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BIBLIOGRAFIA Afeyan, N.B., Fulton, S.P., Gordon, N.F., Mazsaroff, I., Várady, L.,Regnier, F., 1990a. Perfusion chromatography. An approach to purifying biomolecules. Bio/Technology 8, 203–206. Afeyan, N.B., Gordon, N.F., Mazsaroff, I., Varaday, L., Fulton, S.P.,Yang, Y.B., Regnier, R.E., 1990b. Flow-through particles for highperformance liquid chromatographic separation of biomolecules: perfusion chromatography. Journal of Chromatography 519, 1–29. Arnold, F.H., Blanch, H.W., Wilke, C.R., 1985. Analysis of affinity separations II: the characterization of affinity columns by pulse techniques. The Chemical Engineering Journal 30, B25–B36. Athalye, A.M., Gibbs, S.J., Lightfoot, E.N., 1991. Predictability of chromatographic protein separations: study of size-exclusion media with narrow particle size distribution. Journal of Chromatography A 589, 71– 85. Bird, R.B., Stewart, W.E., Lightfoot, E.N., 1960. Transport Phenomena.Wiley, New York. (Chapter 6). Bosma, J.C., Wesselingh, J.A., 1998. pH dependence of ion-exchange equilibrium of proteins. A.I.Ch.E. Journal 44, 2399–2409. Carta, G., Rodrigues, A.E., 1993. Diffusion and convection in chromatographic process using permeable supports with a bidisperse pore structure. Chemical Engineering Science 23, 3927–3935. Carta, G., Ubiera, A., 2003. Particle-size distribution effects in batch adsorption. A.I.Ch.E. Journal 49, 3066–3073. Chen, J.L., Bai, S., Sun, Y., 2003. Rapid purification of molecular chaperonins by flowthrough chromatography with customized biporous anion exchanger. Chromatographia 58, 1–6. Chung, S.F., Wen, C.Y., 1968. Longitudinal dispersion of liquid flowing through fixed and fluidized beds. A.I.Ch.E. Journal 14, 857–866.de Ligny, C.L., 1970. Coupling between diffusion and convection inradial dispersion of matter by fluid flow though packed beds. Chemical Engineering Science 25, 1177. Finlayson, B.A., 1980. Nonlinear Analysis in Chemical Engineering. McGraw-Hill Inc., New York.Frey, D.D., Schweinheim, E., Horváth, C., 1993. Effect of intraparticle convection on the chromatography of biomacromolecules.Biotechnology Progress 9, 273–284.

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BIBLIOGRAFIA

Afeyan, N.B., Fulton, S.P., Gordon, N.F., Mazsaroff, I., Várady, L.,Regnier, F., 1990a. Perfusion chromatography. An approach to purifying biomolecules. Bio/Technology 8, 203–206.

Afeyan, N.B., Gordon, N.F., Mazsaroff, I., Varaday, L., Fulton, S.P.,Yang, Y.B., Regnier, R.E., 1990b. Flow-through particles for highperformance liquid chromatographic separation of biomolecules: perfusion chromatography. Journal of Chromatography 519, 1–29.

Arnold, F.H., Blanch, H.W., Wilke, C.R., 1985. Analysis of affinity separations II: the characterization of affinity columns by pulse techniques. The Chemical Engineering Journal 30, B25–B36.

Athalye, A.M., Gibbs, S.J., Lightfoot, E.N., 1991. Predictability of chromatographic protein separations: study of size-exclusion media with narrow particle size distribution. Journal of Chromatography A 589, 71–85.

Bird, R.B., Stewart, W.E., Lightfoot, E.N., 1960. Transport Phenomena.Wiley, New York. (Chapter 6).

Bosma, J.C., Wesselingh, J.A., 1998. pH dependence of ion-exchange equilibrium of proteins. A.I.Ch.E. Journal 44, 2399–2409.

Carta, G., Rodrigues, A.E., 1993. Diffusion and convection in chromatographic process using permeable supports with a bidisperse pore structure. Chemical Engineering Science 23, 3927–3935.

Carta, G., Ubiera, A., 2003. Particle-size distribution effects in batch adsorption. A.I.Ch.E. Journal 49, 3066–3073.

Chen, J.L., Bai, S., Sun, Y., 2003. Rapid purification of molecular chaperonins by flowthrough chromatography with customized biporous anion exchanger. Chromatographia 58, 1–6.

Chung, S.F., Wen, C.Y., 1968. Longitudinal dispersion of liquid flowing through fixed and fluidized beds. A.I.Ch.E. Journal 14, 857–866.de Ligny, C.L., 1970. Coupling between diffusion and convection inradial dispersion of matter by fluid flow though packed beds. Chemical Engineering Science 25, 1177.

Finlayson, B.A., 1980. Nonlinear Analysis in Chemical Engineering. McGraw-Hill Inc., New York.Frey, D.D., Schweinheim, E., Horváth, C., 1993. Effect of intraparticle convection on the chromatography of biomacromolecules.Biotechnology Progress 9, 273–284.

