BiOS2014 Call Cover - SPIEspie.org/Documents/ConferencesExhibitions/PW/BiOS2014...SPIE would like to express its deepest appreciation to the symposium chairs, conference chairs, program

LocationThe Moscone CenterSan Francisco, California, USA

Conferences and Courses1–6 February 2014

ExhibitionBiOS Expo: 1–2 February Photonics West: 4–6 Februarywww.spie.org/bioscall

Call for PapersSubmit your abstract by 22 July 2013

www.spie.org/bioscall

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TECHNOLOGIES

- Photonic Therapeutics and Diagnostics

- Clinical Technologies and Systems

- Tissue Optics, Laser-Tissue Interaction, and Tissue Engineering

- Biomedical Spectroscopy, Microscopy, and Imaging

- Nano/Biophotonics

Advance your research by showcasing your results at BiOS

Call for PapersConferences and Courses: 1–6 February 2014BiOS Expo: 1–2 February 2014Photonics West Exhibition: 4–6 February 2014The Moscone CenterSan Francisco, California, USA


Plan to Participate BiOS is the world’s largest international biomedical optics conference, encompassing clinical, translational, and fundamental research and development in the fi eld of biomedical optics. It provides a premier technical forum for reporting and learning about the latest research and development, as well as for launching new applications and technologies.

BiOS is part of SPIE Photonics West, the largest biophotonics, laser, optoelectronics, and industrial manufacturing event in North America, with more than 5,000 technical attendees from more than 50 countries. Special events include hot topics presentations, the BiOS Expo, focus on Translational Research, and industry leading working groups and panels.

Symposium Chairs

James Fujimoto, Massachusetts Institute of Technology (USA)

R. Rox Anderson, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (USA), and Harvard School of Medicine (USA

SPIE is the international society for optics and photonics, a not-for-profi t organization founded in 1955 to advance light-based technologies. The Society serves nearly 225,000 constituents from approximately 150 countries, offering conferences, continuing education, books, journals, and a digital library in support of interdisciplinary information exchange, professional growth, and patent precedent. SPIE provided $3.2 million in support of education and outreach programs in 2012.

SPIE INTERNATIONAL HEADQUARTERS

P.O. Box 10, Bellingham, WA 98227-0010 USA Tel: +1 888 504 8171 or +1 360 676 3290 Fax: +1 360 647 1445 [email protected] • www.SPIE.org

Be part of the solution–present your work in translational medicine and be recognized by your peers

The new SPIE BiOS Translational Research vir-tual symposium will highlight papers from BiOS that showcase the latest photonics technologies, tools, and techniques with high potential to impact healthcare.

Papers are solicited on the following topics:• Cancer• Heart Disease• Neurological Disease

To be considered for inclusion in the Translational Research virtual symposium, submit your ab-stract online, and enter “TRANSLATIONAL” when prompted. If your paper is accepted, SPIE will con-tact you to request a 1-2 page summary explaining how your research is impacting medicine. If your paper is chosen by the Translational Research se-lection committee, your presentation will be cross-listed in the Translational Research Virtual Pro-gram, and you will be eligible to win a Translational Research Best Paper Award.

Symposium ChairBruce Tromberg,Beckman Laser InstituteUniv. of California, Irvine (USA)

The global community recognizes the need for advances in technology to meet challenges in health care, particularly health issues that impact broad populations and incur large societal and individual costs.

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2 SPIE BiOS 2014 Call for Papers, part of Photonics West • www.spie.org/bioscall

Photonic Therapeutics and DiagnosticsProgram Chair: Brian Jet-Fei Wong, Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine (USA)

BO100 Photonics in Dermatology and Plastic Surgery (Kollias, Choi, Zeng) . . . . . . . . . 5

BO101 Therapeutics and Diagnostics in Urology (Kang) . . . . . . . . . . . . . . . . . . 5

BO102 Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology (Wong, Ilgner) . . . . . . . . . . . . . . . . . . . . . 6

BO103 Optical Techniques in Pulmonary Medicine (Suter, Lam, Brenner) . . . . . . . 6

BO104 Endoscopic Microscopy (Tearney, Wang) . . . . . . . . . . . . . . . . . . . . 7

BO105 Diagnostic and Therapeutic Applications of Light in Cardiology (Tearney, Gregory, Marcu) . . . . . . . . . . . . 8

BO106 Optical Techniques in Neurosurgery, Brain Imaging, and Neurobiology (Hirschberg, Madsen) . . . . . . . . . . . . . . . 8

BO107 Neurophotonics (Luo, Jansen) . . . . . . . . 9

BO108 Optogenetics and Optical Control of Cells (Mohanty, Thakor) . . . . . . . . . . 10

BO109 Optics in Bone Surgery and Diagnostics (Mandelis) . . . . . . . . . . . . . 11

BO110 Lasers in Dentistry (Rechmann, Fried) 11

BO111 Ophthalmic Technologies (Manns, Söderberg, Ho) . . . . . . . . . . . . 12

BO112 Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy (Kessel, Hasan) . . . . . . . . . . . . 13

BO113 Mechanisms for Low-Light Therapy (Hamblin, Carroll, Arany) . . . . . . . . . . . . 13

BO114 Frontiers in Biological Detection: From Nanosensors to Systems (Miller, Fauchet, Cunningham) . . . . . . . . 14

Clinical Technologies and SystemsProgram Chairs: Tuan Vo-Dinh, Fitzpatrick Institute for Photonics, Duke Univ. (USA) and Anita Mahadevan-Jansen, Vanderbilt Univ. (USA)

BO200 Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine (Izatt, Fujimoto, Tuchin) 15

BO201 Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems (Vo-Dinh, Mahadevan-Jansen, Grundfest) . . . . . . . . . . . . . . . . . . . . . . . 16

BO202 Design and Quality for Biomedical Technologies (Raghavachari, Liang). . . 17

BO203 Multimodal Biomedical Imaging (Azar, Intes) . . . . . . . . . . . . . . . . . . . . . . 18

BO204 Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications (Gannot) . . . . 19

BO205 Biomedical Vibrational Spectroscopy VIII: Advances in Research and Industry (Mahadevan-Jansen, Petrich) . 20

BO206 Optical Biopsy (Alfano, Demos) . . . . . . 21

LA113 Frontiers in Ultrafast Optics: Biomedical, Scientifi c, and Industrial Applications XIV (Heisterkamp/Herman/Meunier/Nolte) . . . . . . . . . . . . . . . . . . . . 22

MF104 Microfl uidics, BioMEMS, and Medical Microsystems XII (Gray/Becker) . . . . . 24

Tissue Optics, Laser-Tissue Interaction, and Tissue EngineeringProgram Chairs: Steven L. Jacques, Oregon Health & Science Univ. (USA) and William P. Roach, Air Force Offi ce of Scientifi c Research (USA)

BO300 Optical Interactions with Tissue and Cells (Jansen, Thomas) . . . . . . . . . . . . . 26

BO301 Dynamics and Fluctuations in Biomedical Photonics (Tuchin, Duncan, Larin, Leahy, Wang) . . 27

BO302 Photons Plus Ultrasound: Imaging and Sensing (Oraevsky, Wang) . . . . . . . 28

BO303 Biophotonics and Immune Responses (Chen) . . . . . . . . . . . . . . . . 29


+1 360 676 3290 • [email protected] • twitter (#SPIEPW) 3

BO304 Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue (Nordstrom, Bouchard, Allen) . . . . . . . . 30

BO305 Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications (Wilmink, Ibey) . . . . . . . . . . . . . . . . . . . . 30

BO306 Optical Elastography and TissueBiomechanics (Sampson, Larin) . . . . . 32

Biomedical Spectroscopy, Microscopy, and ImagingProgram Chairs: Ammasi Periasamy, Univ. of Virginia (USA) and Daniel L. Farkas, SMI (USA)

BO400 Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues (Farkas, Nicolau, Leif) . . . . . . . . . . . . . . 34

BO401 Multiphoton Microscopy in the Biomedical Sciences (Periasamy, König, So) . . . . . . . . . . . . . . 33

BO402 Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing (Cogswell, Brown, Wilson) . . . . . . . . . . . 36

BO403 Single Molecule Spectroscopy and Superresolution Imaging(Enderlein, Gregor, Gryczynski, Erdmann, Koberling) . . . . . . . . . . . . . . . 37

BO404 Optical Diagnostics and Sensing: Toward Point-of-Care Diagnostics (Coté) . . . . . . . . . . . . . . . . . . . . . . . . . . . 38

BO405 Biomedical Applications of Light Scattering (Wax, Backman) . . . . . . . . . 39

BO406 Optical Methods in Developmental Biology (Rollins, Lo) . . . . . . . . . . . . . . . 40

Nano/BiophotonicsProgram Chairs: Paras Prasad, SUNY/Buffalo (USA) and Dan V. Nicolau, McGill Univ. (Canada)

BO500 Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications (Cartwright, Nicolau) . . . . . . . . . . . . . . . 41

BO501 Colloidal Nanoparticles for Biomedical Applications (Parak, Yamamoto, Osinski) . . . . . . . . . . 42

BO502 Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications (Achilefu, Raghavachari) . . . . . . . . . . . . 43

BO503 Plasmonics in Biology and Medicine (Vo-Dinh, Lakowicz) . . . . . . . . . . . . . . . . 44

BO504 Bioinspired, Biointegrated, Bioengineered Photonic Devices (Lee, Rogers, Yun) . . . . . . . . . . . . . . . . . 45

General Information . . . . . . . . . . . . . . . . . . . . . . . . .46

Abstract Submission . . . . . . . . . . . . . . . . . . . . . . . .47

Exhibition Information . . . . . . . . . . . . . . . . . . . . . . .48

Critical DatesAbstract Due Date: 22 July 2013

Manuscript Due Date: 10 January 2014 Please Note: Submissions imply the intent of at least one author to register, attend the conference, present the paper as scheduled, and submit a full-length manuscript for publication in the conference proceedings.



Executive Organizing CommitteeSamuel Achilefu, Washington Univ. School of

Medicine in St. LouisRobert Alfano, The City College of New YorkDavid Allen, National Institute of Standards and

TechnologyPraveen Arany, National Institute of HealthFred Azar, Philips Medical SystemsVadim Backman, Northwestern Univ.Jean-Pierre Bouchard, INO (Canada)Matthew Brenner, Univ. of California, IrvineThomas Brown, Univ. of RochesterJames Carroll, THOR Photomedicine Ltd. (United

Kingdom)Alexander Cartwright, Univ. at BuffaloWei Chen, Univ. of Central OklahomaBernard Choi, Beckman Laser Institute and

Medical ClinicCarol Cogswell, Univ. of Colorado at BoulderGerard Coté, Texas A&M Univ.Brian Cunningham, Univ. of Illinois at Urbana-

ChampaignStavros Demos, Lawrence Livermore National Lab.Donald Duncan, Portland State Univ.Jörg Enderlein, Georg-August-Univ. Göttingen

(Germany)Rainer Erdmann, PicoQuant GmbH (Germany)Daniel Farkas, SMIPhilippe Fauchet, Vanderbilt Univ.Scott Fraser, California Institute of TechnologyDaniel Fried, Univ. of California, San FranciscoJames Fujimoto, Massachusetts Institute of

TechnologyIsrael Gannot, Tel Aviv Univ.Ingo Gregor, Georg-August-Univ. Göttingen

(Germany)Kenton Gregory, Oregon Medical Laser Ctr.Warren Grundfest, Univ. of California, Los

AngelesZygmunt Gryczynski, Univ. of North Texas

Health Science Ctr. at Fort WorthMichael Hamblin, Wellman Ctr. for

PhotomedicineTayyaba Hasan, Massachusetts General HospitalHenry Hirschberg, Beckman Laser Institute and

Medical ClinicArthur Ho, Brien Holden Vision InstituteBennett Ibey, Air Force Research Lab. Justus Ilgner, Univ. Hospital Aachen (Germany)Xavier Intes, Rensselaer Polytechnic InstituteJoseph Izatt, Duke Univ.E. Duco Jansen, Vanderbilt Univ.Steven Jacques, Oregon Health and Science

Univ.Hyun Wook Kang, Pukyong National Univ.

(Republic of Korea)David Kessel, Wayne State Univ.Felix Koberling, PicoQuant GmbH (Germany)Nikiforos Kollias, ConsultantKarsten König, Univ. des Saarlandes (Germany)Joseph Lakowicz, Univ. of Maryland School of

MedicineStephen Lam, The BC Cancer Agency Research

Ctr. (Canada)Kirill Larin, Univ. of Houston

Martin Leahy, National Univ. of Ireland, Galway (Ireland)

Luke Lee, Univ. of California, BerkeleyRobert Leif, Newport InstrumentsRongguang Liang, College of Optical Sciences,

The Univ. of ArizonaCecilia Lo, Univ. of PittsburghWilliam P. Roach, Air Force Offi ce of Scientifi c

ResearchSteen Madsen, Univ. of Nevada, Las VegasAnita Mahadevan-Jansen, Vanderbilt Univ.Andreas Mandelis, Univ. of Toronto (Canada)Fabrice Manns, Univ. of MiamiLaura Marcu, Univ. of California, DavisYuji Matsuura, Tohoku Univ. (Japan)Benjamin Miller, Univ. of Rochester Medical Ctr.Samarendra Mohanty, The Univ. of Texas at

ArlingtonDan Nicolau, McGill Univ. (Canada)Robert Nordstrom, National Institutes of HealthAlexander Oraevsky, TomoWave Laboratories, Inc.Marek Osinski, The Univ. of New MexicoWolfgang Parak, Philipps-Univ. Marburg (Germany)Ammasi Periasamy, Univ. of VirginiaWolfgang Petrich, Roche Diagnostics GmbH

(Germany)Paras Prasad, Univ. of BuffaloRamesh Raghavachari, U.S. Food and Drug

AdministrationPeter Rechmann, Univ. of California, San FranciscoJohn Rogers, Univ. of Illinois at Urbana-ChampaignAndrew Rollins, Case Western Reserve Univ.David Sampson, The Univ. of Western AustraliaPeter So, Massachusetts Institute of TechnologyPer Söderberg, Uppsala Univ. (Sweden)Melissa Suter, Massachusetts General HospitalGuillermo Tearney, Wellman Ctr. for PhotomedicineNitish Thakor, Johns Hopkins Univ.Robert Thomas, Air Force Research Lab.Valery Tuchin, N.G. Chernyshevsky Saratov State

Univ. (Russia)Tuan Vo-Dinh, Fitzpatrick Institute for Photonics,

Duke Univ.Kenneth Wang, Mayo ClinicLihong Wang, Washington Univ. in St. LouisRuikang Wang, Univ. of WashingtonThomas Wang, Univ. of MichiganAdam Wax, Duke Univ.Gerald Wilmink, Air Force Research Lab.Tony Wilson, Univ. of Oxford (United Kingdom)Brian J. Wong, Beckman Laser Institute and

Medical ClinicKenji Yamamoto, National Ctr. for Global Health

and Medicine (Japan)Seok Hyun Yun, Wellman Ctr. for PhotomedicineHaishan Zeng, The BC Cancer Agency

Research Ctr. (Canada)

2014 BiOS Call for Papers

SPIE would like to express its deepest appreciation to the symposium chairs, conference chairs, program committees, session chairs, and authors who have so generously given their time and advice to make this symposium possible.

The symposium, like our other conferences and activities, would not be possible without the dedicated contribution of our participants and members. This program is based on commitments received up to the time of publication and is subject to change without notice.



Photonic Therapeutics and Diagnostics

Photonics in Dermatology and Plastic Surgery (BO100)Conference Chairs: Bernard Choi, Beckman Laser Institute and Medical Clinic (USA); Nikiforos Kollias, Consultant (USA); Haishan Zeng, The BC Cancer Agency Research Ctr. (Canada)Program Committee: Anthony J. Durkin, Beckman Laser Institute and Medical Clinic (USA); Iltefat Hamzavi, Henry Ford Hospital (USA); Jessica C. Ramella-Roman, The Catholic Univ. of America (USA); Lise Lyngsnes Randeberg, Norwegian Univ. of Science and Technology (Norway)The research and development of highly selective lasers has forever transformed the clinical practice of dermatology and plastic surgery by allowing vas-cular lesions, pigmented lesions, tattoos, and hair to be removed without scarring. These important examples of selective photothermal injury continue to be refi ned and extended. The potential for laser or non-laser applications in skin diagnosis, imag-ing, and treatment for burns and other conditions such as psoriasis, acne, and vitiligo far exceeds their present use. A detailed understanding of skin optics, photo-thermal, photoacoustic, and photobiological pro-cesses is emerging. Innovative schemes for delivery and control of laser irradiation, including robotics, can potentially improve therapy. Optical spectros-copy, microscopy, and imaging techniques hold signifi cant diagnostic promise in dermatology, and submissions in these areas are especially welcome. New laser therapeutics, including burn treatment, fractional laser technology, wound healing, drug delivery and photodynamic therapy of infl amma-tory skin conditions and cancer, will also be topics of interest for this session. Laser/tissue interaction, therapeutics, and diagnostics relating to light and skin, as well as competing technologies in the same scope, are also invited. Contributions from all medical, dental, and vet-erinary specialties, military-related applications, and basic sciences contributions are encouraged. Presentations that focus on translational research in dermatology and plastic surgery are also welcomed.

Therapeutics and Diagnostics in Urology (BO101)Conference Chairs: Hyun Wook Kang, Pukyong National Univ. (Korea, Republic of)Program Committee: Geoffrey N. Box, The Ohio State Univ. (USA); Kin Foong Chan, Dermira, Inc. (USA); Nathaniel M. Fried, The Univ. of North Carolina at Charlotte (USA); Ronald Sroka, Laser-Forschungslabor (Germany); Joel M. Teichman, St. Paul’s Hospital (Canada); Rudolf M. Verdaasdonk, Vrije Univ. Medical Ctr. (Netherlands)This era of high technology in urology includes many new and routine uses of lasers for treatment and diagnosis. In addition, the use of light for both pho-todiagnostic purposes and photodynamic therapy continues to move from research lab to clinical use. Laser applications assisted with robotic devices enable high precision tissue cutting and ablation during surgery. Other energy-based treatments are also being applied for tissue destruction in urology. This conference covers the use of lasers and thermal technology for treatment and diagnosis in urology and provides an opportunity to share ideas and technical information among scientists, engineers, and clinicians. Papers are solicited in urological applications of therapeutic and diagnostic modalities including, but not limited to, the following:

Lasers for phototherapeutics • Fundamental laser-cell/tissue interactions in

urological applications • Laser coagulation/ablation/resection of tumors

in bladder, kidney, ureter, and renal pelvis • Photodynamic therapy of upper and lower

urinary tracts• Lithotripsy with lasers, shockwave, high-intensity

focused ultrasound (HIFU), and pneumatic systems

Other energy forms for tissue treatment • Minimally invasive surgical techniques including

radio frequency, microwave, HIFU, cryo, plasma, and irreversible electroporation (IRE)

• Tissue treatment effects and healing responses during energy-based treatments

Tissue imaging for diagnostics • Cellular/molecular imaging, probing, and optical

biopsy in urology • Pre-clinical/clinical applications of optical

imaging including optical coherence tomography (OCT), photoacoustic tomography (PAT), fl uorescence, polarization, confocal, spectroscopy, microscopy, and photodynamic diagnosis (PDD)

• MRI, CT, PET, ultrasound, and terahertz imaging for detection of urological diseases

Advanced technology in urology • Novel designs and applications of optical fi bers

and endoscopic delivery devices• Robotic-assisted surgery including radical

prostatectomy and nephrectomy • 3-D modeling and simulation on surgical

procedures • Optical nerve stimulation for dysfunctional

urinary systems• Nanoparticle-assisted and image-guided therapy




Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology (BO102)Conference Chairs: Brian J. F. Wong, Beckman Laser Institute and Medical Clinic (USA); Justus F. Ilgner, Univ. Hospital Aachen (Germany)Program Committee: Christian S. Betz, Ludwig-Maximilians-Univ. München (Germany); Waseem K. Jerjes, Univ. College London (United Kingdom); Milind Rajadhyaksha, Memorial Sloan-Kettering Cancer Ctr. (USA); Chung-Ku Rhee, Dankook Univ. Hospital (Korea, Republic of); Henricus J. C. M. Sterenborg, Erasmus MC (Netherlands)

In conjunction with:

Otolaryngology and head and neck surgery is a fertile fi eld for applications of emerging technolo-gies. Precise focused beams and advanced energy delivery systems provide the foundation for the de-velopment of innovative microsurgical techniques. Optical spectroscopic diagnostics, including elastic scattering, differential path-length, fl uorescence and infrared spectroscopy, enhance tissue dif-ferentiation and identifi cation. Interferometric and stroboscopic optical techniques such as OCT (opti-cal coherence tomography) can be used to monitor motion of the vocal folds and/or of the tympanic membrane. Diagnostic systems increasingly inter-act with robotic and/or master-slave devices to allow for high precision cutting and ablation. Progress in OCT technology and other areas is facilitated successfully by interactions among clinicians, sci-entists, engineers, and researchers. This conference covers the use of lasers and opti-cal technology in otolaryngology and head and neck surgery, and provides an informative and crucial face-to-face interaction between the basic scientist and the clinician: a win-win scenario. Papers from clinicians, scientists, engineers, and manufacturers are solicited in the following medical subspecialty areas:• imaging of the vocal cords and airway • cochlear imaging • femtosecond laser surgery applications • CO2 laser ablation • middle ear surgery/Stapes surgery • endoscopic cancer resection • RF surgical applications • plasma-mediated ablation • robotic and master / slave systems • optical diagnostic techniques • laryngology and speech science• translational research.

