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Normal Breast Histology• Primary Learning Objective
– Describe breast anatomy and function, including changes of lactation.
• Secondary Learning Objectives– Describe the gross anatomy and normal histology
of the female breast.– Describe the changes that occur in the breast
during puberty, pregnancy, and lactation.
Intralobular Stroma
Basement Membrane
Luminal Epithelial Cells
Myoepithelial Cells
Myoepithelial Cells
Key Points To RememberAbout the Normal Breast
• The TDLU, the functional unit of the breast, contains: – Terminal duct and lobules lined by myoepithelial cells and
ductal epithelial cells.– Contains delicate intralobular stroma (gives rise to
fibroadenoma)– Dense collagenous stroma separates the TDLUs
• TDLUs respond to estrogen stimulation by proliferating and during pregnancy and lactation undergo marked hypertrophy and hyperplasia to produce milk.– Withdraw of estrogen leads to glandular cellular atrophy
and apoptosis.
Thank you!After reflecting on the normal breast histology, contact me if you have
any questions at [email protected]
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