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Page 1 • Biologics - Why What How • September 12, 2015 Forward-Looking Statements This presentation may contain forward-looking statements based on current assumptions and forecasts made by Bayer Group or subgroup management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayer’s public reports which are available on the Bayer website at www.bayer.com. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.

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Page 1: Biologics & Integrated Crop Solutions - Eltjo Huizenga - Sept ......Page 6 • Biologics - Why What How • September 12, 2015 Fruit & Vegetables account for the largest share of our

Page 1 • Biologics - Why What How • September 12, 2015

Forward-Looking Statements

This presentation may contain forward-looking statements based on current assumptions and forecasts made by Bayer Group or subgroup management.

Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayer’s public reports which are available on the Bayer website at www.bayer.com.

The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.

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Biologicals & Integrated Crop SolutionsEltjo Huizengaglobal Segment Manager Biologics

BLX & ICS – 2015

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Page 3 • Biologics - Why What How • September 12, 2015

Why Biologicals & what are Integrated Crop Solustions?

Bayer CropScience has many very succesfull chemical products in its portfolio and an interesting product pipeline so why is it interested in Biologicals & what are Integrated Crop Solustions?

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Page 4 • Biologics - Why What How • September 12, 2015

Contents Biologics in Integrated crop solution for F&VGrower trends for biological products

How to develop an Integrated crop solution

How to test/present/demonstrate Integrated crop solutions

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Page 5 • Biologics - Why What How • September 12, 2015

6,4

6,3

4,7

4,34,1

3,5

1,7

1,4

1,3

1,3

1,30,8

0,73,3

SoybeansCerealsCornVegetablesFruit & NutsRiceCottonOilseed rapeSugar caneGrapesPotatoesPlantationsSugar beetsOthers

11.7 bn €(28.6%)

Source: TriCast 2013

Total40.9 bn €

Global Crop Protection MarketFocus on Fruit & Vegetables

2013 : About 1 in every 3,5 Euros is spent on Horticultural crops globally

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Page 6 • Biologics - Why What How • September 12, 2015

Fruit & Vegetables account for the largest share of our portfolio today

€ 2.0 bn2013 sales in F&V

strengthening position towards

F&V market leadership and

aspiring

€ 3.6 bn2020 sales target

Rice

Cotton

Oilseeds

Soy

Corn

Cereals

BCSsales2013*

Diverse crop spectrum:• Fruits & nuts, grapes/vines,

plantations• Vegetables & flowers,

potato

Fruit & Vegetables

* by major crop groups excluding industrial business and non-agricultural solutions

others

Sugar crops

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Market Megatrends

Value ChainConsumption

+

Production

Climate variability Competition for water Available farmland Increasing production

and energy costs Techn. evolution

Global sourcing and global trade

Food value chain requirements

Liability of produce Technology

evolution

Population growth Increasing disposable

incomes / rise of the middle class

Urbanization Consumer behavior

+

Increasing need for:• Higher productivity of agricultural production systems through innovation, sustainable technologies

(e.g. mechanization, IPM, hybridization) and improved management practices (e.g. digitalization, integrated crop solutions) while reducing loss and waste

• Close collaboration within the value chain to address trends and for fast technology adoption• Active dialogue with stakeholders to comprehend unmet needs and opportunities

=

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“Leadership in Horticulture” is fueled by five strategic Key Enablers

Build innovative portfolio for fruit & vegetable crops

Expand teams of Fruit & Vegetable Experts

Partner and connect players along Food Value Chain

Build Integrated Crop Solutions

Provide innovative and high-quality vegetable seeds

1 2 3 5

4

Strengthen Customer Centricity

Lead the Wayin Innovation

ExpandSeeds Business

EnhanceCrop Protection & Environmental Science

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Page 9 • Biologics - Why What How • September 12, 2015

Category What? Example

Microbials

Biorationals

Macrobials

Other

• Bacteria (microbe and/or biochemical) • Fungi

• Plant extracts & essential oils• Pheromones (semiochemicals)

• (Attractants)

• Beneficial insects including predatory nematodes

• Viruses• Cyclic peptides• RNAi*• Gene delivery• Excluding inorganics (like Copper and Sulphur)

Biological Product Categories

* RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression (potentially using microbes as inducer/carrier)

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Challenges

• Weed, pest & disease control

• Resistance management

• Worker exposure

• Chemical input

Sustainableintensification of agriculture

Benefits

Across the value chain

• Yield Quantity

• Yield Quality

• Integrated Pest Manage-ment (IPM)

