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A glimpse into the field of Bioinformatics
Kelly YoungNovember 15,2011
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Bioinformatics Statistical toolsHistory of
BioinformaticsApplicationsEthical/legal
considerations
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Bioinformatics DefinitionBioinformatics is the creation, development
and operation of databases and other computing tools to collect, organize, and interpret biological data in order to find solutions to biological problems.
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History of Bioinformatics1865:Father of Genetics: Gregor Mendel
discovers the concept of genetic inheritance1930: Electrophoresis introduced1953:Watson and Crick suggest double-helix
model for DNA1955:Bovine Insulin is first protein to be
sequenced1978: the term Bioinformatics first used
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History continued1984: FASTP algorithm program published1990: BLAST program published1994: PRINTS database published1995:First bacterial genomes sequenced2000: EMOTIF database released
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Statistical ToolsData Mining
platformsAlgorithmsDatabase
Management Systems
FASTA/BLAST
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ApplicationsUnderstanding normal biological processesUnderstanding abnormal biological processesPredicting gene expressionDrug discoveryAgricultureIncreases the speed at which research
information can be examined
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Human Genome ProjectBegan 1990Purpose: map the
entire human genome
Complete sequencing of human genome completed 2003
The Human Genome of one person fits on a flash drive
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DNA chipsDNA Chip Technolog
yTest drinking water
for multiple microbes at once
Potential to be able to predict gene expression in cancer, thus providing physician with best treatment option.
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Molecular EvolutionStudy of
evolutionary patterns of nucleic acids and proteins
Mutations: disease and adaptation
Look at the history of evolution to possibly predict the future of evolution
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Mycoplasma LaboratoriumCreated May 20,2010Synthesized from the genome of Mycoplasma
Myocoides (from a record on a computer)First species of bacteria to be genetically
designed by humans and a computer“Synthia”
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Genetically Modified FoodCell structures in many types of plants have
already been genetically modified to be heartier, stay fresh longer, and to produce a more sizable yield.
Insect and disease resistantFarmers lose much less of their crops
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Ethical and legal ConsiderationsWill there be copyright issues with
discoveries of new algorithms or technologies?
A law pertaining to the use of genetic information will probably be implemented.
Who is to stop anyone from creating a biological weapon with this technology?
Is creating synthetic organisms a good idea?How else will this technology be used in the
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AfterthoughtsWhat else can be done with this knowledge?Without all that has been discovered in this
remarkable field, where would medicine be today? Agriculture?
Bioinformatics has been sped up the process of studying biology
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Bibliography Richon, Allen B. "A Short History of
Bioinformatics." NetSci - Resources for Science in Drug Discovery. NetSci. Web. 14 Nov. 2011. http://netsci.org
"DNA Chip Technology." Welcome to Sumanas, Inc. Sumanas, 2008. Web. 15 Nov. 2011. <http://www.sumanasinc.com/webcontent/animations/content/dnachips.html>.
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