GroupCastres

Located in a building purchased from the family of Dr.

Chabbert in 1989, this site hosts the Group’s Human

Resources Management teams. Between 1990 and

1993, the adjoining sites were acquired in order to

create green spaces. The Skills Development Division

is located next door, in Théron-Périé, in the building that

also houses the Pierre Fabre Foundation.

MiredamesHuman ResourcesManagement

Théron-PériéPierre Fabre FoundationHead Offi ce

This former residence of a Castres textile industria-

list family is surrounded by a hundred-year-old park

that runs along the river Agout that supplies Castres

with water. It is now the head offi ce of the Pierre

Fabre Foundation.

MiredamesThéron-PériéCastres

PéraudelPierre Fabre Research Centerfor NeuropsychiatryCastres

Activities> Neuropsychiatric research

> Synthetic chemistry

> Analytical chemistry

> Molecular biology

> Research informatics

> Intellectual property

> Scientifi c documentation

HistoryPierre Fabre acquired the Péraudel site in

1960.

During World War II, it was in this historic

building that the agreement for surrendering

the occupation troops’ garrison was signed

on Sunday, August 20th, 1944, at 3:00 P.M.,

in the presence of Commander Dunoyer de

Segonzac (Hugues) and Captain Lamon

(Dumoulin) for the French Forces of the In-

terior, and of Colonel Machts and Captain

März for the German army.

It is in Péraudel that Pierre Fabre’s re-search began to truly take shape in 1968.

In 1969, this property already housed a

number of departments including those

dealing with scientifi c documentation ser-

vices, biochemistry, phytochemistry, organic

synthesis, as well as a virology laboratory.

Our three main areas of research into active

ingredients already coexisted at this time

(synthetic chemistry, natural substances,

biology).

Located on the Péraudel site in Castres, this Research Center is specialized in central nervous system disorders, particularly psychoses (schizophrenia,

bipolar disorders, depression) and neurology (chronic pain).

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Les Fontaines Pierre Fabre Santéand Naturactive

La ChartreuseLes FontainesCastres

La Chartreuse Pierre Fabre Pharmaceuticals

The 2 La Chartreuse buildings, to the west of

Castres, house the Pierre Fabre Pharceuticals

general management and teams.

La Chartreuse I was built in 1985.

La Chartreuse II, a more modern glass building,

was built in 1996.

This former private clinic belonging to the Galibert

family was acquired by Mr. Pierre Fabre in 1990,

and converted into offi ce space.

It now houses the Group’s family health, oral care

and natural health (Naturactive brand) general

management and teams.

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Le SidobreLe CausseCastres

Le SidobrePierre Fabre Administrative Center

Typical of early 20th century industrial architecture, this former textile

factory located in the center of Castres was acquired by Pierre Fabre in

1975 and became one of the Group’s administrative centers.

It currently houses the IT Department, and the Facilities and Property

Management Department.

Le CaussePierre Fabre Administrative Center

Located in Le Causse business park in eastern Castres, part of this

modern building houses the Group’s administrative services, including

management control, tax and accounting, purchasing, and property

insurance and safety.

Part of the Castres-Mazamet Technopole, La Causse business park is

a technology area that meets high quality and environmental standards.

LévezouPierre Fabre Sports associationSaïx

Activities> 3 indoor tennis courts

> 3 outdoor tennis courts

> 1 multi-purpose team sports room

Activités

> 1 shooting gallery

> 1 rugby fi eld

> 1 soccer fi eld

> 1 petanque area

Activités

> 1 fi tness and weights room

> 70 m² mat area for fl oor exercise

> changing rooms for 25 players

per changing room

> 250 m track

Le Lévezou is the head offi ce of the Pierre Fabre Sports Association. Its

layout is modeled off of farms from the Lauragais area.

It provides employees with high-quality facilities for many kinds of sports.

The entire facility is equipped with night lighting for training.

The Pierre Fabre Sports Association holds several French corporate championship titles in handball, rugby, soccer, tennis, equestrian sports and basketball.

Le Lévezou is also the rugby training center for the Castres Olympique

team, which belongs to the elite of in French rugby.

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Pierre Fabre in the Tarn

Castres

Gaillac

Lavaur

Sorèze

SoualSaïx

BurlatsPuylaurens

Mazamet

Completed in 2001, the Botanical Conservatory is a research,preservation and conservation area with more than 1,200 plantspecies, 500 of which are protected species.