• Tradeability

• Storability / Reduce loses

Contribution to Food Security

• Canola• Cotton• Rice• Soybean• Wheat• Vegetables

• Disease control• Pest control• Plant Health• Nutrition

efficiency

• Herbicides• Fungicides• Insecticides• Seed treatment

Higher yieldHigher qualityConvenience

Risk management

GROWERDEMAND

• On-field consulting

• Training• Diagnostic

tools

Focusing on Customer needs

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0

1

2

3

4

5

6

2005 2010 2015 2020 2025

Microbials

Biorationals

Macrobials

Source: Frost & Sullivan, Nov. 2009; BCC Research Survey 2010; CPL Business Consultants 2010

bn $Short term (<3 years) Food Chain demands Sustainable Use Directive EU New Biological product introductions Country low chem programs (e.g. F)

Mid term (>5 years) Increasing demand for Biological solutions

in emerging markets (Brazil, China and India)

Sustainable growth of Biological solutions in the US and EU

Investments BASF, Syngenta, Bayer

Long term (>10) Introduction of new Biological technologies

• Average Market Growth (2005-2025): > 10 % Biologicals vs. Chemical < 3% CAGR• Biologicals Market (2010-2020): 1.2 – 3.7 bn. US$

Biologicals are in demand!

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Category What? Example Market approach

•Bacteria (microbe and/or biochemical) •Fungi

•Plant extracts & essential oils•Pheromones (semiochemicals)

•(Attractants)

•Beneficial insects including predatory nematodes

• Viruses• Cyclic peptides• RNAi*• Gene delivery• Excl. inorganics (like Copper and Sulphur)

Biological Product Categories & BCS focus

* RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression (potentially using microbes as inducer/carrier)

Microbials

Biorationals

Macrobials

Other

invest to lead

exploitopportunities

partnering

evaluate opportunities

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Why do Biologicals fit so perfectly into our portfolio?

SolutionThinking

ProductThinking

Because they fit perfectly in

Integrated Crop Solutions i.e.

solutions that help farmers to

address unmet cropping needs

(needs that they cannot fulfil with

conventional methods)

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Our basis to build on - excellent pipeline for Fruit & Vegetable crops

Chemicals

Seeds

Biologicals

Integrated crop solutions

• Improved ROI• Higher yield• Supreme quality• Convenience• Risk management

Grower benefits

• Alion™

• Movento™

• Sivanto™

• Luna™

• Emesto™

• Velum ™

• 700 new varieties in 10 vegetable crops until 2016

• Serenade™

• Sonata™

• Requiem™

• BioAct™

Page 14

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Integrated Crop Solutions are offers of any combination of Seeds, Traits, Chemicals and Biologicals with Services thatare tailored towards the needs of our target customers and create sustainable value for them, the value chain and BCS

What areIntegrated Crop Solutions (ICS)

Chemical

Services / Tailored advice

Seed Trait Biological

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With (biologicals in) Integrated Crop Solutions,farmers will be able to address unmet needs

Potential unmet needs* Enabling Global Trade (residue management)

Sustainable Cropping

IPM / ICM compatible (e.g. safe for beneficials)

Extending shelf life / reducing losses

Compete some difficult pests/ diseases (e.g. thrips, bacteria, nematodes, etc.)

Yield increase (quality & quantity)i.e. plant health/yield enhancement

Resistance Management

Low chemical input

Flexibility in use (low REI or PHI)

Worker exposure

SolutionThinking

ProductThinking

* different unmet needs can also be addressed with chemical

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For Integrated Crop Solutionsa Biological portfolio is neededPortfolio today

Product Microbe/Extract Reg. & Distribution

NA AP LA EU

VoTiVo and Flocter (BioNematicide SGr) Bacillus firmus I-1582 X X

Dipel and Xentari (BioInsecticide) Bacillus thuringiensis Kurstaki & Azawai XTP XTP

