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Abdulaziz H. Hashi
Acknowledgements
Understanding the Relationship Between HFCS & Alzheimer’s
Disease.
What is Alzheimer’s disease (AD)?
• What is AD?• Why does it concern us?
– 30 million individuals world wide– $266 Billion cost in the US– $605 Billion worldwide.
General Description
Symptoms
Alzheimer's Disease at the Molecular Level
Alzheimer's Disease at the Molecular Level
Formation of Beta Amyloid Plaques
Formation of Beta Amyloid Plaques
Formation of Beta Amyloid Plaques
Neurofibrillary Tangles
Neurofibrillary Tangles
Hypothesis • A high fructose corn syrup diet may
cause or increase the progression of
Alzheimer's disease.
High fructose corn syrup • What is HFCS?• How does it relate to AD?
High fructose corn syrup • HFCS is a liquefied sweetener,
which is a substitute to sucrose (table sugar) used in many foods and beverages
• HFCS has shown to significantly increase risk factors that relate to many types of chronic diseases.
HFCS as it Relates to Memory loss.
• A new study done by UCLA showed a HFCS diet slows brain function; obstructing memory and learning.
Materials and Methods • Doo Yeon Kim, Ph.D.• Rudolph Tanzi, Ph.D.
Materials and Methods • Human Neuron cells made from
stem cells grown in 3D gel systems. • The cells are introduced with genes
that code for AD.
Procedure • First 300 petri dishes containing the human neuron cells will be
grown in a 3D gel system.
• 100 out of the 300 will be introduced with the AD gene.
• Another 100 out of the 300 will be introduced with the AD gene and given a growth medium containing HFCS. – Solid form of HFCS will be melted and spread around the
cells.
• The last 100 will only have human neuron cells; no AD gene and no HFCS
Budget • Lab (402,000)• Schools cut (250,000)• 7 Undergrads (87,360) • 3 Graduates (88,128) • Equipment (107,512) • my salary (58,000)
Reference • Johnson, R. J., Perez-Pozo, S. E., Sautin, Y. Y., Manitius, J., Sanchez-Lozada, L. G., Feig, D.
I.Nakagawa, T. (2009). Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes? Endocrine Reviews,30(1), 96–116. doi:10.1210/er.2008-0033
• Holtzman, D. M., John, C. M., & Goate, A. (2011). Alzheimer’s Disease: The Challenge of the Second Century. Science Translational Medicine, 3(77), 77sr1. doi:10.1126/scitranslmed.3002369
• Sheng, M., Sabatini, B., & Südhof, T. C. (2012). Synapses and Alzheimer’s disease. Cold Spring Harbor Perspectives in Biology, 4(5), 10.1101/cshperspect.a005777 a005777. doi:10.1101/cshperspect.a005777
• Takahashi, R. H., Capetillo-Zarate, E., Lin, M. T., Milner, T. A., & Gouras, G. K. (2013). Accumulation of Intraneuronal β-Amyloid 42 Peptides Is Associated with Early Changes in Microtubule-Associated Protein 2 in Neurites and Synapses. PLoS ONE
• Capetillo-Zarate, E., Gracia, L., Yu, F., Banfelder, J. R., Lin, M. T., Tampellini, D., & Gouras, G. K. (2011). High-Resolution 3D Reconstruction Reveals Intra-Synaptic Amyloid Fibrils. The American Journal of Pathology, 179(5), 2551–2558. doi:10.1016/j.ajpath.2011.07.045
Thank You
• “The Important thing is never stop questioning” ~Albert Einstein