The Conservatory’s initiatives help enrich knowledge on botanical

diversity among the laboratories and lab researchers of Pierre Fabre.

Covering 4 hectares of land, the Conservatory is surrounded by vast fi elds

where Rhealba® oat and cornfl ower are grown.

The Pierre Fabre Botanical Conservatory is the only private scientifi c

institution that has been granted CITES* certifi cation. Our collections

showcase 500 CITES-listed species.

Activities

> The apothecary houses a collection of

18th and 19th century apothecary jars

> The herbarium has specimen sheets that

make it possible to defi nitively identify

plant species

> A rich library of over a thousand works

on botany

> A conference room

> A botanical laboratory for preparing

samples

> A greenhouse for humid tropical plants

> An greenhouse for tropical dry plants

> The Botanical Garden: This 5,000 m2

garden cultivates plants for medicinal,

dermo-cosmetic, edible, tinctorial and

botanical interest purposes.

HistoryThis mansion is located south of Castres

and was built in 1834, in typical Directoire

style: straight, symmetrical lines with classical

pediments.

The site’s other key feature is its French

Formal Garden, dating from the 1920s. It was

inspired by the Bishop’s Garden in the city of

Castres, which was designed by Le Nôtre (in

the 17th century).

The arabesque-trimmed hedges in the beds

are gone now, but there are still 82 topiaries

that confer majesty upon the garden. These

topiaries create a perspective that guides

one’s eye down to the banks of the Sor.

*CITES: The Convention on International Trade in Endange-

red Species of Wild Fauna and Flora. CITES aims to ensure

that international trade in specimens of wild animals and

plants does not threaten the survival of their species.

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Soual - Cambounet sur le SorBotanical Conservatory Tarn

Activities> Manufacturing and packaging

dermo-cosmetic products: cream, liquid,

milk and lotion

> Manufacturing and packaging sterile

cosmetic products

> Product component supply, verifi cation

and release prior to sale

Key Dates1969 Soual factory constructed

(18 000 m²)

1974 Logistics transferred to the Muret

Distribution Center (near Toulouse)

1989 Main workshop extended

(1 500 m²)

1990 Bagatelle (Castres) packaging

warehouse opened near the factory

1995 Site specializes in cosmetic

products

1996 Soaps and hypoallergenic cleansing

bars manufacturing transferred to

the Mazamet (Tarn) workshop

2010 Extension construction begins

(13 500 m²)

2012 Production begins on the new

premises

Certifi cations& Approvals

Pharmaceutical company

Good Manufacturing Practices -

Medicines (ANSM)

Good Manufacturing Practices -

Cosmetics (ISO 22716)

ISO 9001 (Quality Management

System)


System for Medical Devices)

The Soual site is a historical dermo-cosmetics factory. It manufactures

and packages dermo-cosmetic products of brands such as Ducray,

A-Derma, René Furterer, Klorane, Galénic, and Elancyl. In terms of pro-

duction volume and number of employees, Soual is the Group’s largest

industrial site. It has 35 packaging lines, and 15 manufacturing platforms.

In 2012, the site was expanded to better respond to increasing demand

and requirements from our clients worldwide. This 13,500 m2 extension

is primarily used to produce sterile cosmetic products.

Pierre Fabre invented a new standard for dermo-cosmetics: sterile cosmetics.This standard is the only one of its kind in the world, combining three major innovations (formulation, packaging and manufacturing). This new standard that guarantees that products are free of preservatives and preservative substances, that they remain sterile and protected throughout their use, via a hermetically sealed patented packaging system named (DEFI).

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SoualPierre Fabre Dermo-cosmeticsManufacturing SiteTarn

Le SidobreCentre Administratif Pierre FabreCastres

Built in 1983 in the town of Mazamet, this 2,500 m2 production unit pro-

duces hypoallergenic bars, scented soaps and sticks for all of our dermo-

cosmetic brands.

Products include Anne de Péraudel scented soaps and Klorane Bébé

soaps for babies. The site is ISO 9001 (Quality Management System) and

ISO 22716 (Good Manufacturing Practices – Cosmetics) certifi ed.

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MazametProduction unit for sticksand hypoallergenic cleansing barsTarn

Terre d’AvoinePuylaurens, Lissertel siteTarn

Terre d’Avoine is an exceptional natural and authentic environment that is

home to the Rhealba® Oat, the unique and exclusive active ingredient of

the A-DERMA Dermatological Laboratories.