Bio1020 (soil) (BioInsecticide) Metarhizium anisopliae Met52 XTP

Kodiak (BioFungicide SGr) Bacillus subtilus GB03 X

Serenade (BioFungicide) Bacillus subtilus QST713 X X X X

Sonata (BioFungicide) Bacillus pumilus QST2808 X X

Requiem (BioInsecticide) Blend of 3 terpenes X X X

Contans (BioFungicide) Coniothyrium minitans CON/M/08-91 X X X X

BioAct (BioNematicide) Paecilomyces lilacinus 251 X X X

Esquive (BioFungicide) Trichoderma atroviride I-1237 XTP

Charane CM-F/OFM-F (BioInsecticide) Codlemone (pheromones) XTP XTP XTP XTP

Decis Trap (attract & kill) (BioInsecticide) Deltamethrin + attractant(s) X

Optimize 200 (inoculent) Rhizobium XTP

Biagro 10 (inoculent) Rhizobium X

more countries

more crops

TP = Third party

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Contents Biologics in Integrated crop solution for F&V

Grower trends for biological productsHow to develop an Integrated crop solution

How to test/present/demonstrate Integrated crop solutions

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Drivers & Barriers to use biologicals

Not

e: b

ased

on

252

in d

epth

inte

rvie

ws

in 1

5 co

untri

es o

n 11

cro

ps

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Page 20 • Biologics - Why What How • September 12, 2015

Usage will increase as biologicals get integrated into spray programs

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Farmers say they would use biologicals for its

More than efficacy only!!!

Note: in total 7 interviews per country per crop

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Farmers say they would use biologicals for

Note: in total 7 interviews per country per crop

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Contents Biologics in Integrated crop solution for F&V

Grower trends for biological products

How to develop an Integrated crop solutionHow to test/present/demonstrate Integrated crop solutions

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Page 24 • Biologics - Why What How • September 12, 2015

Integrated Crop Solutions are offers of any combination of Chemicals and Biologicals supported by Services that are tailored towards needs of our target customers and create sustainable value for them, the value chain and BCS

Chemical

Services / Tailored advice

How to integrate Biologicals inIntegrated Crop Solutions (ICS)

Chemical Biological Biological

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09Green

leaf tips

57 Pink bud

stage

60 - 65 First

flowersopen/Fullflowering

72 Fruit sizeup to 20

mm

74 Fruit

diameter up to 40 mm; fruit erect

81

Ripening

87

Ripening

pre and post harvest application disease control and residue management

Conventional CPPDriver: reduce residue level

Integrated Crop Solution (ICS)

Biological

BiologicalConventional Conventional

Positioning of Biologicals in ICS (example)

Driver: alternation for resistance managementor safe use during flowering

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*not approved until 2016

Applied near plant with new root flush- 9,4 l / ha in chemigation

1)

1) Serenade™ is a versatile product that can be used to control various fungi and bacteria giving also a plant enhancement/yield effect

Improved performance / ResistanceStrawberries in USA (Soil diseases, Botrytis & PM)

1) 1)

Sales

Powdery mildew& Botrytis

Powdery mildew& Botrytis

Powdery mildew& Botrytis

Botrytis Powdery mildew

Verticillium & Plant Health

DRIVERS for use of Serenade1. Improved performance on soil diseases & plant health2. Resistance management (Botrytis & PM)3. Workforce management at harvest time (short REI/PHI)4. Yield increase

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Flexibility and sustainabilityTable grapes in Chile (disease control)

DRIVERS for use of Serenade1. Prevent infection 2. Alternate modes of action / resistance management3. Global trade i.e. residue management and PHI

Sales

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Improve performancePommes fruits in Spain (fire blight)

Program:• Pre-flowering: copper (250 g Cu/hl)• Flowering: Serenade MAX / Aliette. 3-7 days interval or under alert system advise• Full vegetative development (summer): Aliette 24 hours after a storm.• Autumn/Winter: copper (250 g Cu/ha) 2 treatments after leaves fall

DRIVERS for use of Serenade1. Prevent infection of bacterial disease (Fire Blight / Erwinia amilovora)

2. Less Chemical load / replacement of antibiotics

Cuprosan Cuprosan+

Sales

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Reduce losses / Global trade Apples in Brazil (foliar disease & fruits rot)

30 – 40 days 1-2 days20 days 14 days

&&

7 days

DRIVERS for use of Serenade1. Reduce losses (pre-harvest disease control with post-harvest effect)

2. Global trade i.e. residue management and PHI

days before harvest

Sales

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Soil Application Foliar Application Residual treatment Pre-Planting Post-Planting

OptionalPost Harvest

DRIVERS for use of Contans1. Improved and long lasting performance by specific pre- and post-harvest

use of Contans and in-season use of Luna and Serenade2. Enabling cropping in high infested fields3. Reduce losses (in field & in storage)4. Treatment outside of high work peak period

