Bone Morphogenetic Protein

By: Kim Stephens

What is Bone Morphogenetic Protein?

• Stimulates a patient's own cells to induce the formation of bone and cartilage

Recombinant human bone morphogenetic protein-2, or rhBMP-2

• Generates and repairs bone faster and more reliably

• Latest in bone growth enhancement

Changing Points

1965: Dr. Marshall Urist, UCLA Department of Orthopedic Surgery in Los Angeles, CA discovered that the proteins needed to heal bone was inside bones

1997: First clinical trial with 11 patients

2001: New Hampshire Spine Institute

Applications• Available in an oral form• A supplement for bone and joint health

Regenerative Medicine:• Delivered to the site of the fracture • Released gradually to allow bone formation • Delivery in a purified collagen matrix

Potential Applications Osteoinductive characteristics make

BMPs valuable as an alternative to bone grafts

Other methods of delivering BMPs to patients are undergoing evaluation

Non-skeletal tissues

Organogenesis

Advantages

• Less pain, shorter hospital stays

• More rapid return to a normal life

• As effective as bone grafts

• Eliminate the need for bone transplantation

• Avoids the potential side effects and complications of bone harvesting or grafts

Disadvantages

• BMP has only been FDA approved for one type of spinal fusion

• Expensive• Side effects are not

fully understood

Future

Use of BMP will potentially extend beyond skeletal disease and injury

Approval from the FDA to use BMP’s for dental work

Better understand these proteins and their benefits

Works cited

http://www.spineuniverse.com/treatments/surgery/spinal-fusion-bone-morphogenetic-protein

http://www.spineuniverse.com/exams-tests/bone-morphogenetic-protein-bmp

http://www.medscape.com/viewarticle/446738_3 http://www.zycalbio.com/research.htm http://

en.wikipedia.org/wiki/Bone_morphogenetic_protein http://

www.spine-health.com/treatment/spinal-fusion/bmp-bone-morphogenetic-proteins

http://www.freepatentsonline.com/4294753.html http://webapps.css.udel.edu/biotech/rDNA.html http://www.sciencedirect.com/science/article/pii/

S0006291X07017147