Dedicated exclusively to oat cultivation, this location uses an educational,

interactive and emotionally engaging approach to convey the secrets of

these oats in life-size, both inside and outside the country house.

Activities

> Organic farming of Rhealba® Oats

> Reception area for A-DERMA brand

and Pierre Fabre Group partners

and visitors

> Training center

> Conference room, meeting rooms,

museum area, teaching gardens,

restaurant

HistoryLocated on the “LISSERTEL” site in Puylau-

rens (which means “cleared land” in Occitan),

Terre d’Avoine is a 25 hectare agricultural plot

with a fortifi ed Provençal estate dating from

1640.

Acquired by Pierre Fabre Laboratories in

2011 and developed in coordination with the

Museum of Natural History of Toulouse, this

site is a center of excellence that is part of the

history of the A-DERMA brand.

A symbol of our laboratories’ commitment to

science and innovation, this site is focused on

the future, more than anything else.

Les Cauquillous is the head offi ce of Pierre Fabre Dermo-cosmetics. The

building was designed by the architect Roger Taillibert, and was inaugu-

rated in 2000. The lines of the building are reminiscent of a shell, and are

inspired from the Pierre Fabre logo, which is actually a symbolic interpreta-

tion of yin and yang itself. The building has six fl oors of open space offi ce

areas, accessible via a central hallway that is lined with an indoor garden.

ActivitiesDermo-cosmetic and dermatological brands

marketing and sales teams, as well as their

General Management and support teams are

located in Les Cauquillous:

> A-Derma

> Eau thermale Avène

> Ducray

> Elancyl

> Galénic

> Klorane

> Pierre Fabre Dermatologie

> René Furterer

HistoryThe name “Cauquillous” is related to the

history of the Saint James of Compostela

pilgrimage, as Lavaur was a point on the

route between Castres and Toulouse.

The word “Cauquillous” comes from the

Occitan word “cauquilha” (shell). The shell

was a symbol of pilgrims traveling toward

Santiago de Compostela.

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Les CauquillousPierre Fabre Dermo-CosmeticsLavaur

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BelairAdministrative CenterPierre Fabre Dermo-CosmeticsLavaur

Some of the support teams for the Group’s dermo-cosmetic activities have been located in this former clinic since 2005. These include the customer

service, market research, and merchandising support functions, the Dermaweb and Pharmaweb website teams, and the dermo-cosmetic division’s

accounting department.

PastelArt et CaractèreLavaur

Art et CaractèreArtistic printing

PastelPierre Fabre creation studioThis 1,500 m2 former furniture shop located in the center of the

city of Lavaur has two sections: the old shop built in the 20th

century, and a more recent extension.

The Group acquired this building in 1991 (prior to building Les

Cauquillous). It is now home to “Pastel Création”, the Pierre

Fabre creation, POS production and internal publishing studio.

Pastel creation, Pastel production, Pastel promotional material

(since 2002), and the Group’s Quality Services (since 2009) are

all located on this site.

Located in Lavaur, close to Les Cauquillous, the Art & Caractère

print shop is nationally recognized. Its clientele entrusts it with all

types of offset printing, primarily work that requires specialized

print services.

Art & Caractère also prints magazines, brochures, trade publi-

cations and sales catalogues. It has six 4-color, 6-color and

8-color printing presses with integrated forwarding, gilding and

embossing. The print shop has been awarded serveral times in

the “Most beautiful French books” competition, and is the fi rst

publisher in France to have successfully performed on AFAQ

26000 evaluation.

Our Gaillac site develops and produces pharmaceutical, cosmetic and

nutraceutical active ingredients for all of the Group’s activity sectors:

prescription drugs, health care and dermo-cosmetics.

We have developed in-depth expertise in plant extraction, purifi cation,

synthesis, hemisynthesis and fl uorination on this site. We also have

cutting-edge expertise in several promising technological fi elds (supercri-

tical fl uids and plant cell culture) that are trying to respond to the growing

challenges of sustainable development and green chemistry.

Our Gaillac site is an essential part of Botanical Expertise Pierre Fabre, an EFQM certifi ed approach to developing safe, innovative and effective active plant ingredients.

Activities> Natural product extraction

> Hemisynthesis

> Cytotoxic production

> Fluorination

> Purifi cation

> Plant cell culture

> Center for supercritical fl uids

development

Key datesCreated in 1976, the Gaillac site has conti-

nued to grow. It focuses on both technolo-

gical and human development, founded on

innovation and new expertise. It now has 9

production units.

