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Biomimetic Ingredients based on cell membrane structurePolyquaternium-51
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Olicohydro-8100Molecular-nail effect , Intelligent moisturizing effect
CONTENTS
Olicohydro-8107Multidimensional moisturizing system, Super moisturizing effect
Organism cell
Nerve Cells
Lymphocyte
Muscle Cells
phagocyte
Epidermal cells
Stem-Cell
Red Blood Cells
photosensitive and excitement transmission
Antigen phagocytosis elimination
Protecting Tissues Exercise
Immunity featuresDifferentiation
Oxygen Carrier
Cells are the basic unit of the human body;
There are about 40 trillion to 60 trillion cells;
The average diameter of each cell is between
10-20ɥm;
Cells, tissues and organs work together to
keep alive.Cell Cell Population Organ Human Body
Basic unit of hum
an bodylife activities
Cell — The basic unit of human body
Cell life activities include immunity,
signal transmission, protection of
tissues, exercises, etc., They
coordinate with each other to
maintain normal life activities.
The functions ofCell membrane
The cell membrane was composed by phospholipid biomolecules with bilayer structures.The phospholipids are composed of hydrophilic phosphate groups and hydrophobic alkyl chains.
Cell membrane — The basic unit of phospholipid and has the function of maintaining life activities
Isolation effect: Separating cells from the external environment and maintaining cells’ stable internal environment.Transferring substance: Selectively transmitting cellular metabolic substratesInformation recognition and transmission: Recognizing the site of cellular enzymatic reaction and transmitting information between membranes.
Hydrophobic alkyl chain
PhospholipidCell membrane phospholipid bilayer
structure
Hydrophilic phosphate group
2-Methacryloyloxyethyl phosphorylcholine ( MPC ) has
excellent tissue and blood compatibility, and is often used
in biomedical fields such as medical organ transplantation,
ophthalmic care, wound dressing, etc.
MPC phosphatidylcholine: Same structure as phospholipid polar group in cell membrane
Polyquaternium-51Copolymerization: Increase hydrophobic alkyl chain
Polyquaternium-51— Synthesis of phospholipids based on cell membrane structure
Skin surfacePer after applying Polyquaternium -51
Performance in cosmetic applications :
Super moisturizing effect—— it performs better than hyaluronic acid
by forming a breathable water-blocking film to achieve water-retention
and moisturizing effects.
Relieve skin irritation——It could inhibit the irritation from products and
form a film to shield irritated substances outside. Cationization could also
show bacteriostatic effect.
Anti-static ,Anti-pollution——It could shield adsorption of the PM2.5
by the skin under polluted environment. The stable charge layer could
conduct static electricity.
Polyquaternium -51— Perfect performance
Test method :0.2% Hyaluronic acid Aqueous solution; 0.025% Polyquaternium-51 Aqueous solution; 30 clinical volunteers.
Experimenting Result:0.025% polyquaternium-51 could reduce the rate of trans-epidermal water loss by 13.7%, and improvehydration features by 17.6%, which was significantly better than 0.2% Hyaluronic acid.
-20
-15
-10
-5
0
Blank0.2%Hyaluronic acid
0.025% Polyquaternium -51
0
5
10
15
20
Change in Moisturization(%, 4h)
Blank0.2% Hyaluronic acid
0.025% Polyquaternium -51
TEWL(%, 4h)
Transepidermal water loss and Hydration features
Polyquaternium -51— Super moisturizing effect
Test method : Characterization:
Analysis of the surface element contents of polyquaternium-51 membrane by XPS
sample P/C proportionFreeze-dried membrane
(Wet) 0.0769
Vacuum-dried membrane film(Dry) 0.0598
Freeze-dried membrane
→Wet status model
Vacuum-dried membrane
→Dry status model
Change the molecular configuration, according to the environmental humidity.
Hydrophilic groups sneak into the membrane to show water retention under low humidity
Unique property:Could change the molecular configuration to show water retention , with the changing of the environmental humidity.
Wet DryPhosphate group
Polyquaternium -51— Super moisturizing effect
Wet stattus dry status
Role Assignment Film
Polar Hydrophilic group
Hydrophobic alkyl chain Kuroda Hideo
Cell type: SIRC cells (derived from rabbit cornea) SDS:100ug/ml
Experimenting Results: Polyquaternium-51 could significantly reduce the stimulation of SDS to cells. Polyquaternium-51 could significantly reduce the stimulation of Alpha Hydroxyl Acid to cells.It can also relieve redness and erythema of the skin.
Except pq-51, the other samples failed to relieve the stimulation of SDS and resulted in cell death.
After adding Polyquaternium-51, SDS stimulation decreased
significantly
*From Lipidure Product Report
Polyquaternium -51— Reducing irritation property
l
Cellular survival
(%
)
PQ-51
MPC monomer
Lipid analogues
Phospholipid analogues
Xanthan gum
Methylcellulose
Hydroxypropyl cellulose
Polyethylene glycol
Synthetic polysaccharides
Polyvinyl alcohol
Gelatin
Sodium hyaluronate
Sodium alginate
Peg-ppg copolymer
Polyvinylpyrrolidone
glycerol
Concentration(%)
Test method : Test method : 30% Alpha Hydroxyl Acid Aqueous
solution 5%Polyquaternium-51+30% Alpha
Hydroxyl Acid Aqueous solution
30% Alpha Hydroxyl Acid Aqueous solution
5%Polyquaternium-51+30% Alpha Hydroxyl Acid Aqueous solution
Polyquaternium-51— Anti-static and anti-pollution property
Test method:
Applied 25 mg samples on sheet material, and observed the adsorption of dust particles in the atmosphere (recorded by the amount
of dust by the unit mm2).
