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Bioinformatics, Genomics &Libraries
Training: A Librarian’s Guide toNCBIApril 7-11, 2014Bethany Harris
NCBI :: National Center for BiotechnologyInformationNLM :: National Library of MedicineNIH :: National Institutes of Health
National Center for BiotechnologyInformation
• PubMed & over 40 biomedical and genomic databases andbioinformatics tools
Genomics
• Genome = complete set of an organism’s DNA
• DNA contains the information needed tobuild the entire humanbody
Genomics
• Every human cell contains approximately:– 3 billion DNA base pairs (A,T,C,G) [Alphabet]– 20,000 genes (special segments of DNA) [Words]– 250,000 to 1,000,000 proteins [Machines]
• Genes make proteins and other molecules thatbuild our body and make it function
Bioinformatics
• Applying computer and information sciencemethods to biological information
Problems & Possibilities
• Molecular basis of disease• Sequencing techniques and big data• Personalized medicine• Knowledge extraction from the literature
Knowledge extraction
Problems & Possibilities
“Educational reform is needed across the
continuum of medical education, from thestudent to the faculty training them, andrequires a shift in focus from factualknowledge to data management andinterpretation.”
- Nelson and McGuire, Genome Medicine, 2010, 2:18http://genomemedicine.com/content/2/3/18
Library roles
Enter the library:
– Experts in information management, navigation & dissemination– Example: PubMed analogy
Consumer health & genomicinformation service provider
Who:• Anyone with a reference or public
service role
What:• Internal consumer health and
genomic literacy training– Public and library resources
Why:• Become an informed health care
PubMed & Entrez search instructor
Who:• Health and life sciences liaisons What:• Instruction on searching and
navigating Entrez system– PubMed and numerous connections
to NCBI bioinformatics resources Why:• Promote enhanced usage of
Bioinformatics instructor
Who:• Health and life sciences liaisons
What:• Library or curriculum-based instruction on
bioinformatics tools– BLAST in undergraduate genetics or
translational science course
Why:• Enhance genomic literacy and teach useful
informatics skills• Relate course material to informatics in action