1993 Cytotoxic production workshop

and FDA approval for the active

ingredient vinorelbine

1995 Center for chemistry development

1996 Synthetic chemistry workshop

1999 Fluorination workshop (for vinfl unine

production)

2000 Quality Control laboratory expanded

2004 Supercritical fl uids workshop

2007 Synthetic chemistry workshop

expanded

2008 FDA approval for the active

ingredient milnacipran hydrochloride42

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Quality: Good Manufacturing Practices

- ICH Q7 (site inspected by the ANSM

and FDA, french and american health

agencies)

Safety: OHSAS 18001 in 2010

Environment: ISO 14001 certifi ed in

1998, renewed every 3 years.

Epidaure Prize in 1999 (new infras-

tructure installed to treat pollutant

emissions)

Sustainable development: ISO 26000

in 2012



GaillacActive ingredient extractionand production siteTarn

In 1993, this former abbey and school was acquired by a joint union com-

posed of the Midi-Pyrénées region, the Tarn department and the town of

Sorèze, in the interest of protecting the site.

As a partner in this project, Pierre Fabre restored this historic site’s original vocation as an educational and cultural hub by creating the Pierre Fabre University.

This facility trains over 1,000 Pierre Fabre employees annually.

In partnership with the Toulouse Business School, the Pierre Fabre School

of International Marketing grants young graduates a Master’s in Health

Management, with a view to hiring them at Pierre Fabre.

Activities> Pierre Fabre University

> Seminar site

HistoryA former royal military school founded by

Louis XVI, the Sorèze Abbey and School

fl ourished in the mid-19th century, under

Father Lacordaire.

Involved in restoring the Dominican order,

Father Lacordaire breathed new life into

the school, with its reputation extending far

beyond the region and the country.

Sorèze has become a remarkable center of

intelligence and education: true to its origins,

this site has been an intellectual nexus from

as early as the 18th century, where the uni-

versalism of the Enlightenment was taught

with innovative methods.

Up until the school closed in 1991, students

from around the world came to this institu-

tion. This school always focused on intel-

lectual competition, through debates for

example. Many of these debates are still

famous.

Certifi cations & ApprovalsA recognized rural center of excellence,

the Sorèze Abbey and School is listed as

one of the major historic sites in the Midi-

Pyrénées.

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SorèzePierre Fabre UniversityTarn

Pierre Fabre in the Midi-Pyrénées

Cahors

Toulouse

MuretAignan

Located on the Oncopole campus in Toulouse, the Pierre Fabre Research

and Development Center is exceptional in its class. This site hosts all of

the teams and equipment that are required for new molecules develop-

ment and production. Based on public and private partnerships, the Cen-

ter’s research efforts focus on chemical, biological and natural molecules.

This Center also hosts a Research and Service Unit as per French law,

USR 3388. This unit includes teams from both the CNRS (the French

National Center for Scientifi c Research) and the Pierre Fabre Research

Institute. Its mission is to conduct research on mechanisms for the epige-

netic regulation of cancer and to screen anti-cancer active ingredients.

This unusual building designed by the architect Roger Taillibert is a futuris-

tic and functional working tool that embodies the company’s commitment

to “inventing” the future. In 2012, it received the International Architecture

Award from the Chicago Athenaeum Museum.

The Pierre Fabre Research and Development Center at theOncopole is the result of the Group’s desire to be a global player in the oncology fi eld. Wile focusing, it focuses its R&D investments in France, particularly in the region in which the Group was founded.

Activities> Identifying new biological targets

of therapeutic interest, through

genomics and proteomics

> Implementing research projects that use

innovative treatments for solid tumors

and hematological malignancies

> Early development of new chemical

and biological entities

> Developing new clinical indications

and presentations

> Identifying and perfecting innovative

substances for use in dermo-cosmetics

HistoryThe Oncopole project is fi rst and fore-most a commitment to a region to which our company is deeply attached.

After the dramatic explosion of the nitrogen

fertilizer factory in Toulouse in September

2001, Mr. Pierre Fabre made a personal

commitment to rehabilitating the site, with

the Greater Toulouse community. He there-

fore suggested hosting part of our Research

and Development Activities on the site.

