Biomedical optics - 10380

brought to you by

the BIOP centerA joint initiative between the Technical University of Denmark, Risø National

Laboratory and Danish Industry

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Bio-optics course

Welcome

Introduction

Practical notes regarding the course

The BIOP center

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Biomedical optics

The term biomedical optics could be ”defined” as

– irradiation of tissue or biological material by light source (eg. laser) causing response;» photo-thermal reaction,» optical (reflectance/transmittance),» photo-chemical reaction,» fluorescence,» ...

The response may be used to

– diagnose (sensing, imaging, concentration, etc.)

– treatment (photodynamics therapy)

– surgery and manipulation (eg. tweezers)

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Biomedical optics

Why do we need to learn about

– light sources and laser systems,

– light propagation in tissue,

– spectroscopy,

– signal and image processing?

Because

– these are the ’fundamentals’ you need to understand or describe the device, application or system you work with or wish to develop.

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Example 1: Choose light source

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Example 1: Choose light source Light propagation (Monte Carlo

simulation)

Incident light

Ballistic component

“Snake” component

Diffuse reflectance

Absorption

Diffuse transmittance

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Example 1: Choose light source

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Example 2: describe system

Superluminescent diode (SLD)

Detector

Fiber-opticbeamsplitter

Tissue

Scanningreference mirror

Computer

Amplifier Bandpass filter

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Example 2: Build the system

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Example 2: Signal

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Example 2: Modeling the OCT signal

L. Thrane et al., J. Opt. Soc Am. A 17, 484 – 490 (2000).

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Example 2: OCT image

OCT as optical diagnostic tool in ophthalmology

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Example 2: OCT image

3D rendering of data

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Practical notes

Course overview

– divided into four major areas,

– experts in various fields will teach,

– outside lecturers and visits.

Course material

– copies (free) of book chapters and/or articles

– why? – because the topic is diverse you would need several text books = too expensive!

Assignments during course

– hands-on and home work assignments.

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Practical notes

Exam

– the last ¼ of the course is allocated for individual/group assignments,

– topic is chosen starting April,

– small report;»should be handed in on May 15, 2002,

– presentation of report – another group appointed ’opponents’»defense will take place on June 7, 2002.

P. E. Andersen - 04/19/23

Optics and Fluid Dynamics Department

RISØ

Practical notes

Course coordinator

– Peter E. Andersen, Risø»e-mail: peter.andersen@risoe.dk,» tel: 46 77 45 55.

Messages and updates are published at

– www.biop.dk.