Optical Techniques in Pulmonary Medicine (BO103)Conference Chairs: Melissa J. Suter, Massachusetts General Hospital (USA); Stephen Lam, The BC Cancer Agency Research Ctr. (Canada); Matthew Brenner, Univ. of California, Irvine (USA)Program Committee: Johannes de Boer, Vrije Univ. Amsterdam (Netherlands); Edmund Koch, Universitätsklinikum Carl Gustav Carus Dresden (Germany); David D. Sampson, The Univ. of Western Australia (Australia); Luc Thiberville, Rouen Univ. Hospital (France); Victor X. D. Yang, Ryerson Univ. (Canada); Septimiu D. Murgu, The Univ. of Chicago (USA); Robert A. McLaughlin, The Univ. of Western Australia (Australia)Due to the high prevalence of lung diseases and the lack of available technologies to adequately evaluate the complex processes of the respiratory system, the use of optical techniques for studying, diagnosing, and treating the pulmonary airways has rapidly increased in recent years. While the application of optical technologies in pulmonary medicine is an emerging trend, scientists in this fi eld are working towards developing new, and ad-vancing existing, optical technologies for disease detection, diagnosis, and treatment, and for guiding and evaluating pulmonary interventions. In addi-tion, these techniques are being utilized to study respiratory physiology and pathophysiolgy including airway structure and function relationships such as perfusion, ventilation, mechanics and re-modeling. This conference will cover all aspects relating to optical based molecular, structural and functional imaging, diagnosis, and treatment of the lung. The goal is to bring together scientists and clinicians to discuss and progress current state-of-the-art opti-cal diagnostic and therapeutic techniques, and to use the developed optical approaches to challenge and further develop our current understanding of the physiology and pathophysiology of the respira-tory system. Topics include:• optical techniques for assessing bronchial and

alveolar lung structure • optical evaluation of pulmonary function:

perfusion, ventilation, mechanics and re-modeling

• optical diagnostics • evaluation of normal and diseased/injured

airway • optical detection, evaluation of treatment • optical coherence tomography • diffuse optical tomography • confocal and two-photon microscopy • spectroscopy • optical molecular imaging • fl uorescence imaging • optical imaging and activation of inhaled agents • novel bronchoscopy techniques • laser/radiofrequency ablation treatment

techniques • optical monitoring of therapeutics.



Call for Papers

Endoscopic Microscopy IX (BO104)Conference Chairs: Guillermo J. Tearney, Wellman Ctr. for Photomedicine (USA); Thomas D. Wang, Univ. of Michigan (USA)Program Committee: David L. Dickensheets, Montana State Univ. (USA); Arthur F. Gmitro, The Univ. of Arizona (USA); Ralf Kiesslich, Johannes Gutenberg Univ. Mainz (Germany); Francois Lacombe, Mauna Kea Technologies (France); Stephen Lam, The BC Cancer Agency Research Ctr. (Canada); Hiroshi Mashimo, VA Boston Healthcare System (USA); Kenzi Murakami, Olympus Corp. (Japan); Norman S. Nishioka, Massachusetts General Hospital (USA); Wibool Piyawattanametha, National Electronics and Computer Technology Ctr. (Thailand); Mark J. Schnitzer, Stanford Univ. School of Medicine (USA); Peter T. C. So, Massachusetts Institute of Technology (USA); Melissa J. Suter, Massachusetts General Hospital (USA)

Papers for this session focus on the development of high resolution imaging systems that are endoscope compatible and include novel techniques for early detection, screening, diagnosis, intervention, and treatment of disease in either pre-clinical models or human subjects. In general, remote detection is based on the use of an optical fi ber to transmit light between the instrument and the tissue, and involves the collection of information about molecular and cellular processes without physical excision of tissue. These methods of in vivo optical imaging extends across a wide range of resolution, from molecular, sub-cellular and cellular to tissue and organ levels. The creation of an image may require a variety of different scanning mechanisms. Endoscopic techniques provide unique advan-tages over other (e.g. whole body) imaging modali-ties for evaluating disease present over the epithelial surface of hollow organs. The direct proximity of collection optics to regions of disease can result in unparalleled achievement of resolution, unraveling of molecular mechanisms, and use of fl uorescence contrast agents. Examples of applications of endoscopic microscopy to medicine include the detection of pre-malignant lesions, identifi cation of disease below the tissue surface, assessment of depth of tumor invasion, localization of cancer margins, evaluation of effectiveness of pharmaco-logical therapy, and reduction in number of physical biopsies and frequency of surveillance. This conference provides an inter-disciplinary forum for physicians, molecular biologists, chem-ists, biochemists, optical engineers, and instrument designers to report and discuss recent results, im-provements, and new approaches in the emerging fi eld of endoscopic microscopy. Contributed papers are solicited concerning, but not limited to, the following areas: • confocal microendoscopy • multi-photon microendoscopy • endoscopic OCT • endoscopic OCM • fl uorescence endoscopic imaging • video capsule endoscopy • endocytoscopy • high magnifi cation endoscopy • light scattering spectroscopy • Raman spectroscopy • infrared spectroscopy • MEMS scanning mechanisms • micro-actuators • luminal optical contrast agents • endoscopic image processing and analysis.

JOINT SESSION BO104 and MOEMS-MEMS MF105Microscopy This special joint session is in conjunction with MOEMS-MEMS conference MF105: MOEMS and Miniaturized Systems. Papers are solicited that address the unique challenges to deliver high-fi delity microscopic imaging of tissue with a miniaturized instrument platform. Example topics include mechanisms for distal beam scanning, focus control and aberration correc-tion using MOEMS devices, MEMS actuators or electrowetting optics; proximal scanning based on DMD or other SLM technologies; novel opti-cal assembly and alignment techniques; highly corrected miniature optical systems.




Diagnostic and Therapeutic Applications of Light in Cardiology (BO105)Conference Chairs: Guillermo J. Tearney, Wellman Ctr. for Photomedicine (USA); Kenton W. Gregory, Oregon Medical Laser Ctr. (USA); Laura Marcu, Univ. of California, Davis (USA)Program Committee: Gijs van Soest, Erasmus MC (Netherlands); Carlo Di Mario, Univ. College London (United Kingdom); Stanislav Y. Emelianov, The Univ. of Texas at Austin (USA)During the last decade there have been signifi cant scientifi c developments in the diagnosis and treat-ment of cardiovascular diseases using lasers and optical technology. Recent progress in vulnerable plaque detection has motivated the development of a variety of new optical techniques for intracoronary diagnosis. The scientifi c and medical communi-ties have additionally continued to search for new technologies and to improve on existing technolo-gies that can be applied to areas such as cardio-vascular recanalization or angioplasty, welding of vascular anastomoses, ablation of arrhythmogenic foci, transmyocardial revascularization, etc. The interdisciplinary research and collaboration among physicians, scientists, engineers, and manufacturers is paramount to maintaining and strengthening the fi eld of biomedical cardiovascular laser applications. This conference intends to bring together re-searchers and industry partners to present and dis-cuss the important advances in laser and diagnostic applications in cardiovascular medicine. The intent is to stimulate interactions, which will contribute to future progress in developing effective clinical cardiovascular diagnostic and therapeutic systems. Topics will include, but are not limited to, the following:• new laser sources for transmyocardial laser

revascularization• mechanisms of laser revascularization• ablation of arrhythmogenic foci and bypass pathways• excimer laser applications• ablative and nonablative applications• catheter design for laser therapy of arrhythmias• evaluation of available laser angioplasty devices• new fi bers and catheter designs for laser angioplasty• new lead extraction laser catheters• optical methods of assessing cardiovascular

structure, biomechanics and function• vascular welding• vascular reactivity to laser energy• approaches to control and assess the extent of

laser injury• new applications for laser thrombolysis• spectroscopy• fl uorescence spectroscopy and imaging• new catheter design for intravascular optical

diagnostics• photodynamic therapy• photodynamic therapy for intimal hyperplasia• MEMS for cardiovascular diagnostics• optical coherence tomography• Raman, fl uorescence, and absorption spectroscopy• angioscopy• thermography• optical studies of the cardiovascular system in

animal models• contrast agents for cardiovascular diagnosis

and therapy • translational research.

Optical Techniques in Neurosurgery, Brain Imaging, and Neurobiology (BO106)Conference Chairs: Henry Hirschberg, Beckman Laser Institute and Medical Clinic (USA); Steen J. Madsen, Univ. of Nevada, Las Vegas (USA)Program Committee: David Abookasis, Ariel Univ. Ctr. of Samaria (Israel); Frederic Leblond, Ecole Polytechnique de Montréal (Canada); Herbert Stepp, Ludwig-Maximilians-Univ. München (Germany); Victor X. D. Yang, Ryerson Univ. (Canada)Recent technological advances have opened excit-ing opportunities for lasers and optical techniques in neurosurgery and brain imaging. Therapeutic applications include: tumor debulking/removal via thermal or photochemical interactions, and spinal decompression and discectomy. Optical techniques have also shown promise in a number of diagnostic applications, including fl uorescence-guided tumor resection, imaging of cortical function and intra-vascular examinations. Of special interest is the use of optical or other imaging modalities in the detection and therapy of neuro-degenerative diseases such as Alzheimer’s or Parkinson’s. The purpose of this conference is to provide a forum for clinicians, scientists, engineers and manu-facturers to report on current developments and to discuss future opportunities for optical techniques in neurosurgery and brain imaging. Contributed papers are solicited concerning, but not limited to, the following areas:• laser surgery in the brain and spine • fl uorescence-guided resection • optical spectroscopy of normal brain and

neoplastic tissue • functional imaging of the brain using optical

techniques • photodynamic therapy in neurosurgery • optical instrumentation and devices, including

microscopes and endoscopes • optical localization and registration techniques

for neuronavigation • fMRI/PET • techniques for in vivo microscopy • microscopic imaging and advanced

microscopic techniques • virtual reality • real-time functional imaging in the OR • co-registration (optical and other imaging

modalities) • translational research.



Call for Papers

Neurophotonics (BO107)Conference Chairs: E. Duco Jansen, Vanderbilt Univ. (USA); Qingming Luo, Huazhong Univ. of Science and Technology (China)Conference Co-Chairs: Jun Ding, Stanford School of Medicine (USA); Anna W. Roe, Vanderbilt Univ. (USA)Program Committee: Yu Chen, Univ. of Maryland, College Park (USA); Hongwei Dong, Univ. of California, Los Angeles (USA); Congwu Du, Stony Brook Univ. (USA); Z. Josh Huang, Cold Spring Harbor Lab. (USA); Matthew D. Keller, Lockheed Martin Aculight (USA); Beop-Min Kim, Korea Univ. (Korea, Republic of); Vesa Kiviniemi, Univ. of Oulu (Finland); Pengcheng Li, Britton Chance Ctr. for Biomedical Photonics (China); Anita Mahadevan-Jansen, Vanderbilt Univ. (USA); Timothy H. Murphy, The Univ. of British Columbia (Canada); Francesco Saverio Pavone, European Lab. for Non-linear Spectroscopy (Italy); Kambiz Pourrezaei, Drexel Univ. (USA); Claus-Peter Richter, Northwestern Univ. (USA); Shy Shoham, Technion-Israel Institute of Technology (Israel); Vladislav Toronov, Ryerson Univ. (Canada); Shaoqun Zeng, Britton Chance Ctr. for Biomedical Photonics (China)

Neurophotonics bridges optical physics and neu-roscience. Neurons are the basic building blocks of the nervous system and study of neuronal structure, function and behavior forms the basis of understanding and manipulating neural activity. Conventional methods in the research laboratory as well as in the clinic rely on electrical methods for stimulating, modulating and recording neural activity. The past decade has seen the rise of opti-cal methods in this domain. Direct stimulation of neural cells and tissues using (laser) light has seen tremendous interest in the past few years. The use of infrared light to stimulate neural activity in the peripheral and central nervous system is only the beginning of this fi eld. Application of light-based technologies for stimulating neural tissue and cells using different wavelengths from the UV through the infrared so that discussion on the mechanism of the light induced neural activation can be initiated. Novel optically inducible ion channels such as the -opsins for neural targeting, present an additional dimension to this area of research and opportunities for cross-fertilization of research ideas. “Function follows form”, anatomic structure is the basis for understanding the brain’s function and brain diseases. Genomics and proteomics have opened up an era providing new approaches and new tools for neuroscience research, particularly in optical neuroimaging. Brain function depends on neuronal networks and so from a systems biology perspective, should be studied not only the neuron level, but also at the neuronal networks and system levels. Optical imaging can be applied at multiple levels from gene to molecular, from cellular to tis-sue and from organ to system levels to yield critical information bridging molecular structure and physi-ological function. The purpose of this conference is to provide a forum for scientists, clinicians, engineers and manufactures to report current developments and to discuss future opportunities for optical stimulating, modulating, manipulating, detecting, or imaging the brain or neural circuits at gene, molecular, cel-lular, tissue, organ, or system level, in physiology and anatomy.

Topics will include, but are not limited to, the following:

Novel photonic or optoelectronic methods• photon-neuron interaction, modulating,

manipulating neural activity and/or interfacing the central nervous system

• infrared neural stimulation (INS)• optogenetics: optical activation of neurons

(genetically targeted light activated ion channels)

• detecting brain swelling or neural/seizure activity.

Optical neuroimaging• high resolution optical imaging for synaptic

physiology, in vivo and/or in vitro neural circuits and networks

• diffusion, fl uorescence and polarization spectroscopies, optical coherence tomography, Doppler, photo acoustics, speckle, or optical intrinsic signal imaging for brain cortex activity and neurovascular physiology

• functional near-infrared imaging (fNIRI) for human brain activity, such as working memory

• diffusive optical tomography for animal or human brain studies

• optical imaging for brain-wide neuroanatomical architecture or connectivity

• brain models and specimen preparation including mouse, treeshrew, marmoset, monkey, or human brain

• optical reporters, markers, dyes, nanoparticles, and molecular probes for brain models or neuronal circuits

• segmentation, identifi cation and visualization of brain-wide dataset

• multimodal imaging integrating structural and functional information.

Applications• optical neural prosthetics• nerve conduction• therapeutic interventions• feedback control• diagnosis of nerve dysfunction• pain control and modulation• traumatic brain injury• neural regeneration• artifi cial neurons.




Optogenetics and Optical Control of Cells (BO108)Conference Chairs: Samarendra K. Mohanty, The Univ. of Texas at Arlington (USA); Nitish V. Thakor, Johns Hopkins Univ. (USA)Program Committee: Anna W. Roe, Vanderbilt Univ. (USA); Elizabeth M. Hillman, Columbia Univ. (USA); Isaac P. Clements, Plexon Inc. (USA); John P. Welsh; Rafael Yuste, Columbia Univ. (USA); Xue Han, Boston Univ. (USA); George J. Augustine, Duke-NUS Graduate Medical School (Singapore); Richard Kramer, Univ. of California, Berkeley (USA); Klaus B. Gerwert, Ruhr-Univ. Bochum (Germany); Alfred L. Nuttall, Oregon Health & Science Univ. (USA)

By combining genetic and optical methods, “opto-genetics” has allowed control (stimulation or silenc-ing) of electrically-activatable, genetically-targeted cells with high temporal precision. This has heavily impacted neuroscience research by allowing dis-section of functioning of neuronal circuitry. Since its fi rst in-vivo demonstration, optogenetics technology has been applied to freely moving mammals and could eventually form the basis of treatments of neurological disorders such as for vision restoration, psychiatric treatment and pain-control. Optogenetic technology is also impacting other biomedical re-search areas such as for control of cardiac func-tion, stem cell differentiation and reprogramming of metabolic activities in mammalian cells. In all of these settings, optics is playing a crucial role in both delivering light for cellular control, and in some cases for imaging the consequences of this control. The introduction of non-linear optics has further allowed very precise and in-depth spatial control of optogenetic stimulation. Though fi ber optic and waveguide technology is enabling delivery of light to targeted tissue regions, other photonic imaging technologies have the potential to significantly contribute to imaging read-outs of neural/cellular activities during optogenetic stimulation (e.g. intra-vital microscopy, diffuse-refl ectance, fl uorescence, and SHG etc). While a detailed understanding of tissue optics is essential for delivery of stimulation light, use of crystallography and spectroscopic methods will enhance the understanding of the interaction processes between light and optoge-netic molecules. Innovative schemes for delivery and control of light irradiation, including miniaturized light source, fi ber optics, waveguides and special beams can potentially improve optogenetic therapy. Optical microscopy, spectroscopy, and imaging techniques hold signifi cant promise for characterizing optoge-netic probes and submissions in these areas are especially welcome. New therapeutic applications, including control of central and peripheral nervous system, cardiac system, stem cells as well as control of metabolic activities will also be topics of interest for this conference. Contributions from all biomedi-cal specialties and basic sciences are encouraged. Technical and scientifi c papers related to advance-ment in development of optogenetics probes, their characterization, and applications, as well as other emerging hybrid optical technologies, coupled with new imaging and detection modalities are solicited.

These include:

Applications of optogenetic modulation • neural modulation for medical applications • controlling stem cell activity and their

differentiation • manipulation of Cardiac and other excitatory

cellular systems • reprogramming of metabolic activities • dissection of neural circuitry: functional

connectomics • modulation of other cellular functions.

Optical imaging and detection of cellular stimulation • scattering/absorption based functional imaging

during optical stimulation • calcium probes and voltage-sensitive dye-

based imaging • in vivo fi ber-based imaging and monitoring of

opsin expression • other novel optical imaging of physiological

activity.

Biophysics and spectroscopic characterization of opsins • characterization of opsins by FTIR, Raman and

other optical spectroscopic methods • elucidation of the molecular structure of opsins

by crystallography • novel electrophysiological evaluation methods • modeling of opsin-photocycle.

Novel sources for optogenetic stimulation • two-photon optogenetics • spatially and temporally modulated beams • waveguides and light delivery methods for in-

vivo applications • μLED array based devices for prosthetic

applications • modeling propagation of stimulating light in

tissue.

New opsins and delivery methods for optogenetics • functionally-improved opsins with enhanced

spectral and electrical properties • viral vectors and new expression strategies • optically-controlled delivery and gene

expression • advanced combinatorial optogenetic probes.

Other emerging hybrid optical technologies • photochemical stimulation • optoelectric activation • optofl uidic manipulation • photothermal stimulation.



Call for Papers

Optics in Bone Surgery and Diagnostics (BO109)Conference Chairs: Andreas Mandelis, Univ. of Toronto (Canada)Conference Co-Chairs: Michael D. Morris, Univ. of Michigan (USA)Program Committee: Robert R. Alfano, The City College of New York (USA); Bennett T. Amaechi, The Univ. of Texas Health Science Ctr. at San Antonio (USA); Peter Fratzl, Max-Planck-Institut für Kolloid- und Grenzfl ächenforschung (Germany); Huabei Jiang, Univ. of Florida (USA); Stephen J. Matcher, The Univ. of Sheffi eld (United Kingdom); Eleftherios P. Paschalis, Ludwig Boltzmann Institut (Austria); Rahul Tandon D.D.S., Loma Linda Univ. (USA); Victor X. D. Yang, Ryerson Univ. (Canada)With the penetration of lasers, optics, and imaging techniques in the fi eld of tissue diagnostics, a rapid growth in bone-related biophotonics and optics-aided bone surgery has emerged. While x-ray bone diagnostics and imaging are well established photonic techniques due to their deep sub-dermal penetration, bone research has been associated more with endo-scopic technologies for which light waves face serious penetration barriers. However, we are witnessing an explosion in optical probes and diagnostics of bones and bone disease in the last 4-7 years. This conference emphasizes optical applications to bone biology and surgery. It targets interdisciplin-ary research reports which bring out the interactions of bone with photons including relevant energy conversion mechanisms (ultrasound, heat) and can be used as a forum for the cross-fertilization and advancement of the science and technologies as-sociated with bone optics and photonics. Technical and scientifi c papers related to the interactions and studies of bones with photons with energies span-ning the entire spectral range from gamma rays to microwave and millimeter waves are solicited. These include:• mineral density, mechanical strength, strain,

optical and other bone property measurements using optical absorption, refl ection, transmission and scattering techniques

• optics in bone biology • optics guided bone surgery • optical topographical imaging • gamma - and x-ray imaging and bone

densitometry • general bone radiography • bone applications of ultrafast laser techniques • advanced optical techniques for the study

of bones and osteopathologic processes: optical coherence tomography, terahertz, photoacoustic and photothermal detection and spectroscopy, diffuse photon techniques

• bone spectroscopies, microscopies and diagnostic instrumentation

• in-vitro and in-vivo imaging and tomographies • fl uorescence imaging and emission tomography • transdermal optics and bone osteogenesis

imaging • optics in bone endoscopy and surgery • bone optical engineering and clinical systems • non-linear effects in bone-photon interactions. • optically-guided treatment of bone trauma • bone tissue ablation with lasers • bone grafting: autogenous, allografts, xenografts • dental osseointegration into bone.