When the french national cancer strategy

(“Plan Cancer”) was announced, Pierre

Fabre naturally wanted to participate in the

development of the Oncopole in Toulouse.

This facility contains several public and

private research bodies, and also houses a

public clinic, the University Cancer Institute.

Certifi cations & ApprovalsANSM (french health agency) approved

Pharmaceutical site Company

Approved by the Departmental population

protection division (“Direction departe-

mentale de la protection des populations”)

Approved by the Nuclear Safety Authority

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Toulouse - OncopolePierre Fabre Researchand Development CenterToulouse

The Clinical Research and Development Center located in the historical

General Hospital (“Hôtel-Dieu”) in Toulouse aims to understand normal

skin physiology and the biological, physicochemical, and other mecha-

nisms involved in skin imbalance.

It includes a Center for Clinical Investigations where cutaneous explo-

ration techniques are perfected and used to assess clinical phenomena

observed during studies. Pierre Fabre Dermo-cosmetics conducts nearly

900 clinical studies annually.

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Hôtel DieuClinical Researchand Development CenterToulouse


VigouletPierre Fabre Dermo-cosmeticsResearch and Development Center Toulouse

The Research and Development Center in Vigoulet-Auzil, near Toulouse,

aims to develop products from the laboratory to the industrial production

stage, products that meet the expectations of doctors and patients.

Around 150 formulae that satisfy the strictest regulatory and safety

requirements are developed here annually, with a view to reaching market

place.

ActivitiesThe Distribution Center is a pharmaceutical

site that intervenes in the fi nal phase of the

Group’s logistics chain:

> Receiving fi nished products from

production units

> Storing products

> Preparing orders

> Shipping orders to our clients

(wholesalers, pharmacists, doctors,

dentists, hairdressers, subsidiaries and

distributors)


Quality: Good Manufacturing Practices

and Good Distribution Practices (ANSM)

Integrated Management System: quality,

safety and the environment (IMS)

Built in the south of Toulouse in 1974, the buildings at this site occupy

30,000 m2 on a 7.5 hectare plot. Muret is the Pierre Fabre Group’s

historical distribution site.

The site’s logistical organization makes it possible to meet the needs of

the dermo-cosmetic and health care divisions in terms of storage, prepa-

ring orders, and distributing Pierre Fabre products in France and world-

wide.

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MuretDermo-cosmetic and Health careProduct Distribution Center Midi-Pyrénées

Nestled in the heart of the Saint-Mont vineyard an hour and a half from

Toulouse, the Aignan site is located in the Gers department. This site

develops, manufactures and packages pharmaceutical confectionery. In

2008, it invested in a state-of-the-art continuous production line for phar-

maceutical confectionery, which enabled the site to triple its capacity and

offer a procedure better adapted to sensitive molecules. It is currently the

only site of its kind in France. Aignan is ANSM (french health agency) cer-

tifi ed for the production of pharmaceutical confectionery, and approved

by the European Medicines Agency (EMA).

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AignanPharmaceutical Manufacturing SiteMidi-Pyrénées

Built in 1988, our Cahors site has focused on a specifi c area of expertise

since 2005.

This ANSM approved site manufactures and packages gelatin capsules

and capsules in pill containers, primarily for natural phytotherapy and

aromatherapy products.

It also produces powders (talcum powder for babies, dry shampoo) for

our dermo-cosmetic brands.

The industrial and logistical organization of the site makes it possible the

manufacture very small series, in order to respond to specifi c market

demands.


CahorsPharmaceutical Manufacturing SiteMidi-Pyrénées

Pierre Fabre in Southwestern France

Ussel

Saint-Augustin

AvènePau

Banyuls

Avène Hydrotherapy Center Southwestern France

Ever since 1743, when the very fi rst spa facility was built near the Sainte-

Odile spring, the vocation of the spa resort of Avène has remained the

same: the resort is exclusively devoted to dermatology and to dermato-

logical treatments for skin diseases, for people of all ages, even infants.

Located in the heart of the Haut-Languedoc nature reserve (“Parc Natu-

rel du Haut-Languedoc”), the facility hosts about 2,700 patients annually,

25% of which are children. In 2010, the Avène establishment was the

fi rst dermatology approved resort to obtain Aquacert HACCP Therma-

lisme® certifi cation. This certifi cation is a form of quality assurance for our

patients: It guarantees the quality and health safety of our thermal waters.