Performance / Global tradeLettuce in various countries (Sclerotinia spp. control)

Fungicide

Sales

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Page 31 • Biologics - Why What How • September 12, 2015

Soil Application Foliar Application Residual treatment Pre-Planting Post-Planting

OptionalPost Harvest

DRIVERS for use of Contans1. Improved and long lasting performance by specific pre- and post-harvest

use of Contans and in-season use of Luna and Serenade2. Reduce losses (in field & in storage)3. Treatment outside of high work peak period

Improve performance / Global tradeOSR in various countries (Sclerotinia spp. control)

FungicideFungicide

Sales

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DRIVERS for use of Contans1. Improved and long lasting performance2. Enabling global trade (residue reduction)3. Reduce losses (in field & in storage - pre-harvest treatment with post harvest effects)

Performance / Global tradeRed Currant in N-EU (disease control)

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Improved performancePotatoes in USA (soil diseases*)

pre-row closureend of June 1st JulyJune 15Planting

10-14 days

10-14 days

10-14 days

10-14 days

Seed treatment10-14 days

4,6 l/hectare in furrow

4,6 l/hectarechemigation

DRIVERS for use of Serenade1. Improved performance on soil diseases (Rhizoctonia solani and Phytophthora erythroseptica)

2. Reduce losses (pre-harvest disease control with post-harvest - e.g. pink rot - effect)

3. Increase yield

*

*

* key soil diseases like Rhizoctonia, Fusarium, Pythium and Phytophthora (Pink rot)

Sales

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seed planting harvesting---------------------------- growing -----------------------

White flies/aphids White flies/aphids

Flexibility and sustainability (PHI / REI)Leafy vegetables e.g. in MEX (white fly & aphids)

DRIVERS for use of Requiem1. Flexibility (REI, PHI and wide application window)

2. Residue management 3. Worker exposure

Sales

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Improve performance by synergyPotatoes in Texas, USA (Psyllid & Zebra Chip)

70

Tuber development

80

MaturationBulking-up

90

Senescence

30

Main stem elongation

40

Tuber formation

50

Flower emergence

60

Flowering

0 10

Emergence

20

Stem formation

2 applications

7-10 days

ADMIRE PRO

Presumed, primary ZC “infection” window Psyllid control window

1-2 applications

7-10 days

abamectin1 application each

or tank-mix

7-10 days

adult KDif needed PH

7-10 days

DRIVERS for use of Requiem against Psyllids1. Improves performance on a difficult to control insect2. Resistance prevention (alternation program)3. Synergistic effect (knock-down - Requiem & residual compounds - Keteonols)4. Fit in IPM program (treatment following monitored flight of adults)

Planting

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seed planting floweringgrowth ---------------------------- harvesting period -----------------------fruiting

nursery 0 30 60 DAT10 20 40 50

Improved performanceCucumber in Spain (thrips)

Amblyseius swirskii 50 A. swirskii/m2 (repeat 12 weeks later 50 A. swirskii/m2)

MAIN THRIPS INFESTATION PERIOD

DRIVERS for use of Requiem against thrips1. Improves performance on difficult to control insect(s)2. Safe on beneficials / compatible in IPM programs3. Flexibility (short PHI, short REI, wide application window, multiple sprays, etc.)4. Resistance prevention

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JAN DECFEB MAR APR MAY JUN JUL AUG SEP OCT NOV

FloweringShooting BuddingSucker Development Ripening

Innovative & sustainable approachBananas in CR (nematodes)

DRIVERS for use of BioAct against nematodes1. Higher yield when used in alternation2. Excellent safety profile 3. Lowers annual chemical load significantly4. Residue management5. Healthier plant due to increased functional roots 6. Increase sustainability

Sales

drench / granular

Radopholus similis, Helicotylenchus spp., Pratylenchus spp.