Lasers in Dentistry XX (BO110)Conference Chairs: Peter Rechmann, Univ. of California, San Francisco (USA); Daniel Fried, Univ. of California, San Francisco (USA)Program Committee: Gregory B. Altshuler, Palomar Medical Technologies, Inc. (USA); Tatjána Dostálová M.D., Charles Univ. in Prague (Czech Republic); John D. Featherstone, Univ. of California, San Francisco (USA); David M. Harris, Bio-Medical Consultants, Inc. (USA); Harvey A. Wigdor D.D.S., Advocate Illinois Masonic Medical Ctr. (USA)Laser applications for dental hard tissue are a clinical reality. Exciting future applications are being developed and will be featured at this conference. An entire session will be devoted to lesion detec-tion by optical methods. This is one of the areas of rapidly expanding interest in dental research and applications to clinical practice, especially in relation to dental caries. Soft tissue clinical applications con-tinue to be expanded. This conference will provide a forum for presentation of both basic and applied research in laser dentistry. Presentations of clinical studies are especially welcome. Manuscripts will be reviewed prior to publication. Papers are solicited in all dental laser and bio-medical optics dental application areas including, but not limited to, the following:• optical methods for lesion detection, especially

dental caries • early caries detection • optical coherence tomography in dentistry • dental 3D imaging • caries removal with lasers • caries prevention with lasers • laser endodontics • laser applications in periodontology • lasers and dental implants • laser photopolymerization • laser hard-tissue and soft tissue surgery • CO2 laser use in dentistry • Nd:YAG laser use in dentistry • Diode laser use in dentistry • Er:YAG/ErCr:YSGG use in dentistry • other wavelengths for hard or soft tissue use • clinical trials of lasers for dental applications • hard-tissue ablation and plasma production • laser-tissue interactions relevant to dentistry • wavelength and energy dependence of dental

laser applications • translational research.




Ophthalmic Technologies XXIV (BO111)Conference Chairs: Fabrice Manns, Univ. of Miami (USA); Per G. Söderberg, Uppsala Univ. (Sweden); Arthur Ho, Brien Holden Vision Institute (Australia)Program Committee: Rafat R. Ansari, NASA Glenn Research Ctr. (USA); Michael Belkin, Tel Aviv Univ. (Israel); Kostadinka Bizheva, Univ. of Waterloo (Canada); David Borja, Alcon Labs., Inc. (USA); Ralf Brinkmann, Univ. zu Lübeck (Germany); Wolfgang Drexler, Medizinische Univ. Wien (Austria); Daniel X. Hammer, U.S. Food and Drug Administration (USA); Karen M. Joos, Vanderbilt Univ. (USA); Kirill V. Larin, Univ. of Houston (USA); Ezra Maguen, American Eye Institute (USA); Donald T. Miller, Indiana Univ. (USA); Daniel V. Palanker, Stanford Univ. (USA); Jean-Marie Parel, Bascom Palmer Eye Institute (USA); Roberto Pini, Istituto di Fisica Applicata Nello Carrara (Italy); Luigi Rovati, Univ. degli Studi di Modena e Reggio Emilia (Italy); Georg Schuele, OptiMedica Corp. (USA); Jerry Sebag, The Univ. of Southern California (USA); Peter Soliz, VisionQuest Biomedical, LLC (USA); Valery V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)

SPECIAL ABSTRACT REQUIREMENTS: PEER REVIEWSubmissions to this conference must include the following: • 100-word text abstract (for online program) • 250-word text abstract (for abstract digest) • 2-page extended abstract (for committee

review only)

The extended abstract is limited to two pages, including tables and figures. Include author names and affi liations; text; any fi gures, tables, or images; and suffi cient data to permit peer review. All submissions will be peer-reviewed by the Program Committee to determine acceptance. The best extended abstracts will be nominated for the Pascal Rol Award. Extended abstracts will be used only for the purpose of peer review, and will not be published.

NOTE ON DUPLICATE ABSTRACTSAuthors that submit an abstract on a similar topic for presentation at another BiOS conference may be invited to present a short communication that should focus on ophthalmic issues.

PASCAL ROL AWARD 2014Outstanding extended abstracts submitted to the Ophthalmic Technologies XXIV conference will be nominated for the Pascal Rol Award for Best Paper in Ophthalmic Technologies. The award and prize will be presented after the last scientifi c session of the conference to recognize the best paper and presentation. The 2013 recipi-ent of the Pascal Rol Award was Dr. Yossi Mandel and his colleagues from Stanford University (see www.pascalrolfoundation.org).

SPECIAL PRESENTATION Unmet Ophthalmic Technology NeedsThis presentation series was established to promote the exchange of ideas between clini-cians with a technological need and engineers interested in solving problems in ophthalmology. The invited lecture is sponsored by the Pascal Rol Foundation (www.pascalrolfoundation.org). The topic and keynote speaker will be announced in the preliminary program.

Submit your abstract today!www.spie.org/bioscall

You are invited to submit papers to Ophthalmic Technologies XXIV - the premier international meet-ing on therapeutic and diagnostic technology in the fi eld of ophthalmology, which brings together engineers and scientists developing the next inno-vations, and clinicians and practitioners extending the technology. Some recent topics covered include:• ophthalmic diagnostics • ophthalmic applications of OCT • adaptive optics • retinal prosthesis and bionic vision • wavefront sensing and wavefront-guided

surgery • laser surgical systems • femto second laser applications • artifi cial cornea and keratoprostheses • optoacoustic monitoring • functional and molecular imaging of the eye • imaging of retinal and choroidal vasculature • selective retinal photocoagulation • optics of the eye and vision correction • ocular biometrics • ocular diagnostics of neural diseases • virtual reality in ophthalmology • optics and laser applications in ophthalmic drug

delivery.



Call for Papers

Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIII (BO112)Conference Chairs: David H. Kessel, Wayne State Univ. (USA); Tayyaba Hasan, Massachusetts General Hospital (USA)Program Committee: Charles J. Gomer, Children’s Hospital Los Angeles (USA); Nancy L. Oleinick, Case Western Reserve Univ. (USA); Ravindra K. Pandey, Roswell Park Cancer Institute (USA); Brian W. Pogue, Thayer School of Engineering at Dartmouth (USA); Kenneth K. Wang, Mayo Clinic (USA)

Photodynamic therapy (PDT) has been approved by health agencies in several countries for treat-ment of neoplasia in a variety of sites and has been used for treatment of other pathologic conditions including actinic keratosis, atherosclerosis, and age related macular degeneration (AMD). PDT can be used to target different subcellular sites for photodamage, e.g., the endoplasmic reticulum, ly-sosomes, mitochondria, and the plasma membrane. Photodamage can elicit cell death by activation of apoptosis, circumventing many common modes of drug resistance. This conference will emphasize drug develop-ment, mechanisms, clinical applications, instrumen-tation for light delivery and dosimetry determina-tions along with new information on photodynamic mechanisms. Abstracts are encouraged dealing with these topics: • drug development and characterization • clinical protocols and outcomes • mechanisms of phototoxicity • techniques for light delivery and dosimetry • tissue optics.

Mechanisms for Low-Light Therapy IX (BO113)Conference Chairs: Michael R. Hamblin, Wellman Ctr. for Photomedicine (USA); James D. Carroll, THOR Photomedicine Ltd. (United Kingdom); Praveen Arany, National Institute of Dental and Craniofacial Research (USA)Program Committee: Juanita Anders, Uniformed Services Univ. of the Health Sciences (USA)

Low levels of visible light (frequently red or near-infrared) can have signifi cant therapeutic effects on multiple classes of diseases, injuries and medi-cal disorders. In particular it is effective for wound healing and pain control as well as reduction of infl ammation and swelling. It is believed that the primary cellular chromo-phore that absorbs low levels of red and near-infrared light is cytochrome c oxidase, which is located in mitochondria. This absorption of energy may lead to increase in ATP synthesis and release of reactive oxygen species from the electron transport chain that can subsequently activate transcription factors and lead to cell proliferation and migration. Despite many reports of positive fi ndings from ex-periments conducted in vitro, in animal models and in randomized controlled clinical trials, LLLT remains controversial. This likely is due to two main reasons; fi rstly the biochemical mechanisms underlying the positive effects are incompletely understood, and secondly the complexity of rationally choosing amongst a large number of illumination parameters such as wavelength, fl uence, power density, pulse structure and treatment timing has led to the pub-lication of a number of negative studies as well as many positive ones. This conference covers a fi eld that is rapidly achieving a general level of acceptance in the medi-cal and biomedical communities and will cover all of the important areas of LLLT research. Contributed papers are solicited in the following areas (among others):• mechanistic studies and cellular chromophores • development of light sources for LLLT (LED

photomodulation; pulsed IR light therapy) • study of LLLT dosimetry • in vitro research in mammalian cells • in vitro research in micro-organisms in culture • stimulation of wound healing and scar reduction

in animal models • nerve regeneration and neural stimulation • prevention of ischemia-induced tissue death

and regeneration.

Well-controlled clinical trials in the following areas:• stimulation of wound healing such as non-

healing ulcers • treatments for stroke and degenerative brain

disease • pain reduction in post-surgical and neuralgia

patients • dental applications • dermatology applications • reduction of pain and infl ammation in arthritis

and other orthopedic conditions • macular degeneration prevention • reduction of edema.




Frontiers in Biological Detection: From Nanosensors to Systems (BO114)Conference Chairs: Benjamin L. Miller, Univ. of Rochester Medical Ctr. (USA); Philippe M. Fauchet, Vanderbilt Univ. (USA); Brian T. Cunningham, Univ. of Illinois at Urbana-Champaign (USA)Program Committee: Xudong Fan, Univ. of Michigan (USA); Laura Maria Lechuga; Catalan Institute of Nanoscience and Nanotechnology (Spain); Frances S. Ligler, U.S. Naval Research Lab. (USA); Michael J. Sailor, Univ. of California, San Diego (USA); Oliver G. Schmidt, Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden (Germany); Christopher C. Striemer, Adarza BioSystems, Inc. (USA); Sharon M. Weiss, Vanderbilt Univ. (USA)

Detection of biological materials, from DNA strands to whole pathogens, is increasingly becoming a concern throughout society, not only in diagnostic laboratories in hospitals but also for on-site uses by health care providers or soldiers. From monitoring incidence of drug-resistant bacteria in hospitals and detecting harmful pathogens for homeland security to ensuring that our food is safe and our water clean, new, simple, inexpensive, sensitive, and fast methods of identifying biological molecules and pathogens are a pressing need. Optical solutions promise to provide many of these advantages and as a result many platforms for optical detection are being demonstrated in the laboratory. The deploy-ment of bio-detection systems however requires that stringent specifi cations be met, for example in terms of sensitivity, false-positive and false-negative assessments, automated sample processing and analysis, system design and integration, and low cost. This conference seeks to gather scientists, en-gineers and users active in biological detection. Contributions are sought in all areas, from novel optical detection platforms to nanosensors to sys-tem integration and commercialization.

Topics of interest include but are not limited to:• new sensing platforms • ultrasensitive (single pathogen) detection

methods • utilization of nanomaterials and new optically

responsive materials for pathogen detection • miniaturized optic components such as

microring resonators, photonic crystals, integrated optical waveguides, and nanoparticles

• label-free vs. tagged detection systems • organic and inorganic platforms • probe design • strategies to eliminate non-specifi c binding • integration of optics and microfl uidics • systems demonstrations • new applications for environmental, medical,

and food testing.

A portion of the symposium will focus on optical sensors and diagnostics for the developing world; submissions in this topic area are particularly en-couraged.



Clinical Technologies and Systems

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII (BO200)Conference Chairs: Joseph A. Izatt, Duke Univ. (USA); James G. Fujimoto, Massachusetts Institute of Technology (USA); Valery V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)Program Committee: Peter E. Andersen, Technical Univ. of Denmark (Denmark); Kostadinka Bizheva, Univ. of Waterloo (Canada); Stephen A. Boppart M.D., Univ. of Illinois at Urbana-Champaign (USA); Zhongping Chen, Beckman Laser Institute and Medical Clinic (USA); Johannes de Boer, Vrije Univ. Amsterdam (Netherlands); Wolfgang Drexler, Medizinische Univ. Wien (Austria); Christoph K. Hitzenberger, Medizinische Univ. Wien (Austria); Robert A. Huber, Ludwig-Maximilians-Univ. München (Germany); Rainer A. Leitgeb, Medizinische Univ. Wien (Austria); Xingde Li, Johns Hopkins Univ. (USA); Yingtian Pan, Stony Brook Univ. (USA); Adrian Gh. Podoleanu, Univ. of Kent (United Kingdom); Andrew M. Rollins, Case Western Reserve Univ. (USA); Natalia M. Shakhova, Institute of Applied Physics (Russian Federation); Guillermo J. Tearney M.D., Wellman Ctr. for Photomedicine (USA); Ruikang K. Wang, Univ. of Washington (USA); Maciej Wojtkowski, Nicolaus Copernicus Univ. (Poland); Yoshiaki Yasuno, Univ. of Tsukuba (Japan)

Optical coherence tomography and other optical methods and instruments based on coherent light interactions with inhomogeneous tissues are prom-ising for noninvasive medical diagnostics and for monitoring a wide spectrum of human pathologies. The focus of this conference will be on discussion of the physical and mathematical basis of coher-ence domain methods, and their applications in biomedical science and clinical practice. Directions of research and development in areas such as opti-cal coherence tomography (OCT), low-coherence interferometry, speckle and speckle interferometry measurement and imaging technologies, polarized light diagnostic methods, coherent light microscopy, and coherence technologies for fl ow and functional imaging will be considered. Applications of coher-ence domain optical methods for studies of living tis-sue and clinical applications will also be discussed. Papers are solicited on the following and related topics:• optical coherence tomography (OCT) systems,

theory, image processing techniques in OCT • spectral/Fourier domain and swept source OCT • optical coherence microscopy (OCM) full-fi eld

OCT• molecular, spectroscopic and functional OCT • Doppler and polarization-sensitive OCT •phase-contrast techniques •novel light sources for OCT •imaging devices and probes for OCT •low-coherence interferometry and topography •white-light interferometry•novel contrast mechanisms•clinical applications of OCT•ophthalmic•cardiovascular•cancer imaging•endoscopic•small animal imaging•developmental biology.

SPECIAL ABSTRACT REQUIREMENTS: PEER REVIEWSubmissions to this conference are due no later than 29 July 2013 (one week after the main BiOS due date) and must include the following:• 100-word text abstract (for online program)• 250-word text abstract (for abstract digest)• 3-page summary (for committee review)

All submissions will be peer reviewed by the full program committee. To facilitate the thorough review of submissions and accommodate the peer review process, abstracts/summaries will not be accepted after 29 July 2013. The summary should be three pages in length and should have suffi cient technical and scientifi c information to permit review of the paper.


Post-Meeting Manuscript Due Date: 10 January 2014 Please Note: Submissions imply the intent of at least one author to register, attend the conference, present the paper as scheduled, and submit a full-length manuscript for publication in the conference proceedings.




Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII (BO201)Conference Chairs: Tuan Vo-Dinh, Fitzpatrick Institute for Photonics, Duke Univ. (USA); Anita Mahadevan-Jansen, Vanderbilt Univ. (USA); Warren S. Grundfest M.D., Univ. of California, Los Angeles (USA)Program Committee: Maurice C. Aalders, Forensic Technical Solutions (Netherlands); Francesco Baldini, Istituto di Fisica Applicata Nello Carrara (Italy); Jennifer K. Barton, The Univ. of Arizona (USA); Stephen A. Boppart M.D., Univ. of Illinois at Urbana-Champaign (USA); Gerald Grant, Duke Univ. (USA); Hong Liu, The Univ. of Oklahoma (USA); Laura Marcu, Univ. of California, Davis (USA); Mary-Ann Mycek, Univ. of Michigan (USA); Jianan Y. Qu, Hong Kong Univ. of Science and Technology (Hong Kong, China); Urs Utzinger, The Univ. of Arizona (USA); Georges A. Wagnières, Ecole Polytechnique Fédérale de Lausanne (Switzerland); Christopher W. Woods M.D., Duke Univ. (USA); Pixuan ‘Joe’ Zhou, DMetrix, Inc. (USA)

Special sessions on FDA-related topics• FDA approval requirements for clinical

instrumentation• strategy towards faster FDA approval

As surgical systems and clinical diagnostics adapt to new methods, instrumentation and assay tech-nology, the pace of system innovations continues to accelerate. Many technologies originally developed for other applications, e.g., defense, energy, and aerospace, have found applications in the medical industry/environment. This conference provides a forum for scientists, engineers, manufacturers, and clinical providers to present the most recent advances in instrumentation and methods of diag-nostic and therapeutic guidance systems for clinical applications. The conference goal is to provide an interdisciplinary forum for state-of-the-art methods in instrumentation research and development of biomedical technologies, approaching the transla-tion from research and development prototypes to user application. The emphasis will be on clinical translation and implementation. The conference will address the interests of researchers, applied scientists, engineers, and clinicians whose goal is to implement clinical systems with extended, improved performance capabilities. Papers are sought that describe the methodolo-gies, instrumentation systems and analysis of bio-medical optics technologies for clinical implementa-tion. Topics will span the areas of instrumentation, system engineering, assay automation, delivery technology, and data management for biomedical diagnostics and surgical assistance in the clinical setting in developed countries as well as in devel-oping countries. Examples include stereotactic systems developed for brain surgery, fl exible mi-cronavigation devices engineered for medical laser ablation treatments, real-time monitoring system of critical function, online sensing of biological assays, and digital pathology. Oral and poster sessions are planned in the fol-lowing subject areas:

Clinical diagnostic systems• minimally invasive diagnostics systems based

on Fluorescence, Raman scattering, diffuse refl ectance

• early screening applications • clinical monitoring of early pathological or

physiological states • multi-modality diagnostic systems (optics

combined with acoustic, ultrasound, MRI, PET, X-ray)

• component/system design, engineering, and performance of biomedical instruments

• microinstrumentation and miniaturized clinical systems

• integrated instrument systems • high throughput systems.• digital pathology• automated data analysis algorithms• point-of-care diagnostics• diagnostics for personalized medicine

Advanced sensors for medicine• clinical applications of optical biosensors

(enzyme, antibody, gene probe-based systems) • physical sensors and chemical in vivo sensors • biochip technologies • bio-electrics and nanosecond pulsing

technology • sensors for burn diagnostics • advances in assay automation and delivery

technology.

Medical imaging techniques and devices • Fluorescence, IR, OCT and other optical

imaging systems • advanced endoscopy techniques and devices • smart catheters • laser radar sensing and imaging • RF radar imaging • terahertz techniques and systems (imaging,

spectroscopy, and modeling) • optical methods of assessing structure and

function • trauma and critical care • telemedicine, telesurgery • virtual reality technologies.

