Bradley MooreNatural Products, Genomics, Drug Discovery

Currently funded projects:1. Bioengineering marine antibiotics (NIAID – R01)2. Biosynthesis and mechanism of proteasome inhibitor drugs (NCI – R01)3. Developing new genome mining technology (NIGMS – R01 with Dorrestein)4. Mining marine bacterial genomes for new pharmaceuticals (NIGMS – R01)5. Natural marine contaminants and human health (NIEHS & NSF – P01)

• Scripps Center for Oceans and Human Health – Program Director6. Next generation antibiotics and discovery tools (Roddenberry Foundation)

Core Expertise

Expertise:Natural products chemistry EnzymologyBiosynthesis – Metabolism Bacterial geneticsGenomics Synthetic biology

Therapeutic areas of interest:Infectious disease – antibiotics Cancer – proteasome inhibitorsEnvironmental toxins – PBDEs, dioxins

Materials available:1. Natural product chemical libraries2. Synthetic biology tools3. Engineered bacterial expression hosts

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Proposed Collaborations with SSPPS Faculty

On-going collaborations:1. Developing new genome mining technology (NIGMS – R01 with Dorrestein)

• Joint group members, publications (23), grants2. Testing new antibacterial agents (Nizet) – 3 pubs3. Biosynthesis and MOA studies (Gerwick) – 7 pubs

Proposed collaborations:1. UCSD Natural Product Biosynthetic Biology Production Center

• pending $11M NIH U01 grant application with Dorrestein and Palsson(Bioengineering) – NIH Council meets on 1/22/15

Always open for new collaboration projects!