Gebauer, K.H., Thömmes, J., Kula, M.R., 1997. Breakthrough performance of high-capacity membrane adsorbers in protein chromatography.Chemical Engineering Science 52, 405–419.

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Heeter, G.A., Liapis, A.I., 1995. Perfusion chromatography: performance of periodic countercurrent column and its comparison with fixed-bed operation. Journal of Chromatography A 711, 3–21.

Kaczmarski, K., Antos, D., Sajonz, H., Sajonz, P., Guiochon, G., 2001.Comparative modeling of breakthrough curves of bovine serum albumin in anion-exchange chromatography. Journal of Chromatography A 925,1–17.

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Leitão, A., Rodrigues, A., 1999. Modeling and simulation of protein adsorption in permeable chromatographic packings: a double lineardriving force model. Biochemical Engineering Journal 3, 131–139.

Leitão, A., Li, M., Rodriogues, A., 2002. The role of intraparticle convection in protein adsorption by liquid chromatography using POROS 20 HQ/M particles. Biochemical Engineering Journal 11,33–48.

Li, W., Zhang, S.P., Sun, Y., 2004. Modeling of the linear-gradient dye–ligand affinity chromatography with a binary adsorption isotherm. Biochemical Engineering Journal 22, 63–70.

Liapis, A.I., McCoy, M.A., 1992. Theory of perfusion chromatography.Journal of Chromatography 599, 87–104.

Liapis, A.I., Xu, Y., Crosser, O.K., Tongta, A., 1995. “Perfusion chromatography”. The effect of intra-particle convective velocity anmicro-sphere size on column performance. Journal of Chromatography 702, 45–57.

McCoy, M., Kalghatgi, K., Regnier, F.E., Afeyan, N., 1996. Perfusion chromatography characterization of column packings for chromatography of proteins. Journal of Chromatography A 743,221–229.

Regnier, F.E., 2002. Perfusion chromatography. Nature 30, 634–635.Rendueles de la Vega, M.R., Chenou, C., Loureiro, J.M., Rodrigues, A.E.,1998. Mass transfer mechanism in Hyper D media for chromatographic protein separation. Biochemical Engineering Journal 1, 11–23.

Rodrigues, A.E., Lopes, J.C., Lu, Z.P., Loureiro, J.M., Dias, M.M.,1992. Importance of intraparticle convection in the performance of chromatographic processes. Journal of Chromatography 590, 93–100.

Shi, Y., Dong, X.-Y., Sun, Y., 2002. Development of rigid biporous polymeric adsorbent for protein chromatography. Chromatographia 55,405–410.

Skidmore, G.L., Horstmann, B.J., Chase, H.A., 1990. Modeling singlecomponent protein adsorption to the cation exchanger S Sepharose FF. Journal of Chromatography 498, 113–128.

Suen, S.-Y., Etzel, M.R., 1992. A mathematical analysis of affinity membrane bioseparations. Chemical Engineering Science 47,1355–1364.

Sun, G.-Y., Shi, Q.-H., Sun, Y., 2004. A novel biporous polymeric stationary phase for high speed protein chromatography. Journal of Chromatography A 1061, 159–165.

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Villadsen, J.V., Stewart, W.E., 1967. Solution of boundary-value problems by orthogonal collocation. Chemical Engineering Science 22,1483–1501.

Villadsen, J.V., Michelsen, M.L., 1978. Solution of Differential Equation Models by Polynomial Approximation. Prentice-Hall, Eaglewood Cliffs, NJ.Whitney, D., McCoy, M., Gorden, N., Afeyan, N., 1998. Characterization of large-pore polymeric supports for use in perfusion chromatography. Journal of Chromatography A 807, 165–184.

Wu, L., Bai, S., Sun, Y., 2003. Development of rigid bidisperse porous microspheres for high-speed protein chromatography. Biotechnology Progress 19, 1300–1306.

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Xu, Y., Liapis, A.I., 1996. Modeling and analysis of the elution stage of “perfusion chromatography”. Effect of intraparticle convective velocity and micro-sphere size on system performance. Journal of Chromatography A 724, 13–25.

Yang, H., Etzel, M.R., 2003. Evaluation of three kinetic equations in models of protein purification using ion-exchange membranes. Industrial & Engineering Chemistry Research 42, 890–896.

Zhang, S.P., Sun, Y., 2001. Further studies on the contribution of electrostatic and hydrophobic interactions to protein adsorbent on dye–ligand adsorbents. Biotechnology and Bioengineering 964, 35–46.

Zhang, S.P., Sun, Y., 2002a. Ionic strength dependence of protein adsorption to dye–ligand adsorbents. A.I.Ch.E. Journal 48, 178–186.

Zhang, S.P., Sun, Y., 2002b. Study on protein adsorption kinetics to dye–ligand adsorbent by the pore diffusion model. Journal of Chromatography A 964, 35–64.d

Steven C.Chapra, Metodos numéricos 21,619-640