Medical guidance systems • image guidance• tracking technology (optical, acoustic, etc.) • stereotactic technology • catheter navigation • anatomical identifi cation • tumor demarcation, margin identifi cation • therapeutic assessment • dexterity-enhanced surgery • robotics-assisted surgery • surgical simulators • real-time feedback systems • virtual reality techniques

Global health technologies• low-cost diagnostic technologies• portable or hand held instrumentation• low-power medical systems• remote data transfer• rapid fi eld measurements• simple screening tests



Call for Papers

Design and Quality for Biomedical Technologies VI (BO202)Conference Chairs: Ramesh Raghavachari, U.S. Food and Drug Administration (USA); Rongguang Liang, College of Optical Sciences, The Univ. of Arizona (USA)Conference Co-Chairs: T. Joshua Pfefer, U.S. Food and Drug Administration (USA)Program Committee: Anthony J. Durkin, Beckman Laser Institute and Medical Clinic (USA); Kenji Taira, Olympus Corp. (USA); Jeeseong Hwang, National Institute of Standards and Technology (USA); Stephen P. Morgan, The Univ. of Nottingham (United Kingdom); Robert J. Nordstrom, National Institutes of Health (USA); Jannick P. Rolland, Univ. of Rochester (USA); Eric J. Seibel, Univ. of Washington (USA); Tomasz S. Tkaczyk, Rice Univ. (USA); Rudolf M. Verdaasdonk, Vrije Univ. Medical Ctr. (Netherlands); David W. Allen, National Institute of Standards and Technology (USA)

Rapid advances in optical technologies and com-putational power have brought about a revolution in biomedical diagnostics and therapeutics. However, these advances necessitate parallel progresses in techniques used for development and evaluation. This conference will focus on three key areas that are critical to the design and production of safe, ef-fective, and commercially-viable biomedical devices and technologies: 1. systems and components which require unique

solutions for biomedical applications 2. the evaluation of quality and safety of

biomedical imaging devices and technologies 3. the establishment of device reliability, including

failure and performance degradation.

This conference provides a unique forum for sci-entists and engineers from academia, industry and government to discuss issues that are relevant to all biomedical imaging modalities. Interactions between these parties should facilitate the develop-ment of biomedical devices and evaluation methods that will benefi t medical/biological knowledge and patient care. Submissions pertaining to optical di-agnostics and therapeutics for all fi elds of medicine as well as optical evaluation of pharmaceuticals and biotechnology products are solicited for this conference.

Devices • optical and biophotonic devices and

instruments for research and clinical applications

• biosensor, noninvasive photonics medical sensors

• biomedical instrumentation • image guided biopsy, surgical and therapeutic

device and technologies • cost effective optics and devices • preclinical, in vivo-simulating device, and

technologies.

Design• tomography, polarization, confocal,

multispectral, multiphoton, spectroscopic, and multimodal imaging systems

• optics for biomedical imaging technologies and devices

• illumination and detection geometry for imaging and spectroscopic systems

• fi ber optic imaging systems • novel optical sensing and detection • micro-optics and MEMS based optical systems • sources, detectors and other components • maximum permissible light exposure levels in vivo • development, validation, and application of

computer-aided design tools.

Quality • maximum permissible light exposure levels in vivo • Quality by Design (QbD) • device calibration and intercomparison • standards in biomedical imaging and

spectroscopy • standards in devices and components • standards in image/data processing and storage • phantoms and test methods • metrology • development/evaluation of novel measurement

tools • computer-aided diagnosis algorithms • critical metrics for assessing quality • quality, compliance and regulatory issues

related to biomedical devices • statistical approaches for designing, evaluating,

and validating medical device, databases, and technologies

• patient and user safety; photothermal, biochemical, etc.

Reliability • physics, analysis, failure mechanisms and

testing for failure • aging, dormancy and component degradation • computational and analytical modeling • determination of factors of safety • reusability of new optical devices.

Biomedical imaging technologies • hyperspectral, spectroscopic techniques • image enhancing techniques • CMOS technologies for biomedical applications • multi-modal techniques, including hybrid

devices with non-optical (e.g., x-ray, MRI, ESR, ultrasound) components

• small animal imaging • molecular imaging • digital Imaging and telemedicine

JOINT SESSIONA special joint session is planned with the Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue (BO304) conference.




Multimodal Biomedical Imaging IX (BO203)Conference Chairs: Fred S. Azar, Philips Medical Systems (USA); Xavier Intes, Rensselaer Polytechnic Institute (USA)Program Committee: Caroline Boudoux, Ecole Polytechnique de Montréal (Canada); Yu Chen, Univ. of Maryland, College Park (USA); Qianqian Fang, Massachusetts General Hospital (USA); Sergio Fantini, Tufts Univ. (USA); Gultekin Gulsen, Univ. of California, Irvine (USA); Theodore J. Huppert, Univ. of Pittsburgh (USA); Tim Nielsen, Philips Research (Germany); Vasilis Ntziachristos, Helmholtz Zentrum München GmbH (Germany); Brian W. Pogue, Thayer School of Engineering at Dartmouth (USA); Siavash Yazdanfar, GE Global Research (USA); Arjun G. Yodh, Univ. of Pennsylvania (USA)

Optical techniques offer the potential to contribute greatly to the expansion of clinical multimodality techniques. Their ability to image structural, func-tional, and molecular information at different spatial and temporal scales makes them very attractive to the biomedical community. There is critical need for new instrumental approaches and computational techniques to provide rapid, accurate and cost-effective means for acquisition, quantifi cation and characterization of multimodal data. Multimodality approach can be understood as the combination of multiple optical techniques in an instrument and/or fusion of an optical technique with other well-established imaging modalities such as CT, MRI, US, or PET. These instrumental and computational methods will enable faster acceptance of novel imaging modalities into viable clinical and/or pre-clinical systems. The applications are diverse and range from imaging at the cellular level to the whole body while incorporating molecular, functional and anatomical information. The conference objectives are to provide a forum:

• to review and share recent developments in novel multimodal imaging techniques,

• to report development of novel computational methods, and

• to bring together the optical imaging and image analysis communities.

Topics include, but are not limited to:• Multimodal imaging integrating structural,

molecular and functional information• Multimodal microscopic imaging• 2D, 3D, 4D tomographic and / or multi-spectral

imaging• Imaging analysis and/or image processing

techniques applied to optical imaging (e.g. visualization, segmentation, registration)

• Multimodal imaging instrumentation and system design

• Detection and diagnostic analysis techniques which may provide better quantitative and/or diagnostic insight into clinical and pre-clinical imaging (e.g. methods for quantitative measurements, computer-assisted diagnosis)

• Imaging analysis and/or image processing techniques used to combine optical imaging with other imaging modalities (e.g. MR, x-ray, PET)

• Image analysis, computational methods and reconstruction approaches which may help bring optical imaging into the clinic (visual rendering of complex data set, novel algorithms for assisted optical reconstruction)

• Clinical evaluation of these new technologies (physiological and functional interpretation of image data, visual perception and observer performances, validation of quantitative assessment of optical signatures in-vivo).



Call for Papers

Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIV (BO204)Conference Chairs: Israel Gannot, Tel Aviv Univ. (Israel)Program Committee: James P. Clarkin, Polymicro Technologies, A Subsidiary of Molex Incorporated (USA); Ilko Ilev, U.S. Food and Drug Administration (USA); Jin U. Kang, Johns Hopkins Univ. (USA); Karl-Friedrich Klein, Technische Hochschule Mittelhessen (Germany); Pierre Lucas, The Univ. of Arizona (USA); Yuji Matsuura, Tohoku Univ. (Japan); Angela B. Seddon, The Univ. of Nottingham (United Kingdom)

Optical devices and components, lab on chip, deliv-ery devices, fi bers, waveguides, bundles, detectors, and sensors are essential components needed to perform biological and clinical laboratories and in-vivo medical procedures. This conference will cover various topics in these fi elds. In the medical fi eld there are still pressing de-mands for the following:• new fi bers and waveguides, other delivery

devices, and transendoscopic tools for the x-ray, UV, visible, and IR regions of the spectrum

• invasive and noninvasive optical, biological, and chemical sensors for UV/VIS/NIR/IR fl uorescence, Raman, absorption and evanescent-wave and photothermal spectroscopy, optical, and thermal bundles

• biosensors for the medical and biological areas • fi ber sensors for physical, chemical, and

immunoassays • waveguide sensors, including molecular

diagnostic arrays • covering an increasing number of laser output

wavelengths (i.e., ultrafast lasers, x-ray lasers, and fi ber lasers)

• Femto,Atto, Zepto and Yocto pulse delivery • low loss waveguides and fi ber bundles for

terahertz, thermal, and optical imaging • theory of waves and signals delivery in fi bers • fi ber damage thresholds for high energy pulse

delivery, nonlinear effects • making the therapeutic and diagnostic systems

more intelligent and safer, i.e., by increasing the number and the role of fi ber based and control devices in the diagnostic and surgical apparatus (this will lead to safer operative procedures for both patients and physicians)

• optical fi ber and waveguides materials (i.e. 1D and 2D photonic bandgap crystals) and devices required specifi cally for medical applications

• new surgical and diagnostic procedures based on optical fi bers and waveguides

• fi ber based methods and systems • imaging bundles for the visible and IR • embedded optical sensors • imaging capsules • bio-compatibility of fi ber materials for

endoscopic tools • mechanical properties of fi bers (bending, tensile

strength) for endoscopic applications • new fi bers and catheter designs for laser

surgical applications • sensor and detector arrays • sensors for the smart medical home • tran-endoscopic optical methods such as OCT,

confocal, Bragg sensing.

The aim of the conference is to bring together groups of researchers, applied scientists, engineers, clinicians, and students belonging to different dis-ciplines who have as a common link the develop-ment and use of optical sensing and fi ber based techniques and methodologies. The conference subject is particularly suitable to obtain the right balance among the various disci-plines. To this aim, the papers should report on both technical and biomedical advances. Contributions focusing on the development of fi bers, endoscopic delivery, and diagnostic systems sensing methods for applications in all biomedical areas are solicited.





Biomedical Vibrational Spectroscopy VIII: Advances in Research and Industry (BO205)Conference Chairs: Anita Mahadevan-Jansen, Vanderbilt Univ. (USA); Wolfgang Petrich, Roche Diagnostics GmbH (Germany)Program Committee: Andrew J. Berger, Univ. of Rochester (USA); Rohit Bhargava, Univ. of Illinois at Urbana-Champaign (USA); Airton Abrahão Martin, Univ. do Vale do Paraíba (Brazil); Michael D. Morris, Univ. of Michigan (USA); Dieter Naumann, Robert Koch-Institut (Germany); Jürgen Popp, Institut für Photonische Technologien e.V. (Germany); Nicholas Stone, Gloucestershire Royal Hospital (United Kingdom)

Vibrational spectroscopy provides molecular spe-cifi c information that has long been used in the fi eld of biochemistry. Technical advances in the last decade have led to the application of vibra-tional spectroscopy to address many biological and biomedical problems. In particular, NIR and mid-IR absorption as well as Raman spectroscopy have received tremendous interest in biomedicine. Furthermore, special techniques such as SERS, CARS, TERS, or even MIR-laser spectroscopy have begun dedicating a lot of attention to the application in biology and medicine. The fi ngerprint nature of all of these techniques allows precise analysis of bio-logical materials that can be used for applications ranging from the macroscopic to the micro and sub-microscopic levels. The development of diode lasers and novel designs of fi ber optic probes have led to the potential of applying these techniques in vivo. This year’s conference will be organized based on medical or biological systems rather than tech-niques to facilitate cross-fertilization of solutions to problems in implementation. Where feasible, the specifi c sessions will be co-localized with the spe-cifi c clinical conference to ensure increased aware-ness of vibrational spectroscopy by clinicians. This year’s conference will focus on bringing together a variety of different fi elds wherein vibrational spec-troscopy has played a powerful role in their devel-opment for a specifi c application. We would like to particular encourage the participation of molecular processes community to foster interactions with the researches active in the fi eld of tissues and cells. An added agenda will be interaction between research and industry and the synergy therein. This call solicits abstracts in biomedical ap-plications of vibrational spectroscopy as well as new discoveries in its implementation. This con-ference will encompass methodologies that probe vibrational energies at tissue, cell, sub-cellular and molecular levels.

Such modalities include but are not confi ned to:• conventional Raman spectroscopy • spatially offset Raman spectroscopy (SORS) • Raman microscopy and microspectroscopy • surface enhanced Raman spectroscopy (SERS) • coherent anti-Stokes Raman spectroscopy

(CARS) • Tip-enhanced Raman spectroscopy (TERS)• NIR and MIR spectroscopy • NIR and MIR microscopy and

microspectroscopy • Mid-IR and THz laser spectroscopy.

The techniques may be applied in biology as well as medicine. Potential areas of applications include but are not confi ned to: • histopathology • cytology • tissue and cellular probes and processes • sub-cellular and molecular probes and

processes • protein and DNA analysis • pharmacology • analysis of biological fl uids such as blood • infectious agents • disease identifi cation • guidance of therapy • microbiology.

Sessions will be organized according to medical application areas such as neurology, dermatology, endocrinology etc. and supplemented by a techni-cal session.



Call for Papers

Optical Biopsy XII (BO206)Conference Chairs: Robert R. Alfano, The City College of New York (USA); Stavros G. Demos, Lawrence Livermore National Lab. (USA)Program Committee: Irving J. Bigio, Boston Univ. (USA); Nicole J. Crane, Naval Medical Research Ctr. (USA); Zhiwei Huang, National Univ. of Singapore (Singapore); Amir Gandjbakhche, National Institutes of Health (USA); Israel Gannot, Tel Aviv Univ. (Israel); Xiaohui Ni, Harvard Univ. (USA); Milind Rajadhyaksha, Memorial Sloan-Kettering Cancer Ctr. (USA); Kestutis Sutkus, The City College of New York (USA); Sebastian Wachsmann-Hogiu, NSF Ctr. for Biophotonics Science and Technology (USA); Siavash Yazdanfar, GE Global Research (USA)

Sponsored by: copy, multiphoton and photonic methods to modify the tissue and body fl uids properties or functions implemented in vivo or ex-vivo covering the tech-nology development steps from bench-to-bedside. Compact smart spectral explorers, multi-spectral imagers, coherence effects, and hyper spectral imaging will be highlighted and covered, in part, by speakers. Topics include: • origin of tissue optical properties • optical methods for tissue diagnosis and

treatment • methods for in vivo assessment of physiological

state of tissue • excitation, absorption, fl uorescence

spectroscopy and imaging • Raman spectroscopy and imaging • inelastic light scattering spectroscopy and

imaging • stimulated Raman gain spectroscopy and

imaging • Stokes shift spectroscopy • polarization and diffusive refl ectance spectral

imaging • THz spectroscopy and imaging • phosphorescence spectroscopy and imaging • novel coherence methods • multi photon spectroscopy and imaging • time resolved spectroscopy and imaging • speckle spectroscopy for diagnoses • ultraviolet diagnostic methods • infrared diagnostic methods • optical biopsy mapping with linear excitation

methods • nonlinear optical biopsy mapping • instrumentation for in-vivo optical biopsy • video spectral imaging and mapping of tissue • nano particle tagging and contrast agents • chemo- and molecular targeting agents • STED nano-scale imaging • supercontinuum for medical and biological

applications • noninvasive detection and imaging of cancer • diabetes noninvasive detection • assessment of tissue injury • high resolution imaging methods for in vivo

pathology • instrumentation of in vivo optical biopsy • in vivo spectroscopy and imaging • endoscopes and micro-endoscopes for optical

biopsy • tissue modifi cation with light pulses • laser tissue welding and real time monitoring • integration of optical detection and therapy

systems • dynamics of laser-tissue interactions • novel methods for optical biopsy.• “optical metabolomics” maybe a future growth

area.

SUPERCONTINUUM ANNIVERSARY SESSIONS: Wednesday 5 February 2014The 2014 conference will include special ses-sions featuring pioneer speakers to commemo-rate the 45th anniversary of the discovery of supercontinuum generation and applications.

The goal of this conference is to present novel state-of-the-art work in non-invasive spectroscopic methods to detect the onset and progression of disease, including pre-malignancy and malignancy, and tissue response to external conditions, includ-ing therapeutic intervention, unintended injury, and laser energy deposition. The conference will focus on work investigating the differences in single and multiphoton excitation optical signatures of normal and diseased tissues, and on understanding the underlying biochemical and structural changes of tissues and cells responsible for the observed spectroscopic signatures. It is worth noting that this symposium has hosted in recent years a number of contributions on the detection of disease using optical spectroscopy signatures of body fl uids such as urine or blood plasma. As the fi eld of metabolo-mics continues to grow, it is possible that “optical metabolomics” maybe a new frontier in the fi eld of Optical Biopsy. This conference covers a wide array of well-es-tablished optical techniques and novel approaches to diagnose tissues changes, including: in vivo and ex vivo fl uorescence spectroscopy, Stokes shift spectroscopy, spectral imaging, Raman spectros-




This conference of related interest is part of LASE 2014, co-located at Photonics West: www.spie.org/lasecall

Frontiers in Ultrafast Optics: Biomedical, Scientifi c and Industrial Applications XIV (LA113)Conference Chairs: Alexander Heisterkamp, Friedrich-Schiller-Univ. Jena (Germany); Peter R. Herman, Univ. of Toronto (Canada); Michel Meunier, Ecole Polytechnique de Montréal (Canada); Stefan Nolte, Friedrich-Schiller-Univ. Jena (Germany)Program Committee: Craig B. Arnold, Princeton Univ. (USA); James E. Carey III, SiOnyx Inc. (USA); Xun Gu, ABB Corporate Research (Switzerland); Denise M. Krol, Univ. of California, Davis (USA); Eric Mazur, Harvard Univ. (USA); Michael M. Mielke, Raydiance, Inc. (USA); Eric P. Mottay, Amplitude Systèmes (France); Christopher B. Schaffer, Cornell Univ. (USA); Alexander Szameit, Friedrich-Schiller-Univ. Jena (Germany); Alfred Vogel, Univ. zu Lübeck (Germany); Wataru Watanabe, Ritsumeikan Univ. (Japan)

Recent advances in ultrafast laser technology have resulted in widespread availability of robust, practi-cal laser sources. As a result, useful applications for these sources have emerged in many different fi elds, from micromachining and THz-imaging to nonlinear microscopy and semiconductor testing to laser surgery and communications. Now in its four-teenth year, this conference is the premier venue for discussing the development of new ultrafast laser sources and the use of ultrafast lasers for this wide variety of applications. To refl ect this transformation, the title of the conference was changed in 2010 to Frontiers in Ultrafast Optics: Biomedical, Scientifi c and Industrial Applications. We anticipate a larger conference than ever that will bring together a multi-disciplinary group consisting of university research-ers from diverse fi elds, as well as scientists and engineers from industry. A program that includes invited and tutorial presentations will provide the context for contributed talks and posters, and for stimulating discussions. We encourage submission of papers on all aspects of applications of ultrafast lasers and on ultrafast laser technology development. In ad-dition, all graduate and undergraduate students are encouraged to enter their submissions in the Student Competition for best presentation (see below). General topics include, but are not limited to, the following areas:• emerging ultrafast laser technologies and novel

systems • ultrafast laser source engineering for industrial

and biomedical use • ultrashort pulse delivery and beam manipulation • ultrashort pulse propagation and nonlinear

effects in materials • interaction of ultrashort pulses with materials • surface and bulk micromachining using ultrafast

lasers • interactions and modifi cation of biological

tissues • tissue and surgical applications of ultrashort

pulse lasers • optical manipulation of biological systems with

ultrashort pulses • micro and nano manipulation of cells and

organelles, optical transfection • ultrafast lasers in plasmonics, interaction with

nanoparticles • novel medical applications of ultrafast lasers • applications and generation of x-ray ultrashort

pulses.

CONFERENCE HIGHLIGHTS In addition to the exciting technical program that has been the hallmark of previous years, we plan several highlights this year:• Joint sessions with LA110, addressing the

fi eld of laser processing by ultrashort lasers • Biomedical sessions on Sunday, covering

recent advances in imaging and manipulation using ultrashort laser pulses

• Student competition, awarding the best student paper.

JOINT SESSIONS with LA110 and LA113Ultrafast Laser MicromachiningThis session will address important emerging technologies at the picosecond, femtosecond and attosecond time scale, for a broad audience of researchers in the fi elds of ultra-fast lasers and laser processing, together with experts at the forefront of alternative micro- and nanofab-rication technologies. The topics will cover, but will not be limited to, fundamentals of ultra-fast laser-matter interaction and novel machining techniques.

BIOMEDICAL SESSION For several years we have successfully estab-lished several sessions on biomedical applica-tions on Sunday, in good overlap with sessions and topics of the BiOS conference. In recent years, special focus was on the use of ultrashort laser systems for high resolution imaging and manipulation from in-vitro to in vivo systems, covering topics like optical transfection, nerve regeneration, and multiphoton imaging.



Call for Papers

STUDENT COMPETITION Thanks to generous corporate sponsorship, we are happy to announce that a student competi-tion will be held again this year. Due to the great success in previous years, the competition will be a general best student award, taking posters and talks into account. The winner will be announced and awarded a $1000 cash prize directly at the end of the student competition session, with the runner-up students receiving a cash prize as well.