Sample:(1)Polyquaternium-51(2)CarbomerConcentration of polymer :1%Solvent: water/ethanol =1/1
Results:
Blank PQ-51 Carbomer Polyquaternium-51 obviously inhibited the adsorption of PM2.5
Blank PQ-51 Carbomer
*From Lipidure Product Report
PM2.5 absorption(%
/mm
2)
Test method:
(1)Labeled the PQ-51 with fluorescence; (3)After 3 hours, washed the skin surface for 10 times;
(2)Applied PQ-51 on the artificial skin; (4)Sliced the artificial skin and observed the cross section by microscope.
Polyquaternium-51 forms an excellent water-resistant film and retains on the skin surface after washing for
many times.Based on the molecular-nail effect, all the performances of PQ-51 could maintain for a long
time,including water retention, irritation reduction and anti- pollution, etc.
Differential interference images Observation under fluorescence
Polyquaternium-51— water resistant (Molecular-nail effect)
Polyquaternium-51
Corneum
Molecular-nail effects:
*From Lipidure Product Report
Super moisturizing effect:
Intelligent adjustment; showing
better moisture retention than
hyaluronic acid.
Application:
Super moisturizing products
Reduction of irritation:
Reducing irritation by SDS and
acids, and etc.
Product application:
Mild products, Reducing the
irritation to the skin.
Anti-static, Anti-pollution:
Reducing adsorption of PM2.5, indirectly
reducing the external stimulation and
virus adsorption.
Application:
Mild products, Antiviral products
Application of Polyquaternium-51
Application in cosmetics — Various brands and products
伊丽莎白雅顿铂粹御肤精华液
城野医生VC100化妆水
海蓝之谜精华乳霜
资生堂百优优效修护眼霜
雅诗兰黛鲜亮焕采精粹水
倩碧水嫩保湿水精萃
PQ-51PQ-51
PQ-51
PQ-51
PQ-51
PQ-51
Num
ber of products
Polyquaternium-51 has been used in various products and
high-end brands and are mainly used in face and neck care.
Shanghai OLI — The third company in the world to commercialize PQ-51
OLI owns the independent property rights to break the industry monopoly!
Owns the unique innovative production process toeliminate the harmful solvents and to prevent high-riskprocesses;
Accurately controlling the reaction, conversion rate, andpost-treatment;
Unique powder production technology and lipidosomestructure technology;
Patent-protected technology.
Monomer capacity :12 t/a
Market size: $250-300 Billion,
The main sales come from biomedical (diagnostic
drugs, medical equipment, eye care products). The
sales in cosmetics is $100 million.
Monomer capacity :10 t/a
The products are mainly sold in the contact
lenses market.
Olicohydro-8100
Product Features :
Super moisturizing effect: Olicohydro-8100 could form a transparent and breathable film on the skin and hair surface so that to show super moisturizing and powerful water retention.
Shielding external stimulation : Olicohydro-8100 could shield the irritation from products and external irritant substances and show high biological safety.
Molecular-nail with long-lasting effect :Polyquaternium-51has a molecular nail effect to show long-lasting performance.
Comfortable skin feeling :Olicohydro-8100 has a cell membrane structure to show good skin adhesion and fresh skin feeling.
Properties: Colorless and transparent
liquid .Good compatibility with water, glycerin,
alcohols, surfactants, etc.
Key application: skin moisturizing, damaged-
skin repairing, hair care
Recommend dosage: 1% - 10%
Key Ingredients:PQ-51
Forming moisturizing
film on the skin
Deep repairing on the skin
Absorbing water on the
skin
MultidimensionalMoisturizing
Deep repairing on the skin: It could moisturize the skin by penetrating into cuticle, supplying intercellular lipids and NMF.
Absorbing water on the skin: It could moisturize the skin by absorbing water from the environment.
Forming moisturizing film on the skin: Forming water-retention film and reducing water-loss.
Multiple Skin Moisturizing System
Improve penetration
Surface-modification technology :
The lipophilic property was improved and could show good adhesion on the skin.
With the surface-modification technology, intercellular lipids and NMF could easily penetrate into the skin.
Intercellular lipids
Keratinocyte
Moisturizer–Water absorption
Moisturizer film-Water Retention
NMF – Water Retention
Intercellular lipids-Water retention/Skin repairing
Water molecular
Keratinocyte
Good skin adhesion
Good penetration of actives
Multidimensional Skin Moisturizing System
Olicohydro-8107
Product Features :Super moisturizing effect: Olicohydro-8107 could show super moisturization by absorbing water and water retention.
Good penetration and comfortable skin feeling : Olicohydro-8107 could penetrate into skin effectively and give comfortable skin feeling.
Shielding external stimulation : Olicohydro-8107 could shield the irritation from external irritant substances and show high biological safety.
Molecular-nail with durable effect : With molecular-nail effect, Polyquaternium-51 and Cetyl-PG Hydroxyethyl Palmitamide achieves durable performance
Key Ingredients:PQ-51, Cetyl-PG Hydroxyethyl Palmitamide
Properties: Colorless and transparent liquid.Good compatibility with
water, glycerin, alcohols, surfactants, etc.
Key application: skin moisturizing, damaged-skin repairing, hair care
Recommend dosage: 1% - 10%