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AvèneWater LaboratorySouthwestern France

The Water Laboratory was inaugurated on the Avène hydrotherapy

site in 2008. Its mission is to control the quality of the Avène thermal

waters (bacteriology and physical chemistry), to enrich its knowledge

(of areas ranging from the geology to the pharmacological properties of

this water), and to ultimately share this knowledge with a wide audience,

including health care specialists (pharmacists, dermatologists), patients

and students. The Water Laboratory is part of the “Avène, water nature,

health” rural center of excellence, a label obtained by the Community of

the towns of Avène, Orb and Gravezon in December 2006.

An economic development project, this center of excellence builds

infrastructure and organizes activities related to water. The Avène Water

Laboratory provides a scientifi c dimension to this joint sustainable deve-

lopment initiative.

AvèneManufacturing SiteSouthwestern France

The Avène plant manufactures and packages products for the Avène

thermal spring water brand. These products are derived from Avène

thermal water, which has been recognized since the 18th century for its

anti-irritant soothing properties.

The plant is focused on the future. It is constantly developing by offering

innovative products issued from its industrial mastery of products derived

from thermal water. To respond to ever increasing production needs,

some adjustments have been made to the site.

The most recent one is a 4,000 m2 extension built in 2011, which made it

possible to install new equipment specifi cally for sterile production units.

Activities> Manufacturing and packaging products

in sterile units

> Producing aerosols in sterile units

> 10 manufacturing platforms for

emulsions and liquids

> 12 packaging lines

Key Dates1990 Avène factory built (3,500 m2)

1994 Storage facility built, and production

and verifi cation areas extended

(4,200 m2)

1998 Administration area extended,

and new storage facility created

(2,750 m2)

2003 Technical and production areas

extended (4,800 m2)

2007 Packaging warehouse opened in

La Tour-sur-Orb (2,100 m2)

2011 Raw materials storage facility and

central weighing area created;

production area extended to house

sterile cosmetic manufacturing

facilities (4,000 m2)

2012 Construction started on new aerosol

workshop (4,000 m2)

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Pharmaceutical Company

Good Manufacturing Practices

- Medicines (ANSM)

Good Manufacturing Practices

- Cosmetics (ISO 22716)


System)


System for Medical Devices)

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UsselPharmaceutical Distribution CenterSouthwestern France

Designed by Roger Taillibert and inaugurated in September 1999, the

international center in Ussel stores and distributes our ethical and OTC

products throughout the world, as well as our medical devices and

biocides.

The distribution center stores 12,000 pallets of fi nished products, distri-

buted under the Group’s brand names: Pierre Fabre Pharmaceuticals,

Pierre Fabre Santé (health care), Pierre Fabre Dermatologie, Naturactive

and Elusept. One-third of the center’s activity is international.

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Saint AugustinPharmaceutical DevelopmentCenterSouthwestern France

In the heart of the Corrèze countryside, the Saint-Augustin laboratory handles the pharmaceutical development of health care products. It is the Group’s

center of expertise for phytotherapy products.

PauPharmaceutical Manufacturing SiteSouthwestern France

Our Pau site is devoted to the production of injectable drugs with high

added value. It specializes in using isolators to aseptically insert cytotoxic

and biotechnology anti-cancer products into bottles in liquid or lyophilized

form, and into pre-fi lled syringes.

The site’s internationally renowned expertise is offered to major pharmaceutical laboratories that have entrusted some of theirproduction to Pierre Fabre.

Activities

Our Pau site has more than 20 years of

experience in aseptically fi lling containers with

conventional injectable, anti-cancer, and bio-

technology drugs:

> In 1-10 ml solution vials

> In 1-40 ml solution bottles or in

lyophilized form

> In lots ranging from a dozen to several

hundreds of liters

History

The site was developed in 1991 to produce

the Pierre Fabre Laboratories’ new anti-

cancer product, Navelbine ®, using isolator

technology for the fi rst time. Since 1996, this

site has offered its expertise in manufactu-

ring (subcontracting) injectable drugs to the

world’s largest pharmaceutical companies,

for the entire world.

For the past twenty years, the Pau site has

continued to build innovative production

workshops that use isolators to manufacture

highly toxic anti-cancer products.

In 2005, Pierre Fabre built a second unit

on this site, dedicated to the production of

lyophilized and liquid anti-cancer products.