Judging and RequirementsPapers submitted by graduate and undergradu-ate students are eligible. In order to ensure a fair evaluation the conference chairs and the pro-gram committee will judge the students within a special session held during the conference. Here, the students have to present a brief summary of their original talk or poster presented at our conference with a time limit of 5 minutes. Presen-tations will be judged based on content, scientifi c impact, organization, quality of presentation, and presenter’s mastery of the subject. Candidates for the award need to be the presenting author, a full-time student, must have conducted the majority of the research presented in the paper, and must submit their manuscript to the confer-ence proceedings.

NominationsTo be considered, submit your abstract online, select “Yes” when asked if you are a full-time student, and select yourself as the speaker. Note that prior fi rst prize holders may participate, but will not be eligible for a cash prize.




Microfl uidics, BioMEMS, and Medical Microsystems XII (MF104)Conference Chairs: Bonnie L. Gray, Simon Fraser Univ. (Canada); Holger Becker, microfl uidic ChipShop GmbH (Germany)Program Committee: Brian W. Anthony, Massachusetts Institute of Technology (USA); Yolanda Fintschenko, Sandia National Labs., California (USA); Bruce K. Gale, The Univ. of Utah (USA); Albert K. Henning, Aquarian Microsystems (USA); Yu-Cheng Lin, National Cheng Kung Univ. (Taiwan); Yuehe Lin, Pacifi c Northwest National Lab. (USA); Ciara K. O’Sullivan, Univ. Rovira i Virgili (Spain); Ian Papautsky, Univ. of Cincinnati (USA); Thomas Stieglitz, Albert-Ludwigs-Univ. Freiburg (Germany); Sindy Kam-Yan Tang, Harvard Univ. (USA); Albert van den Berg, Univ. Twente (Netherlands); Wanjun Wang, Louisiana State Univ. (USA); Bernhard H. Weigl, PATH (USA)

Conference Best Student Paper Award Cosponsors:

The purpose of this conference is to provide an international technical forum to showcase recent advances in microfl uidics, BioMEMS, and medical microsystems. Microfl uidic devices and systems have created a tremendous interest in many ap-plication fi elds, including life sciences, point of care (POC) diagnostics, and environmental ap-plications. They offer many advantages over the existing macroscale systems, including compact size, disposability, higher speed and parallelism of analyses, increased functionality and decreased sample/reagent volumes. In the life sciences, recent research efforts have focused on bio/chemical anal-yses, pharmaceutical high-throughput systems, and biomaterial surface modifi cation. The interaction of microsystems with living cells or tissues opens a pathway to novel methods of medical diagnostics and therapeutics. Thus, the range of interests has expanded from the molecular scale over single cells to more complex biological systems, and fi -nally, living organisms. Further, several conventional methods in medical engineering for diagnosis and therapy have also been shifting towards miniaturiza-tion and MEMS technologies, including minimally invasive surgery, in vivo and ex vivo monitoring, and smart implants. Last, but not least, environmental applications have focused on developing inexpen-sive sensors for in situ monitoring of contaminants in the environment for public safety or measuring a person’s exposure to environmental contamination. For many of these applications, microfl uidics and other MEMS technologies are essential, as they provide the functional basis of many research tools as well as commercial devices and applications. Thus, over the past several years, there has been a signifi cant increase in the activities associated with understanding, development, and application of micromechanical and microfl uidic devices and systems for BioMEMS and medical microsystems.

Papers are solicited on the following major topics and other related subjects:

Micro/Nano Fluidic Components• fl uid delivery, transport, and control • micro -valves, -pumps, -mixers, and -reactors • nanofl uidic devices and systems • microdroplet generation and manipulations • micro-heating/cooling devices • emerging microfl uidic approaches (inertial

microfl uidics, electrofl uidics, optofl uidics) • CAD, modeling, and analysis.

Microfabrication Technologies for Microfl uidics and BioMEMS• polymer microfabrication methods • emerging fabrication technologies (e.g., paper

microfl uidics) • fl uidic modules and interconnects • fl uidic packaging and assembly • microstructuring of organic materials • functional materials for microfl uidics and

BioMEMS • surface texturing and modifi cation.

Applications of Microfl uidics, BioMEMS, and Medical Microsystems • point-of-care (POC) medical monitoring and

diagnostics • nano bio/medical sensors • optofl uidics, on-chip waveguides and optical

detection • cell-based sensing devices and systems, fl ow

cytometry • implantable medical microsystems • sensors and systems for environmental monitoring • sensors and systems for in vitro/in vivo

monitoring and diagnosis • microfl uidic-based drug development and analysis.


This conference of related interest is part of MOEMS-MEMS 2014, co-located at Photonics West: spie.org/moemscall



Call for Papers

JOINT SESSION with MF104 and BiOS BO114Microfl uidics plays an important role in the re-alization of devices and systems for pathogen detection in applications such as food safety or biothreat detection. Miniaturization and function-al integration can lead to portable instruments which can be fi eld-deployed or applied in-line in production monitoring. The recent advances in this fi eld and its growing importance will be recognized in a joint sessions between the two conferences “Frontiers in Biological Detection” (BO114) and “Microfl uidics, BioMEMS and Medi-cal Microsystems” (MF104).

BEST STUDENT PAPER AWARDA $500 cash prize sponsored by microfl uidic ChipShop GmbH and the Ohio Center for Mi-crofl uidic Innovation will be awarded to the best student paper.

Judging and RequirementsPresentations and manuscripts will be judged based on scientifi c merit, impact, and clarity. Candidates for the award need to be the pre-senting author, a full-time student, must have conducted the majority of the research presented in the paper, and must submit their manuscript by the deadline (6 January 2014).

NominationsTo be considered, submit your abstract online, select “Yes” when asked if you are a full-time student, and select yourself as the speaker.


Manuscript Due Date: 10 January 2014Please Note: Submissions imply the intent of at least one author to register, attend the conference, present the paper as scheduled, and submit a full-length manuscript for publication in the conference proceedings.



Tissue Optics, Laser-Tissue Interaction, and Tissue EngineeringOptical Interactions with Tissue and Cells XXV (BO300)Conference Chairs: E. Duco Jansen, Vanderbilt Univ. (USA); Robert J. Thomas, Air Force Research Lab. (USA)Program Committee: Randolph Glickman, The Univ. of Texas Health Science Ctr. at San Antonio (USA); Steven L. Jacques, Oregon Health & Science Univ. (USA); Beop-Min Kim, Korea Univ. (Korea, Republic of); Duncan J. Maitland, Texas A&M Univ. (USA); Jessica C. Ramella-Roman, The Catholic Univ. of America (USA); William P. Roach, Air Force Offi ce of Scientifi c Research (USA); Marissa Nicole Rylander, Virginia Polytechnic Institute and State Univ. (USA); Alfred Vogel, Univ. zu Lübeck (Germany); Gerald J. Wilmink, Air Force Research Lab. (USA)

The basic mechanisms of laser tissue and cell interactions fall into three categories: photochemi-cal, photomechanical, and photothermal. These mechanisms form a fundamental basis for the fi eld but are now expanded to include the cellular and bio-molecular response to irradiation from lasers and laser systems both in vitro and in vivo. Understanding the fundamental mechanisms of interactions between light, tissue and cells is the basis for the development of future biomedical optic technologies that include both therapeutic and diagnostic applications. This conference will focus on papers which exam-ine the fundamental mechanisms of the light-tissue interaction, at both the tissue and cellular levels, and their role in the emerging optical technologies for biomedical applications. The conference seeks papers regarding both theoretical and experimental approaches, including approaches for advanced numerical simulations. The aim of this confer-ence is to provide a forum for those investigating fundamental physics, biochemistry, and biology in order to seed future engineering approaches. The conference identifi es optical technologies that will be useful in addressing problems of biomaterials, tissue engineering and tissue mechanics. As a special recognition of the 25th anniversary of this research conference, the organizers invite par-ticipants from the early conferences to contribute papers as part of a special retrospective session. These invited talks will open the conference and include leaders in the fi eld who presented pioneer-ing fundamental work in those early days of the BiOS symposium.

A preliminary list of session topics is listed:• photothermal interactions • photochemical and photo-oxidative interactions • photomechanical effects • mechanisms of pulsed laser ablation • ultrafast pulsed laser interactions • optical monitoring of tissue mechanics • optical properties of tissues • local laser treatment and immune responses • cellular micro-and nanosurgery • laser-induced lysis, microdissection and

catapulting of cells • cellular biomolecular response • novel applications of lasers and light in

biomedicine • laser welding and soldering of tissue • numerical approaches simulating laser-tissue

interactions and response.



Call for Papers

Dynamics and Fluctuations in Biomedical Photonics IX (BO301)Conference Chairs: Valery V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation), Univ. of Oulu (Finland); Donald D. Duncan, Portland State Univ. (USA); Kirill V. Larin, Univ. of Houston (USA); Martin J. Leahy, National Univ. of Ireland, Galway (Ireland); Ruikang K. Wang, Univ. of Washington (USA)Program Committee: Pierre O. Bagnaninchi, The Univ. of Edinburgh (United Kingdom); Wei R. Chen, Univ. of Central Oklahoma (USA); Joseph P. Culver, Washington Univ. School of Medicine in St. Louis (USA); Ekaterina I. Galanzha, Univ. of Arkansas for Medical Sciences (USA); Miya Ishihara, National Defense Medical College (Japan); Jingying Jiang, Tianjin Univ. (China); Sean J. Kirkpatrick, Michigan Technological Univ. (USA); Jürgen M. Lademann, Charité Universitätsmedizin Berlin (Germany); Hong Liu, The Univ. of Oklahoma (USA); Qingming Luo, Huazhong Univ. of Science and Technology (China); Igor V. Meglinski, Univ. of Otago (New Zealand); Brian S. Sorg, Univ. of Florida (USA); Vladislav Toronov, Ryerson Univ. (Canada); Lihong V. Wang, Washington Univ. in St. Louis (USA); Ying Yang, Keele Univ. (United Kingdom); Anna N. Yaroslavsky, Univ. of Massachusetts Lowell (USA); Vladimir P. Zharov, Univ. of Arkansas for Medical Sciences (USA); Dan Zhu, Huazhong Univ. of Science and Technology (China)

The conference will be devoted to applications of recent developments in dynamics and control, coherence and synchronicity in networks, and statistical physics to biomedical photonics with a particular emphasis on functional monitoring and imaging. The goal of the conference is to gather essentially fi ve groups of leading researchers:• biophysicists• physicians • biologists and neuroscientists • mathematicians • optical and laser engineers

along with graduate and undergraduate students to facilitate future progress in the development of optical and laser technologies based on a dynamics approach to biomedical science and clinical appli-cations. This approach will be useful for diagnosis and therapy of diseases such as those of the heart and vasculature, cancer, psoriasis, mental illness, and many others that manifest as a breakdown of the living organism’s auto-regulation systems at the level of molecule, cell, organ, or organism as a whole. This methodology is also intended to promote a deeper understanding of the role of complex dynamics in biological development across all length scales from embryos, to tissues, to organs and systemic functions. This conference contributes to the development of interdisciplinary fi elds of science and applications such as dynamics and structures of living systems, biomedical optics, and laser medicine, and we hope that it will continue to be helpful for scientists, physicians, engineers, and students.

Papers are solicited on photonics technologies, including diffusion, fl uorescence and polarization spectroscopies, OCT, Doppler, speckles, photo-acoustics, and nanophotonics, applied for estima-tion, monitoring,imaging and/or controlling of:• dynamics of stochastic systems in biology and

medicine • circulation in the blood and lymph microvessels • brain functioning • dynamics of heartbeat, breath, fi brillary tremor,

eyeball tremor, etc. • bio-vibrations, tremor and breath measuring

technologies and instruments • contractile activity of blood and lymph vessels,

fl ow measurement and imaging • microcirculation imaging • red blood cell and other bio-particle

sedimentation and aggregation processes • cell proliferation • cell drug and dye uptake • intracellular fl ows and contractile activity of cells • molecular agents, intelligent particles and

collective behavior • molecular motor driving • stochastic cluster dynamics of macromolecules • nonlinear diffusion of metabolic and exogenous

agents and nanoparticles in tissues • glucose sensing • fractal point processes and cell structure

analysis • fl uctuations and chaos in living systems and

organisms • stochastic resonance and synchronization in

neural science and cardiology • adaptive coherent optical systems for medicine • engineered tissues and organs.



Tissue Optics, Laser-Tissue Interaction, and Tissue EngineeringPhotons Plus Ultrasound: Imaging and Sensing 2014 (BO302)Conference Chairs: Alexander A. Oraevsky, TomoWave Laboratories, Inc. (USA); Lihong V. Wang, Washington Univ. in St. Louis (USA)Program Committee: Mark A. Anastasio, Washington Univ. in St. Louis (USA); Paul C. Beard, Univ. College London (United Kingdom); A. Claude Boccara, Institut Langevin (France); Gerald J. Diebold, Brown Univ. (USA); Charles A. DiMarzio, Northeastern Univ. (USA); Stanislav Y. Emelianov, The Univ. of Texas at Austin (USA); Rinat O. Esenaliev, The Univ. of Texas Medical Branch (USA); Martin Frenz, Univ. Bern (Switzerland); Steven L. Jacques, Oregon Health & Science Univ. (USA); Robert A. Kruger, OptoSonics, Inc. (USA); Pai-Chi Li, National Taiwan Univ. (Taiwan); Andreas Mandelis, Univ. of Toronto (Canada); Vasilis Ntziachristos, Helmholtz Zentrum München GmbH (Germany); Matthew O’Donnell, Univ. of Washington (USA); Günther Paltauf, Karl-Franzens-Univ. Graz (Austria); Wiendelt Steenbergen, Univ. Twente (Netherlands); William M. Whelan, Univ. of Prince Edward Island (Canada); Vladimir P. Zharov, Univ. of Arkansas for Medical Sciences (USA); Qifa Zhou, The Univ. of Southern California (USA); Quing Zhu, Univ. of Connecticut (USA)

This conference will be dedicated to imaging, sensing, monitoring and spectroscopy based on the combination of light and sound by synergisti-cally utilizing the high optical contrast and the high ultrasonic resolution. The images based on optical contrast are complementary to images based on ultrasonic contrast. The hybrid technology can provide anatomical and functional imaging for com-prehensive tissue characterization. It is also capable of providing high-resolution molecular imaging. The areas of interest include methods involving opti-cally and thermally induced acoustic waves and acoustically modulated optical waves and a variety of photothermal and photoacoustic phenomena, covering basic research, instrumentation and ap-plications. Biomedical applications include cancer detection, localization, and differentiation, detection of atherosclerotic plaques, vascular imaging and angiography. A preliminary list of topics includes the following, where optoacoustic and photoacoustic are used synonymously:

Large-scale optoacoustic/photoacoustic tomography• imaging of human organs: breast, prostate, and

brain • functional imaging of hemoglobin concentration

and oxygen • saturation (oxymetry with spatial resolution) • detection of lymph nodes and image-guided

biopsy • monitoring of therapeutic intervention

Small animal optoacoustic/photoacoustic tomography• maging of the brain and other organs • imaging with contrast agents • molecular imaging and monitoring • imaging of cancer in animals • whole body three-dimensional small animal

imaging

Microscopic optoacoustic/photoacoustic imaging• characterization of blood vessels • imaging of angiogenesis network • detection of superfi cial and microscopic lesions • contrast-agent-based angiography • measurement of blood perfusion • microscopy of cells and organelles • biosensing of single cells and micro-organisms

Optoacoustic/photoacoustic tomography with optical and interferometric detection • novel free-space interferometric devices • novel fi ber-optic interferometric devices • validation in phantoms • validation in tissue

Optoacoustic/photoacoustic monitoring of therapy • monitoring of thermal therapy by lasers, RF, and

ultrasound • imaging of physiological changes in tissue • imaging with optical and ultrasonic contrast

agents • monitoring of laser-induced cavitation • monitoring of drug delivery

Optoacoustic/photoacoustic spectroscopy and analytic monitoring • measurements of tissue optical properties • infrared sensors and thermal sensors • monitoring of health related gases and

environment • detection of physiologically important

molecules in human tissue and body liquids • contrast agents

Thermal wave and thermoacoustic imaging• systems and methods • diagnostic and therapeutic applications • thermal waves in biological systems • optical monitoring of thermal processes in cells • combination of electromagnetic energy and

ultrasound

Clinical applications of optoacoustic/photoacoustic imaging • in oncology and photodynamic therapy • in monitoring digestive system • in dentistry • in ophthalmology • in monitoring trauma and other acute conditions

Signal processing and image reconstruction• algorithms for 2D and 3D image reconstruction • fi lters and denoising procedures • wavelets and multiresolution imaging • post-processing methods



Call for Papers

Novel technologies and applications • ultrasound-modulated optical (acousto-optical)

tomography • time-reversed ultrasonically encoded (TRUE)

optical focusing• hybrid technologies employing combination of

light and ultrasound • combined systems employing ultrasound and

optoacoustic/photoacoustic imaging • comparative studies of optoacoustic/

photoacoustic imaging versus other imaging modalities

• gold, silver, and other strongly absorbing nanoparticles as contrast agents

• thermoacoustic nanothermolysis of cells • novel ultrawide-band acoustic transducers and

arrays • new biomedical applications of photons plus

ultrasound.

BEST PAPER AWARD and BEST POSTER AWARD Seno Medical Instruments of San Antonio, Texas, will sponsor two Awards for this Confer-ence: Best Paper and Best Poster presented. Authors to compete for the two awards must email a 1-page Summary of their research to Ms. Marina Shipova ([email protected]) and copy both conference chairs by 7 January 2014. The chairs’ email addresses are Alexander A. Oraevsky ([email protected]) and Lihong V. Wang ([email protected]).

Biophotonics and Immune Responses IX (BO303)Conference Chairs: Wei R. Chen, Univ. of Central Oklahoma (USA)Program Committee: Yuncheng Ge, Beijing Glass Research Institute (China); Sandra O. Gollnick, Roswell Park Cancer Institute (USA); Yueqing Gu, China Pharmaceutical Univ. (China); Michael R. Hamblin, Wellman Ctr. for Photomedicine (USA); Tomas Hode, Immunophotonics, Inc. (USA); Yih-Chih Hsu, Chung Yuan Christian Univ. (Taiwan); Zheng Huang, Univ. of Colorado Denver (USA); Mladen Korbelik, The BC Cancer Agency Research Ctr. (Canada); Mark F. Naylor, Dermatology Associates of San Antonio (USA); Karl-Goran Tranberg, CLS Ltd. (Sweden); Valery V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation); Xunbin Wei, Shanghai Jiao Tong Univ. (China); Da Xing, South China Normal Univ. (China); Vladimir P. Zharov, Univ. of Arkansas for Medical Sciences (USA)

Immunological responses are crucial in the treat-ment of diseases. Phototherapy (photothermal, photochemical, and photomechanical), often used in conjunction with immunotherapy, has shown promise in stimulating and enhancing host immune systems. Recently, many researchers have started human clinical studies using photo-immunotherapy. This conference will provide a forum for discussion and interaction among people from academia, industry, and health professions who are working in this area. It will serve as a bridge between tech-nology development and clinical applications, in the fi eld of phototherapy-related immune activities. This conference will focus on induction, enhance-ment, mechanisms, and detection of immune re-sponses induced by phototherapy and combination modalities. It will specifi cally address the issue of searching for an effective immunological modality for different diseases, ranging from autoimmune dis-eases to cancer, using optical methods. It will also address the issue of detecting immune activities, using modern technologies such as molecular and cellular imaging, as well as other imaging modalities. It will include research using different combination modalities, novel approaches for stimulations of sys-temic responses, innovative methods in monitoring and guiding photo-immunotherapy, and immuno-logical responses related to nanotechnology-based phototherapeutics and diagnosis. Preliminary session topics include: • opto-immune therapies • novel technologies in monitoring immune

activities • novel combination therapy in cancer treatment • new approaches in inducing immune responses • local and systemic effects of low intensity laser

irradiation • local and systemic effects of high intensity laser

irradiation • sensing and sensors for immune activities • molecular imaging for immune responses • in vitro cellular and biomolecular responses • in vivo cellular and biomolecular responses • photodynamic therapy and immune responses.• photoimmunotherapy in clinical applications• light-induced vaccination.