Harvest

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floweringStart - - - - - - - - - - - - - - - - - - - harvest - - - - - - - - - - - - - - - - - - -fruitset

If mildew present: alternation with Vivando or Fungaflor

If Botrytis present:Alternation with Teldor/Switch

Improved performanceCucumbers in Northern Europe (powdery mildew)

DRIVERS for use of Serenade1. Resistance management Luna2. Flexibility (wide application window + low PHI)3. Minimizing residue 4. Fit in IPM program (pollinator & beneficial safety )

/ /

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DecJan Feb Mar Apr May Jun Jul Aug Sept Oct Nov

Followed by:

Meltatox&

Followed by:

Meltatox&

SwitchKarma Rocket

&Meltatox

& Collis

Rocket &

Karma Followed by:

Meltatox&

Followed by:

Meltatox&

SwitchMeltatox&

Collis

Preventing resistance developmentRozes in the Netherlands (powdery mildew)

DRIVERS for use of Serenade1. Resistance management (alternation of a.i.´s)

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Contents Biologics in Integrated crop solution for F&V

Grower trends for biological products

How to develop an Integrated crop solution

How to test/present/demonstrate Integrated crop solutions

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Integrated Crop Solutions are offers of any combination of Chemicals and Biologicals supported by Services that are tailored towards needs of target customers and create sustainable value for them, the value chain and BCS

Tailored advice = communication & information, training, demonstration and promotion (aligned with farmers & chain partners)

How to advice/promote/presentIntegrated Crop Solutions

BiologicalBiologicalChemical Chemical

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Farmers say they don’t use biologicals because of

Note: in total 7 interviews per country per crop

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Farmers say they don’t use biologicals because of (perceived)

= a misconception largely based on assumed stand-alone performance

Note: in total 7 interviews per country per crop

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Standalone Efficacy= season long spray• Shows that the BLX does

have some control• Needed for registration

purposes• Not what will be ultimately

marketed

Performance of ICS= integrated in spray program• Identify unmet needs in crop• Create spray program to

meet unmet needs• Measure performance of ICS

with SMol and BLX

Value Proposition of ICS= real solution offer• Measure value proposition –

residues; quality; yield• Measure profitability / ROI• Launch / market the benefits

of the ICS

Time

Marketability of our offer

Moving from product positioning to ICSFrom standalone efficacy to spray programs to value proposition trials

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Value proposition of biologics – efficacy is only one criteria illustrative

Applications Programs

A Teldor Luna Privilege Teldor Teldor Luna

PrivilegeLuna

Privilege Serenade

B Teldor Teldor Serenade Serenade Serenade Serenade SerenadeC Serenade Serenade Serenade SerenadeD Serenade Serenade

Efficacy

medium disease

pressure ++++ ++++ +++ ++++ ++++ ++++ ++

highdisease

pressure +++(+) ++++ +++ +++ +++ +++(+) +

The right positioning in a BCS spray program is a key success factor for biologics

Provide efficacious performance on

targeted proposition and control of pests

and diseases

Understanding of relevant value

propositions and transfer into BCS spray programs

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0

10

20

30

40

50

60

70

80

90

15 DA-A 13 DA-B 7 DA-C 14 DA-C 14 DA-D 7 DA-E 5 DA-F 13 DA-F 6 DA-G 13 DA-G

% L

eaf S

ever

ity

UTC Standard Program SERENADE Program Skipped Applications

Fischer, Columbia Ag Research, Hood River, OR – 2010. Materials were applied using a CO2 handgun sprayer equipped with one D6 hollow cone nozzle per row delivering 70-180 GPA at 100 psi. Flint 1.5oz at ACF; Quintec 5floz at BD; Procure 6floz, Serenade Optimum 1lb, or no applications at EG. A = 5/19, B = 6/3, C = 6/16, D = 6/30, E = 7/15, F = 7/29 and G = 8/12. Erysiphe necator.(10-06-509)

a

ccd

b

1st SERENADE App. 2nd SERENADE App.

A TrifloxystrobinB QuinoxyfenC TrifloxystrobinD QuinoxyfenEF TrifloxystrobinG

A TrifloxystrobinB QuinoxyfenC TrifloxystrobinD QuinoxyfenE SERENADEF TrifloxystrobinG SERENADE

A TrifloxystrobinB QuinoxyfenC TrifloxystrobinD QuinoxyfenE TriflumizoleF TrifloxystrobinG Triflumizole

Demonstrate ICS benefitsin specially adjusted comparative trials

Disease control in grapes comparing an integrated program to a chemical program

Demonstrate contribution of BLX on efficacy via “blank sprays”

Sales

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Show disease control & residue levelFlint, Teldor & Serenade in (small) tomatoes

05

101520253035404550

Control FT/FT/FT FT/Ser/Ser FT/X/X0DAC 7DAC 14DAC

% disease severity

NL: trial number 13906 (2013)

