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Brain Imaging in AD. Mony J. de Leon Professor of Psychiatry Center for Brain Health NYU School of Medicine NY NY 10016 [email protected]. General Atrophy in Alzheimer’s Disease. Brain Staging Model for AD. Normal MCI AD. Entorhinal Cortex Hippocampus Temporal Neocortex. - PowerPoint PPT Presentation
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© TND 2005
Brain Imaging in ADBrain Imaging in AD
Mony J. de Leon
Professor of Psychiatry
Center for Brain Health
NYU School of Medicine
NY NY 10016
© TND 2005
General Atrophy in Alzheimer’s Disease
© TND 2005
© TND 2005
© TND 2005
Brain Staging Model for ADBrain Staging Model for AD
NormalNormal
MCIMCI
ADAD
Entorhinal CortexEntorhinal Cortex
HippocampusHippocampus
Temporal NeocortexTemporal Neocortex
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
ConclusionsConclusions
• In vivo imaging is of use in the early identification of brain changes associated with AD.
• The patterns of imaged brain changes appear to first involve the entorhinal cortex, then the hippocampus, and later the neocortex.
![Brain Amyloid Imaging · D = 6.7 nM AD brain 2014 2012 [18F]AV-45 florbetapir HN O CH 3 O N O 18 F K D = 3.1 nM AD brain Approved 18F-Labeled Amyloid Radiotracers [18F]3’F-PIB](https://img.dokumen.tips/doc/110x75/5ec436274d34d13b041ea689/brain-amyloid-imaging-d-67-nm-ad-brain-2014-2012-18fav-45-florbetapir-hn-o.jpg)