Certifi cations& ApprovalsThe site is certifi ed by the main health

agencies in several countries:

- ANSM (France)

- EMA (Europe

- FDA (United States)

- PMDA (Japan)

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BanyulsARAGO LaboratoryOceanological ObservatorySouthwestern France

Conscious of the marine world’s exceptional biological diversity, Pierre

Fabre wanted to explore this diversity in order to access original natural

molecules, and preserve marine biodiversity at the same time.

In 2002, after several years of fruitful collaboration between Pierre

Fabre Laboratories and the laboratory ARAGO, a joint research

team was created to develop applications on the basis of marine

biomolecules.

This team is based on the premised of Paris VI University at Banyuls-sur-

mer, specializes in microbial ecology, and studies the diversity of marine

microorganisms. It has developed a collection of microorganisms that is

listed in the World Federation for Culture Collections.

With over 2,000 marine micro-organisms, this collection is perio-dically enriched. It facilitates research on original biological active substances that may be used in medicine and dermo-cosmetics.

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Activities> Characterizing the bacterial diversity

associated with aquatic ecosystems

> Building an original marine strain

collection: using innovative isolation

techniques and exploring atypical

ecosystems

> Selecting candidate strains based on

their ability to survive in hostile environ-

ments (UV radiation, oxidative stress,

competition, etc.) or on the presence of

genes that are of scientifi c interest

> Producing organic extracts and conduc-

ting pharmacological prescreening to

identify innovative active substances

for use in dermo-cosmetics or in cancer

treatments

HistorySince its creation in 1882 by professor Henri

de Lacaze-Duthiers, a marine zoologist

and member of the Academy of Sciences,

the Banyuls-sur-Mer ARAGO laboratory

has been a research center internationally

renowned for the quality of its expertise in

oceanology. Affi liated with Pierre and Marie

Curie University (Paris VI), this marine station

also aims to train future scientists in marine

sciences. It plays a key role in the French

and European oceanic observation network.

Located on the rocky coast of Le Roussillon,

near a natural marine reserve, this laboratory

provides privileged access to exceptional

ecosystem diversity, as well as a research

structure specialized in marine microbiology.

1995 Collaboration begins, focused on

Avène thermal resources.

2002 Pierre Fabre Laboratories, Pierre

and Marie Curie University, and the CNRS

create a joint research team.

2003 Development of research programs

on the study of marine microorganisms and

on natural substances of bacterial origin for

dermo-cosmetic applications.

Marine bacterial strain collection created.

2009 Leveraging of microbial ecology

expertise, in the course of clinical research

work.

2010 The strain collection is made avai-

lable for anti-tumor research.

For 2016 Pierre Fabre participation in buil-

ding new research laboratories dedicated

to marine biotechnology, and in a space

for scientifi c mediation on marine and land

biodiversity.

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Pierre Fabre in France

St-Julienen-Genevois

Gien

Boulogne

Paris Madeleine

Château-Renard

Saint-Julien-en-GenevoisPierre Fabre Immunology CenterFrance

The Pierre Fabre Immunology Center in Saint-Julien-en-Genevois is dedicated to fi ghting cancer and is specialized in targeted biothe-rapy research. It focuses on researching monoclonal antibodies for oncology, and on producing active biotechnology ingredients.

Several monoclonal antibodies from this center are currently being

developed.

An Antibody Biotechnology Unit (“UBA”) has been operational since

2011. It supports this research center in fulfi lling a two fold objective:

> Developing our biotechnology cancer research capacities

> Increasing our industrial biotechnology capacity, particularly in terms

of cell culture and antibody purifi cation

With this new Antibody Biotechnology Unit that is the only one of its kind

in France, the Pierre Fabre Immunology Center takes advantage of a

continuum between research, development and clinical lot production.

Activities> Designing and characterizing monoclonal antibodies aimed

at fi ghting cancer

> Producing clinical lots of monoclonal antibodies

HistoryThe Pierre Fabre Immunology Center was built by Roger Taillibert in 1989

on land purchased from the town of Saint-Julien-en-Genevois, at the

French border with Switzerland.

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GienPharmaceutical Manufacturing SiteFrance

Built in 1963 on Rhône Poulenc’s insistence, the Gien site has been part

of Pierre Fabre Laboratories since 1993. It has continued to grow ever

since then, doubling its production capacity.

It is now the Group’s largest pharmaceutical production unit. It manu-

factures and packages dry (capsules, pills, pouches), pasty and liquid

substances, under pharmaceutical, dermo-cosmetic and medical device

statuses. It places its expertise at the disposal of external clients and

offers manufacturing activities for all product forms.