F = 0,0125% Flint Ser = 8L/ha Serenade ASOT = 0,1% Teldor X = no application

0

0,5

1

1,5

2

2,5

3x FT FT/Ser/Ser FT/X/X1DAC 3DAC 7DAC 14DAC 21DAC

MRL fenhexamid = 1 mg/kg

MRL

mg/kg fenhexamid

50% MRL

30% MRL

mg/kg fenhexamid1. Demonstrate contribution of BLX on efficacy via “blank sprays”

2. Demonstrate ICS value proposition

reduction of residues

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1

0,45

0,22

0,33

0,94

0,33

0,13

0,82

0,67

0,54

0,110,15

0,93

0,51

0,16

0,39

0,5

0,3

0,090,15

0,54

0,28

0,08

0,32

0

0,2

0,4

0,6

0,8

1

1. T/T/T/S 2. T/T/S/S 3. T/S/S/S 4. T/S/T/S 5. S/T/T/T 6. S/T/T/S 7. S/T/S/S 8. S/T/S/T

1 Day after last applcation 7 days after last applcation 14 days after last applcation

Residues in mg/kg, MRL fenhexamid = 1 mg/kg

Show residue levelfenhexamid in protected tomatoes

MRL

50% MRL

30% MRL

T = TeldorS = Serenade

NL residue trial 2013

Demonstrate ICS value proposition

reduction of residues

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Show residue levelCalypso + Requiem in protected tomatoes

Residues in mg/kg, MRL thiacloprid = 0,5 mg/kg

0

0,1

0,2

0,3

0,4

0,5

1. C/C/C/R 2. C/C/R/R 3. C/R/R/R 4. C/R/C/R 5. R/C/C/C 6. R/C/C/R 7. R/C/R/R 8. R/C/R/C

1 Day after last applcation 7 days after last applcation 14 days after last applcation

C = CalypsoR = Requiem

MRL

50% MRL

30% MRL

NL residue trial 2013

Demonstrate ICS value proposition

reduction of residues

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Reduce losses / Increase efficiencyPeaches in Spain

-150

-100

-50

0

50

100

UTC Program w/oSerenade

Program w/ Serenade

100 100 100

-28-8

-85

-44

-10

Loss post-harvest

Loss at harvest

Total production for consumption

213 kg 152 kg 110 kg Production needed tomeet 100 kg of demand

47% 66% 91% Production Efficiency %

6 Days before harvest

Demonstrate ICS value proposition

Less post-harvest waste

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Untreated SERENADE95%

100%

105%

110%

115%

In-furrow applications of SERENADETM Fungicide increase yield

• Good disease control and positive

growth effects, best illustrated with

the control of Verticillium wilt

• Growth effects are observed

in root & plant size and yield

• Results are independent of

strawberry variety

• Application demonstrated crop

safety to all varieties tested

Performance and yield increaseStrawberries in the US (soil disease control)

Cen

tral C

A, G

row

er D

emos

201

4

root

&pl

ant s

ize

yiel

d

Sales

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-25%

-15%

-5%

5%

15%

25%

35%

45%

55%

65%

Soil disease control (Serenade SOIL)Potatoes in USA

9,5% yield improvement over standard (average)with yield improvement in 75% of the cases

Standards include Maxim, azoxystrobin, Ridomil, phosphite, PCNB, Monceren, Sportak, Tecto, Rizolex, Moncut and Ranman

% y

ield

vs.

sta

ndar

d

Sales

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Lasting control of bacterial spotRed pepper in Korea with Serenade MAX

0 1 2 3 4

0 1 2Long lasting efficacy on clayx was seen

Rating: Disease Area on calyx0 = No disease1 = Less than 5% 2 = 5.1% to 20 % 3 = 20.1 % to 50% 4 = Greater than 50%

Serenade MAX(x500)

Untreated

Sales

Demonstrate ICS value proposition Quality and yield

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Demonstrate the Value Proposition of ICSQuality & Profit - Potatoes in Turkey (Rhizoctonia solani, yield & quality)

Demonstrate ICS value proposition Quality and yield

Sales

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Services / Tailored advice

SUMMARY / GUIDELINE1. Understand unmet needs of farmers & value chain partners and define

the value proposition that addres the unmet needs2. Develop* an ICS based on the proposition an design trials accordingly3. Demonstrate/present/communicate the ICS trial results Then the pieces of the puzzle will begin to match

Chemical BiologicalTrait

Integrated Crop Solutions (ICS)

