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a
ab
bc
c
0.00
0.25
0.50
0.75
1.00
Pref
eren
ce (m
ean
± se
m)
0.0 mg/kg 0.5 mg/kg 1.0 mg/kg 2.0 mg/kg
Dose of Sodium Selenate
Initial Magnitude of Selenate-Induced CTA
2.0 mg/kg1.0 mg/kg0.5 mg/kg0.0 mg/kg
0.00
0.25
0.50
0.75
1.00
Pref
eren
ce (m
ean
± se
m)
1 2 3 4 5 6 7 8 9 10 11 12 13 14
2-Bottle Test (Day)
Extinction of Selenate-Induced CTA
2.0 mg/kg1.0 mg/kg0.5 mg/kg0.0 mg/kg
0.00
0.25
0.50
0.75
1.00
Pref
eren
ce (m
edia
n ±
mse
)
1 2 3 4 5 6 7 8 9 10 11 12 13 14
2-Bottle Test (Day)
Extinction of Selenate-Induced CTA
Figure 1
aa
a a
b
0
25
50
75
100
c-Fo
s Ce
lls /
Sect
ion
0 mg/kg 0.5 mg/kg 1 mg/kg 2 mg/kg LiCl
Dose of Sodium Selenate
E. SON
aa
a
ab
b
0
75
150
225
300
c-Fo
s C
ells
/ Se
ctio
n
0 mg/kg 0.5 mg/kg 1 mg/kg 2 mg/kg LiCl
Dose of Sodium Selenate
D. PVN
a
ab
b
abab
0
125
250
375
500
c-Fo
s C
ells
/ Se
ctio
n
0 mg/kg 0.5 mg/kg 1 mg/kg 2 mg/kg LiCl
Dose of Sodium Selenate
C. CEA
a
aa
aa
0
50
100
150
200
c-Fo
s C
ells
/ Se
ctio
n
0 mg/kg 0.5 mg/kg 1 mg/kg 2 mg/kg LiCl
Dose of Sodium Selenate
B. PBN
0
25
50
75
100
c-Fo
s C
ells
/ Se
ctio
n
0 mg/kg 0.5 mg/kg 1 mg/kg 2 mg/kg LiCl
Dose of Sodium Selenate
A. NTS
Figure 2
Figure 3
Selenate-LiClNaCl-LiClSelenate-NaClNaCl-NaCl
0.00
0.25
0.50
0.75
1.00
Pref
eren
ce (m
ean
± se
m)
1 2 3 4 5 6 7 8 9 10 11 12 13 14
2-Bottle Test (Day)
Selenate Pre-Treatment Attenuates LiCl-Induced CTA
a a
b
abSelenate-LiClNaCl-LiClSelenate-NaClNaCl-NaCl
0.00
0.25
0.50
0.75
1.00
Pref
eren
ce (m
ean
± se
m)
NaCl-NaCl Selenate-NaCl NaCl-LiCl Selenate-LiCl
Selenate Attenuation: Initial Magnitude of LiCl-Induced CTA
Selenate-LiClNaCl-LiClSelenate-NaClNaCl-NaCl
0.00
0.25
0.50
0.75
1.00
Pref
eren
ce (m
edia
n ±
mse
)
1 2 3 4 5 6 7 8 9 10 11 12 13 14
2-Bottle Test (Day)
Selenate Pre-Treatment Attenuates LiCl-Induced CTA