The site is approved by the drug agencies of various countries, inclu-

ding France (ANSM), Europe (EMA) and Brazil (ANVISA), as well as other

national agencies relevant to our markets.

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Château-RenardPharmaceutical Manufacturing SiteFrance

Built in 1971, the site was acquired by Pierre Fabre laboratories in 1978

to initially produce cosmetic preparations, followed by dry pharmaceutical

preparations.

It now manufactures and packages pasty, liquid and semi-solid prepa-

rations (toothpaste, pharmaceutical varnishes, syrups, mouthwash, skin

lotions and throat preparations, as well as patches (Nicopatch), in com-

pliance with the strictest quality standards: ISO 9001 (Quality Manage-

ment System) and ISO 13485 (Quality Management System for Medical

Devices).

The site is approved by the drug agencies of various countries: ANSM

(France) and SFDA (Saudi Arabia) for the production of all product forms,

and since 2010, by the ANVISA (Brazil) for pharmaceutical varnishes.

Boulogne-BillancourtFrance

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Our regulatory teams, as well as Pierre Fabre Oncology team, and part of our Communications Department are located at our Boulogne site, in the

Hauts-de-Seine.

Paris La MadeleineRené Furturer InstituteFrance

The René Furturer Institute is a serene and sophisticated space exclusively devoted to scalp health and hair beauty.

Pierre Fabre worldwide

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Pierre Fabreworldwide

Very early on, Pierre Fabre was determined to develop a presence out-

side of France. The company fi rst looked to Southern Europe. This was

a natural choice for a company based closed to Spain. It was actually in

Barcelona that the Group opened its fi rst subsidiary, in 1970. Spain was

soon to be followed by Portugal, Italy, and Greece. Our dermo-cosmetic

brands are now prominent players in these four countries.

Our international development is rooted in a faithful application of the

model that made the company a success in France. Mr. Pierre Fabre,

a licensed pharmacist, always wanted to offer products covering all the

therapeutic needs and well-being of his patients, ranging from health to

beauty. As such, we rely on the recommendations and advice of health

professionals. In every single country where we operate, the principle

of this virtuous continuum - doctor, pharmacist, patient – does prevail,

for drugs obviously but we also apply it to OTC and dermo-cosmetics.

However, this is a model that we will adjust to the particularities of each

international market.

This is how China has become the fl agship of our international success.

Avène is the best-selling dermo-cosmetic brand in China. It was launched

in 2003, and has been a partner of the China Dermatologist Association

since 2008. To adapt to the specifi cities of the Chinese market, Avène

is mainly distributed in department stores, in dedicated spaces run by a

network of advisors trained in skin care diagnosis and appropriate pro-

duct recommendations.

In our approach, we listen to all cultures, develop trustworthy relationships

with local health professionals, and adapt to the reality of the distribution

channels for each market, while always staying true to our high standards

in professional advice provided in the right environment to refl ect the tech-

nical sophistication of our products. This is how we brought to the world

what we have built in our birthplace.

Through a network of subsidiaries in 44 countries*, including all the major emerging economies, and distribution agreements in over 130 countries, Pierre Fabre achieves nearly 60% of its sales on foreign markets. The company has nearly 3,500 employees outside of France, an increase of 50% between 2003 and 2013.

Global reach through a network of subsidiaries in 44 countries* across 5 continentsAlgeria - Argentina - Australia - Austria - Belgium - Brazil - Bulgaria - Canada - Chile - China - Czech Republic - Denmark - Finland - France - Germany

Great Britain - Greece - Hong-Kong - India - Italy - Ivory Coast - Japan - Korea - Lebanon - Madagascar - Mexico - Morocco - Poland - Portugal

Romania - Russia - Senegal - Singapore - Slovakia - South Africa - Spain - Sweden - Switzerland - Taiwan - Tunisia - Turkey - United States - Uruguay

Vietnam.

* As of March 30, 2014

Bulgaria

Morocco

USA

Brazil

Spain

Tunisia

Germany

Australia

Photo Credits: Damien CABROL - Alain BASCHENIS - Jessica DAVID - Laurent FREZOULS

Design and layout: Agence Vent d’Autan - 81000 ALBI

Printed by: Art & Caractère - 81500 LAVAUR

Documents

Brochure Pierre Fabre in France 09-15-2014