ST. ANNE‘S UNIVERSITY HOSPITAL BRNOINTERNATIONAL CLINICAL RESEARCH CENTER

CORE FACILITY

Biostatistics

HEAD OF CORE FACILITY

KEY INTERESTSSurvival Analysis • Mixed Models • Likelihood and Information Theory • Image Analysis (Facial Imaging and Neuroimaging) • Spatio-Temporal Modelling of Biological Signals • Gene Expression Omnibus Query • GO Enrichment Analysis

RESEARCH OBJECTIVES Study of the accuracy of the p-value for semiparametric models Applications of mixed models methodology in biomedical research Spatio-Temporal Modelling of Biological Signals

RESEARCH FOCUSThe primary mission of the Biostatistics (BST) is to support FNUSA-ICRC investigators in the conduct of high-quality, innovative health-related research by providing expertise in biostatistics, statistical programming, and data management. BST researchers and staff collaborate with investigators on all aspects of research: study design and grant development; data capture and statistical analysis; interpretation of results and manuscript preparation. The BST team contributes to all types of research, including basic science, clinical, epidemiological, and health services.BST current methodological research interests are in the areas of survival data, clinical trials, and biomarker studies, as motivated by problems that arise in studies of neurologic diseases and cancer.Research activities include study of the high order asymptotics, the saddlepoint approximation for the density and distribution function and study of delayed entry in Cox proportional hazards model.

Mgr. Bc. Silvie BĚLAŠKOVÁ, Ph.D.

E-mail: silvie.belaskova�fnusa.czPhone: (+420) 732 949 731

CREATING THE FUTURE OF MEDICINE

EDUCATION

2017:Ph.D. in Applied Mathematics and Biostatistics, Palacký University, Olomouc, Czech Republic

2007:Bc. in Law of Social Security Science, Masaryk University, Brno, Czech Republic

2002: Mgr. in Theoretical Mathematics and Descriptive Geometry, Masaryk University, Brno, Czech Republic

TRAINING

2013, 2014: Visiting Scientist, Faculty of Biostatistics, LSU School of Public Health, New Orleans, LA, USA

CLINICAL RESEARCH CORE FACILITIESBASIC RESEARCHTRANSLATIONAL RESEARCH

TOP PUBLICATIONS

TECHNOLOGICAL EQUIPMENT SW StatSoft, Inc., 2013. STATISTICA (data analysis software system), version 12. SW SAS Institute Inc., 2011. Base SAS® version 9.4 Procedures Guide. Cary, NC:SAS. SW R Development Core Team (2008). SW REDCap (Research Electronic Data Capture).

MAIN PARTNERS AND COLLABORATING INSTITUTIONS Mayo Clinic, Rochester, MN, USA University of Glasgow, Glasgow, Scotland, UK Louisiana State University, Baton Rouge, LA, USA

BEST RESULTS Device for Non-Contact Scanning and Regression of Non-Stationary Temperature Fields – Especially in Biological Objects. Covered by the Czech Patent (PV 2012-124).

VOLNÝ, O., KRAJINA, A., BĚLAŠKOVÁ, S., BAR, M., CIMFLOVÁ, P., HERZIG, R., SANAK, D., TOMEK, A., KÖCHER, M., ROCEK, M., PADR, R., CIHLAR, F., NEVŠÍMALOVÁ, M., JURÁK, L., HAVLÍČEK, R., KOVÁŘ, R., ŠEVČÍK, P., ROHAN, V., FIKSA, J., MENON, B., MIKULÍK, R. Mechanical thrombectomy performs similarly in real world practice: a 2016 nationwide study from the Czech Republic. Journal of NeuroInterventional Surgery.

BĚLAŠKOVÁ, S., FIŠEROVÁ, S. Improvement of the Accuracy in Testing the Effect in the Cox Proportional Hazards Model Using Higher Order Approximations. Filomat. 2017, 31(18), 5591-5601.

POMPEIANO, A., HUARANCCA REYES, T., MOLES, T. M., VILLANI, M., VOLTERRANI, M., GUGLIELMINETTI, L., SCARTAZZA, A. Inter- and intra-specific variability in physiological traits and post-anoxia recovery of photosynthetic efficiency in grasses under oxygen deprivation. Physiologia Plantarum. 2017, 161 (3): 385–399.

VANÍČKOVÁ, L., NAGY, R., POMPEIANO, A., KALINOVÁ, B. Epicuticular chemistry reinforces the new taxonomic classification of the Bactrocera dorsalis species complex (Diptera: Tephritidae, Dacinae). PLoS ONE. 2017, 12(9): e0184102.

SULOVSKÁ, K., FIŠEROVÁ, E., CHVOSTEKOVÁ, M., ADÁMEK, M. Appropriateness of gait analysis for biometrics: Initial study using FDA method. Measurement. 2017, 105, 1-10.

St. Anne‘s University Hospital BrnoInternational Clinical Research Center

Pekařská 53, 656 91 Brno | Czech Republic | ID: 00159816Phone: (+420) 543 181 111 | E-mail: icrc@fnusa.cz | www.fnusa-icrc.org

Supported by the project no. LQ1605 Translational Medicine from the National Program of Sustainability II (MEYS CR)

OFFERED SERVICES AND EXPERTISEThe BST researchers and staff are eager to help you to meet the statistical needs of your research. The BST contributes to all types of research including basic science, clinical, epidemiological, and health services. The areas of expertise include but are not limited to: Categorical Data Analysis Survival Data Analysis Longitudinal Data Analysis Repeated Measures Data Analysis Genetic Data Analysis High Dimensional Data Analysis Clinical Trial Design Database Design and Management

CORE FACILITIESAdvanced Laboratories for Experimental Medicine and Translational Research