Blockbuster Drugs

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    BLOCKBUSTER DRUGS

    END OF THE ERA?

    YET NEW AVENUES..

    1MBA(pharma tech) IVth YEAR

    KAKULI SINHA

    ROLL -18

    DIV- A

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    1. END OF BLOCKBUSTERERA.

    2. DRY R&D PIPELINE

    3. DRUG PRICING PRESSURES

    4. STRICT REGULATORY

    REQUIREMENTS

    PHARMACEUTICAL

    INDUSTRY :

    DRAMATIC CHANGE

    3MBA(pharma tech) IVth YEAR

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    THE DRY DESERT OF PATENT EXPIRATION

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    MBA(pharma tech) IVth YEAR 7

    Fig: This figure demonstrates the sharp fall(26.78%) in the stock price of Merck, on

    September 30, 2004 .

    Source: 12 PR catastrophe that crushed company shareholders, Alyson shontell,

    Oct 30,2010

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    WHAT NEXT???

    SHIFT FROM MARKET SHARE CAPTURE TO MARKET

    CREATION.

    ADOPT DIFFERENTIATED STRATEGIES AND BUSINESS

    MODEL.

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    ENSURING ACCESSIBILITY.

    STRENGTHEN SALES AND MARKETING

    CAPABILITIES.

    9MBA(pharma tech) IVth YEAR

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    INNOVATION AND NEW TECHNOLOGIES

    UNTAPPED POTENTIAL OF BIOTECHNOLOGY Excellent alternative to dried pipelines

    improved safety profiles, efficacies and cost to

    benefit ratio The biologics sector is experiencing robust

    growth. The rate of sale of biotech products is

    double that of pharmaceuticals in the last year

    10MBA(pharma tech) IVth YEAR

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    Biologics are almost impossible to replicate becauseeach one of it is uniquely dependent on the cell line

    and the manufacturing process used.

    There is no regulatory norm through which FDA can

    grant biosimilars or follow-on biologics approval

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    PHARMACOGENOMICS AND PERSONALISED

    MEDICINE

    right drug for the right patient.

    It describes how an individuals genetic

    inheritance affects bodys response to drugs.

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    GENE VARIANTS IDENTIFIED

    BIOMARKERS- STRATIFICATION INTO SUBGROUPS.

    BEST TREATMENT FOR EACH SUBGROUP

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    CANCER: SETTING THE BEST EXAMPLE

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    CONCLUSION

    Pharmaceutical firms must refocus its energy to

    discover superior drugs that will genuinely help

    sick people.

    . Biotech and personalized drugs offer an ideal

    platform to do this.

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    Two developments will help the industry reinvigorate its

    pipeline:

    First, the widespread recognition of the fact that the

    commercial potential of drugs that fit the conventional

    therapeutic product profile is declining.

    Second, the increase in the understanding and application

    of the molecular sciences.

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