Tissue Optics, Laser-Tissue Interaction, and Tissue EngineeringDesign and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI (BO304)Conference Chairs: Robert J. Nordstrom, National Institutes of Health (USA); Jean-Pierre Bouchard, INO (Canada); David W. Allen, National Institute of Standards and Technology (USA)Program Committee: Anant Agrawal, U.S. Food and Drug Administration (USA); Gerald T. Fraser, National Institute of Standards and Technology (USA); Rongguang Liang, College of Optical Sciences, The Univ. of Arizona (USA); Ramesh Raghavachari, U.S. Food and Drug Administration (USA); Heidrun Wabnitz, Physikalisch-Technische Bundesanstalt (Germany)

If biomedical optical technologies are to cross the chasm from bench to bedside, they must be subjected to the rigors of validation at many levels. Phantoms, in addition to their current use in re-search, will play a crucial role as independent veri-fi cation artifact to insure data consistency across multiple instruments and even vendors. Phantoms used in the highly regulated phase of clinical trials and fi eld use will have to be fabricated to the same quality standards as the biomedical optical devices they are serving. In addition, their physical proper-ties will have to be accurately known and traceable to the international system of units. This conference provides a forum for scientists and engineers from academia, industry, and govern-ment to discuss the issues affecting the design and required performance characteristics of phantoms for optical devices in medicine. Papers are encour-aged that describe the application of phantoms for performance comparison and validation of instru-ments. In addition, phantom design and validation procedures, quality control, testing and uncertainty analysis, shape and boundary issues, dynamic methods, and disease conditions being simulated are welcome. Submissions dealing with simulation of benign and disease-free tissue condition as well as the simulation of various disease conditions such as cancer precursors are also encouraged.

Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications (BO305)Conference Chairs: Gerald J. Wilmink, Air Force Research Lab. (USA); Bennett L. Ibey, Air Force Research Lab. (USA)Program Committee: Hope Thomas Beier, Air Force Research Lab. (USA); Benjamin P. Born, Weizmann Institute of Science (Israel); Patrick Bradshaw, Air Force Offi ce of Scientifi c Research (USA); Elliott R. Brown, Wright State Univ. (USA); Ibtissam Echchgadda, Air Force Research Lab. (USA); Yuri Feldman, The Hebrew Univ. of Jerusalem (Israel); Gian Piero Gallerano, ENEA (Italy); Martina Havenith, Ruhr-Univ. Bochum (Germany); Peter Uhd Jepsen, DTU Fotonik (Denmark); Kodo Kawase, Nagoya Univ. (Japan); Martin Koch, Philipps-Univ. Marburg (Germany); Richard Nuccitelli, BioElectroMed Corp. (USA); Gun-Sik Park, Seoul National Univ. (Korea, Republic of); Emma Pickwell-MacPherson, Hong Kong Univ. of Science and Technology (Hong Kong, China); William P. Roach, Air Force Offi ce of Scientifi c Research (USA); Peter H. Siegel, Jet Propulsion Lab. (USA); Joo-Hiuk Son, The Univ. of Seoul (Korea, Republic of); Koichiro Tanaka, Kyoto Univ. (Japan); Robert J. Thomas, Air Force Research Lab. (USA); Paul Thomas Vernier; Shu Xiao, Old Dominion Univ. (USA); Hao Xin, The Univ. of Arizona (USA)The terahertz (THz) region of the electromagnetic (EM) spectrum is defi ned as frequencies rang-ing from 0.1 to 10 THz (1 THz = 1012 Hz = 1 ps). Historically, few sources have been available to effi ciently generate THz radiation; however, several recent technological advances have resulted in the unprecedented development of many new types of THz sources and components. These technologies are now being used as tools for a plethora of novel basic science investigations, and they are increas-ingly being integrated into innovative sensing and imaging operational schemes, which are fi nding widespread use in a host of medical, military, and defense applications. Ultrashort electromagnetic pulses (USEP) are defi ned as pulses with duration below one micro-second and a rise time at or below a nanosecond. Direct application of USEP on tissue has been shown to elicit an array of biological effects includ-ing plasma membrane breakdown, cellular swell-ing, nuclear granulation, and initiation of apoptotic death. These observed phenomena have spawned quick advancement of USEP-based techniques into clinical devices to treat both superfi cial and deep cancers. USEP-based technologies have a distinct advantage of causing desired effects only within the profi le of the electric fi eld with little to no thermal footprint. Future technology is pushing beyond direct application into shorter pulse regimes (picoseconds) to enable free fi eld propagation of USEP into deep tissue. These efforts have required advancements in pulse generators and antenna construction. The drive to shorter pulse duration bridges the gap between electrical pulses and those commonly generated by THz sources.



Call for Papers

Fundamental knowledge gaps exist regarding how electric fi elds with frequency components from the MHz to the THz interact with biological structures. This conference aims to highlight USEP and THz source development, biological applications, and fundamental interactions with tissues, cells, and biomolecules. Scientifi c papers that push the state-of-the-art are solicited. These include:

Basic Science and Phenomenology: interaction mechanisms, biological effects, and molecular dynamics • THz time-domain spectroscopy (THz-TDS):

transmission, refl ection, KITA, and attenuated total refl ection (ATR)

• Biological effects of THz radiation and USEP at organism, tissue, cellular,

and biomolecular level • Molecular dynamics in meso-space: water

relaxation components, hydration and biosolvation dynamics

Biomedical Diagnostics and Therapeutics: Imaging, Spectroscopy, and Multi-modality approaches • Cancer diagnosis and margin detection: skin,

breast, liver, and oral tissues• Skin burns, sweat gland monitoring, corneal

hydration sensing, retinal imaging, and wound repair

• Therapeutic bio-stimulation: exploitation of THz and USEP for non-contact control of biological functions

Advanced systems, sources, and bio-analytic tools • Nanoscale FTIR, near-fi eld microscopes,

sub-wavelength THz microscopy, 3D THz tomography, THz OCT

• Microfl uidics, micromachined probes, microcantilever systems, and THz integrated circuits

• Bio-environmental, agricultural, food testing, pharmaceutical applications

• Lasers: Far-IR molecular gas, p-type germanium, THz-Quantum cascade lasers (QCLs)

• Frequency down-conversion and non-linear optical sources: optical rectifi cation, difference frequency generation, parametric amplifi cation, and laser-induced plasma sources

• Frequency up-conversion: electronic solid-state devices, schottky diodes, varactors/varistors, multiplier sources

• Accelerating electron based-sources: photocurrent in semiconductor (photoconductive switches, photomixing, UTC); free electrons in vacuum (backward wave oscillators, traveling wave tubes TWTs, gyrotrons, and free electron lasers (FELs)

• Nanosecond and picoseconds high electric fi eld pulse generators and electric fi eld measurement systems

Novel materials and transmission technologies • Transmission technologies: free space optics,

waveguides, and fi ber optics Materials: active and passive metamaterials, photonics crystals, plasmonics, graphene, and THz phonon-polaritons

• Lenses: superfocusing, microlenses, liquid crystals, dielectric-based lenses

• Nanoparticles and nanotubes: carbon nanotube structures





Tissue Optics, Laser-Tissue Interaction, and Tissue Engineering

Optical Elastography and Tissue Biomechanics (BO306)Conference Chairs: Kirill V. Larin, Univ. of Houston (USA); David D. Sampson, The Univ. of Western Australia (Australia)Program Committee: Jeffrey C. Bamber, Institute of Cancer Research (United Kingdom); A. Claude Boccara, Institut Langevin (France); Stephen A. Boppart M.D., Univ. of Illinois at Urbana-Champaign (USA); Brett E. Bouma, Wellman Ctr. for Photomedicine (USA); Zhongping Chen, Beckman Laser Institute and Medical Clinic (USA); Donald D. Duncan, Portland State Univ. (USA); Kishan Dholakia, Univ. of St. Andrews (United Kingdom); Daniel S. Elson, Imperial College London (United Kingdom); Mathias Fink, Institut Langevin (France); Brendan F. Kennedy, The Univ. of Western Australia (Australia); Sean J. Kirkpatrick, Michigan Technological Univ. (USA); Seemantini K. Nadkarni, Harvard Medical School (USA); Kentaro Nakamura, Tokyo Institute of Technology (Japan); Amy L. Oldenburg, The Univ. of North Carolina at Chapel Hill (USA); Francesco Saverio Pavone, European Lab. for Non-linear Spectroscopy (Italy); Giuliano Scarcelli, Harvard Medical School (USA); Gijs van Soest, Erasmus MC (Netherlands); Victor X. D. Yang, Ryerson Univ. (Canada); Seok Hyun A. Yun, Wellman Ctr. for Photomedicine (USA); Ruikang K. Wang, Univ. of Washington (USA)

Optical elastography is the use of optics to charac-terize tissues and cells based on their elastic and viscoelastic mechanical properties. In deploying the high-resolution capability of optics, this rapidly emerging fi eld builds on and complements the re-lated fi elds of ultrasound and MR elastography, as well as complementing existing methods for bio-mechanics such as AFM and rheology. Mechanical forces play an important role in the behavior and de-velopment at all spatial scales, from cells and their constituents, to tissues and organs. Such forces have a profound infl uence on the health, structural integrity, and normal function of cells and organs. Accurate determination of tissue biomechanical properties (e.g., Young’s or shear modulus) could help with clinical diagnosis and interpretation of various diseases. This conference is devoted to developments and applications of biomedical optics and biophotonics for biomechanical monitoring and imaging of cells and their constituents in vitro, and tissues and whole organs in animal models and hu-mans. The multidisciplinarity of optical elastography and tissue biomechanics will see this conference bring together technology and application experts in bioengineering, biophysics, cell biology, clinical sciences, medical imaging, optics and photonics, and tissue engineering. In so doing, we hope to contribute to the development of interdisciplinary bonds in supporting scientists, engineers, biolo-gists and physicians interested in the broad fi eld of tissue biomechanics. Papers are solicited on biomedical optics, bio-photonics and biomechanical methods and tech-nologies applied or related to estimation, monitor-ing, and functional assessment of the mechanical properties of normal and pathological biomaterials at all spatial scales, from cells and their constituents to tissues and organs. Relevant topics include (but are not limited to):• Optical elastography methods in general• Optical coherence tomography/elastography• Speckle and particle tracking, and holography• Signal processing methods for optical

elastography• Quantitative methods, including combining

modeling and measurement• Novel loading schemes, such as focused

ultrasound, photothermal and magnetomotive• Methods for measuring viscoelastic properties

in particular

• Photoacoustics directed towards biomechanics• Brillouin scattering for biomechanics• Optical tweezers applied to cellular and

subcellular mechanical properties• Scanning probe and other nanoscale methods

for biomechanics• Dynamic methods for characterizing tissue

vibration, such as in the ear and vocal chords• Optical elastography applications in general• In vivo elastography• Elastography applied to characterization of ex

vivo and in vivo tissue pathology• Intraoperative elastography applications: breast

cancer, lung cancer and others• Elastography in cardiology• Biomechanics of the eye• Ophthalmic applications of optical elastography• Hard tissue biomechanics in bones and dental

applications• Biomechanics in animal models• Biomechanics in tissue engineering• Biomechanics in developmental biology• Rheology measurements using optical

techniques• Single cell mechanics, motility, and adhesion.



Biomedical Spectroscopy, Microscopy, and ImagingMultiphoton Microscopy in the Biomedical Sciences XIV (BO401)Conference Chairs: Ammasi Periasamy, Univ. of Virginia (USA); Peter T. C. So, Massachusetts Institute of Technology (USA); Karsten König, Univ. des Saarlandes (Germany)Program Committee: Wolfgang Becker, Becker & Hickl GmbH (Germany); Alberto Diaspro, Istituto Italiano di Tecnologia (Italy); Chen-Yuan Dong, National Taiwan Univ. (Taiwan); Kevin W. Eliceiri, Univ. of Wisconsin-Madison (USA); Scott Fraser, California Institute of Technology (USA); Paul M. W. French, Imperial College London (United Kingdom); Hans C. Gerritsen, Utrecht Univ. (Netherlands); Enrico Gratton, Univ. of California, Irvine (USA); Min Gu, Swinburne Univ. of Technology (Australia); Stefan W. Hell, Max-Planck-Institut für Biophysikalische Chemie (Germany); Paul J. Campagnola, Univ. of Wisconsin-Madison (USA); Satoshi Kawata, Osaka Univ. (Japan); Fu-Jen Kao, National Yang-Ming Univ. (Taiwan); Arnd K. Krueger, Spectra-Physics®, a Newport Corp. Brand (USA); Joseph R. Lakowicz, Univ. of Maryland School of Medicine (USA); Steve M. McDonald, Coherent, Inc. (USA); Angelika C. Rueck, Univ. Ulm (Germany); Junle Qu, Shenzhen Univ. (China); Steven S. Vogel, National Institutes of Health (USA); Paul W. Wiseman, McGill Univ. (Canada); X. Sunney Xie, Harvard Univ. (USA); Bernhard Zimmermann, Carl Zeiss Jena GmbH (Germany); Warren R. Zipfel, Cornell Univ. (USA)

Conference sponsored by: • fl uorescence lifetime imaging (frequency and time domain) (FLIM) and its applications

• fl uorescence correlation spectroscopy and image cross-correlation spectroscopy (FCS, ICCS)

• harmonic generation microscopy (SHG, THG) and its applications

• Raman/SRS/CARS/CRS spectroscopy and microscopy and their applications

• fl uorescence recovery after photobleaching (FRAP), uncaging and photoactivation

• various biological applications including developmental, neurobiology, plant biology, calcium and pH imaging

• photodynamic therapy (PDT) and clinical imaging

• photo-thermal, -chemical and -mechanical effects of IR radiation

• laser safety and other related applications.

STUDENT POSTER SESSION COMPETITIONGraduate students and postdoctoral fellows are welcome to participate in the poster session competition of the conference on Multiphoton Microscopy in the Biomedical Sciences. There is a cash award for the winner(s). Participants should follow the rules and regulations of SPIE for submission of their abstract and manuscript. Participants should also register their names for the competition with the conference Chair during the fi rst day of the conference. Submitted pro-ceedings manuscripts are allowed for resubmis-sion to the Journal of Biomedical Optics (please visit www.spie.org/x85029.xml for details).

JENLAB YOUNG INVESTIGATOR AWARDWe encourage graduate students, postdocs, and scientists or junior faculty who are not more than 32 years old to apply for the JenLab Young Inves-tigator Award. To be eligible for this $2000 cash award, participants must be both the primary author and presenter of an accepted abstract and the proceedings paper must be submitted by the due date, prior to the meeting, for review by the selection committee. Submitted proceedings manuscripts may be resubmitted to the Journal of Biomedical Optics (please visit www.spie.org/x85029.xml for details). To self-nominate, please enter “Jen Lab Young Investigator Award” as a keyword in your abstract. Prize donated by JenLab GmbH, Germany.

Multiphoton microscopy has been established as the 3D imaging method of choice for studying biomedical specimens, from single cells to whole animals, with sub-micron resolution. Two decades have passed since the realization of two-photon microscopy, and the ever-expanding scope of ap-plications and continuing instrumental innovations require a forum where new ideas can be exchanged and presented. Our conference in the SPIE BiOS 2014 meeting continues to address this need. Submitted proceedings manuscripts may also be submitted to the Journal of Biomedical Optics (please visit http://spie.org/x85029.xml for details). Topics include:• multiphoton (one- or two- or three- or more

photons) microscopy theory and system development

• multiphoton (MP) in wide-fi eld and laser scanning confocal microscopy

• infrared lasers for MP systems (femtosecond vs. picosecond vs. CW)

• tissue engineering, endoscopy, and animal imaging using 2-photon microscopy

• endogenous molecular imaging and its applications

• stimulated emission depletion (STED) microscopy

• fl uorescence resonance energy transfer imaging (FRET)



Biomedical Spectroscopy, Microscopy, and ImagingImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII (BO400)Conference Chairs: Daniel L. Farkas, SMI (USA); Dan V. Nicolau, McGill Univ. (Canada); Robert C. Leif, Newport Instruments (USA)Conference Co-Chairs: James F. Leary, Purdue Univ. (USA); Attila Tarnok, Univ. Leipzig (Germany); Rebecca R. Richards-Kortum, Rice Univ. (USA)Program Committee: Vadim Backman, Northwestern Univ. (USA); Christopher H. Contag, Stanford Univ. School of Medicine (USA); Paul M. W. French, Imperial College London (United Kingdom); DaeGab Gweon, KAIST (Korea, Republic of); Charles P. Lin, Wellman Ctr. for Photomedicine (USA); Sacha Loiseau, Mauna Kea Technologies (France); Ramesh Raghavachari, U.S. Food and Drug Administration (USA); Sebastian Wachsmann-Hogiu, NSF Ctr. for Biophotonics Science and Technology (USA); Warren S. Warren, Duke Univ. (USA)

This interdisciplinary conference addresses the knowledge continuum from molecular structure and fundamental mechanisms to biological, energy production, and medical applications, focusing on new approaches to imaging, manipulation, and analysis of biomolecules, cells, and tissues, both in vitro and in vivo. The conference will report on the latest developments in functional and multispectral imaging, optogenetics, analysis, algorithms, quanti-fi cation, separation, sorting, and standards for cells (cytomics) and tissues (histomics). The principal aim is to further improve the interdisciplinary dialog between those who design and implement critical technologies and the primary users who study im-portant problems that drive developments, in order to advance translational research. Reports of original research contributions are solicited on the following topics:

Functional imaging of biomolecules, live cells and tissues • light microscopy of living cells and tissues (2D,

3D, 4D) • spectral imaging of multiple cellular and tissue

components • new and automated methods for monitoring

biological structure and physiology • microscopic imaging of electric potentials and

events • mesoscopic (microscopic resolution in vivo)

tissue imaging • multimodality tissue imaging in vivo.

Biophotonic techniques for regenerative medicine• stem cell characterization in vitro • stem cell imaging and tracking in vivo • in vivo studies of immunologic events • imaging methods in organ transplantation • functional monitoring of tissue engineering

constructs • imaging of tissue oxygenation and

vascularization. Optical manipulation of cells and tissues• cell micromanipulation using optical trapping • cellular effects of localized energy deposition

into micro- and nano-absorbers • cells and biomolecules in micro- and

nanoconfi ned spaces • scanning probe microscopy of cells and

surface-immobilized biomolecules.

Spectral imaging and multiparameter measurements (microscopic and macroscopic):• spectral pathology • digital imaging for quantitative pathology and

clinical applications {RCL clinical and pathology are related

• small animal imaging • bioenergy applications • tools and approaches for combining optical and

other measurements • tools and approaches for combining several

optical imaging methods • advanced registration and visualization.

Advanced quantitation in cells (cytomics) and tissues (histomics)• fl uorescence and phosphorescence lifetime

imaging • instrumentation and technology • probes, including new dyes • high-throughput cytometry • in situ diagnostic applications • new technologies for multispectral and

multiparameter imaging, including acquisition, segmentation and analysis methods

• new components for cytometry instrumentation, including ultraminiature and nanosystems

• clinical and research applications of cytometry, with emphasis on new and unusual approaches

• new methods for cell separation including high-speed, optical and magnetic-paramagnetic sorting

• circulating stem, fetal, cancer, and other rare cells

• mutant selection.

Microarrays for biomolecules, cells and tissues• printing technologies • readout methods, including image analysis and

quantifi cation • applications of microarrays in diagnostics and

drug discovery.



Call for Papers

Bioinformatics, image and data processing, quantifi cation, standards, and display methods • cell-based high-throughput and high-content

screening clustering algorithms • analytical quantifi cation, including new methods

for multiparameter cell and tissue analysis and data manipulation

• automated 3D image processing, including tracking of tissue section surfaces, image segmentation, and fl uorimetry/densitometry

• software standards and regulatory requirements for spectroscopy, fl ow cytometry, and imaging

• image formats, databasing, and retrieval • advanced image registration and display

methods, including co-display of multimodality image sets.

Monitoring of pilot and industrial cell and tissue growth and production for• biomedical products applications • tissue engineering • energy applications.

JOINT SESSION with BO400 and MOEMS-MEMS MF109Biomedical Imaging and Cell Manipulation using a Digital Micromirror Device or MEMS ArrayThis special joint session is in conjunction with MOEMS-MEMS conference MF109: Emerging Digital Micromirror Device Based Systems and Applications VII. The utilization of the DMD and other optical MEMS arrays to manipulate light has numerous medical applications ranging from cancer detection to operating room aids to the manipulation of individual cells. Papers are solicited that address the uses of a DMD and other Optical MEMS arrays with:• 3D medical visualization • confocal microscopes • hyperspectral imaging • image-guided intervention • optoelectronic tweezers • organs on a chip • oxygenation measurements • phototherapy • selectable wavelength light sources • structured light • tissue illumination.


Manuscript Due Date: 10 January 2014 Please Note: Submissions imply the intent of at least one author to register, attend the conference, present the paper as scheduled, and submit a full-length manuscript for publication in the conference proceedings.