Seed

* preferably jointly with market partners like the Food value Chain

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Biologicals are key drivers for ICS

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Back up slides

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Integrated Solution for Disease ControlOSR – France (DuPont partnership)

Page 58

DRIVERS for use of co-pack with BALLADTM

1. Meet EcoPhyto 2018 (France) reduced chemical requirements2. Maintain disease control3. Maintain/improve yield

% Control - Disease Severity

Equivalent control with ½ rate of

chemical

Equivalent control with ½ rate of

chemical

104

106

108

110

112

114

116

118

120

122

124

ACANTO250gai

Ballad 2L ACANTO +Ballad

125gai+1L

% UTC

Yield

Equivalent yield with ½ rate of

chemical

• Serenade Update • December 2014

Sales

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Page 59 • Biologics - Why What How • September 12, 2015

or

orSwitch

DRIVERS for use of Contans1. Improved and long lasting performance by specific pre- and post-harvest

use of Contans and in-season use of Luna and Serenade2. Resistance management (alternation or mix with systemic chemistry)3. Enabling global trade (reducing residues)4. Reduce losses (in field & in storage)

Performance / Global tradeBeans in various countries (Botrytis & Sclerotinia control)

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Our Portfolio: Serenade™

Active: spores from the bacterium Bacillus subtilis strain QST 713 + natural anti-fungal, anti-bacterial and growth promoting chemistry

Crops: fruits, vegetables, potatoes, ornamentals, oilseed rape, pulses and various other broad acre crops

Registrations: in more than 35 countries worldwide

Pest / disease spectrum: broad spectrum efficacy on various fungi(e.g. Botrytis and Alternaria), bacteria, growth promoting & plant activating

Product category: prophylactic BioFungicide/Bactericide

“Mode of action”: disrupt the cell membrane of the pathogen resulting in a physical breakdown (FRAC 44)

Main formulations: WP (MAX and OPTI) and SC (ASO and SOIL)

Key benefits: very stable, broad spectrum product with foliar and soil contact/protectant activity, proven yield increase, no resistance risk, no residue, excellent root colonizer

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Our Portfolio: Requiem™

Active: blend of 3 natural plant-derived terpenes modeled after a plant extract of Chenopodium ambrosioides near ambrosioides

Crops: wide range of protected/glasshouse and field fruits and vegetables, potatoes, some row crops, plantations and ornamentals

Registrations*: USA, Mexico, Israel

Pest / disease spectrum: control of sucking pests, especially thrips, whiteflies, mites & aphids

Product category: knock down BioInsecticide

“Mode of action”: degrades the soft insect cuticle, disrupts insect mobility and respiration + anti-feeding properties + vapor activity

Main formulations: EC

Key benefits: knock down efficacy, non-specific MoA (no resistance), safe for beneficials,flexible use rates, multiple applications possible and flexible timing (now PHI and low REI)

*Status: February 2013

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Our Portfolio: BioAct™

Active: spores from the fungus Purpureocillium lilacinum strain PL 251 (synonym for Paecilomyces lilacinus)

Crops: banana, citrus, nuts, peach, grapevine, coffee, ornamentals, fruiting vegetables, carrots, peanuts, cotton, potato, tobacco, turf

Registrations*: in 14 countries worldwide

Pest spectrum: e.g. Meloidogyne, Pratylenchus, Heterodera, Radopholus, Globodera, Rotylenchulus, Tylenchulus

Product category: nematode control product

“Mode of action”: parasitism (feeding on body content) of all stages of common plant parasitic nematodes (esp. larvae and eggs)

Main Formulations: WG, WP, DC Liquid

Key benefits: Broad spectrum product for management of various nematodes(the only known nematicide with a direct effect on egg-stages) + yield increase

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Our Portfolio: Contans™WG

Active: Spores from the fungus Coniothyrium minitansstrain CON/M/91-08

Crops: Fruits & vegetables, oilseed rape, sunflower, pulses and various others

Registrations*: in more than 30 countries worldwide

Disease spectrum: Sclerotinia sclerotiorum, Sclerotinia minor and Sclerotinia trifoliorum

Product category: Fungicide

“Mode of action”: parasitism of mycelium and sclerotia of Sclerotinia spp.

Main formulations: WG

Key benefits: Reduces inoculum sources in the soil before it can cause disease; Lettuce: Best known control agent against Sclerotinia sclerotiorum