BME 130 – Genomes

Lecture 1

History of Genomics

Administrivia

Course policies

Grading

Assignments

Readings

Charles DarwinOn the Origin of Species1859

Gregor MendelExperiments in PlantHybridisation1866

Francis GaltonStatistical genetics, law of ancestral heridity (basis ofeugenics)1876

WalterSutton

TheodorBoveri

Propose that hereditary factors reside on chromosomes and are inherited by Mendellian laws (1902)

Archibald GarrodAlkaptonuria is not caused by bacterial infection, but is inherited (recessive), 1908

Thoman Hunt MorganExperimental validation of chromosomal theory of inheritance, established fruit fly as model genetic organism, 1910

James Watson and Francis Crick describe a model for

the structure of DNA, 1953;Crick enunciates central

dogma of molecular biology 1957

Marshall NirenbergCracks the genetic code by translating (first) poly-U, 1961

Paul BergCreates first recombinant DNA molecules, 1972

Herber Boyer and Stan CohenClone DNA into foreign cells; birth of recombinant DNA technology, 1973

Walter Gilbert and Fred SangerDevelop methods to sequence DNA, 1977

Kary MullisInvents the polymerase-chain reaction for DNA amplification, 1983

Scheibye-Alsing et al. (2009),Comp. Biology & Chemistry 33(2):121

Genomes!

1995 Hemophilus influenzae1996 yeast1998 worm1999 fruit fly2001 human2002 mouse2004 rat

http://www.genomenewsnetwork.org/