Biomedical Spectroscopy, Microscopy, and ImagingThree-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXI (BO402)Conference Chairs: Thomas G. Brown, Univ. of Rochester (USA); Carol J. Cogswell, Univ. of Colorado at Boulder (USA); Tony Wilson, Univ. of Oxford (United Kingdom)Program Committee: Martin Booth, Univ. of Oxford (United Kingdom); G. J. Brakenhoff, Univ. van Amsterdam (Netherlands); José-Angel Conchello, Harvard Univ. (USA); Charles A. DiMarzio, Northeastern Univ. (USA); Raimund J. Ober, The Univ. of Texas at Dallas (USA); Chrysanthe Preza, Univ. of Memphis (USA); Monika Ritsch-Marte, Innsbruck Medical Univ. (Austria)

For over 20 years, this conference has been a venue to present exciting advances in multidimensional microscopy, including confocal- and coherence-based imaging systems, and microscopes based on fl uorescence, phase imaging, and nonlinear optics. While many of the instruments are oriented toward biomedical imaging, the papers usually include applications such as materials science, industrial inspection, and nanoscale metrology. Many micro-scopes are now fully integrated systems, including computer hardware and software. It is hoped that the broad range of relevant topics being presented at this conference will serve to encourage interac-tion among instrumentation engineers, computer image analysts, and researchers in the various fi elds of application. We consider papers that cover overall system design, as well as more specialized areas: optical image formation, image recording, deconvolution and image restoration in two, three, or more dimen-sions, image classifi cation, and digital methods of producing and displaying the resulting recon-struction. We especially encourage submission of articles on novel optical and digital techniques for imaging or detecting object features approaching the nanometer-scale range. In addition, we encourage submission of articles on the growing research area of full-fi eld quantita-tive phase imaging, including hardware, models, multiview tomography, algorithms and applications.

Papers are invited in the following and related areas: • instrumentation and methods for microscopy in

2, 3, or more dimensions • innovations in optical modes for microscopy

(such as interference, fl uorescence, or polarizing) in refl ection or transmission

• full-fi eld quantitative phase imaging, including quantitative DIC and holographic imaging techniques

• innovations aimed toward nanostructure detection and imaging, including STED, PALM, STORM, etc.

• superresolution • confocal microscopy • new modes of multiphoton fl uorescence

excitation microscopy • probe microscopy (atomic force microscopy,

near-fi eld scanning optical microscopy) • time-resolved image acquisition systems • image processing and analysis • image reconstruction in 2, 3, or more

dimensions • deconvolution and image estimation in 2, 3, or

more dimensions • computational models • computational optical sensing and imaging

(COSI) techniques for microscopy • point spread function engineering for enhanced

image information content • wavefront manipulation techniques for

correcting aberrations, extending depth of fi eld, etc.

• spectral and hyperspectral imaging • specimens and procedures for testing and

evaluating new instruments and algorithms • spatio-temporal reconstruction of living cells

and tissues • applications in materials science • 3D image visualization techniques, including

volume rendering, animation, stereoscopic and holographic displays

• holographic microscopy • single-plane illumination microscopy (SPIM) • microtomography • total internal refl ection fl uorescence (TIRF)

microscopy.



Single Molecule Spectroscopy and Superresolution Imaging VII (BO403)Conference Chairs: Jörg Enderlein, Georg-August-Univ. Göttingen (Germany); Ingo Gregor, Georg-August-Univ. Göttingen (Germany); Zygmunt Karol Gryczynski, Univ. of North Texas Health Science Ctr. at Fort Worth (USA), Texas Christian Univ. at Fort Worth {United States); Rainer Erdmann, PicoQuant GmbH (Germany); Felix Koberling, PicoQuant GmbH (Germany)Program Committee: Sohail Ahmed, A*STAR Institute of Medical Biology (Singapore); Michael Börsch, Friedrich-Schiller-Univ. Jena (Germany); Christian Eggeling, Univ. of Oxford (United Kingdom); Paul M. W. French, Imperial College London (United Kingdom); Ewa M. Goldys, Macquarie Univ. (Australia); Johan Hofkens, Katholieke Univ. Leuven (Belgium); Zhen-Li Huang, Huazhong Univ. of Science and Technology (China); Thomas R. Huser, Univ. Bielefeld (Germany); Maria Teresa Neves-Petersen, International Iberian Nanotechnology Lab. (Portugal); Markus Sauer, Univ. Bielefeld (Germany); Shimon Weiss, Univ. of California, Los Angeles (USA); Andong Xia, Institute of Chemistry (China)

This conference will include a Keynote presentation by Stefan Hell, Max Planck Institute for Biophysical Chemistry (Germany). The focus of this conference are all fi elds of optical single molecule spectroscopy and imaging, ranging from fundamental physics, technical and method-ological questions, towards applications in chemi-cal, biological and biomedical research as well as medical diagnostics. It provides a state-of-the-art interdisciplinary forum for information exchange on new technological developments, advanced ap-plications, and fundamental questions of the fi eld. Ultrasensitive spectroscopic techniques have become an important tool in fundamental biologi-cal and biomedical research, allowing study of the function and interaction of individual biomolecules. Improving and extending the existing arsenal of techniques for studying specifi c biophysical and biochemical questions on a single molecule level is of paramount interest for the life-science com-munity. This conference puts special emphasis on time resolved methods of fl uorescence spectroscopy which allow for investigating not only structural properties but also the function of molecular pro-cesses, down to the single molecule level. There-fore, we encourage to submit work related also to Fluorescence Lifetime Imaging (FLIM), Advanced single-molecule techniques such as Fluorescence Correlation Spectroscopy (FCS), Fluorescence Coincidence Analysis or single-molecule burst analysis are also favorite subjects of this confer-ence. In particular Förster resonance energy trans-fer (FRET) analysis frequently benefi ts from theses time-resolved methods and this conference will be an excellent platform to discuss their application at the molecular level. A topic of particular interest has become the employment of the single-molecule nature of fl uorescence excitation and emission to achieve sub-diffraction superresolution in fluorescence microscopy. It has opened previously unknown opportunities to image live cells in the optical far fi eld with unprecedented optical resolution. This resulted in new microscopy modalities such as Stimulated Emission Depletion (STED) microscopy, single molecule localization microscopy (PALM, STORM, dSTORM, GSD-IM), stochastic optical fl uc-tuation microscopy (SOFI), or structured illumina-tion microscopy (SIM) techniques. The conference provides an interdisciplinary platform for these new and exciting developments in fl uorescence imaging. The need for ultrasensitive and specifi c biomedi-cal diagnostics requires development of optical and

photonic detection/sensing technologies capable of reaching the single molecule level. The technical challenges to rapidly and specifi cally detect chemi-cal and biological agents at minimal concentration levels are enormous and largely yet to be realized. All spectroscopic techniques (optical spectroscopy, fluorescence spectroscopy, elastic scattering, Raman scattering, IR spectroscopy, terahertz spectroscopy) as well as the chemical and bio-logical sciences themselves including genetically encoded fl uorescent markers, are potentially criti-cal components for a multidisciplinary approach to ultrasensitive sensing and diagnostics. Invited and contributed papers are solicited concerning, but not limited to, the following areas: • techniques and methods of single molecule

(SM) detection • techniques and methods of SM spectroscopy

(such as FCS, FLCS, FLIM, FRET) • techniques of single molecule manipulation • superresolution fl uorescence imaging (STED,

PALM, (d)STORM, GSD-IM, SOFI, SIM and related techniques)

• multi-modal SM detection such as combining AFM with confocal microscopy

• correlative microscopy such as combining optical and electron microscopy

• fundamental aspects of SM spectroscopy • biophysical applications of SM spectroscopy

and imaging • medical applications of SM spectroscopy and

imaging SM imaging and tracking in cells and tissues

• ultrasensitive biomedical diagnostics • high-throughput screening applications • chemical and biochemical sensing photonic

materials for ultrasensitive optical detection • plasmonics and metal-enhanced fl uorescence

for ultrasensitive optical detection • microfl uidics and capillary devices.

PICOQUANT YOUNG INVESTIGATOR AWARD Young scientists (age 32 or below and not yet full faculty members) are encouraged to participate in this best paper competition which offers a 1000 USD cash award. Participants must be both the primary author and presenter of an ac-cepted abstract to be eligible. Please note in your abstract submission to this conference “Young Investigator best paper competition BO403” to be considered. This award is sponsored by PicoQuant GmbH Berlin and presented Sunday afternoon.

Call for Papers



Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics (BO404)Conference Chairs: Gerard L. Coté, Texas A&M Univ. (USA)Program Committee: Werner Gellermann, The Univ. of Utah (USA); Jürgen M. Lademann, Charité Universitätsmedizin Berlin (Germany); Kristen C. Maitland, Texas A&M Univ. (USA); Michael J. McShane, Texas A&M Univ. (USA); Kenith E. Meissner, Texas A&M Univ. (USA); Risto Myllylä, Univ. of Oulu (Finland);Kexin Xu, Tianjin Univ. (China); Shaoqun Zeng, Britton Chance Ctr. for Biomedical Photonics (China); Dmitry Zimnyakov, Saratov State Technical Univ. (Russian Federation)

Biomedical Spectroscopy, Microscopy, and Imaging

The focus of this conference will be on invasive and noninvasive optical methods for the diagnostics and sensing of all types of biological fl uids: blood, lymph, saliva, mucus, gastric juice, urine, aqueous humor, semen, etc. both in vitro and in vivo. The optical properties of these fl uids and the techniques to monitor the fl uids will be discussed in-cluding: elastic, quasi-elastic, and inelastic (Raman) light scattering, Doppler fl owmetry, spectrophotom-etry, polarimetry, diffraction, holography, speckle, fl uorescence, imaging, and related spectroscopic and microscopic techniques. Studies of biological fl uid components on cellular and macromolecular levels, as well as nondestructive measurements of gas and analyte content, will be presented. Theoretical and model studies, as well as clinical applications of the developed optical methods and instrumentation, will be outlined. Diagnostics and sensing systems for point-of-care and global health applications are particularly encouraged.

Suggested topics include, but are not limited to, the following areas: • point-of-care diagnostic and sensing systems • global health diagnostics and sensing systems • In-home diagnostics and monitoring systems • glucose monitoring approaches • analyte monitoring in vivo and in vitro • biological fl uid spectroscopy and imaging • local fl ow velocity measurement • blood microcirculation and tissue perfusion

monitoring • blood cell and macromolecular interaction and

aggregation sensing • blood cell deformation, orientation, diffusion,

and sedimentation imaging • fl uid viscosity measurement • effects of physical and chemical factors on fl uid

composition, rheological, and other properties • disease diagnostic potential of optical

techniques.

The paper you present will live far beyond the conference roomAll proceedings from this event will be published in the SPIE Digital Library, promoting breakthrough results, ideas, and organizations to millions of key researchers from around the world.

www.SPIEDigitalLibrary.org

Helping engineers

and scientists stay

current and competitive



Biomedical Applications of Light Scattering IX (BO405)Conference Chairs: Adam Wax, Duke Univ. (USA); Vadim Backman, Northwestern Univ. (USA)Program Committee: Irving J. Bigio, Boston Univ. (USA); Stephen A. Boppart M.D., Univ. of Illinois at Urbana-Champaign (USA); Bernard Choi, Beckman Laser Institute and Medical Clinic (USA); Dirk J. Faber, Academisch Medisch Ctr. (Netherlands); Steven L. Jacques, Oregon Health & Science Univ. (USA); Lev T. Perelman, Harvard Univ. (USA); Brian W. Pogue, Thayer School of Engineering at Dartmouth (USA); Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (USA)

Light scattering techniques are under develop-ment as biomedical diagnostics for their ability to accurately and precisely determine structures within biological samples. Clinical applications have included detecting pre-cancerous and cancerous tissue states both in vivo and with ex vivo biopsy samples, characterizing the mechanical proper-ties of cells and tissues for identifying disease and for assessing the presence and concentration of biochemicals for diagnostic purposes. The devel-opment of these clinical modalities has relied upon implementing light scattering instruments, creating models of light scattering by normal and diseased tissues and devising new analysis methods. In ad-dition, light scattering has also been employed in pre-clinical cell biology studies which seek to detect structural changes of sub-cellular components such as mitochondria and cell nuclei. Improved under-standing of the relationship between light scattering signals and underlying morphological changes has relied upon these pre-clinical studies in developing new clinical modalities. The increasing use of light scattering techniques for biomedical applications has led to a signifi cant presence at Photonics West in recent years, with invited and contributed talks appearing across sev-eral conferences. This conference consolidates this presence with a focused conference on biomedical applications of light scattering.

Papers are solicited on (but not restricted to) the following areas:• Clinical applications of light scattering methods,

including: - dynamic light scattering- speckle contrast imaging- elastic scattering spectroscopy - polarized light scattering spectroscopy - low coherence light scattering - diffuse refl ectance spectroscopy - enhanced backscattering spectroscopy.

• Applications of light scattering for identifying biochemicals

• Light scattering methods for assessing structural properties of cells and tissues for clinical diagnostics, such as cancer detection

• Methods for determination of biological structure based on analysis of optical properties

• Pre-clinical cell biology investigations using light scattering, including:- light scattering microscopy - goniometry.

• Light scattering instrumentation for biomedical diagnostics, including- confocal microscopy - spectroscopic optical coherence tomography.

• Novel light scattering techniques for clinical applications

• Quantitative phase imaging for assessing scattering features

• Theoretical modeling of light scattering for clinical applications, including- numerical modeling - analytical treatments.

• Experimental and modeling studies of microscopic origins of light scattering in tissue.

Call for Papers





Optical Methods in Developmental Biology II (BO406)Conference Chairs: Andrew M. Rollins, Case Western Reserve Univ. (USA); Cecilia W. Lo, Univ. of Pittsburgh (USA); Scott E. Fraser, California Institute of Technology (USA)Program Committee: Michael A. Choma M.D., Yale School of Medicine (USA); Anjul M. Davis, Thorlabs Inc. (USA); Mary E. Dickinson, Baylor College of Medicine (USA); Robert G. Gourdie, Virginia Polytechnic Institute and State Univ. (USA); Michael W. Jenkins, Case Western Reserve Univ. (USA); Bradley B. Keller, Univ. of Louisville (USA); Kirill V. Larin, Univ. of Houston (USA); Kersti K. Linask, Univ. of South Florida (USA); Charles D. Little, The Univ. of Kansas Medical Ctr. (USA); David Sedmera M.D., Charles Univ. in Prague (Czech Republic); Ruikang K. Wang, Univ. of Washington (USA); Michiko Watanabe, Case Western Reserve Univ. (USA); Talât Mesud Yelbuz, Medizinische Hochschule Hannover (Germany)

Developmental biology is approaching a deeper understanding of how dynamic events shape the embryo, requiring more quantitative and higher resolution tools and approaches. Studying the tiny, fragile embryo, with its rapid morphogenesis, is a signifi cant challenge, especially at early stages when the body plan is being established, organ systems first develop, and trajectories toward congenital defects are initiated. Many mechanisms underlying normal and abnormal development are not well understood and technologies are needed to analyze structure/function relationships in the living embryo. In this postgenomic era, the development of new genetic and optogenetic tools is providing unprec-edented opportunities to experimentally manipulate and observe the living embryo. There is also growing interest in developing fetal interventions based on basic biological mechanisms underlying congenital disease. Imaging is changing the face of develop-mental biology and the clinical, in utero management of congenital diseases. Because of the spatial and temporal resolution they enable, optical methods underlie many emerging imaging and quantitative tools that are playing an increasingly prominent role in these areas. This conference will bring together technology and application experts and will emphasize novel technologies and quantitative methods based on optical tools for developmental biology and fetal medicine.

Papers are welcome that address opportunities and challenges including:• real-time, minimally invasive live embryo

imaging • anatomical, functional and molecular imaging • optical imaging of embryonic/fetal

cardiovascular development, anatomy, and physiology

• comprehensive volumetric imaging of whole embryos

• time-lapse in vivo imaging of cell, tissue, and organ motion during morphogenesis

• spatial-temporal molecular expression in the living embryo

• optogenetic approaches in live embryo imaging • computational image analysis • cilia-driven fl uid fl ow and ciliary motion analysis • fetoscopy/embryoscopy • laser surgery • novel optical imaging methods.

Biomedical Spectroscopy, Microscopy, and Imaging



Nano/Biophotonics

Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications X (BO500)Conference Chairs: Alexander N. Cartwright, Univ. at Buffalo (USA); Dan V. Nicolau, McGill Univ. (Canada)Program Committee: Vamsy P. Chodavarapu, McGill Univ. (Canada); Piotr A. Grodzinski, National Cancer Institute (USA); Sung Jin Kim, Univ. of Miami (USA); Brian D. MacCraith, Dublin City Univ. (Ireland); Paulo C. Morais, Univ. de Brasília (Brazil); Paras N. Prasad, Univ. at Buffalo (USA); Sharon M. Weiss, Vanderbilt Univ. (USA)

Novel applications and/or solutions to technologi-cal problems involving i) the use of nanostructures, nanoparticles, metamaterials and nanostructured materials for biological applications; ii) photonic studies of nanoscale interactions in biology and medicine; and iii) the use of biological materials/templates for the development of nanostructured nanophotonic imaging and sensing devices are signifi cant foci of both industrial and academic research. These applications and solutions are in-herently interdisciplinary by nature and thus require a seamless transfer of knowledge between physics, chemistry, biology, medicine and engineering. Recent integrative research efforts have included, for example, (a) nanotechnology (fabrication and ap-plication) as a tool in developing new, and improving existing, optical imaging techniques for real-time sub-wavelength imaging of cellular processes, (b) developing the next generation of nano-biosensors for improving biological / chemical sensing applica-tions, (c) using nanoparticles / nanostructures for optical engineering of methodologies for targeting and treatment of disease, (d) applying computer and information technologies in the development of new models and data analysis for understanding cellular mechanisms, (e) developing new photonic devices and systems that are hybrids of traditional polymeric and semiconductor materials with bio-logical materials; and (f) very large scale and/or very sensitive detection down to single molecule level for drug discovery and diagnostics applications, such as nanoarrays. The objective of this conference is to bring to-gether scientists and researchers interested in the latest advances in the advancement of materials and methods that combine nanophotonics with biology. More specifi cally, this conference is to discuss the development of processing, charac-terization, and simulation of bioinspired and bio-derived nanophotonic structures, metamaterials for sub-wavelength imaging, nanoscale interactions in biological systems, functionalized nanoparticles for biological applications and the use of nanostruc-tures / nanoparticles for high throughput analysis (nanoarrays). The conference will focus on three streams of contributions: • nanoparticle use in imaging and sensing • nanostructures used for nanoscale / sub-

wavelength imaging • nanospectroscopy and nano-scale sensing

biomedical applications.

Papers from industry, government, academia, and other research organizations are solicited on the following and related topics:

Fundamentals (materials and tools) • studies of cellular and membrane biophysics

using nanophotonics (nanoparticles and nano-optics)

• characterization of nanoscale interactions in biological systems, e.g, near-fi eld microscopy, scanning force microscopy

• development of sub-wavelength imaging (e.g., hyperlenses from metamaterials)

• nanocomposites of inorganic/organic hybrids for biophotonics

• biological templates for fabrication of nanophotonic devices

• bio-inspired and bio-derived nanstructured materials

• localized fl uorescence spectroscopy using nanostructures and nanoparticles

• modeling and simulations of bio/nanophotonics • manipulation of biomolecules and cells at the

nano-level.

Technology (devices) • nanoscale device design and processing for

biological applications • biological sensors based on nanophotonic

structures (e.g. photonic bandgap materials, porous silicon, metamaterials)

• multifunctional nanoparticles (targeting, imaging, and treatment)

• hybrid bionanodevices, e.g. molecular motors and nanofl uidics.

Applications • optical imaging using nanophotonics principles

(nanostructures, nanoparticles, etc.) • in-vitro and in-vivo applications of

nanophotonics (functionalized nanoparticles, surfaces, etc.)

• biomedical instrumentation development (nanosensors or nanoscale imagers).



Colloidal Nanoparticles for Biomedical Applications IX (BO501)Conference Chairs: Wolfgang J. Parak, Philipps-Univ. Marburg (Germany); Marek Osinski, The Univ. of New Mexico (USA); Kenji I. Yamamoto M.D., National Ctr. for Global Health and Medicine (Japan)Program Committee: Antigoni Alexandrou, Ecole Polytechnique (France); Jesus M. de la Fuente, Univ. de Zaragoza (Spain); James B. Delehanty III, U.S. Naval Research Lab. (USA); Niko Hildebrandt, Institut d’Électronique Fondamentale (France); Jennifer A. Hollingsworth, Los Alamos National Lab. (USA); Thomas M. Jovin M.D., Max-Planck-Institut für Biophysikalische Chemie (Germany); Antonios G. Kanaras, Univ. of Southampton (United Kingdom); Hedi Mattoussi, The Florida State Univ. (USA); Igor Medintz, U.S. Naval Research Lab. (USA); Paul Mulvaney, The Univ. of Melbourne (Australia); Jay L. Nadeau, McGill Univ. (Canada); Subramanian Tamil Selvan, A*STAR Institute of Materials Research and Engineering (Singapore); Claudia Tortiglione, Istituto di Cibernetica Eduardo Caianiello (Italy); Tania Q. Vu, Oregon Health & Science Univ. (USA); Horst Weller, Univ. Hamburg (Germany)

Ongoing rapid progress in the synthesis of a variety of biofunctionalized colloidal nanoparticles with fascinating electronic, magnetic, and optical proper-ties not associated with bulk materials symbolizes a fundamental breakthrough in physics and chemistry of condensed matter, which signifi cantly extends our knowledge about the nature of materials and our abilities to manipulate their properties. Inor-ganic nanostructures that interface with biological systems are attracting an increasingly widespread interest in biology and medicine. Quantum dot intravascular probes can be used in a remarkable number of biomedical applications, such as highly specifi c markers for cellular microscopy, fl ow cy-tometry, DNA and protein chips, immunoassays for diagnostics, histology, cancer detection, in situ hybridization, PCR DNA detection, biochemical and cell-based drug screening, single molecule studies, and correlation spectroscopy. There are abundant opportunities for improved or completely novel probes and seemingly endless new applications. Also plasmonic and magnetic nanoparticles can be used for a large number of biomedical applications. This conference will consider biomedical appli-cations of colloidal nanocrystals, as well as recent advances in new materials and methods of synthe-sis, coating, and bioconjugation. Its objective is to provide a widely interdisciplinary forum for practic-ing clinicians, biomedical scientists, development engineers, physicists, and chemists specializing in different fi elds to benefi t from each other’s expert knowledge and to create trend-setting interdisciplin-ary links that will accelerate progress in this fi eld. Previously unpublished experimental and theo-retical papers are solicited on the following and related topics: • synthesis of colloidal nanoparticles such as

II-VI, I-VII, III-V, and group-IV semiconductor quantum dots; ternary compounds; core-shell nanoparticles; nano-onions; nanoshells; plasmonic nanoparticles; metal nanoparticles; magnetic nanoparticles; shape and size control; assembly of nanoparticles to bigger (micro) particles

• bioconjugation and biolabeling; bioconjugate chemistry; dendron ligands; thiol and oligonucleotide coatings; phospholipid micelles; biotin/avidin; sticky polymers; targeting peptides; target specifi city

• measurement techniques; microscopy (AFM, SFM, STM, TEM, HRTEM, SNOM); XRD; spectroscopy (FTIR, EELS, ICP, DFS); spectroscopy of single quantum dots; multiphoton spectroscopy; frequency upconversion; magnetic sensing and imaging; plasmon spectroscopy

• physics and characterization of colloidal nanoparticles; electronic structure, band alignment; dielectric screening; optical, electronic, and magnetic properties; excitons and biexcitons; quantum effi ciency; intraband transitions; spin dynamics; blinking mechanisms, surface-enhanced Raman spectroscopy; plasmons

• theoretical and experimental studies of interactions with surrounding ambient, including dynamics and electronic structures

• numerical modeling; multiscale modeling; density functional modeling; molecular dynamics; Brownian dynamics; quantum Monte Carlo simulations

• biomolecular sensing; FRET; molecular interactions

• biocompatibility; development of non-toxic nanoparticles; intracellular behavior; long-term effects

• biological applications of colloidal nanoparticles; in vitro and in vivo imaging; biology at molecular level; receptor-ligand interactions; protein folding/unfolding; DNA conjugation, sequencing, and assembly; cell motility; gene expression mutation, etc.

• medical applications of colloidal nanoparticles; immuno-fl uorescent assays; applications in neuroscience; drug delivery and screening; cancer diagnostics and therapy; screening; cancer diagnostics and therapy; biomechanics; etc.

OCEAN OPTICS YOUNG INVESTIGATOR AWARD The award will be given for the best contributed paper presented by a leading author who is either a graduate student or has graduated within less than fi ve years of the paper submission date. The award consists of a $1,000 cash prize to the Young Investigator and $2,000 Ocean Optics equipment credit to the laboratory where the work was performed. To be eligible, manuscripts of self-nominating authors must be received by the due date.

Nano/Biophotonics



Call for Papers

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications (BO502)Conference Chairs: Samuel Achilefu, Washington Univ. School of Medicine in St. Louis (USA); Ramesh Raghavachari, U.S. Food and Drug Administration (USA)Program Committee: Bohumil Bednar, Merck & Co., Inc. (USA); Mikhail Y. Berezin, Washington Univ. School of Medicine in St. Louis (USA); Richard B. Dorshow, MediBeacon, LLC (USA); Paul M. W. French, Imperial College London (United Kingdom); Yueqing Gu, China Pharmaceutical Univ. (China); Hisataka Kobayashi, National Institutes of Health (USA); Ashok Kumar Mishra, Indian Institute of Technology Madras (India); D. Michael Olive, LI-COR Biosciences (USA); Gabor Patonay, Georgia State Univ. (USA); Attila Tarnok, Univ. Leipzig (Germany); Yasuteru Urano, The Univ. of Tokyo (Japan)

Chemical and genetic sensors, reporters, and molecular probes are the cardinal elements in molecular imaging and analyses of normal and pathophysiological processes at the cellular and molecular levels. Diverse molecular designs with unique optical signatures have been developed and are currently used to sense the presence and activity of molecular targets that characterize spe-cifi c biological processes. These have been used to probe human diseases, explore the mechanisms of pathogenesis, monitor drug effi cacy, discrimi-nate healthy from diseased tissues, and assess therapeutic outcomes. These applications deploy molecular probes over a range of scales from microscopy and subcelluar resolution to optical tomography of entire organisms. Development and use of these probes typically involve multidis-ciplinary teams that have assembled to address specifi c biological questions. The objective of this conference is to provide a forum to present and collate signifi cant and excit-ing studies involving chemically or biologically developed optical molecular probes that have been used in biomedical research. Papers appropriate for this solicitation include, but not limited to studies performed with dyes, bioluminescent enzymes, photoproteins such as GFP, activatable probes, receptor-, tissue-, or function-specific probes, nonspecific contrast effectors, nanoparticles, quantum dots, and multimodal molecular probes, monitoring molecular and physiological processes in cell and living organisms, clinical use of imaging agents, and applications of biomarkers and sensors in medicine and biology. This conference will target state-of-the-art studies where these probes have been used, in vitro or in vivo, and encompasses a wide variety of applications. To accommodate the multidisciplinary nature of the conference, papers are requested from a variety of subject areas, in-cluding the following topics:

Design, synthesis, development, or analyses of near-infrared and other fl uorescent dyes • novel dyes (fl uorescent, absorption, and

environment-sensitive dyes) • novel luminescent probes • absorption-, fl uorescent-, and light scattering-

based agents.

Design, synthesis, development, and analyses of nanoparticles • caged complexes or chelated optical markers • quantum dots, micro- and nanoparticles.

Development of bioluminescence and fl uorescent proteins, intrinsic probes, and molecular reporters • function-specifi c chemical and biological

sensors • molecular beacons.

Markers for membrane potential, electrolytes, and pH regulations • structure-dependent spectroscopy • intracellular and extracellular pH measurements • functional analysis of biological processes in

cells and animals.

In vitro and in vivo applications of contrast agents and molecular probes • genomics and proteomics, including gene

expression biological assays, including immunoassays, cell internalization, receptor binding, LRET, FRET and FISH studies

• physiologic function monitoring, including molecular and cellular events, pH, electrolytes, metabolites, minerals, and membrane potential

• in vivo organ function monitoring • molecular, cellular, and tissue imaging • site-specifi c delivery mechanisms and

endoscopy methods • multicolor and multimodality imaging systems

and upconversion markers • real-time monitoring of disease progression or

regression • tandem diagnostic and therapeutic interventions • molecular ruler design and application • monitoring treatment response • contrast agents for imaging applications.

Time-resolved tissue spectroscopy for medical diagnosis and imaging • fl uorescence lifetime spectroscopy and imaging • fl uorescence lifetime of endogenous and

exogenous fl uorescent materials and molecules • time-resolved fl uorescence methods based on

endogenous and exogenous molecules.

Biomarkers • new disease biomarkers • imaging disease biomarkers • methods for identify and amplify signals for

imaging biomarkers.

Pathway to clinical translation of imaging probes and nanomaterials • human studies using imaging agents • challenges of human translational studies with

contrast agents and optical probes • regulatory issues related to human studies by

optical methods.

JOINT SESSION with OPTO OE118Nonbleaching and Ultrasmall Fluorescent TagsThis special joint session is in conjunction with OPTO Conference OE118: Advances in Photon-ics of Quantum Computing, Memory, and Com-munication VII.



Plasmonics in Biology and Medicine XI (BO503)Conference Chairs: Tuan Vo-Dinh, Fitzpatrick Institute For Photonics, Duke Univ. (USA); Joseph R. Lakowicz, Univ. of Maryland School of Medicine (USA)Program Committee: A. Claude Boccara, Ecole Supérieure de Physique et de Chimie Industrielles (France); Michael T. Canva, Lab. Charles Fabry (France); Volker Deckert, Institut für Photonische Technologien e.V. (Germany); Bruce S. Dunn, Univ. of California, Los Angeles (USA); Christopher D. Geddes, Univ. of Maryland, Baltimore (USA); Zygmunt Karol Gryczynski, Univ. of North Texas Health Science Ctr. at Fort Worth (USA); Naomi J. Halas, Rice Univ. (USA); Ho-Pui A. Ho, The Chinese Univ. of Hong Kong (Hong Kong, China); Jiri Homola, Institute of Photonics and Electronics of the ASCR, v.v.i. (Czech Republic); Laura Maria Lechuga, Ctr. d’Investigacions en Nanociència i Nanotecnologia (Spain); Boris Mizaikoff, Univ. Ulm (Germany); Shuming Nie, Emory Univ. (USA); Krishanu Ray, Univ. of Maryland School of Medicine (USA); Wei-Chuan Shih, Univ. of Houston (USA); Weihong Tan, Univ. of Florida (USA); Andrew Taton, Univ. of Minnesota, Twin Cities (USA); Richard P. Van Duyne, Northwestern Univ. (USA); Jeffrey I. Zink, Univ. of California, Los Angeles (USA)

The goal of this conference is to provide an inter-disciplinary forum for state-of-the-art methods and instrumentation related the new research area of plasmonics and related nanosystems and their applications in biology and medicine. Plasmonics refers to the investigation, development and ap-plications of enhanced electromagnetic properties of metallic nanostructures. The term plasmonics is derived from plasmons, which are the quanta asso-ciated with longitudinal waves propagating in matter through the collective motion of large numbers of electrons. Incident light irradiating these surfaces excites conduction electrons in the metal, and induces excitation of surface plasmons leading to enormous electromagnetic enhancement. A forum that integrates interdisciplinary research and development is critically needed for scientists, engineers, and clinical providers to present the most recent advances in instrumentation and methods as well as biomedical applications in the new fi eld of plasmonics in biology and medicine.

The focus is on the following topics: • properties of metallic nanostructures • nanophotonics systems • plasmonics-based sensors • surface plasmon resonance (SPR) sensing systems • surface-enhanced Raman scattering (SERS)

and biomedical applications • surface-enhanced luminescence (SEL) and

biomedical applications • bioprobes and nanoprobes • nanosensors • nanoarchitectures and nanooptics • fabrications of nanostructured substrates • spectroscopies related to plasmonics • single-molecule spectroscopy • single-molecule manipulation • single-cell analysis • cellomics using nanoparticle technology • metallonomics detection using plasmonics • nanosystems for drug delivery • metal nanoparticle contrast agents for medical

diagnostics • photonic atoms • metal-enhanced fl uorescence MEF • surface plasmon-coupled emission SPCE.

Nano/Biophotonics



Call for Papers

Bioinspired, Biointegrated, Bioengineered Photonic Devices II (BO504)Conference Chairs: Luke P. Lee, Univ. of California, Berkeley (USA); John A. Rogers, Univ. of Illinois at Urbana-Champaign (USA); Seok Hyun A. Yun, Wellman Ctr. for Photomedicine (USA)Program Committee: David Erickson, Cornell Univ. (USA); Malte C. Gather, Technische Univ. Dresden (Germany); Viktoria Greanya, Defense Threat Reduction Agency (USA); Hongrui Jiang, Univ. of Wisconsin-Madison (USA)

Sponsored by:

This conference will cover a variety of biomedical photonic devices using principles, materials, and structures that are biologically inspired or bioen-gineered, implantable, biodegradable, wearable, and that often mimic nature at scales from nano to macro levels. Such devices are primarily used for sensing, diagnostics, and therapeutic applications in medicine, solving the limitations of conventional optical devices and conventional approaches. Forward-looking, innovative ideas driven by intel-lectual curiosity are also welcome. With emphasis placed on biomimetic technologies and biomaterials at the device level, this conference invites papers describing novel concepts, proofs of concept, fabrications, in vitro tests, and in vivo studies, as well as applications in the fi eld. Specifi c topics include the following: • optical devices and components made of

biocompatible materials • implantable photonic and optoelectronic

devices • bioimplants consisting of light-interacting cells

and molecules • bioimplants for imaging and controlling cells

and tissues • biodegradable, bioresorbable optical devices • biointegrated optical sensors • wearable, implantable optofl uidic devices • biological lasers and biomolecular light sources • biointegrated light delivery into deep tissues • novel biomaterials for photonic devices • bioinspired photonic structures for applications • biomimetic macro, micro, or nano optical

devices.

SAMSUNG ADVANCED INSTITUTE OF TECHNOLOGY AWARDSamsung will sponsor one award for this confer-ence. Authors who would like to be considered for this award should email a 2-page summary of their accepted paper, along with the abstract, to S. H. Andy Yun ([email protected] ) by 1 January 2014.

Prize donated by Samsung (Korea)




General Information



VenueThe Moscone Center747 Howard StreetSan Francisco, CA 94103-3118 USA

San Francisco is often called “Everybody’s Favorite City,” a title earned by its scenic beauty, cultural attractions, diverse communities, and world-class cuisine. Visitors rate the atmosphere and ambience as their top reason for visiting San Francisco. Mea-suring 49 square miles, this walkable city is dotted with landmarks like the Golden Gate Bridge, cable cars, and Alcatraz.

RegistrationSPIE Photonics West registration will be available October 2013

All participants, including invited speakers, con-tributed speakers, session chairs, co-chairs, and committee members, must pay a registration fee. Authors, coauthors, program committee members, and session chairs are accorded a reduced sympo-sium registration fee. Fee information for conferences, courses, a regis-tration form, and technical and general information will be available on the SPIE website in October 2013.

Hotel InformationOpening of the hotel reservation process for SPIE Photonics West 2014 is scheduled for the beginning of June 2013. SPIE will arrange special discounted hotel rates for SPIE conference attendees. The website will be kept current with any updates.

Student Travel GrantsA limited number of SPIE student travel grants will be awarded based on need. Applications must be received no later than 25 November 2013. Eligible applicants must present an accepted paper at this meeting. Offer applies to undergraduate/graduate students who are enrolled full-time and have not yet received their PhD.

Clearance InformationIf government and/or company clearance is required to present and publish your presenta tion, start the process now to ensure that you receive clearance if your paper is accepted.

Important News for All Visitors from Outside the United StatesFind important requirements for visiting the United States on the SPIE Photonics West website. There are new steps that ALL visitors to the United States need to follow.Online at: www.spie.org/visa



By submitting an abstract, I agree to the following conditions: An author or coauthor (including keynote, invited, oral, and poster presenters) will:• Register at the reduced author registration rate

(current SPIE Members receive an additional discount on the registration fee).

• Attend the meeting.• Make the presentation as scheduled in the pro-

gram.• Submit a full-length manuscript (4 pages mini-

mum) for publication in the SPIE Digital Library, Proceedings of SPIE, and CD-ROM compilations.

• Obtain funding for registration fees, travel, and accommodations, independent of SPIE, through their sponsoring organizations.

• Ensure that all clearances, including government and company clearance, have been obtained to present and publish. If you are a DoD contractor in the USA, allow at least 60 days for clearance.

Submit an abstract and summary online at: www.spie.org/bioscall• Abstracts should contain enough detail to clearly

convey the approach and the results of the re-search. Accepted abstracts will be published and made available at the meeting. Please submit a 250-word abstract for review.

• Please also submit a 100-word text summary suitable for early release. If accepted, this sum-mary text will be published prior to the meeting in the online or printed programs promoting the conference.

• Only original material should be submitted.• Abstracts should contain enough detail to clearly

convey the approach and the results of the re-search.

• Commercial papers, papers with no new research/development content, and papers where support-ing data or a technical description cannot be given for proprietary reasons will not be accepted for presentation in this conference.

• Please do not submit the same, or similar, ab-stracts to multiple conferences.

• TRANSLATIONAL RESEARCH: If your research is connected with improvements in healthcare related to cancer, heart disease, or neurological disease, enter “TRANSLATIONAL” when prompt-ed during the abstract submission. If your paper is accepted, SPIE will contact you to request a 1-2 page summary explaining how your research is “translational.” If your paper is chosen by the selection committee, your presentation will be cross-listed in the SPIE Translational Research Virtual Program, and you will be eligible to win an SPIE Translational Research Best Paper Award.

Review, Notifi cation, and Program Placement Information• To ensure a high-quality conference, all submis-

sions will be assessed by the Conference Chair/Editor for technical merit and suitability of content.

• Conference Chair/Editors reserve the right to reject for presentation any paper that does not meet content or presentation expectations.

• The contact author will receive notifi cation of ac-ceptance and presentation details by e-mail no later than 30 September 2013.

• Final placement in an oral or poster session is subject to the Chairs’ discretion.

Proceedings of SPIE and SPIE Digital Library Information• Manuscript instructions are available from the

“For Authors/Presenters” link on the conference website.

• Conference Chair/Editors may require manuscript revision before approving publication and reserve the right to reject for publication any paper that does not meet acceptable standards for a sci-entific publication. Conference Chair/Editors’ decisions on whether to allow publication of a manuscript is fi nal.

• Authors must be authorized to transfer copyright of the manuscript to SPIE, or provide a suitable publication license.

• Only papers presented at the conference and received according to publication guidelines and timelines will be published in the conference Proceedings of SPIE and SPIE Digital Library.

• Published papers are indexed in leading scientifi c databases including Astrophysical Data System (ADS), Chemical Abstracts (relevant content), Compendex, CrossRef, Current Contents, Deep-Dyve, Google Scholar, Inspec, Portico, Scopus, SPIN, and Web of Science Conference Proceed-ings Citation Index, and are searchable in the SPIE Digital Library. Full manuscripts are available to SPIE Digital Library subscribers worldwide.

When submitting your manuscript to the pro-ceedings, we encourage you to consider also submitting it to the SPIE peer-reviewed Journal of Biomedical Optics (JBO). Manuscripts submitted to the journal will go through the normal JBO peer-review process. No reformatting is necessary for initial submission to the journal, but manuscripts intended to be reviewed by JBO must adhere to the generally higher standards of content required of a refereed journal. For more information, please visit the JBO Author Information at www.spie.org/x85036.xml or contact [email protected]

Submission of Abstracts




Experience BiOS Expo—your booth will put you face-to-face with over 5,000

weekend attendees and 235 exhibiting companies,

plus access to a technical conference devoted to

biomedical optics and biophotonics. BiOS Expo is

where you need to be to connect with customers in

this growing industry.

The BiOS Expo kicks off the Photonics West week,

held Saturday and Sunday, and is followed by the

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Interested in exhibiting, sponsoring an event, advertising with SPIE? Learn more:

www.spie.org/pwexhibition

ExhibitionsBiOS Expo: 1–2 February 2014Photonics West: 4–6 February 2014

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IN YOURMARKETING PLAN


Experience the unparalleled scope ofSPIE Photonics WestAttend the premier technical event and marketplace for the photonics, biophotonics, and laser industry.

The science and the sources of all types of lasers and their applications

The world’s largest international biomedical optics and biophotonics conference

The latest photonics technologies, tools, and techniques with high potential to impact healthcare

Conferences and Courses: 1–6 February 2014BiOS Expo: 1–2 February 2014Photonics West Exhibition: 4–6 February 2014The Moscone CenterSan Francisco, California, USA

SUBMIT YOUR ABSTRACT TODAYwww.spie.org/pw

Advancements in integrated optoelectronic devices, semiconductor lasers, and LEDs

Enabling the mass-produced miniaturized products and systems of the future

Cutting-edge developments in photonics-driven green technologies and applications

Two world-class exhibitions• 1,300-Company Photonics West Exhibition• 235-Company BiOS Expo

Industry and research insights• More than 65 professional courses• Roundtables and poster sessions• Industry perspectives and plenary sessions• Numerous networking opportunities


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